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Introduction

Antibiomania is characterized by the emergence of a manic episode in reaction to antibiotics. Although relatively uncommon, this kind of side effect is observed in a growing number of cases and mostly occurs in patients who do not have a history of bipolar disorder. Several dozen cases have been reported showing the onset of manic symptoms after taking antibiotics. The antibiotic most frequently involved is clarithromycin.

Clinical case

We report the case of a 61-year-old patient who presented a manic episode after taking an antibiotic combination to treat Helicobacter pylori. Five days after the start of highly active antiretroviral therapy (HAART), behavioral problems appeared (aggressiveness, irritability, talkativeness, insomnia). At the time of hospitalization, she had an acute delusional symptomatology, with a theme of persecution, associated with intuitive, interpretive and imaginative mechanisms. Manic symptoms were obvious: psychomotor excitement, aggressiveness and irritability, flight of ideas, verbal disinhibition and a denial of problems. There was no toxic cause. Brain magnetic resonance imaging (MRI) was normal. Her condition improved very quickly and delusions disappeared in four days. Mrs. H. could critic her delirium and recovered a euthymic state. During hospitalization, treatment divalproate sodium was introduced (250 mg, 3 times a day), was maintained following hospital discharge for 2 years for prevention, and then decreased to the stop. There are currently no further behavioral problems or sleep disorders two years after this episode.

Discussion

Facing this clinical case, several questions arise: Which drug therapy is the most suitable for this type of mental disorder? Are there predictors of antibiomania? Is there a risk of recurrence of mood episodes following an antibiomania that occurs spontaneously? What are the pathophysiological mechanisms that could explain this reaction? In all cases identified, stopping the antibiotics was decisive. However, the introduction of a psychotropic and the duration of this treatment remain unclear. First, longitudinal follow-up would assess this variable. Second, it is unclear whether the presence of personal psychiatric history is a predictor of antibiomania. Finally, there are several hypotheses to explain antibiomania: the competitive effect of GABAergic inhibitory receptors, seizure-like phenomena that mimic psychiatric symptoms, and disruption of the intestinal microbiota by antibiotics leading to a modification of the functioning of the central nervous system. The explanatory model of antibiomania is not yet known and requires further research.  相似文献   

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BackgroundThe burden of mental disorders is high in sub-Saharan Africa but the reliable epidemiological data for its prevalence are too scarce in this setting. We aimed to determine the prevalence of major mental disorder in a rural community in northern Benin.MethodsIt was a cross-sectional study with a door-to-door survey and included all people aged more than 18 years in the Tourou rural community in northern Benin. The face-to-face interview were done with respect the confidentiality. The French version of Composite International Diagnostic Interview (CIDI) was used for the screening of mental disorders. The data were analyzed by using EPI-INFO 7.1 software. The prevalence of each disorders were determined and their 95% confidence interval.ResultsA total of 603 subjects were included, including 62.23% of men and 18 to 77 years old with an average of 27.29 years ± 9.24 years. Among them, 327 subjects had at least one mental disorder with an overall prevalence of 54.22% [95% CI: 41.56–69.14]. The prevalences of the major mental disorders were for the current major depressive episode (MDE) 32.34% [28.65–36.26%]; past MDE 11.61% [9.22–14.50%]; current social phobia 14.26% [11.62–17.37%]; Current Obsessive Compulsive Disorders 20.73% [17.61–24.23%]; generalized anxiety 9.62% [7.44–12.33%]; psychotic syndrome whole life 30.18% [26.57–34.05%]; antisocial personality disorders 5.47% [7.44–12.33%]; alcohol dependence 3.98% and drug dependence 1.33%.ConclusionThese findings suggest an increased incidence of mental illness in rural community in northern Benin and calls for urgent prevention and community care.  相似文献   

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Senegal was hit once again by a shipwreck that caused the drowning deaths of 21 women and 54 survivors. This shipwreck took place in Bettenty, an isolated island town in Senegal, focused entirely on the local population. Psychological care for survivors, families and local stakeholders was needed. A psychological care mission was dispatched. The mission of this team was medico-psychological care for the 54 survivors, psycho-social support for the families of the victims, and psychological support for the local medical staff. She provided immediate post-treatment care through talk groups, individual debriefings and home visits. This intervention in Bettenty remains a first mission coordinated with the advent of the Mobile Response and Support Team (EMIS) Psychosocial, set up in 2016 by the Center for Sanitary Emergency Operations of the MSAS for actions taken medical and psychological care of disaster victims and their relatives. In fact, Senegal, a developing country, is gradually learning how to set up formal and structured cells for psychological care. From the experiences of medico-psychological intervention, it will be possible to rectify their setting up and unfolding, for later actions to be more effective.  相似文献   

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Scorpion envenomation is caused by an accidental scorpion sting. In its severe form, it involves life-threatening respiratory or cardiac damage; it may also cause the neurological severity of systemic manifestations. We report the case of a young 35-year-old woman stung by an Androctonus mauretanicus scorpion, who developed impaired consciousness, hemiplegia and respiratory distress. At admission, the brain computed tomography showed a hypodense area in the right parietal region; the chest radiograph revealed a bilateral alveolar syndrome. Troponin was elevated and hemostasis disorders were present. The clinical course was remarkable: cardiogenic shock with multiple organ failure followed by death on day 3. This case illustrates a rare complication of scorpion envenomation: ischemic stroke due to an undetermined mechanism, which in addition to the cardiac and respiratory injuries, led to the serious complications and fatal outcome.  相似文献   

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