Cortical deafness following head injury —a case report

Cortical deafness is a rare entity. Only few case reports are available. In this paper, a case of right fronto-temporal contusion following head injury causing bilateral cortical deafness has been reported. Most of the cases reported in the past were because of cerebral infarcts due to arterial occlusion.     

Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behcet's disease

Chronic myeloid leukemia (CML) is a myeloproliferative disease arising from abnormal stem cells and associated with splenomegaly and leukocytosis. Hydroxyurea and interferon alpha are used in treatment very frequently. Behcet's disease (BD) is a chronic, repetitive disease of unknown etiology and associated with mucocutaneous, ocular, vascular and central nervous system involvement. Cases with symptoms of BD have been reported during interferon alpha treatment of CML. However, similar symptoms due to hydroxyurea treatment have been reported in only one case until now. A 32-year-old female patient under follow up because of CML and BD, developed a large genital ulcer during hydroxyurea treatment. Ulcers due to hydroxyurea treatment and the co-existence of these two diseases has been reported in only one case in the literature while large genital ulcers have not been reported previously.     

Malignant melanotic schwannoma of maxilla

Malignant schwannoma in the naso-maxillary region is very rare. Only 20 eases have been reported in the literature (Maheshwari et al 99) Melanotic variety of this tumor is extremely rare and only 4 cases have been found in internet search. Surgery followed by radiotherapy has been advocated for treatment. A case is reported involving maxilla in a 13 year old female patient because of its extreme rarity. The case was treated by surgery and showed no recurrence during a 3 year follow-up period.     

Olfactory neuroblastoma

About 160 well established cases of olfactory neuroblastomas have been reported in world literature upto 1975. It is because of the rarity of this lesion, that the present case of Olfactory Neuroblastoma is being reported.     

B-cell leukemia in a rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus

Conditions associated with abnormal B-cell proliferation have an increased incidence in the HIV-infected population. A longitudinal study conducted at the Tulane Regional Primate Research Center has followed more than 1,000 rhesus macaques infected with simian-immunodeficiency virus (SIV) since 1984. While spontaneous B-cell malignancy in SIV-negative macaques has not been reported, 42 cases of SIV-associated-lymphoma (SAL) have been documented in this cohort. Recently we identified a single case of B-cell leukemia, first suggested by clinical abnormalities and confirmed and further characterized by molecular analysis. The case is important because it models the occurrence of B-cell leukemia in the human AIDS patient and because it extends our understanding of the B-cell lymphoproliferative diseases associated with AIDS.     

A case of esophageal stricture due to metastatic breast cancer diagnosed by endoscopic mucosal resection

Metastasis of breast cancer to the esophagus has been reported but is rare. It is often difficult to diagnose metastases of breast cancer to the esophagus because they are often located in the submucosa and covered with normal mucosa. Although several methods have been reported in order to obtain specimens for pathological diagnosis, the adverse effects including bleeding and perforation were considerable problems. We report a case of a patient with esophageal stricture due to metastatic breast cancer to the esophagus. Pathological diagnosis was successfully obtained using endoscopic mucosal resection of the esophagus.     

Acute liver failure because of chronic lymphocytic leukemia: case report and review of the literature

Infiltration of the liver by hematologic malignancies is an uncommon cause of liver failure. B-Cell chronic lymphocytic leukemia (cll) is a usually indolent disease that may infiltrate the liver, but based on a review of the literature, has never been reported to induce acute liver failure. Here, we describe the case of a 78-year-old woman with acute liver failure secondary to infiltration with cll being unresponsive to chemotherapy and causing death. This case is notable because of its atypical presentation and ultimate poor prognosis.     

Bilateral lipoma arborescens of the subdeltoid bursa

Lipoma arborescens is a rare cause of chronic monoarticular arthritis. It is most commonly seen in the knees, but only a few cases involving other joints, especially the subdeltoid bursa, have been described. To our knowledge, this is the first reported case of lipoma arborescens involving bilateral subdeltoid bursae. Although it is associated with joint effusion, synovial cysts and erosions, the presence of reactive bone formation has not been reported. Magnetic resonance imaging is a very effective method for the diagnosis of this rare condition because of its ability to do tissue characterization.     

Pineal Ganglioneuroblastoma in an Adult

A 57-year-old male with pineal ganglioneuroblastoma was reported. The tumor was composed of a predominant ganglioneuromatous component and a small neuroblastic component. Primary ganglioneuroblastoma of the pineal region is extremely rare. To our knowledge, only three cases have been documented. This case may have a good prognosis because there is a predominant ganglioneuromatous component defined by both neurofilament triplet proteins and synaptophysin. The clinical significance of the neuronal differentiation in the present case and pathological considerations are discussed.     

A case of retrocecal appendicitis occurrence during effective chemotherapy in lung cancer

Reported is the case of 61-year-old male patient who developed an abscess, secondary to a ruptured retrocecal appendicitis, while undergoing effective chemotherapy for lung cancer. Patients undergoing cancer chemotherapy are especially susceptible to infectious complications because chemotherapy can cause myelosuppression. To our knowledge, has been no previous reported case of retrocecal appendicitis occurring during chemotherapy for the lung cancer. Retrocecal appendicitis is a dangerous form of complication occurring in patients being treated with chemotherapeutic drugs.     

A case of epithelioid sarcoma arising in the vulva

Epithelioid sarcoma of vulva is extremely rare. Only 20 cases have been reported in the literature so far. Early diagnosis is difficult because of its benign appearance as a painless subcutaneous nodule. Therefore treatment can be delayed, although epithelioid sarcoma requires prompt surgery. We report a case of epithelioid sarcoma that occurred in the left vulva with a brief review of literature.     

Mucocutaneous Leishmaniasis

Mucocutaneous Leishmaniasis is considered to be a disease of the New World. It has not been reported from India. This case report presents a 48 year old male, a cattle businessman, with mucocutaneous involvement of mouth of six months duration. The lesion was confirmed by microbiology and histopathology examination. The patient is undergoing treatment with Dapsone and Rifampicin with good results. The case is important from a diagnostic point of view as well, because of its resemblance to a malignant lesion. The lesion can also be mistaken for Hansen’s disease especially if nose is involved, the treatment of which is also the same.     

Chondroid syringoma-scalp. A case report

A case of chondroid syringoma of scalp is reported. The case is of particular interest because of repeated recurrence with bone and dural infiltration.     

Molecular genetic and immunohistochemical analyses of a case of multicentric Castleman's disease

Whether Castleman's disease is primarily hyperplastic or neoplastic in nature is a matter of controversy; however, the classical localized form has been thought clinically benign in itself, because it can be cured by local therapy. Recently, a multicentric form of the disease has been reported and has received attention because of its aggressive clinical course and high incidence of developing malignant lymphoma. Here, we describe a case of multicentric Castleman's disease which occurred in a 24-year-old Japanese man. To ascertain whether a monoclonal population was present or not, we performed a molecular genetic analysis of the genes encoding the T-cell receptor and the immunoglobulin, as well as a conventional immunohistochemical analysis. Using these sensitive methods, no monoclonal population could be found. The findings suggest that our case represents a reactive rather than a neoplastic disorder.     

A malignant Leydig cell tumour associated with testicular trauma and prostatic carcinoma

A case of metastatic Leydig cell carcinoma without sex hormone overproduction is reported. The patient had had a prior testicular contusion trauma on the same side after which the testicle had been swollen and firm. The possible aetiological role of extreme trauma is discussed. Radical orchidectomy is recommended for large tumours because of the difficulty in predicting malignant potential, and routine follow-up with retroperitoneal ultrasound scanning for 10 years in all cases.     

Squamous cell carcinoma of the renal pelvis associated with giant hydronephrosis--report of an autopsy case

An autopsy case of squamous cell carcinoma of the renal pelvis associated with giant hydronephrosis, which is the fourth case in the Japanese literature, is reported. A 37-year-old man, who had been found to have a left abdominal mass was admitted because of dyspnea and lumbar pain. At autopsy the left kidney contained 2,550 ml of turbid yellowish fluid in the pelvis, with a tumor protruding from the cystic wall. Histologically, the tumor was mostly composed of squamous cell carcinoma, which showed keratinization and pearl formation, with focal transitional cell carcinoma and squamous metaplasia. The ureteropelvic junction was slightly obstructed by muscular hypertrophy and fibrosis.     

多发性甲状旁腺瘤一例和胸骨后异位甲状旁腺瘤一例报道(英文)

It is difficult to diagnose primary hyperparathyroidism because of its variable symptoms and limited understandingof doctors. We reported one case of double parathyroid adenomas and one case of ectopic mediastinal parathyroid adenoma.Serum calcium and parathyroid hormone (PTH) was screened. 99mTc sestamibi scintigraphy single photon emission computedtomography (SPECT) had been taken to find the parathyroid adenoma. Combined with ultrasonography or CT, we localizedparathyroid adenomas precisely. After the operation, both patients developed hypocalcaemia, they were treated medically,and followed up.     

A case of oral erosive candidosis in a kidney transplant patient

A case of oral erosive candidosis due to Candida albicans in a 64-year-old female patient, who had undergone kidney transplant 20 days earlier, is reported. Concomitant herpes infection was excluded. The patient achieved clinical and mycological recovery after treatment with topical and systemic antimycotics (200 mg fluconazole per day) for 50 days. The case is reported because of the erosive ulcerating aspect and extent of the lesions, usually only reported in immunodepressed subjects, especially those with neutropenia or AIDS.     

A case of asbestos exposure complicated by a malignant pheochromocytoma

Reported is a case of non-functioning malignant pheochromocytoma. The patient had an occupational history of asbestos exposure and pleural plaque was seen in the chest X-rays. The tumor appeared from right adrenal gland and its size was 12 x 15 cm, which was measured by CT scanning. This determined to be non functioning because catecholamines in the serum and VMA in the urine were within normal limits. A metastasis of this tumor was seen in the lung, the liver, and the bone. So far as is known, this is the first case of asbestos exposure complicated with malignant pheochromocytoma that has been reported in the Japanese literature.     

Multiseptate gall-bladder: Incidental diagnosis on ultrasound

Multiseptate gall-bladder is a very rare congenital condition, and fewer than 30 cases are reported in the literature. Most patients are female adults though it can occur in children and men. Although usually symptomatic, a case is described of a patient diagnosed incidentally on ultrasound. In the former group it is important to recognize because cholecystectomy is curative. Biliary calculi are usually absent in multiseptate gall-bladder while choledochal cysts have been associated.