Clinical study on effects of skin care products containing extract of prinsepia utilis andpurslane in the treatment of acne vulgaris

目的:评估改良配方后含青刺果油、马齿苋的清痘修复精华液(po-1),对改善寻常型痤疮皮损情况及促进皮肤屏障恢复的有效性及安全性.方法:选取83例寻常型痤疮患者,随机分为实验组和对照组,其中实验组43例,对照组40例.实验组使用清痘修复精华液(po-1),对照组使用清痘修复精华液原配方(po-2),早晚各1次外用,分别观察实验组使用前后皮损改善及皮肤生理功能改变情况,并与对照组比较.结果:实验组皮损改善有效率81.39%:对照组为87.5%:两组间差异无统计学意义;皮肤生理功能结果显示:实验组使用前皮肤含水量[(28.57±6.91)%]与使用后[(32.06±4.72)%]比较,差异有统计学意义(P < 0.05),皮脂含量使用前[(161.50±67.70)μg/cm2]与使用后[(115.21±39.26)μg/cm2]比较,差异有统计学意义(P < 0.05),经表皮水分流失使用前[(21.24±9.71)g/(h·cm2)]与使用后[(11.97±5.33)g/(h·cm2)]比较,差异亦有统计学意义(P < 0.05).结论:清痘修复精华液新配方在改善皮损的同时,显著改善痤疮患者皮肤水油状况,对恢复皮肤生理功能有很好的辅助作用.     

基于倾向性评分匹配评价青海地区损容性皮肤病患者皮肤屏障功能及其临床意义

目的 采用倾向性评分匹配方法探讨青海地区损容性皮肤病患者面部皮肤屏障功能的差异，为临床护理与治疗提供依据。方法 收集损容性皮肤病患者资料1866例，其中黄褐斑239例，寻常痤疮545例，玫瑰痤疮1082例，此外选取185名健康体检者作为对照。通过倾向性评分匹配法按照1∶1或1∶n进行病例匹配，通过比较经表皮失水率、表皮含水量、表皮油脂含量、pH值，评估不同损容性皮肤病的皮肤屏障特点。结果 黄褐斑、寻常痤疮、玫瑰痤疮组表皮水含量均低于健康组，PH值均高于健康组，差异有显著统计学意义（P <0.05）；寻常痤疮、玫瑰痤疮组经皮失水率、表皮油脂含量高于健康组，差异有显著统计学意义（P <0.05）。PSM匹配前后结论一致。结论 3种损容性皮肤病的皮肤屏障均有不同程度的受损，提示在这3种损容性皮肤病的治疗中，修复皮肤屏障可能是疾病缓解的关键。健康对照组皮肤屏障功能也有异常，提示青海高原地区健康人群也应加强皮肤屏障的保护。     

北京31例20 ~ 25岁健康在校女大学生面部主观皮肤类型与皮肤微生物的关系

【摘要】 目的 利用高通量测序技术研究北京地区20 ~ 25岁健康女性皮肤细菌、真菌的物种组成,并比较4种不同主观皮肤类型微生物组成和多样性的差异。方法 在北京工商大学招募31例在校女学生,按受试者对面部皮肤油腻及干燥程度的主观感受将其分为干性（6例）、中性（8例）、混合性（9例）、油性（8例）4组,于2017年12月24日检测受试者皮肤水分含量、经皮水分丢失、油脂含量、pH值,比较不同自评皮肤类型皮肤生理指标的差异。用棉拭子采集面颊皮肤样本,提取DNA及PCR扩增后,进行细菌16S rRNA V1 - V2区和真菌内源转录间隔区1 - 2测序,并根据97%的相似度对序列进行OTU聚类和物种分类注释。采用单因素方差分析进行多组间比较,LSD?t检验进行两两多重比较。结果 4组受试者面部皮肤油脂含量和细菌多样性均存在差异,干性、中性、混合性、油性皮肤油脂含量分别为（5.50 ± 4.60）、（7.69 ± 5.26）、（10.56 ± 5.42）、（22.81 ± 8.53） μg/cm2,F = 11.685,P < 0.001;细菌多样性（Shannon指数）分别为3.49 ± 0.70、2.97 ± 1.43、2.49 ± 0.63、1.59 ± 0.59,F = 5.634,P = 0.004。丙酸杆菌属、葡萄球菌属和链球菌属为主要菌群,其中,油性皮肤组丙酸杆菌属相对丰度（68.24% ± 14.78%）显著高于干性组（18.83% ± 14.49%）、中性组（32.18% ± 36.29%）和混合性组（35.22% ± 22.58%）,均P < 0.001。此外,葡萄球菌属相对丰度在混合性皮肤中最高,而链球菌属相对丰度在中性皮肤中最高。4组皮肤真菌多样性和丰富度（Chao指数）差异均无统计学意义（P > 0.05）。4组真菌主要由子囊菌门和担子菌门组成,且相对丰度在4组间差异无统计学意义（均P > 0.05）,丰度大于1%的真菌属差异无统计学意义（均P > 0.05）。结论 年轻女性不同主观皮肤类型面颊皮肤生理指标和细菌多样性均存在一定差异,而真菌多样性和丰富度无显著性差异,提示主观皮肤类型与皮肤细菌定植相关。     

面部痤疮、湿疹、黄褐斑及日光皮炎皮肤屏障功能评价及其临床意义

目的 探讨痤疮、亚急性湿疹、黄褐斑及日光皮炎的皮肤屏障功能的差异.方法 选损容性皮肤病300例,其中痤疮80例,亚急性湿疹80例;黄褐斑80例;日光皮炎60例.健康人60例为对照.运用德国Courage+Khazaha公司的无创性皮肤生理功能测试仪,测量受试者面部皮肤的皮脂含量、角质层含水量和经表皮水分流失值(TWEL).结果 4种损容性皮肤病组与健康对照组相比,痤疮的皮脂含量及TWEL值较健康对照高,角质层含水量较健康对照低,差异有统计学意义(P＜0.01).亚急性性湿疹、日光皮炎及黄褐斑的皮脂含量、角质层含水量均较健康对照组低,TWEL值均较健康对照高,差异有统计学意义(P＜0.01).4种皮肤病组问进行比较,痤疮的皮脂含量比其他3组高,差异有统计学意义(P＜0.01),其余3组间皮脂含量差异无统计学意义(P＞0.05);亚急性湿疹的角质层含水量比痤疮及黄褐斑低,差异有统计学意义(P＜0.01),与日光皮炎的角质层含水量相比,差异无统计学意义(P＞0.05);日光皮炎的角质层含水量比痤疮及黄褐斑低,差异有统计学意义(P＜0.01);痤疮的角质层含水量比黄褐斑低,差异有统计学意义(P＜0.01);黄褐斑的TWEL值比其他3组低,差异有统计学意义(P＜0.01),其余3组TWEL值相比差异无统计学意义(P＞0.05).结论 4种损容性皮肤病皮肤屏障功能均存在损伤,提示恢复皮肤的屏障功能有助于治疗这4种损容性皮肤病.     

乌鲁木齐地区不同民族痤疮患者皮肤生理指标分析

目的检测乌鲁木齐地区维吾尔族、汉族痤疮患者面部皮肤生理指标,比较不同民族之间的差异。方法选取维吾尔族痤疮患者80例及汉族痤疮患者80例,两组患者年龄及性别分布相比差异均无统计学意义(P 0.05)。分别测定额部、鼻部、面颊部的经皮水分丢失量(TEWL)、面部含水量、皮脂量、皮肤红色素值;测定额部、眼部、面颊部的皮肤弹性的数据。结果维吾尔族痤疮患者面部角质层含水量在额部、鼻部、面颊部与汉族相比均低于汉族,差异均有统计学意义(P 0.05);维吾尔族痤疮患者面部TEWL在额部、鼻部、面颊部与汉族相比均高于汉族,差异均有统计学意义(P 0.05);维吾尔族痤疮患者面部皮肤油脂含量在额部、鼻部与汉族相比均高于汉族,差异均有统计学意义(P 0.05);维吾尔族和汉族痤疮患者前额、鼻部的皮肤红色素值差异无统计学意义(P 0.05),面颊部红色素值有统计学意义(P 0.05)。维吾尔族和汉族痤疮患者前额、眼角和面颊部的皮肤弹性值差异无统计学意义(P 0.05)。结论乌鲁木齐地区不同民族痤疮患者可能因为饮食习惯不同导致皮肤屏障功能的差异,需要个体化的干预治疗。     

青春期后女性痤疮与慢性应激及雄激素水平的相关性研究

目的 研究青春期后女性痤疮患者的皮损总数、严重程度、生活质量与慢性应激、肾上腺源性雄激素水平的相关性。方法 100例26 ~ 45岁女性受试者（50例痤疮患者和50例正常对照）被纳入到该研究。通过单次血清采样，用放射免疫的方法测定受试者血清硫酸脱氢表雄酮（DHEAS）、皮质醇水平。同时用生活事件量表对受试者的慢性应激进行定性与定量；用皮肤病生活质量指数测定痤疮对患者生活的影响；用痤疮皮损计数法和痤疮综合分级系统记录患者皮损总数和严重程度。结果 病例组生活事件（总分值189.7 ± 36.5）、血清DHEAS（140 ± 30 μg/L）和皮质醇（348 ± 88 μg/L）水平均显著高于对照组（生活事件总分值104.3 ± 13.3、血清DHEAS 110 ± 17 μg/L、皮质醇142 ± 85 μg/L），两组比较，P 均 < 0.01。病例组的生活事件与血清DHEAS（r = 0.34，P < 0.05）、皮质醇（r = 0.44，P < 0.01）、痤疮皮损总数（r = 0.29，P < 0.05）呈显著正相关；DHEAS水平与痤疮皮损总数呈显著正相关（r = 0.54，P < 0.01）。病例组皮损总数、严重程度均与皮肤病生活质量指数有显著相关性（均为P < 0.01）。结论 青春期后女性痤疮的发病及皮损总数与慢性应激及其导致的肾上腺源性雄激素升高存在相关性。患者的皮肤病生活质量与皮损总数及严重程度相关。对于此期患者，除常规治疗之外需要对抗雄激素的治疗及心理治疗。     

寻常痤疮患者面部皮肤特征的定量评价

目的了解寻常痤疮患者面部皮肤特征表现,并进行定量评价。方法随机选取2011年1月～2012年6月在北京军区总医院激光美容中心进行痤疮治疗的180例痤疮患者和同一时期进行美容咨询的50名健康者,应用VISIA皮肤图像分析仪和SOFT5.5皮肤性质测试仪对患者和健康者皮肤性质进行定量分析和评价。结果 VISIA数据显示与男性健康者相比,男性痤疮患者在纹理、毛孔和紫质均有明显差异性（P〈0.05）,与女性健康者相比,女性痤疮患者在皱纹、毛孔、紫质和红色区均有明显差异性（P〈0.05）;与女性痤疮患者相比,男性痤疮患者在色素斑、毛孔和紫质均有明显差异性（P〈0.05）,与女性健康者相比,男性健康者在色素斑、皱纹、纹理、毛孔和紫质均有明显差异性（P〈0.05）,而红色区未见明显差异性（P〉0.05）;不同严重程度的痤疮患者差别主要在紫质和红色区;SOFT数据显示与男性健康者相比,男性痤疮患者在油脂有明显差异性（P〈0.05）,与女性健康者相比,女性痤疮患者水分和油脂均有明显差异性（P〈0.05）;与女性痤疮患者相比,男性痤疮患者在pH和油脂均有明显差异性（P〈0.05）,与女性健康者相比,男性健康者在水分和油脂均有明显差异性（P〈0.05）,而pH和弹性未见明显差异性（P〉0.05）;不同严重程度的痤疮患者差别主要在水分和油脂。结论寻常痤疮患者面部皮肤特征较健康皮肤表现为皮肤pH、水分和油脂等肤质的差异性且具有明显的性别差异性。     

雄激素受体基因第一外显子CAG重复序列长度多态性与痤疮的相关性

目的 探讨人雄激素受体基因第一外显子CAG重复序列长度多态性与痤疮发生之间的关系。方法 研究对象为中国东北地区238例痤疮患者和207例健康对照，抽取外周血后分离纯化出基因组DNA，采用微卫星扫描（STRs）方法分析CAG重复序列的多态性。结果 男性病例组和对照组的CAG重复均数分别为22.70 ± 3.09和23.48 ± 2.83，两组之间差异有统计学意义（P = 0.046）；将对照组中CAG重复次数的中位数23作为分割点分组比较，长/短CAG片段在男性病例和对照中的分布差异有统计学意义，携带有CAG短片段的男性较携带CAG长片段的男性患痤疮的风险性明显增加（OR值2.07；95%可信限为1.21 ～ 3.54）。女性病例组和对照组的CAG重复均数分别为23.41 ± 2.87和23.85 ± 0.21，两组之间差异无统计学意义（P = 0.115）；按中位数分组比较长/短CAG片段在女性病例和对照中的分布差异有统计学意义，携带有CAG短片段的女性患痤疮的风险性明显增加（P = 0.013，OR值2.05；95%可信限为1.18 ～ 3.56）。结论 雄激素受体基因第一外显子CAG的重复次数与中国东北地区痤疮的发生有关，CAG重复次数少的男性个体患痤疮的风险性增加，雄激素受体基因第一外显子CAG的重复次数可作为痤疮的遗传易感标志之一。     

寻常性痤疮患者皮肤生理指标的研究

对正常人及寻常性痤疮患者面部的油脂分泌量、角质层含水量和pH值进行测定,以分析正常人与寻常性痤疮患者的皮肤生理指标的差异,进而对皮肤生理指标与痤疮发病的相关性做出初步评价。结果：痤疮组面部油脂分泌量明显高于正常组（P〈0.01）,Ⅱ度痤疮患者面部油脂分泌量明显高于Ⅰ度痤疮患者（P〈0.05）,Ⅲ度痤疮患者面部油脂分泌量也明显高于Ⅰ度痤疮患者（P〈0.05）。寻常性痤疮患者面部的pH值与水分在各组比较中均未见明显统计学差异。     

凋亡抑制蛋白c-FLIP在银屑病患者外周血和皮损中的表达

目的 探讨凋亡抑制蛋白c-FLIP在寻常性银屑病患者外周血和皮损中的表达和分布情况。方法 采用流式细胞仪检测30例寻常性银屑病患者和20例正常人对照组外周血T细胞和B细胞内c-FLIP蛋白表达阳性率，采用免疫组化方法检测c-FLIP蛋白在其皮损中的表达。结果 进行期银屑病患者外周血T细胞内c-FLIP表达（6.32% ± 1.17%）明显高于恢复期患者（2.64% ± 0.74%，P < 0.01）和正常人对照组（2.28% ± 0.54%，P < 0.05）。而其在外周血B细胞内的表达3组间差异无统计学意义，3组分别为0.78% ± 0.16%，0.71% ± 0.32%，0.69% ± 0.18%，P值均 > 0.05。c-FLIP蛋白在进行期银屑病患者皮损中的表达（89.73 ± 5.24）明显高于恢复期（117.40 ± 7.50，P < 0.05）和正常人对照组（121.58 ± 7.93，P < 0.01），恢复期患者和正常人对照组之间差异无统计学意义（P > 0.05）。结论 凋亡抑制蛋白c-FLIP在进行期银屑病患者的外周血T细胞和皮损内明显高表达，可能参与银屑病患者T细胞的增殖。     

Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial

Background

Inflammatory and non-inflammatory acne lesions constitute a significant clinical challenge in acne subjects.

Aim

To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions.

Methods

This randomized controlled trial included adults with comedones, post-inflammatory erythema (PIE) and/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum + Mask or serum alone for 8 weeks. Acne severity, comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans-epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d.

Results

Eighty-three participants were included, including 41 and 42 in the Serum + Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed comedones on face, open comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8 weeks of treatment in both groups (all p < 0.05). Addition of the mask improved the number of closed comedones (−6.56 ± 0.39 vs. −5.19 ± 0.44, p = 0.022) and acne severity (−0.39 ± 0.08 vs. −0.12 ± 0.09, p = 0.026) substantially more than using the serum alone. No adverse reaction was reported in either group.

Conclusions

The study serum improved skin conditions by regulating skin barrier function and achieving a balance of skin hydration and sebum secretion, removing comedones and improving PIE and PIH. Addition of the mask accelerated the effects without compromising safety.     

面部糖皮质激素依赖性皮炎患者经皮水分丢失和皮肤含水量分析

目的 分析面部糖皮质激素依赖性皮炎患者的皮肤屏障功能。方法 将面部分为额部、鼻尖、下颌、双面颊、双侧口角的皮损区及左耳后无皮损区共8个点，分别测量95例面部糖皮质激素依赖性皮炎患者及25例健康对照者的经皮水分丢失（TEWL）和皮肤含水量。结果 与健康组相比，面部糖皮质激素依赖性皮炎组下颌、双侧口角、双面颊TEWL值均显著升高（t值分别为4.90，2.60，2.57，2.54，3.77，P < 0.01）；双侧口角、右面颊及额部的皮肤含水量均显著降低（t值分别为3.27，3.81，2.02，2.78，P < 0.05）。在8个测量点中，面部糖皮质激素依赖性皮炎组与健康组TEWL值均为下颌及双侧口角 > 双面颊及额部 > 耳后无皮损区；皮肤含水量降低均为下颌及双侧口角 > 双面颊及额部 > 耳后无皮损区。结论 面部糖皮质激素依赖性皮炎患者下颌、双侧口角、双面颊区域皮肤屏障功能受损，口周区域TEWL值较高，而面颊皮肤水分含量较少。     

Fluorescence diagnostic imaging in patients with acne

Background: Orange‐red fluorescence in the follicle openings, induced by ultraviolet A light, originates from porphyrins, the metabolic products of Propionibacteria acnes. Purpose: To investigate the relationship of orange‐red follicular fluorescence with the severity of acne and the amount of sebum secretion. Methods: Twenty‐five volunteers were included. The severity of acne was rated on a 4‐point scale. The casual sebum level was measured using a Sebumeter and the follicular fluorescence was determined using the camera Visiopor. Results: Casual sebum level and the intensity of fluorescence (percentage of the area and number of orange‐red spots) were higher at the T zone than at the U zone in all patients regardless of their skin type. Sebum amount and area of fluorescence spots were significantly negative in correlation with the clinical grade of acne. There was a significant positive correlation between the orange‐red fluorescence and the casual sebum level. Conclusion: The orange‐red fluorescence showed stronger correlation with the presence of non‐inflammatory acne lesions (comedones) and high sebum amount than the presence of inflammatory acne lesions (pustules) and low sebum amount. The fluorescence diagnostic imaging could be useful in the objective evaluation and monitoring of treatment efficacy in subjects with acne‐prone skin and patients with acne.     

Effects of repetitive superficial chemical peels on facial sebum secretion in acne patients

BACKGROUND: Glycolic acid and Jessner's solution are popular superficial chemical peel agents for the treatment of facial acne, and increased sebum secretion is one of the major aetiological factors of acne. OBJECTIVE: To compare the effects of 30% glycolic acid peels and Jessner's solution peels on sebum secretion in facial acne patients. METHODS: Thirty-eight patients with mild to moderate facial acne were included. Twenty-seven patients were treated with 30% glycolic acid peels and 11 patients with Jessner's solution peels. Each peel was performed twice with an interval of 2 weeks. Before and 2 weeks after each peel, sebum levels of forehead, nose, chin and cheeks were measured by using a Sebumeter (SM810 Courage & Khazaka, Cologne, Germany). RESULTS: The sebum levels were not significantly changed by two peels treatments of 30% glycolic acid peels or Jessner's solution peels on the facial skins of patients with facial acne. CONCLUSIONS: The two types of peels, 30% glycolic acid peels and Jessner's solution peels, did not affect sebum secretion of the facial skins of patients with facial acne after the two peels treatments. The accumulative effects of more than two peels treatments using these modalities need further evaluation.     

Comparison of sebum secretion, skin type, pH in humans with and without acne

Differences of skin type and pH between subjects with and without acne have not been investigated. In addition, the relationship between sebum secretion and pH in these populations has not been determined. This study assessed the differences in objective and subjective skin types between these two groups. Secondly, this study evaluated the difference in pH on five facial areas (forehead, nose, chin, right and left cheeks) between the two populations. Lastly, the relationship between pH and sebum secretion was analyzed in each population. Sebum casual levels (CL) of the five facial areas in 36 Koreans with acne and 47 Koreans without acne were measured by using a Sebumeter SM 815 and subjects were classified into objective skin types by CL. Subjects reported the type of skin they believed they had, which determined the subjective skin type. The pH levels of the five facial areas were measured by the Skin-pH-Meter PH 905. Data were assessed with adequate statistical tests depending on data type and distribution. Among the five areas, the nose of the subjects with acne showed a significantly higher CL, compared to the subjects without acne. This difference in CL on the nose resulted in the difference in CL on the T-zone and mean facial sebum excretions (MFSE). Although CL differed, objective skin types did not differ between the two groups (P > 0.05), but the subjective skin types differed significantly (P = 0.001). In addition, the objective skin types were significantly different than the subjective skin types in subjects with acne (P = 0.001), whereas the two skin types did not differ in subjects without acne. Subjects with acne actually overestimated their skin types and stated their skin types were "oilier" than they were. In respect to pH, none of the five areas differed significantly between the two groups. Among the five sites in subjects with acne, CL showed a significant negative correlation with pH on the left (r (2 )=0.12) and right (r ( 2 )=0.15) cheeks, which resulted in a significant negative correlation on the U-zone (r ( 2 )=0.14). In contrast, in subjects without acne, there was a significant negative correlation between CL and pH on the forehead (r ( 2 )=0.10) and chin (r ( 2 )=0.16), which led to a significant negative correlation on the T-zone (r ( 2 )=0.14).     

SLE患者血清、尿液和肾脏骨桥蛋白的检测及临床意义

目的 探讨骨桥蛋白(OPN)在SLE患者血清、尿液中的含量及与SLE脏器损害、活动性指标的关系.方法 收集100例SLE患者临床资料,ELISA方法检测OPN在100例SLE患者和30例正常人对照外周血清中的浓度,同时用ELISA检测OPN在57例SLE患者和15例正常人对照尿液中的浓度.免疫组化检测3例SLE患者肾脏组织中OPN蛋白的表达.结果 OPN在SLE患者血清和尿液中浓度显著升高,分别为(64.03±72.87)μg/L和(454.87±231.63)μg/L,与正常对照组[(29.88±11.28)μg/L,(122.67±39.47)μg/L]相比,差异有统计学意义(P<0.05), SLE活动组血清和尿液中OPN浓度显著升高,分别为(80.92±87.49)μg/L和(584.36±207.15)μg/L,与SLE非活动组[(36.43±23.48)μg/L,(281.08±131.92)μg/L]相比,差异有统计学意义(P<0.05).血清和尿液中OPN浓度均和SLEDAI积分呈正相关(r=0.462,0.901,P值均<0.01).尿液OPN浓度和尿免疫球蛋白G、尿微量白蛋白、尿α1微球蛋白、尿B2微球蛋白呈正相关(r=0.458,0.359,0.342,0.409,P值均<0.05).OPN在狼疮性肾炎患者肾小管上皮表达.结论 OPN与SLE及肾损有密切关系.     

Does facial sebum excretion really affect the development of acne?

BACKGROUND: It is generally accepted that the severity of acne is correlated with facial sebum secretion. However, previous studies on the relation between seborrhoea and the development of acne did not consider topographical differences in facial sebum secretion and used relatively vague acne severity grading systems. OBJECTIVES: To elucidate the relation between topographical variations in facial sebum secretion and the severity of acne in women. METHODS: Forty-six female controls and 46 women with acne were included in this study. The Sebumeter was used to measure facial sebum secretion in the following facial areas: forehead, nose, chin, and right and left cheek. We counted noninflammatory comedones and inflammatory acne lesions in the same areas. We compared sebum secretion between patients with acne and controls, and analysed the relation between the quantity of sebum secreted and the number of acne lesions. RESULTS: Sebum secretions in the whole face and in the T- and U-zones (areas of high and low sebum secretion, respectively) were higher in patients with acne than in controls. There was no correlation between sebum quantity and acne lesion count in most facial regions. CONCLUSIONS: Increased levels of facial sebum secretion were observed in patients with acne. Our findings indicate that increased sebum levels do not directly cause development of acne lesions.     

The Difference in Sebum Secretion Affecting Development of Acne

BackgroundAlthough sebum secretion is crucial for acne development, acne lesion distribution is not always similar to the topographic differences of sebum secretion.ObjectiveTo analyze whether sebum secretion affects acne development and distribution and to assess other factors possibly influencing the relationship between acne and sebum secretion.MethodsThis single-center retrospective study included 67 acne patients and 50 controls. Acne patients were divided into 3 groups based on acne lesion distribution: T-zone dominant, U-zone dominant, and mixed groups. The secreted sebum level in each zone of acne patients was compared with that of controls. We also conducted correlation analysis between secreted sebum level and acne number, depending on the facial zone.ResultsNo significant difference was found between acne patients and controls regarding age and sex ratio. The U-zone dominant group showed increased sebum levels compared with controls in the U-zone and whole face, but a similar result was not obtained in the T-zone dominant group. Moreover, there was a significant correlation between the number of lesions and secreted sebum level in the U-zone, but not in the T-zone. Further, there was a more significant relation in the U-zone of male and young patients.ConclusionWe found that increased sebum secretion compared with the condition may affect acne development, especially in the U-zone. Sex and age may also influence the relationship between acne and increased sebum secretion. Acne lesion distribution may vary from patient to patient because sebum secretion affects acne differently depending on multiple factors.     

Comparative study of skin sebum and elasticity level in patients with sulfur mustard‐induced dermatitis and healthy controls

Background: Sulfur mustard (SM) – a chemical agent – has both acute and chronic effects on skin. Xerosis, which is deemed to be due to the damage of hydrolipidic barrier of the skin, is the most common complaint of veterans exposed to the chemical. This study was designed to evaluate skin sebum and elasticity in veterans with a history of SM contact. Methods: Three hundred and ten subjects were enrolled in this study and were divided into four groups: SM‐exposed patients with current skin lesions (n=87); SM‐exposed patients without skin lesions (n=71); patients with dermatitis (n=78); and normal controls (n=74). The skin sebum and elasticity were measured in four areas (forehead, suprasternal, palm and back of the hands) using a Sebumeter and a Reviscometer. Results: Skin sebum was higher in participants who presented with dermatitis and had history of contact with SM than others; the difference was only statistically significant on the forehead. There was no significant difference in the skin elasticity between the four groups. Conclusion: While SM may increase skin sebum in long term, there is no evidence that it has a substantial effect on skin elasticity.     

Objective and non‐invasive evaluation of photorejuvenation effect with intense pulsed light treatment in Asian skin

Background Intense pulsed light (IPL) has been widely used for photorejuvenation. Although previous literature has shown clinical effectiveness of IPL treatments on cutaneous photoaging, the associated changes in the biophysical properties of the skin following IPL treatments have not been fully elucidated. Objective The aim of this study was to evaluate changes in skin biophysical properties in patients with photoaging after IPL treatments, using non‐invasive, objective skin measuring devices. Patients and methods A total of 26 Korean women with facial dyschromias underwent three sessions of IPL treatment at 4‐week intervals. Outcome assessments included standardized photography, global evaluation by blinded investigators, patients’ self‐assessment and objective measurements of colour (Mexameter MX18, Chromatometer), elasticity (Cutometer), roughness (Visiometer), sebum (Sebumeter) and skin hydration (Corneometer). Results Intense pulsed light treatments produced a 15% decrease in the size of representative pigmented lesions (P < 0.05). Patients’ self‐assessment revealed that 84% and 58% of subjects considered their pigmented lesions and wrinkles were improved respectively. Objective colorimetric measurement demonstrated significant improvements following IPL treatments that were most remarkable after one session of IPL. Moreover, skin elasticity showed significant improvements at the end of the study. Skin wrinkles as measured using Visiometer showed a mild improvement without statistical significance. Sebum secretion and water content of skin remained unchanged. Conclusions Intense pulsed light provided significant improvement in the appearance of facial pigmented lesions in Korean patients. These effects appeared to be more remarkable in improving pigmentation, skin tone and elasticity.