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关于我国药品召回制度中几个问题的探讨 总被引:1,自引:1,他引:0
赵贤 《国际医药卫生导报》2008,14(24):125-127
目的探讨药章召回制度中召回的责任主体,召回的范围,以及药品召回制度与药品不良反应报告和监测制度之间的关系。方法对药品召回责任主体进行界定,辨析药品召回的范围,分析药品召回制度与药品不良反应监测与报告制度的关联。结论药品召回制度促使我国对缺陷药品的管理更加规范,有利于人民群众的用药安全。药品不良反应报告与监测制度的完善是药品召回制度运行的前提,药品召回降低药品不良反应发生几率,两种制度相互促进。 相似文献
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在我们所意欲设立的药品召回制度中,可以看到美国药品召回制度中所涉及的召回类别、召回的分级、召回策略、召回的公众警示等的身影。但是《药品召回管理办法(征求意见稿)》的体例更适合中国人的思维方式。 相似文献
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论药品召回制度存在的问题及对策 总被引:2,自引:0,他引:2
目的通过对《药品召回管理办法》的研究,探索建立药品召回制度的必要性,药品召回的实施情况,以及对医药企业的影响。方法从监管部门和医药企业两个不同的角度分析我国药品召回实施的不利因素以及改进措施。结果与结论在国际上召回制度早已存在,我国有必要建立药品召回制度;由于我国的药品召回尚处于起步阶段,在开展工作中会存在不利的因素,监管部门和医药企业都要采取积极的应对措施。 相似文献
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老年人食管癌放射治疗的临床价值 总被引:3,自引:1,他引:2
目的评价老年人食管癌放射治疗的临床价值。方法回顾分析35例老年人食管癌采用电子直线加速器6MV—X线外照射治疗相关资料。结果35例老年人食管癌,完全缓解或部分缓解33例,无明显改善2例,总有效率(CR+PR)为94.29%。结论老年人食管癌放射治疗能为老年食管癌患者耐受,对一般状况较好者可达到延长生存期和改善生存质量的治疗目的。 相似文献
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Goldstein RZ Woicik PA Moeller SJ Telang F Jayne M Wong C Wang GJ Fowler JS Volkow ND 《Journal of psychopharmacology (Oxford, England)》2010,24(2):257-266
Few studies have examined the subjective value attributed to drug rewards specifically as it compares with the value attributed to primary non-drug rewards in addicted individuals. The objective of this study is to assess 'liking' and 'wanting' of expected 'drug' rewards as compared to 'food' and 'sex' while respondents report about three different situations ('current', and hypothetical 'in general', and 'under drug influence'). In all, 20 cocaine-addicted individuals (mean abstinence = 2 days) and 20 healthy control subjects were administered the STRAP-R (Sensitivity To Reinforcement of Addictive and other Primary Rewards) questionnaire after receiving an oral dose of the dopamine agonist methylphenidate (20 mg) or placebo. The reinforcers' relative value changed within the addicted sample when reporting about the 'under drug influence' situation (drug > food; otherwise, drug < food). This change was highest in the addicted individuals with the youngest age of cocaine use onset. Moreover, 'drug' 'wanting' exceeded 'drug' 'liking' in the addicted subjects when reporting about this situation during methylphenidate. Thus, cocaine-addicted individuals assign the highest subjective valence to 'drug' rewards but only when recalling cue-related situations. When recalling this situation, they also report higher 'drug' 'wanting' than hedonic 'liking', a motivational shift that was only significant during methylphenidate. Together, these valence shifts may underlie compulsive stimulant abuse upon pharmacological or behavioural cue exposure in addicted individuals. Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour. 相似文献
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《Addiction Research & Theory》2013,21(1):54-63
The aim was to examine the effects of describing alcohol-related aggression incidents on alcohol-aggression outcome expectancies. Male students (N = 122) were allocated to Aggression, Relaxation or Control conditions. Those in the Aggression condition recalled experiences of alcohol-related aggression; those in the Relaxation condition recalled experiences of alcohol-related relaxation; and those in the Control condition recalled neutral events. An alcohol-aggression (AA) outcome expectancy measure showed that recalling alcohol-related aggression led to a significant increase in AA immediately after the intervention, which fell to pre-intervention levels after two weeks. The risk of aggression or violence may be temporarily elevated by talking about AA experiences. 相似文献
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McClernon FJ Beckham JC Mozley SL Feldman ME Vrana SR Rose JE 《Addictive behaviors》2005,30(2):247-257
Smoking topography was measured in trauma survivors with and without posttraumatic stress disorder (PTSD) after recalling trauma-related and neutral experiences. Analysis of covariance was performed on puff topography and mood measures using nicotine dependence scores and current major depressive disorder as covariates. Puff volumes were higher in the PTSD group than in the non-PTSD group. The PTSD group exhibited stable puff onset intervals while the non-PTSD group exhibited significantly shorter intervals following trauma recall. These findings support a "ceiling effect" hypothesis in which individuals with PTSD perpetually smoke in such a way as to maximize nicotine delivery, possibly reducing the potentially reinforcing effects of increased smoke delivery in negative affect-inducing situations. 相似文献
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A single oral dose of 1.5mg of nicotine was administered to healthy young normal males in a placebo-controlled double-blind study. The nicotine produced a significant improvement in the number of words recalled from a 32 item list. An examination of the individual serial position curves showed that most subjects were recalling either predominantly from the first half of the list or predominantly from the second half of the list. Examination of these groups separately showed that nicotine improved recall for the part of the list that was being recalled better in the placebo condition. These results are consistent with the hypothesis that nicotine was supplying additional processing resources and that deployment of these is under the strategic control of the subject. 相似文献
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Pursuing sustainability requires the design of environmentally benign substances and materials and of sufficiently clean processes for their production, as well as careful attention to their usage throughout their life cycle and to their eventual fate. These requirements have prompted the birth of green chemistry and, more recently, of green pharmacy. The current work focuses on relevant common features of the two areas at educational level. After briefly recalling the reasons that have prompted their birth, and the main objectives of their approaches, it devotes major attention to the design of substances as a tool made increasingly more powerful by the continuous progress of computational chemistry. Particular attention is given to the importance of fostering sound attitudes in approaching molecules and of building awareness of the fundamental roles of conceptual and theoretical knowledge to ensure that the obtained results are meaningful. 相似文献
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肿瘤放射增敏剂在鼻咽癌放射治疗的临床价值 总被引:1,自引:0,他引:1
目的探讨肿瘤放射增敏剂希美钠(CMNa)在鼻咽癌放射治疗的增敏作用和临床价值。方法回顾分析综合组(希美钠+放射治疗组)和单纯组(放射治疗组)各35例。综合组采用希美钠800mg/m^2,用100ml生理盐水稀释溶解,于30min内完成静脉滴注,在60min内进行放射治疗。2-3次/周,连续用药至放射治疗结束,用药总量为6000-9000mg。单纯组仅单纯采用放射治疗。结果近期疗效综合组明显高于单纯组,其放射治疗疗效提高37.14%,远期疗效正进一步观察中。结论希美钠不良反应小,安全性高,对鼻咽癌放射治疗增敏效果显著。 相似文献
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Viel C 《Annales pharmaceutiques fran?aises》2008,66(1):34-38
On December 10 1906, Henri Moissan was in Stockholm to receive the Nobel Prize for chemistry for his isolation of fluorine in 1886 and for his electric arc furnace he described for the first time in 1892 then later improved and which opened the way to the new field of high-temperature chemistry. This was the first Nobel Prize for chemistry awarded to a Frenchman and Moissan was the only French pharmacist to have received this high distinction. He died suddenly at the age of 54 years, two months after receiving his Nobel Prize. In this presentation, we report the main elements of his biography, recalling the man, the teacher and the great collector of paintings and autographs, particularly from the period of the French revolution. We have used several unpublished or little known documents concerning this great scientist who with is broad culture and malicious humor always found the time, despite his many obligations, to satisfy his literary and artistic tastes. 相似文献