Q开关Nd:YAG激光治疗雀斑样痣疗效观察

目的:评价波光为532 nm的Q开关Nd:YAG激光对单纯性雀斑样痣的疗效。方法:用Q开关Nd:YAG激光(532 mn,光斑直径2-3 mm,频率5 Hz)治疗26例单纯性雀斑样痣患者,治疗前后相对比进行评价,并观察不良反应。结果:26例患者治疗1-3次,治疗间隔为2-3月。基本治愈率为50%,有效率为61.5%。结论:单纯性雀斑样痣患者用Q开关532 nm Nd:YAG激光安全而有效。     

强脉冲光和调Q倍频Nd-YAG激光治疗面部雀斑的疗效比较

目的:探讨治疗雀斑的有效方法。方法:随机将67例雀斑患者分为2组。A组采用强脉冲光(IPL)治疗;B组采用调Q倍频Nd-YAG 532 nm激光治疗。观察两组患者的平均治疗次数。治疗结束随访24个月,每3个月复诊1次,观察两组的复发率及末次回访时患者的满意度调查。结果:两组的平均治疗次数分别为3.81次和1.77次,两组的复发率分别为47%和26%,两组的平均治疗次数及复发率比较差异均有统计学意义(P均0.05),两组的总满意率分别为84%和91%。结论:雀斑的临床治疗中调Q倍频Nd-YAG532 nm激光较IPL疗效更为确切,远期效果更优。     

调Q—Nd：YAG激光治疗雀斑260例临床疗效观察

目的通过应用调Q—Nd：YAG激光仪观察治疗雀斑的临床治疗效果。方法应用调Q—Nd：YAG激光仪，波长532nm，脉宽4ms，能量密度7J／cm^2。结果通过对260例雀斑患者的治疗总有效率98．8％。结论调Q—Nd：YAG激光仪532nm波长对雀斑治疗准确有效。     

Q开关Nd：YAG激光治疗雀斑样痣疗效观察

目的 评价Q开关Nd：YAG激光对单纯性雀斑样痣的疗效。方法 用Q开关Nd：YAG激光(532nm，光斑直径2～3mm，频率5Hz)治疗26例单纯性雀斑样痣患者，治疗前后相对比进行评价，并观察不良反应。结果 26例患者治疗1～3次，治疗间隔为2～3个月。有效率为76．92％，痊愈率为50％。结论 单纯性雀斑样痣患者用Q开关Nd：YAG激光安全而有效。     

Q开关Nd:YAG激光1064nm联合532nm波长治疗颧部褐青色痣临床观察

目的 观察Q开关Nd:YAG激光1064 nm联合532 nm波长治疗颧部褐青色痣的临床疗效及不良反应.方法 应用Q开关Nd:YAG激光1064 nm联合532 nm波长治疗70例患者,开始选择波长为1064 nm,光斑直径3～4 mm,能量密度3.5 ～ 4.5 J/cm2,频率10 Hz,脉宽10 ns.之后对某些疗效不佳且色素较浅层患者改用或交替选择532 nm波长,光斑直径3～4 mm,能量密度1.5～2.0 J/cm2,频率1～5Hz.治疗间隔时间为2～3个月,一般治疗3～4次.结果 治疗4次后治疗组有效率为100％,痊愈率为75.00％,疗效与治疗次数呈正相关.36例(51.43％)患者出现色素沉着,12例(17.14％)出现暂时性色素减退.结论 Q开关Nd: YAG激光1064 nm联合532 nm波长治疗颧部褐青色痣效果满意,虽然术后色素沉着发生率较高,但均能随时间逐渐消退,未见其他不良反应及并发症.     

Q开关Nd:YAG激光非损伤嫩肤的小鼠动物实验研究

目的:评估Q开关Nd:YAG激光非损伤嫩肤后小鼠真皮胶原蛋白含量的变化,为临床治疗提供理论依据。方法:采用532nm,1064nm的Q开关Nd:YAG激光;对32只小鼠随机分为4组,1组对照组,3组实验组。分别用532nm、1064nm以及这两种波长激光联合各照射5次,间隔7天。免疫组化技术检测32只小鼠真皮中Ⅰ和Ⅲ型胶原蛋白含量,HE染色测定真皮胶原纤维的厚度。结果:(1)胶原纤维的厚度及Ⅰ和Ⅲ型胶原蛋白的含量均比对照组高(P<0.01);(2)532nm组的胶原纤维的厚度及Ⅰ和Ⅲ型胶原蛋白的含量均比1064nm组高(P<0.01);两种波长联合的胶原纤维的厚度及Ⅰ和Ⅲ型胶原蛋白的含量均比532nm组和1064nm组高(P<0.01)。结论:532nm、1064nm以及这两种波长的激光联合照射是有效的嫩肤方法,532nm优于1064nm,两种波长联合优于单用一种波长。     

Q开关1 064nm激光联合光子嫩肤治疗黄褐斑效果观察

目的 探讨Q开关1 064nm激光联合光子嫩肤治疗黄褐斑的美容效果.方法 采用随机数字表法将在某医院2018年1月至2019年1月就诊的80例黄褐斑患者分为两组,各40例.对照组采用光子嫩肤治疗,观察组采用Q开关1 064nm激光联合光子嫩肤治疗,比较两组临床疗效、美容效果.结果 观察组治疗总有效率为92.50％,高于...     

DPL精准光治疗雀斑疗效分析

 目的:探讨DPL精准光治疗雀斑的疗效和安全性。方法：采用DPL550 nm精准光治疗雀斑40例，能量密度8~10.6 J/cm2，脉宽：12 ms，频率：1 Hz。治疗结束1个月后复诊，皮损未痊愈者再次治疗。观察治疗疗效并调查患者满意度。结果：采用DPL550 nm精准光治疗雀斑，1次治疗痊愈率为67.50%（27/40），2次治疗痊愈率76.92%（10/13），3次治疗痊愈率66.67%（2/3），总痊愈率97.50%(39/40)，总有效率为100%。首次治疗后总满意度为87.50%。治疗后无患者出现瘢痕、色素沉着或色素减退，随访1年2例复发。结论：DPL550 nm精准光治疗雀斑临床疗效好，所需治疗次数少，安全性高，值得临床推广应用。     

调Q-Nd:YAG激光及强脉冲光治疗面部雀斑的临床研究

目的比较调Q-Nd:YAG激光倍频532nm波长和强脉冲光560~1 200nm波长治疗面部雀斑的疗效,随访观察两种方法治疗后的复发情况。方法将197例面部雀斑患者随机分为两组,调Q-Nd:YAG激光倍频532nm波长组84例和强脉冲光(IPL)560~1 200nm波长组113例。两组均治疗1~3次,每次间隔时间4~8周。治疗结束后1~3个月判定临床疗效及不良反应。治疗结束后每6个月随访患者的复发时间及复发程度,两组共随访123例。结果调Q-Nd:YAG激光倍频532nm波长组治愈67例(79.76%),平均治愈次数1.33次,复发16例(33.33%),平均复发时间2.25年;IPL560~1 200nm波长组治愈40例(35.40%),平均治愈次数2.15次,复发44例(58.67%),平均复发时间1.36年。两组治愈率和复发率比较,差异有显著性(P均<0.001)。结论Q-Nd:YAG激光532nm治疗面部雀斑较IPL560~1 200nm治愈率高,复发率低,复发时间长。     

Q开关Nd:YAG激光治疗色素增加性皮肤病疗效分析

目的观察Q开关Nd:YAG激光治疗色素增加性皮肤病的临床疗效及治疗次数、间隔时间以及安全性。方法用Q开关Nd:YAG激光(1 064 nm,532 nm波长)治疗570例色素增加性皮肤病,观察、分析其疗效。结果 Q开关Nd:YAG激光治疗色素增加性皮肤病均有效。其中老年斑、雀斑、蓝黑纹身、雀斑样痣、褐青色痣、太田痣总有效率均达87.14%以上。黄褐斑总有效率为85.20%。咖啡斑、炎症后色素沉着总有效率分别为65.00%及60.00%。毛表皮痣总有效率为30.00%。痊愈率由高到低依次为老年斑、雀斑、雀斑样痣、蓝黑纹身、褐青色痣、太田痣、黄褐斑、咖啡斑、炎症后色素沉着、毛表皮痣。治疗次数1～13次,间隔时间1周～半年。临床疗效与治疗次数呈正相关,不良反应少。结论Q开关Nd:YAG激光治疗色素增加性皮肤病的疗效显著,安全性较好。毛表皮痣治疗效果相对较差。     

调Q Nd:YAG激光联合局部用药治疗扁平疣疗效观察

目的观察调Q Nd:YAG激光联合维A酸乳膏和重组人干扰素α-2b凝胶治疗扁平疣的疗效。方法将70例扁平疣患者随机分为两组,实际完成疗程67例,A组34例,B组33例,两组均予调Q Nd:YAG激光532nm波长治疗1～4次,每次间隔2周。A组采用调Q Nd:YAG激光治疗痂脱落后外用0.1%维A酸乳膏,每晚1次;白天外用重组人干扰素α-2b凝胶,4次/d,共4周。B组单采用调Q Nd:YAG激光治疗。结果 A组治愈率(94.12%)、有效率(97.06%)、复发率(6.25%)与B组治愈率(69.70%)、有效率(75.76%)、复发率(30.43%)相比,差异均有统计学意义(P均<0.05)。结论调QNd:YAG激光联合维A酸乳膏和重组人干扰素α-2b凝胶治疗扁平疣安全性高,治愈率高,复发率低。     

窄谱强脉冲光联合长脉冲1 064 nm Nd∶YAG激光用于婴幼儿鲜红斑痣的疗效观察

 目的:探讨窄谱强脉冲光DPL(500～600 nm)联合长脉冲1 064 nm Nd∶YAG激光用于婴幼儿鲜红斑痣的疗效及安全性。方法:纳入98例婴幼儿鲜红斑痣患者,随机分为两组：观察组58例,采用DPL联合长脉冲1 064 nm Nd∶YAG激光治疗;对照组40例,仅采用DPL治疗。连续治疗3~5次,每次间隔4周。所有治疗结束后1个月门诊随访观察。结果:观察组治愈13例(22.41%),显效16例（27.58%）,有效12例(20.68%),总有效率70.69％;对照组治愈2例(5.00%),显效8例（20.00%）,有效5例(12.50％),总有效率37.50％,两组总有效率差异有统计学意义（ X²=10.65,P<0.05）。观察组中有5例（8.62%）出现水疱、结痂反应,对照组有3例（7.50%）出现水疱、结痂反应,两组间不良反应发生率比较,差异无统计学意义（ X²=0.04,P=0.842)。结论:DPL联合长脉冲1 064 nm Nd∶YAG激光治疗婴幼儿鲜红斑痣效果良好,不良反应无明显增加,值得临床推广应用。     

532-nm and 1064-nm Q-switched Nd:YAG laser therapy for reduction of pigmentation in macular amyloidosis patches

Background Macular amyloidosis is a primary form of skin amyloidosis with deposition of small to moderate amyloid material in the upper dermis and mild pigmentary incontinence with resultant clinical hyperpigmentation. Objectives To determine the efficiency of Q‐switched Nd:YAG laser (532 and 1064 nm) in reducing the pigmentations due to skin macular amyloidosis. Methods A prospective, side by side, controlled, clinical trial study was designed. Twenty subjects with clinical diagnosis and pathology confirmation of macular amyloidosis were treated with Q‐switched Nd:YAG laser: 532 nm in a part of their plaques and with 1064 nm in another part of their plaques. Assessment of efficiency was done by colorimetric scores based on Mexameter measurement and also digital photographs before laser therapy and 8 weeks after treatment. Results Mexameter‐based data analysis showed that the two lasers (Q‐switched 532 and 1064 Nd:YAG) are effective in reducing the degree of macular amyloidosis patches pigmentation, and 532 nm is meaningfully more effective than 1064 nm in this matter. Photograph‐based analysis showed that 90% of cases treated by 532 nm had good or very good response, and for the 1064 nm–treated patches, 60% of cases had the good or very good response. Conclusions The results of study showed the net positive effect of Q‐switched Nd:YAG laser, either 532 nm or 1064 nm, in pigment reduction of macular amyloidosis patches, but the 532‐nm laser was more effective than 1064 laser.     

Laser therapy of freckles and lentigines with quasi-continuous,frequency-doubled,Nd:YAG (532 nm) laser in Fitzpatrick skin type IV: a 24-month follow-up

BACKGROUND : Newly developed lasers produce excellent results with minimal complications compared with traditional treatments for freckles and lentigines. OBJECTIVES : To assess the efficacy and safety of the frequency-doubled Nd:YAG (532 nm) laser in the treatment of freckles and lentigines in type IV skin. PATIENTS AND METHODS : Twenty adult patients (14 with freckles and six with lentigines) were subjected to a variable number of treatments with a minimum 4-week interval until no additional improvement occurred or > 75% improvement was obvious. Patients manifesting > 50% improvement were followed up once every 3 months for 24 months. The rest were regarded as treatment failures and not followed up. RESULTS : Sixteen (80%) of 20 patients (freckles, n = 10; lentigines, n = 6) manifested more than 50% improvement. They were irradiated between three and eight times with a 4-12-week interval. Complications included hypopigmentation (25%), mild textural changes (15%) and hyperpigmentation (10%). All these were mild and resolved within 2-6 months. Of 10 patients with freckles followed up for 24 months, four (40%) patients showed partial recurrence. However, all the patients maintained > 50% improvement. None of the patients with lentigines showed recurrence. CONCLUSION : The quasi-continuous, frequency-doubled Nd:YAG (532 nm) laser safely and effectively treats freckles and lentigines in Fitzpatrick skin type IV.     

不同波长的Q-开关激光治疗眶周色素沉着症疗效比较

目的：评价三种Q-开关激光治疗眶周色素沉着症的疗效。方法：83例患者随机分为A、B、C3组，A组和C组分别采用532nm和1064nm Q-开关Nd：YAG激光治疗，B组采用Q-开关翠绿宝石激光(755nm)治疗。结果：A组和C组疗效差，B组经4次及以上的治疗，总有效率可达82．1％，3组的总有效率的差异有显著性。结论：Q-开关翠绿宝石激光治疗眶周色素沉着症有较满意疗效，无明显副作用，可作为首选治疗方法。     

Red ink tattoo reactions: successful treatment with the Q-switched 532 nm Nd:YAG laser

BACKGROUND: In the South-west Thames region there were an unprecedented number of lichenoid tattoo reactions to red ink in patients who had visited a local tattoo parlour. The red ink was found to contain mercuric sulphide, a compound known to cause allergic reactions. Topical Dermovate (clobetasol propionate 0.05%, GlaxoWellcome) ointment alone had little impact. OBJECTIVES: To investigate whether the Q-switched 532 nm Nd:YAG laser could produce permanent flattening of the reaction. METHODS: This was an open nonrandomized clinical trial. Biopsies were taken from the lichenoid areas within the tattoos. Subjects were patch tested to 1% ammoniated mercury in petrolatum prior to treatment with the Q-switched 532 nm Nd:YAG laser. Laser treatments were delivered at 6-weekly intervals by a single operator. Patients also applied topical Dermovate between treatments. Therapy was discontinued when the lesions flattened. Clinical photographs were assessed at baseline and prior to each laser treatment. RESULTS: Seven patients with Fitzpatrick skin types I-III were enrolled in the study (four females, three males, mean age 39 years). All patients completed the trial. Patch testing to mercury was universally negative at 48 and 96 h. Substantial flattening and depigmentation of the red ink within the tattoos was noted after six laser treatments. No adverse effects were recorded. CONCLUSIONS: The Q-switched 532 nm Nd:YAG laser in combination with topical Dermovate ointment is a safe and effective method of treating red ink tattoo reactions.     

Site‐oriented depigmentation in vitiligo patients using Q‐switched Nd:YAG laser (1,064/532 nm), cryotherapy and chemical peels: A comparative study

Depigmentation emerges as a feasible solution for vitiligo universalis and refractory cases of vitiligo vulgaris that hinder patients' quality of life. A range of depigmenting modalities has previously been developed. However, each has its own limitations. Based on skin sensitivity, this study sets out to compare the efficacy and tolerability of “trichloroacetic acid (TCA) peels 25% and 50% and Qs Nd:YAG laser (1,064/532 nm)” for facial depigmentation and “cryotherapy, phenol 88% and Qs Nd:YAG (1,064/532 nm)” for extrafacial skin depigmentation. Forty vitiligo patients were examined and equally divided into facial & extrafacial groups. Regular sessions were performed. Patients' responses were assessed after 3 months or when excellent/complete depigmentation was attained through assessing “depigmentation grade”, “extent of depigmented skin”, “patient satisfaction” and “overall response”. Patients were observed for a six‐month follow‐up period. In facial depigmentation, Qs Nd:YAG showed the highest significant response followed by TCA 50% and 25%. In extrafacial depigmentation cryotherapy, phenol 88% and Qs Nd:YAG laser displayed positive outcomes without significant difference. Among the modalities tested Qs Nd:YAG yielded superior results in facial residual pigmentation in vitiligo when compared to TCA 50% and 25%, whereas in extrafacial sites Qs Nd:YAG, cryotherapy and phenol were equally effective.     

倍频Q开关Nd:YAG 532 nm激光治疗179例颧部褐青色痣回顾性分析

目的：评价倍频Q开关Nd:YAG 532 nm激光治疗颧部褐青色痣的临床疗效、影响因素及安全性。方法：回顾性分析2011年6月～2015年6月我院皮肤科门诊确诊为颧部褐青色痣并单独接受倍频Q开关Nd:YAG 532 nm激光治疗的患者,比较治疗次数、开始治疗的年龄、治疗后不良反应。结果：符合条件的179例患者中,治疗≥3次的患者治愈率为73.0%,显著高于治疗1次的治愈率3.7%(P<0.01)及治疗2次的治愈率16.4%(P<0.01)。入选的患者年龄范围为14～49岁,以年龄进行分组,>30岁组的患者有效率（38.1%）显著低于25～30岁组(41.7%,P<0.01)及≤25岁组(66.2%,P<0.01)。72例（40.22%）患者出现不同程度色素沉着,3～6个月自行消退;2例（1.11%）患者出现水疱,无瘢痕形成。结论：早期、多次使用倍频Q开关Nd:YAG 532 nm激光治疗颧部褐青色痣安全有效。     

Q开关Nd:YAG激光联合高能超脉冲CO2激光治疗脂溢性角化病

目的评价两种激光联合治疗脂溢性角化病的疗效.方法170例患者半随机分两组,96例采用联合治疗,74例单用Q-开关NdYAG激光治疗作对照.结果联合治疗组治疗一次痊愈率为85.4%,二次痊愈率为95.8%;而单一组治疗一次痊愈率为67.6%,二次痊愈率为91.9%,两组比较治疗一次痊愈率有显著性差异.结论Q-开关NdYAG激光联合高能超脉冲CO2激光治疗脂溢性角化病更有效、快捷,无明显副作用,可作为首选治疗手段.