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The peritoneal surface remains an important failure site for patients with gastrointestinal and gynecologic malignancies. In the past, oncologists regarded peritoneal carcinomatosis as an incurable component of an intra-abdominal malignancy. During the last two decades, novel therapeutic approaches have emerged for peritoneal carcinomatosis patients. We report the first case of peritoneal carcinomatosis emerging from an extra-adrenal, intra-abdominal paraganglioma. This 49-year-old male was treated with cytoreductive surgery and hyperthermic intraperitoneal perioperative chemotherapy. Paragangliomas are rare tumors of neural crest-derived chromaffin cells and can originate either from the sympathetic or from the parasympathetic ganglia. It has been estimated that as many as 10% of the paragangliomas arise outside the adrenal glands. This case represents an unreported presentation of paraganglioma. Two possible origins of this malignancy, and the applied therapy, are discussed. We report the feasibility of cytoreductive surgery plus hyperthermic intraperitoneal perioperative chemotherapy in the treatment of this malignancy. 相似文献
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Ugo Pace Gianmarco Contino Antonio Chiappa Emilio Bertani Paolo P. Bianchi Nicola Fazio Giuseppe Renne Giovanni Di Meglio Bruno Andreoni 《Case reports in oncology》2009,2(2):92-96
The colon is a very rare metastatic localization. Here we report a case of colonic metastases from gastric adenocarcinoma whose clinical presentation was suggestive of a de novo adenocarcinoma of the ascending colon. The authors discuss that in the presence of a previous history of gastric cancer, immunohistochemical analysis on endoscopic biopsies may help in the definition of a differential diagnosis. Furthermore, this rare metastatic localization might suggest a poor prognosis and a more accurate diagnostic work-up.Key Words: Gastric adenocarcinoma, Colonic metastases, CDX-2 相似文献
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Mayumi Hoshikawa Hideaki Mochizuki Mio Saito Toshiyuki Noguchi Motoji Sawabe Hideki Takahashi 《Clinical lung cancer》2009,10(4):249-251
A 69-year-old woman with a right cervical lymphadenopathy presented with an adenocarcinoma on excisional biopsy. Computed tomography (CT) scans and a positron emission tomography scan demonstrated that the tumor was localized in the right paratracheal and cervical region. A clinical diagnosis of lung cancer arising from an unknown primary site was made based on the radiologic and immunohistochemical findings. Serial CT scans showed a growing nodule in the left apex from pinpoint size to 1 cm in diameter after several months, which was defined as the primary site at autopsy. The finding of a clinically occult lung cancer directly spreading to the contralateral mediastinal and cervical nodes by skipping ipsilateral hilar and mediastinal nodes is rare. 相似文献
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Rohit Adyanthaya 《Journal of gastrointestinal cancer》2008,39(1-4):22-25
Introduction
Cutaneous metastases from internal malignancies are very common. We describe an extremely rare case of multiple cutaneous metastases from esophageal adenocarcinoma.Case Report
A month before the patient came to us, he had presented to the ER for evaluation of skin lesions and was sent home on a 1-week course of oral antibiotics. He later presented with dysphagia and was diagnosed with esophageal adenocarcinoma and biopsy of the skin lesions revealed metastases.Discussion
This report stresses the importance that newly appearing skin lesions may be the first presentation of esophageal carcinoma. 相似文献11.
Paweł Krawczyk Marcin Nicoś Rodryg Ramlau Tomasz Powrózek Kamila Wojas-Krawczyk Sylwia Sura Bożena Jarosz Justyna Szumiło Edward Warda Tomasz Mazurkiewicz Marek Sawicki Janusz Milanowski 《Pathology oncology research : POR》2014,20(1):107-112
Poor prognosis of lung adenocarcinoma is associated with early occurrence of distant metastases. This type of non-small-cell lung carcinoma more frequently involves EGFR gene abnormalities, which determine the efficacy of EGFR tyrosine kinase inhibitor therapies (EGFR TKIs). It is probable that genetic abnormalities present in primary tumor will also be present in metastases. Unfortunately little is known about the incidence of these mutations in the metastases and about the effectiveness of molecularly targeted therapy in such patients. Formalin-fixed, paraffin-embedded tumor tissue was prepared from 431 samples of primary adenocarcinoma, 61 of adenocarcinoma central nervous system (CNS) metastases and 8 of adenocarcinoma bone metastases. The presence of exon 19 deletions was examined using the PCR technique and amplified PCR product fragment length analysis. The ASP-PCR technique was used to evaluate the L858R substitutions in exon 21, and the results were analyzed using ALF Express II sequencer. In the adenocarcinoma metastases to bone obtained from 8 patients, deletions in exon 19 of the EGFR gene were revealed in 3 smoking men and one non-smoking woman, while L858R substitution in exon 21 was found in one smoking woman and one man of unknown smoking status. The incidence of EGFR gene mutations in the bone metastases was 75 %, in the primary adenocarcinoma - 12.8 %, and in the adenocarcinoma metastases to CNS - 14.75 %. Five patients with EGFR gene mutation revealed in bone metastases were treated with EGFR TKIs; the majority of them had a satisfactory response to therapy. 相似文献
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T. Vasilakaki E. Skafida E. Arkoumani X. Grammatoglou K. Koulia A. Tsavari D. Myoteri E. Mavromati K. Manoloudaki D. Zisis 《Case reports in oncology》2012,5(1):164-168
Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and colon schwannomas are extremely rare. We report a rare case of ascending colon schwannoma with associated synchronous adenocarcinoma of the sigmoid colon. A 68-year-old man presented with a 20-day history of bleeding per rectum. Colonoscopy revealed a mass of 4.2 cm in diameter with endoluminal protrusion in the sigmoid colon and a second submucosal tumor in the ascending colon. Surgical intervention was suggested and ileo-hemicolectomy was done. Microscopically, the submucosal tumor of 4 cm in diameter showed features of schwannoma with degenerative change (ancient schwannoma). Lesional cells were positive for S100p and negative for actin, desmin, CD34, CD117, and pankeratin. The mass showed features of an invasive moderately differentiated adenocarcinoma. Colon schwannoma is a rare submucosal tumor, and the incidental occurrence with adenocarcinoma has not been well described in the literature.Key words: Schwannoma, Ancient schwannoma, Gastrointestinal tract, Adenocarcinoma 相似文献
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Djordjije Saranovic Jelena Djokic Kovac Srbislav Knezevic Snezana Susnjar Aleksandra Djuric Stefanovic Dragana Sobic Saranovic Vera Artiko Vladimir Obradovic Dragan Masulovic Marjan Micev Predrag Pesko 《JOURNAL OF BREAST CANCER》2011,14(3):247-250
Gastrointestinal metastases from invasive lobular breast cancer are uncommon with the stomach and small intestines being the most common metastatic sites. Peritoneal and rectal metastases are very rare and only rarely occur as the first manifestation of disease. We herein report the case of a 47-year-old woman who presented with abdominal carcinomatosis as a first sign of invasive lobular breast carcinoma (ILC). Identifying the most important immunohistochemical markers for ILC: gross cystic disease fluid protein 15, estrogen and progesterone receptors enabled a correct diagnosis. After a six year disease-free period, relapse occurred with severe obstruction due to rectal metastasis from lobular breast carcinoma. Since there was no widespread metastatic disease, surgery with concomitant hormonal therapy was performed. 相似文献
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目的:阐明影响肺腺癌脑转移患者生存的因素,为临床治疗的决策提供参考依据。方法对本院109 例死亡的肺腺癌脑转移患者之临床资料进行回顾性分析,生存期>1 年者57例,<1 年者52例。使用SPSS15.0 分析统计软件进行数据分析,P<0.05为差别有显著性。结果:单因素和多因素分析均显示患者的PS评分、脑转移出现时间及脑转移的治疗方法是影响肺腺癌脑转移患者生存期的独立的预后因素(P<0.05)。 而患者的性别、年龄、有无脑转移症状及有无颅外器官转移对其生存期无显著影响。结论:PS评分为0~1,脑转移出现时间>1 年和应用综合治疗方法的肺腺癌脑转移患者长生存期较长。 相似文献
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Llaguna OH Desai P Fender AB Zedek DC Meyers MO O'Neil BH Diaz LA Calvo BF 《Case reports in oncology》2010,3(3):386-390
Subcutaneous metastasis from a visceral malignancy is rare with an incidence of 5.3%. Skin involvement as the presenting sign of a silent internal malignancy is an even rarer event occurring in approximately 0.8%. We report a case of a patient who presented to her dermatologist complaining of rapidly developing subcutaneous nodules which subsequently proved to be metastatic colon cancer, and we provide a review of the literature. 相似文献
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