中药联合川参通抗生素配伍治疗慢性前列腺炎疗效的观察

目的:探讨川参通注射液与抗生素配伍局部注射,加服中药煎剂治疗慢性前列腺炎的疗效。方法:对2007-2011年90例慢性前列腺炎,随机分为治疗组及对照组,两组均采用川参通注射液与抗生素配伍前列腺内注射,治疗组加服中药,观察两组疗效。结果:治疗组治愈27例,显效13例,有效1例,总有效率为91.1%,治疗组有效率高于对照组(75.6%),差异具有统计学意义(字2=3.920,P0.05)。结论:中药联合川参通抗生素配伍治疗慢性前列腺炎有效率较高,联合中药治疗慢性前列腺炎,对于提高疗效及改善其症状,具有一定的应用价值。     

氨曲南与川参通联用治疗慢性前列腺炎探析

目的探析氨曲南与川参通注射液治疗慢性前列腺炎疗效,并与川参通注射液联合头孢他定前列腺注射疗效作比较。方法以患者自身注射前后对照的方法 ,复查前列腺液及B型超声波,评价氨曲南与川参通注射液治疗慢性前列腺炎的效果与安全性。结果氨曲南与川参通联合治疗慢性前列腺炎临床治愈率为91.3%(头孢拉定为81.3%),总有效率95.3%。结论氨曲南与川参通注射液联合使用治疗慢性前列腺炎安全有效。治愈率明显高于川参通联合头孢拉定。     

复方川参通注射液治疗慢性前列腺炎967例临床观察

目的：评价复方川参通注射液治疗慢性前列腺炎的疗效和安全性.方法：以自身前后对照的方法,观察967例用复方川参通注射液直接注射前列腺内治疗慢性前列腺炎的疗效及安全性.结果：复方川参通单一治疗的显效率为63.1%,总有效率为91.0%.安全、无明显副作用.结论：复方川参通直接前列腺注射治疗慢性前列腺炎是一种高效、安全、值得推广的新方法.     

川参通注射液治疗慢性前列腺炎临床应用体会

目的观察川参通注射液局部注射治疗慢性前列腺炎的疗效。方法 2002年8月～2007年12月用川参通注射液局部注射治疗已确诊的慢性前列腺炎340例,每例患者共注射12次,2周为一疗程。结果 340例慢性前列腺炎患者中治愈160例(47.06%),显效100例(29.41%),有效60例(17.65%),总显效率76.47%。CPSI评分在治疗前后有明显的下降,降幅为78.86%。结论川参通注射液联合抗生素局部注射治疗慢性前列腺炎取得较满意的疗效。     

化瘀通淋方治疗慢性前列腺炎临床研究

目的:探讨化瘀通淋方治疗慢性前列腺炎的疗效.方法:治疗组41例,服用化瘀通淋方;对照组30例,用氟哌酸、前列安栓治疗,疗程为1个月,对其疗效进行观察分析.结果:治疗组痊愈2例(4.9%),显效8例(19.5%),有效24例(58.5%),总显效率为24.4%,总有效率为82.9%.对照组痊愈1例(3.3%),显效5例(16.7%),有效14例(46.7%),总显效率为20%,总有效率为66.7%.两组总有效率比较,差异有显著性(P＜0.05).结论:化瘀通淋方是治疗慢性前列腺炎的有效方剂.     

川参通注射液治疗慢性前列腺炎35例疗效观察

目的探讨川参通注射液治疗慢性前列腺炎35例疗效观察。方法对2009年3月-2011年6月我院采用川参通注射液治疗慢性前列腺炎疗效进行回顾分析。结果治疗组总有效率91．43％,对照组总有效率77．14％,治疗组疗效明显优于对照组（P＜0．05）。结论川参通注射液治疗慢性前列腺炎治愈率提高,效果明显。     

盐酸特拉唑嗪联合蒙药治疗慢性前列腺炎的临床疗效观察

目的:探讨盐酸特拉唑嗪联合蒙药萨丽冲阿治疗慢性前列腺炎的临床效果。方法:选取自2006年1月-2008年12月收治的126例慢性前列腺炎患者随机分为观察组(联合蒙药治疗组)和对照组(常规西药治疗组)各63例,观察两组的治疗效果。结果:观察组痊愈39例,显效18例,总有效率为90.5%;对照组痊愈27例,显效16例,总有效率为68.3%。两组比较差异显著(P0.05),具有统计学意义。结论:盐酸特拉唑嗪联合蒙药治疗慢性前列腺炎疗效好,患者依从性好,因此最具有临床应用价值,且安全性较高,值得推广。     

应用川参通与抗生素经皮注射治疗慢性前列腺炎238例体会

目的探讨应用川参通注射液与敏感抗生素经皮注射治疗慢性前列腺炎的治疗效果。方法对238例慢性前列腺炎的临床资料进行分析。结果前列腺内注射药物吸收良好，疗效显著，总有效率95．0％。结论应用川参通与抗生素经皮注射治疗慢性前列腺炎，值得在基层医院推广使用。     

前列腺内注射联合微波治疗慢性细菌性前列腺炎172例分析

目的:分析前列腺内注射联合微波疗法在慢性细菌性前列腺炎临床治疗中的疗效。方法:选择172例慢性细菌性前列腺炎患者为研究对象,采取前列腺内注射联合微波进行治疗。结果:172例患者中,经3个疗程治疗后,显效138例,有效14例,无效20例,总有效率为88.37%。结论:前列腺内注射联合微波治疗慢性细菌性前列腺炎疗效显著,治愈率高,具有临床推广价值。     

前列腺丸治疗慢性前列腺炎疗效观察

目的:探讨前列腺丸治疗慢性前列腺炎的临床效果。方法:选取慢性前列腺炎患者100例,随机分为观察组和对照组,观察组50例采用口服前列舒丸联合左氧氟沙星胶囊治疗,对照组50例采用左氧氟沙星胶囊治疗,观察两组临床效果。结果:观察组的总有效率为96.0%,对照组的总有效率为70.0%,两组总有效率比较,差异有统计学意义(P<0.05)。结论:前列腺丸联合左氧氟沙星胶囊治疗慢性前列腺炎优于单纯左氧氟沙星胶囊治疗,值得临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.