口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究

目的 探讨口腔内幽门螺杆菌( Helicobacter pylori,Hp)感染与胃内Hp感染以及与牙周炎的关系. 方法 通过13 C尿素呼气试验检测法和幽门螺杆菌唾液测试法对120例有消化道症状的患者进行胃内和口腔内Hp的检测,并对患者进行牙周检查,分析口腔Hp感染与胃Hp感染的关系以及与牙周炎的关系. 结果 120例有消化道症状的患者中,胃Hp阳性患者口腔Hp的阳性率为87. 7%,胃Hp阴性患者口腔Hp的阳性率为42. 6%,两者差异有统计学意义(χ2 =27. 715,P<0. 001);牙周正常者、轻度牙周炎患者、中度牙周炎患者和重度牙周炎患者中口腔Hp感染的阳性率分别为45. 5%、55. 3%、81. 5%和82. 4%,差异有统计学意义(χ2 =11. 711,P<0. 01). 结论 口腔Hp感染与胃Hp感染密切相关,可能是胃Hp感染的来源;口腔Hp感染也与牙周炎的严重程度相关.     

口腔扁平苔藓患者幽门螺杆菌感染状况分析

目的 分析口腔扁平苔藓患者幽门螺杆菌感染状况,探索口腔扁平苔藓与幽门螺杆菌感染的相关性.方法 收集口腔扁平苔藓患者(扁平苔藓组)69例和口腔黏膜慢性炎症患者(慢性炎症组)28例,在初诊时进行14C-尿素呼气试验,其中32例患者(扁平苔藓组23例,慢性炎症组9例)同时检测血清抗幽门螺杆菌(Helicobacter pylori,Hp)抗体.结果 扁平苔藓组14C-尿素呼气试验阳性率为68.12%,慢性炎症组14C-尿素呼气试验阳性率为46.43%,扁平苔藓组高于慢性炎症组,差异有统计学意义(x2=3.970,P=0.046).23例口腔扁平苔藓患者中抗Hp抗体阳性检出率为52.17%,9例口腔黏膜慢性炎症患者Hp抗体阳性检出率为22.22%,差异无统计学意义(x2=2.358,P=0.125).结论 口腔扁平苔藓患者幽门螺杆菌感染率较高,口腔扁平苔藓与幽门螺杆菌感染可能有关.     

幽门螺杆菌感染与口臭的相关性探讨

目的：探讨幽门螺杆菌感染与口臭的相关性。方法：采用鼻嗅法对27例消化科已证实幽门螺杆菌感染者进行口臭值的检测及用^14C尿素呼吸试验仪对口腔科30例口臭者进行有无幽门螺杆菌感染的检测。被检者牙体、牙周基本健康，无鼻咽部疾病及严重肝功能不全、无糖尿病。结果：27例幽门螺杆菌感染者的口臭检测率为93％。30例口臭者的幽门螺杆菌感染率为90％。结论：幽门螺杆菌感染与口臭可能有较大的相关性，是引起顽固性口臭的一大原因。     

236例牙周炎幽门螺杆菌检测结果分析

目的 :证明牙周炎患者的牙龈液及牙周袋渗出物中有HP感染。方法 :对 2 36例牙周炎患者用消毒刮匙采集龈沟液作快速尿素酶试验。结果 :幽门螺杆菌检出的总阳性率为61.02 % ,轻度牙周炎者阳性率为 34.12 % ,中度牙周炎者阳性率为 72.72 % ,重度牙周炎者的阳性率为85.34%。结论 :牙周炎患者的龈沟液有HP的存在 ,HP的感染与牙周炎有直接关系 ,而且与炎症的程度和活动性呈正相关。     

检测牙周组织幽门螺杆菌尿素酶的结果分析

幽门螺杆菌 (ＨＰ)与慢性胃炎及消化性溃疡密切相关。近来不断有学者提出ＨＰ与牙周炎的发病有关 ,本文通过对 112例拔牙患者牙周组织ＨＰ检测 ,旨在进一步证实牙周组织中是否是ＨＰ存在及ＨＰ与牙周炎的关系。1　临床资料和方法1.1　临床资料本组共 112例均为门诊拔牙患者 ,其中男性 6 2人 ,女性 49人 ,年龄 17～ 6 5岁 ,平均 48岁。 6 2例为牙周炎患者 ,5 0例为牙周组织健康者。1.2　材料与方法采用珠海珠信生物工程制品有限公司生产的 1ｍｉｎ快速型胃幽门螺杆菌检测试纸。拔除牙为牙周炎者 ,切取少量牙周袋壁或袋底组织 ,拔除牙为牙周健…     

唾液测试板检测口腔幽门螺杆菌的实用性研究

目的探讨幽门螺杆菌唾液测试板（HPS）与碳-13尿素呼气试验（13C-UBT）检测口腔幽门螺杆菌的相关性及其诊断的特异性及灵敏性。方法选择13C-UBT检测阳性者106例和13C-UBT检测阴性者24例,共130例研究对象,采用HPS法进行口腔幽门螺杆菌检测。以13C-UBT为金标准,对HPS法检测结果用贝叶斯定理方法进行评价。结果HPS的灵敏度为68.87%,特异度为58.33%,准确度为66.92%,阳性预测值为87.95%,阴性预测值为29.79%。二者的符合率为66.92%。结论HPS法与13C-UBT法的检测结果具有一定的相关性,13C-UBT法对口腔幽门螺杆菌检测存在盲区,不适用于作为评价口腔幽门螺杆菌检测方法HPS的金标准。HPS法与13C-UBT法可临床上同步使用。     

幽门螺杆菌感染与胃肠道和口腔疾病的相关性研究

目的：研究幽门螺杆菌（Helicobacterpylori,Hp）感染与胃肠道疾病和口腔疾病的相关性。方法：采用尿素（14C）呼气试验检测11788例体检者,第1组5410例胃肠道疾病组,第2组4312例口腔疾病组,第3组2066例健康组,分别比较Hp感染率,观察其相关性。结果：在11788例中胃Hp感染率为58.53%,第1组和第2组中Hp感染率均高于第3组,差异有统计学意义（P〈0.01）。结论：Hp感染与胃肠道疾病和口腔疾病密切相关。     

牙周健康状况与胃幽门螺杆菌感染相关性的研究

目的探讨牙周健康状况与胃幽门螺杆菌感染率及感染程度的关系。方法通过13C尿素呼气试验（13C-urea breath test,13C-UBT）法检测牙周炎患者胃幽门螺杆菌感染程度,记录牙周健康状况,统计学分析两者之间的相关性。结果 84名患者中幽门螺杆菌感染阳性32名（38.1%）,阴性52名（61.9%）,两组间平均牙龈退缩差异有统计学意义（Z=1.978,P=0.048）;13C-UBT检测结果超基准值（delta over baseline,DOB）与平均牙周袋深度的相关系数r=0.413,两者间有正相关关系（P=0.019）。DOB值与平均牙龈退缩的相关系数r=-0.011（P=0.952）,与平均牙周附着丧失的相关系数r=0.299（P=0.096）。结论胃幽门螺杆菌感染与牙周炎患者的牙周破坏程度关系密切,牙周炎患者的牙周炎严重程度可能与胃幽门螺杆菌数量或菌株类型密切相关。     

幽门螺杆菌与口腔扁平苔藓关系的探讨

目的探讨HP与OLP之间的关系方法对50例口腔扁平苔藓OLP分组作幽门螺杆菌检测一组采用快速尿素酶试验12例HP检出率83.33%二组14C一尿素呼吸试验21例HP检出率61.90%三组HP抗体金标快速检测17例HP检出率76.47%结果50例OLP中HP阳性为36例其中伴有粘膜充血、糜烂或牙龈上皮剥脱、红亮者22例HP检出率为100%结论我们认为HP与OLP之间存在着密切关系     

口腔幽门螺杆菌与胃幽门螺杆菌感染关系的研究进展

幽门螺杆菌是人类最常见的致病菌之一,它与胃部疾病密切相关。要防治幽门螺杆菌,了解其传播过程是必不可少的,而口腔幽门螺杆菌可能在幽门螺杆菌传播的过程中起到重要的作用。本文对近年来口腔幽门螺杆菌在幽门螺杆菌传播、诊断和预防方面所起的作用和目前研究所遇到的难点,以及口腔幽门螺杆菌与口腔疾病的关系等方面的研究新进展进行综述。     

应用漱口液对根治幽门螺杆菌的疗效

目的 :了解漱口液根除口腔内幽门螺杆菌的疗效。方法 :98例胃粘膜幽门螺杆菌阳性的患者随机分为两组 ,A组与B组。两组幽门螺杆菌阳性率相同。两组均采用奥美拉唑、阿莫西林和甲硝唑口服 ,A组另以漱口液 (阿莫西林、甲硝唑 )漱口 ,每日 3次 ,治疗 2周。治疗前后均取牙菌斑、唾液及胃粘膜标本作幽门螺杆菌培养。结果 :A组胃粘膜标本治疗前 5 1例阳性 ,治疗后仅 3例阳性 ,口腔HP治疗前 2 3例阳性 ,治疗后 3例阳性。B组胃粘膜标本治疗前 4 7阳性 ,治疗后仅 2例阳性 ,口腔HP治疗前 2 1例阳性 ,治疗后 18例阳性。胃粘膜HP转阴率两组之间无显著差异 (p >0 0 5 ) ,而口腔HP转阴率两组之间有极为显著的差异 (p<0 0 0 1)。结论 :采用漱口液治疗口腔中幽门螺杆菌可能具有根治幽门螺杆菌的作用。     

Detection of Helicobacter pylori in oral aphthous ulcers

A causative role for Helicobacter pylori (H. pylori) in the pathogenesis of oral mucosal ulcerations has been suggested previously. We have adopted the polymerase chain reaction (PCR) as a rapid and sensitive means to detect H. pylori in swabs of recurrent oral aphthous ulcers and in samples of other oral sites. Of the oral aphthous ulcer samples, 32 (71.8%) were found to be positive, while the saliva and plaque samples (most of them taken from the patients with aphthous ulcers) were consistently negative for H. pylori DNA, as detected by the PCR assay. Only two of the swab samples from the tongue (collected at the time of concurrent, H. pylori-positive oral aphthous ulcers) were found to be positive. The data suggest that H. pylori may be associated frequently with recurrent oral aphthous ulcers, and are consistent with previous studies indicating that saliva and plaque are not likely sources of contamination with this microorganism. There was no apparent correlation with HIV status (infection with human immunodeficiency virus). The possible pathogenic significance of Helicobacter pylori in oral ulcerations is discussed.     

Oral cavity is not a reservoir for Helicobacter pylori in infected patients with functional dyspepsia

Introduction:  Helicobacter pylori infection is very prevalent in Brazil, infecting almost 65% of the population. The aim of this study was to evaluate the presence of this bacterium in the oral cavity of patients with functional dyspepsia (epigastric pain syndrome), establish the main sites of infection in the mouth, and assess the frequency of cag A and vac A genotypes of oral H. pylori .
Methods:  All 43 outpatients with epigastric pain syndrome, who entered the study, were submitted to upper gastrointestinal endoscopy to rule out organic diseases. Helicobacter pylori infection in the stomach was confirmed by a rapid urease test and urea breath tests. Samples of saliva, the tongue dorsum and supragingival dental plaque were collected from the oral cavity of each subject and subgingival dental plaque samples were collected from the patients with periodontitis; H. pylori infection was verified by polymerase chain reaction using primers that amplify the DNA sequence of a species-specific antigen present in all H. pylori strains; primers that amplify a region of urease gene, and primers for cagA and vacA (m1, m2, s1a, s1b, s2) genotyping.
Results:  Thirty patients harbored H. pylori in the stomach, but it was not possible to detect H. pylori in any oral samples using P1/P2 and Urease A/B. The genotype cagA was also negative in all samples and vacA genotype could not be characterized (s-m-).
Conclusion:  The oral cavity may not be a reservoir for H. pylori in patients with epigastric pain syndrome, the bacterium being detected exclusively in the stomach.     

Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR)

Mravak-Stipetic M, Gall-Troselj K, Lukac J, Kusic Z, Pavelic K, Pavelic J: Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR). J Oral Pathol Med 1998; 27: 1–3. © Munksgaard, 1998.
Nested PCR was used for the detection of Helicobacter pylori DNA in specimens collected from seven different topographic sites in the oral cavity. Out of 161 patients, only 21 (13.04%) were positive. There was no correlation between H. pylori status and patient diagnosis and age. No preferential site for bacterial colonization was found in the oral cavity, nor was an association established between a bacterial presence and ulcerated versus non-ulcerated lesions. The results indicate that the oral mucosa does not appear to represent a preferred site of colonization for H. pylori. Furthermore, the evidence presented in this paper suggests that H. pylori is not pathogenic in the oral cavity, nor is it associated with common oral pathologic processes.     

胃幽门螺杆菌感染与口臭关系的初步研究

目的：探讨胃幽门螺杆菌感染与口臭的关系。方法：选择无牙周疾病和全身疾病（上消化道疾病除外）的受试者50例．在胃镜检查或呼气试验前进行口臭测试及口腔相关指标检查,然后进行胃镜活检和呼气试验检测胃内幽门螺杆菌感染情况。使用SPSS11．5对数据进行统计学分析。结果：50例受试者经鼻测法测试有口臭28例,无口臭22例。各项牙周指标表明,受试者均牙周健康。χ^2检验表明,有、无口臭的受试者中,幽门螺杆菌的阳性率分别为57．1％和18．2％．差异具有统计学意义（P〈0．01）。Logistic回归方程显示,胃内幽门螺杆菌感染是方程中唯一有统计学意义的变量（P〈0．05）。结论：幽门螺杆菌可能与牙周健康者的口臭有关。     

HeliprobeTm与鼻闻法测量氨性口臭的相关性

目的 :比较HeliprobeTm与鼻闻法测量氨性口臭的相关性。方法 :用鼻闻法测量 33名受试者 ,并与用HeliprobeTm 测量的结果作相关性分析。结果 :以鼻闻法和HeliprobeTm 测量的结果呈显著性相关 ,r=0 .911 (P <0 .0 0 1)。结论 :HeliprobeTm测量法可准确表达氨性口臭的程度 ,为临床诊治氨性口臭提供可靠的参考依据。