血竭基原的本草考证

血竭又名麒麟竭(骐驎竭),始载于南朝刘宋《雷公炮炙论》,迄今已有1500余年的应用历史。为中医常用的活血散瘀、止痛药。但自古以来,血竭药物的来源多依赖进口。特别是解放以后,中医药事     

五指毛桃的品种考证

五指毛桃为华南地区较常用的草药,经考证其植物来源为桑科粗叶榕Ｆｉｃｕｓ ｈｉｒｔａ Ｖａｈｌ的干燥根,主产于两广地区。     

历代本草侗药考

侗族是我国历史悠久的古老民族之一,有侗族之时,便产生了侗族医药。侗族医药,源远流长、古朴实用,独具特色。成为侗乡人们朝夕相共、不可缺少的抗衡疾病的手段。由于侗族过去没有自已的文字,有关侗药记载多以侗族聚居地所产及侗族人应用的形式散载在历代本草中。     

威灵仙本草新考

唐代《威灵仙传》所载之威灵仙应为毛茛科铁线莲属棉团铁线莲,本属其它数种威灵仙类植物为明代以后在效用基础上的重发现。     

大蓟与小蓟品种的本草考证

通过考证，大蓟和小蓟最初药用品种都是蓟属植物，宋代还用了飞廉属植物。这两属多种植物沿用至今，其中商品原植物：大蓟应是日本蓟，小蓟则含刺儿菜和刻叶刺儿菜Ｃ．ｓｅｔｏｓｕｍ。     

泽泻品种的本草考证

目的 通过对泽泻的本草学研究,考证其基源、产地和品种.方法 系统查阅古今中医药典及有关文献.结果 古代本草文献中所记载的药用泽泻品种与现代文献基本相符.结论 川泽泻为古文献中记载的汉中泽泻,药典收载的泽泻品种为古文献中的东方泽泻.     

金银花品种的本草考证

金银花是中国传统的药用品种。该文通过系统地梳理中国历代本草文献中所记载的药用金银花的植物形态,指出传统中医使用的金银花具有缠绕藤本;茎微紫色,有被毛;叶对生,卵状心形,两面皆有被毛;一蒂双花,单花唇形,花冠长3.2 cm左右,花蕊长,花开先白后黄,总花梗单生于小枝叶腋且总苞片叶状卵形,花期3月中旬到5月中旬等特征。在忍冬科各种植物中,仅忍冬科忍冬Lonicera japonica Thunb.一个品种符合传统药用金银花的植物学特征,应作为正品药用金银花的品种使用。     

牛黄历代品种的本草考证

本文详细考证了历代本草古籍,并结合现代研究报道,对牛黄古今种类名称、基原、形成部位及原因、产地等多个方面的源流变迁进行归纳总结。结果发现,影响牛黄品种变化的因素主要与基原、形成部位、产地相关;古今药用牛黄均以黄牛Bos taurus domesticus Gmelin来源为正品,但由于其数量稀少,也偶用其他品种的牛替代;古代常以牛所吐出的"生黄"为上等,死牛角、心、肝胆中的牛黄为次等,而现代牛黄大多来自于牛的胆囊;我国西边地区的牛黄较受认可,以"西牛黄"之名流传至今。因此,建议对牛黄品种质量进行深入研究,明确其基原、采集部位、药效成分等,再推广进口天然牛黄及其替代品的应用。     

芎Qiong产地及品种考证

川产芎Ｑｉｏｎｇ的确立始地晚唐，古代芎Ｑｉｏｎｇ的药物品种存在混乱，结合产地，栽培等因素分析，笔者认为《本草图经》“永康军芎Ｑｉｏｎｇ”即今之川芎ＬｉｇｕｓｔｉｃｕｍｃｈｕａｎｘｉｏｎｇＨｏｒｔ。     

冬虫夏草的本草新考

为更好的开发利用冬虫夏草资源,古为今用,考证历代中医药典籍,对冬虫夏草进行本草学新考。结果显示古代中医所用冬虫夏草来源于多个品种,历代医家对其药性存在较大争议,四川为冬虫夏草传统产区和集散地。建议加强凉山虫草等近缘品种研究,为冬虫夏草替代资源的寻找和开发利用提供依据;加强冬虫夏草药性研究,结合现代药理药效学研究成果和临床应用实际,明确冬虫夏草寒热药性属性。     

中药水蛭品种考证及资源可持续利用发展探讨

该文通过系统地本草文献梳理与研究指出,传统中医使用的水蛭是生于水中,个头较小且能吸食人及牛马血的水蛭.具有这些特性的水蛭的品种有日本医蛭Hirudo nipponia Whitman、丽医蛭H.pulchra Song、南京牛蛭Poecilobdella nanjingensis sp.Nov.、菲牛蛭P.manillensis (Lesson)以及湖北牛蛭P.hubeiensis Yang 5个品种,与2010年版《中国药典》水蛭项下所规定的动物品种来源不完全一致.建议《中国药典》修改并补充水蛭的品种来源,保留原有日本医蛭H.nipponica Whitman,增补菲牛蛭P.manillensis (Lesson),暂时保留宽体金线蛭Whitmania pigra Whitman、尖细金线蛭W.acranulata Whitman,并进一步加强丽医蛭H.pulchra Song、南京牛蛭P.nanjingensis sp.Nov.以及湖北牛蛭P.hubeiensis Yang的化学成分和药理作用以及资源分布的研究,以待作为药用品种补充.     

Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR-Beclin1 signalling cascade

Gastric cancer (GC) is a malignancy with high morbidity and mortality. Chinese dragon's blood is a traditional Chinese medicine derived from the red resin of Dracaena cochinchinensis (Lour.) S. C. Chen. However, the antigastric cancer effect of Chinese dragon's blood has not yet been reported. Herein, we demonstrated that Chinese dragon's blood ethyl acetate extract (CDBEE) suppressed the proliferative and metastatic potential of human gastric cancer MGC-803 and HGC-27 cells. CDBEE suppressed epithelial–mesenchymal transition in MGC-803 and HGC-27 cells. Moreover, CDBEE induced apoptotic and autophagic cell death in MGC-803 and HGC-27 cells. The cytotoxicity of CDBEE in human gastric epithelial GES-1 cells was dramatically weaker than that in human gastric cancer cells. Mechanistically, the activation of the mitogen-activated protein kinase (MAPK) signalling pathway was involved in the growth inhibition of MGC-803 and HGC-27 cells by CDBEE. Additionally, CDBEE-induced autophagic cell death was mediated by downregulation of the mammalian target of rapamycin (mTOR)-Beclin1 signalling cascade and upregulation of the ATG3/ATG7-LC3 signalling cascade. Importantly, CDBEE exhibited potent anti-GC efficacy in vivo without obvious toxicity or side effects. Therefore, CDBEE may be a promising candidate drug for the treatment of gastric cancer, especially for GC patients with aberrant MAPK signalling or mTOR signalling.     

Studies on the antidiarrhoeal effect of dragon's blood from Croton urucurana.

The red sap obtained by slashing the bark of Croton urucurana Baill. (Euphorbiaceae), also known as dragon's blood, was screened for a possible antidiarrhoeal activity on castor oil-induced diarrhoea in rats, cholera toxin-induced intestinal secretion in mice and on small intestinal transit in mice. Dragon's blood at an oral dose of 600 mg/kg caused in marked inhibition of the diarrhoeal response following castor oil administration as well as the intestinal fluid accumulation promoted by cholera toxin. At a similar dose the red sap significantly inhibited the small intestinal transit which was, however, found to be independent of the opioid mechanism. These results suggest a potential usefulness of the red sap from Croton urucurana Baill. in the control of secretory diarrhoea associated pathologies.     

Inhibition on acid‐sensing ion channels and analgesic activities of flavonoids isolated from dragon's blood resin

Acid‐sensing ion channel (ASIC) serves important roles in the transmission of nociceptive information. To confirm the analgesic mechanism of dragon's blood resin, patch–clamp technique, in vivo animal experiments, and immunohistochemical staining were used to observe the effects of the three flavonoids (loureirin B, cochinchinemin A, and cochinchinemin B) isolated from dragon's blood resin on ASIC. Results showed that the three flavonoids exerted various inhibitory effects on ASIC currents in rat dorsal root ganglion (DRG) neurons. The combination of the three flavonoids with total concentration of 6.5 μM could decrease (53.8 ± 4.3%) of the peak amplitude and (45.8 ± 4.5%) of the sustained portion of ASIC currents. The combination of the three flavonoids was fully efficacious on complete Freud's adjuvant (CFA)–induced inflammatory thermal hyperalgesia at a dose of 6.5 mM similar with amiloride at 10 mM. The analgesic effects of the combination could be weakened by an ASIC activator 2‐guanidine‐4‐methylquinazoline. CFA‐induced hyperalgesia was accompanied by c‐Fos up‐regulation in DRG neurons, and the combination rescued thermal hyperalgesia through down‐regulation of c‐Fos and ASIC3 expression in CFA‐induced inflammation. These collective results suggested that the flavonoids isolated from dragon's blood resin could be considered as the chemical compounds that exert analgesic effects on inflammatory thermal pain due to action on ASIC.     

《神农本草经》海洋中药品种考证

《神农本草经》是我国现存最早的一部中药学专著,现代学者在《神农本草经》学术思想上的研究成果颇丰,在药物研究方面多偏向于陆生和淡水生中药的研究,对于其中海洋中药的研究则相对较少,同时,所见文献对于《神农本草经》中海洋中药的品种数尚存争议。通过查阅历代本草文献,结合现代海洋药物研究及生物学、矿物学、历史地理等多种学科的研究成果,对《神农本草经》所载海洋中药的品种分类、生境分布、不同文献对《神农本草经》海洋中药品种与数量记述的差异等进行比较分析,并对历来存有异议的11个品种进行深入的考证,提出《神农本草经》共收载海藻、牡蛎、大盐等12味海洋中药,为《神农本草经》海洋中药的学术研究提供了有益的参考。     

阿尔茨海默病中医康复方案临床研究探微

阿尔茨海默病(AD)是老年痴呆症最常见的一种,患者早期认知功能受损,记忆力减退;晚期则智能衰退,生活不能自理,严重影响患者生活质量并给家庭与社会带来巨大负担,且发病率只增不减。现代医学深入微观机制研究,治疗以改善胆碱系统功能药物、抗氧化剂、抗炎药物等为主。虽长期用于临床,但西药大多针对单一环节或单一靶点,覆盖面较窄,而且老年患者一般多病缠身、需联合用药,这既加重了药物的毒副作用,也降低了患者服药的依从性。如何在用药之外探寻毒副作用小、刺激人体机能促进自我恢复的康复方案,以缓解AD症状和促进疾病良性发展迫在眉睫。     

水芹的本草考证

目的:通过对水芹的本草学研究,考证其基源及药用品种,方法:查阅有关历代文献,实地考察和应用现代科学技术对水芹的化学成分和药理作用等进行研究,结果:表明历代本草文献中所记载水芹的生长特征及其功能主治与现代研究结果基本一致.结论:水芹基源仅伞形科水芹属植物水芹Oenanthe javanica(B1.)DC,为药用正品.     

中药治疗阿尔茨海默病分子作用机制的研究进展

阿尔茨海默病（Alzheimer’s disease,AD）是一种常见的进行性神经系统退行性疾病,起病隐匿,发病机制复杂,发病人数逐年上升,严重危害我国老年人的身心健康,因此疾病的早期预防与治疗至关重要。目前临床治疗AD药物尚不能有效阻止和显著延缓病程进展,近年中药防治AD作用逐步得到验证,已成为科学研究的热点问题。主要阐述了AD的发病机制,从错误蛋白的沉积及级联反应、神经炎症微环境、线粒体功能障碍、神经递质、铁死亡等层面总结了近年中药抗AD的分子机制等,有助于临床治疗策略的优化,为中药的开发及应用提供新的思路。     

帕金森病疲劳症状中医证候要素特征分析

[目的] 研究帕金森病疲劳症状中医证候要素特征。[方法] 将83例帕金森病患者按照帕金森疲劳量表（PFS-16）分数标准分为疲劳组（PFS-16≥3.3,32例）,非疲劳组（PFS-16<3.3,51例）,采用帕金森病证候要素量表（PD-PES-13）进行证候要素辨别,比较两组中医证候要素积分和所占比例的差异以及复合证候要素分布情况,采用Logistic回归法分析中医证候要素对帕金森病疲劳发病的危险性。[结果] 疲劳组脾虚证、血虚证的比例显著高于非疲劳组（P<0.05或P<0.01）,脾虚证、血虚证、气虚证积分显著高于非疲劳组（P<0.05或P<0.01）。疲劳组脾虚+髓减、脾虚+血虚、肾虚+阴虚复合证候要素比例显著高于非疲劳组（P<0.05或P<0.01）。脾虚、血虚证候要素对帕金森病疲劳发病具有危险性（OR=3.500,P=0.008;OR=2.678,P=0.038）;脾虚+血虚、脾虚+髓减、肾虚+阴虚复合证候要素对帕金森病疲劳发病具有危险性（OR=6.000,P<0.001;OR=2.923,P=0.022;OR=2.679,P=0.034）。[结论] 脾虚、血虚和复合证候要素脾虚+血虚、脾虚+髓减、肾虚+阴虚在伴有疲劳的帕金森病患者中出现频率更高,且可能是其发病的危险因素。