Demonstration in situ of subsets of T-lymphocytes in sarcoidosis

Five biopsy specimens of skin, four of lung, and one of a lymph node were taken from nine patients with sarcoidosis. Monoclonal antibodies were applied to frozen sections of the specimens by an immunoperoxidase technique to test for the presence and distribution of subsets of T-lymphocytes. T-cells expressing the suppressor/cytotoxic phenotype were found predominantly in lymphocytic mantles surrounding sarcoidal granulomas, whereas cells displaying the helper/inducer phenotype were distributed diffusely throughout granulomas. The ratio of helper to suppressor phenotypes in cutaneous sarcoidosis was 5.1 +/- 1.8. The microanatomic location of subpopulations of T-lymphocytes may be important in the pathogenesis of the granulomatous response of sarcoidosis.     

寻常型银屑病几项实验室指标的检测及应用螺旋霉素治疗的观察

对６４例鳞屑性红斑的主要表现的进行期寻常型银屑病作了血液检测和螺旋霉素治疗研究，结果表明，患者血液中Ｎ，Ｌ，ＡＮＡ，ＡＳＯ，ＨＢｓＡｇ，Ｃ３和Ｃ４检测值均为对照组的显著增高，合用螺旋霉素治疗组疗产优于对照组，其治愈率，无效率和总有效率均有显著差别，患者合用螺旋霉素治疗前后，ＡＮＡ，ＡＳＯ，Ｃ３和Ｃ４测定值存在显著差异，提示银屑病患者体内存在着潜在细菌或病毒感染因素，这是该病发生，复发或加重的可能病     

急性肾损伤早期诊断生物标记物的研究进展

急性肾损伤（acute kidney injury，AKI）一直是临床上一个头痛的问题。ICU收治患者中30％-50％是急性肾损伤，其中5％有明确的危险因子。有报道术后发生AKI患者的死亡率在24％-100％之间，重症监护室需要透析患者的死亡率为50％-70％。近年的研究认为，传统的血（肌酐、尿素氮）和尿标志物（管型、滤过钠排泄分数）对AKI的诊断缺乏一定的敏感性和特异性，所以AKI的治疗迫切需要早期生物标记物。但是，     

miRNA调控银屑病角质形成细胞增殖机制的研究进展

MicroRNA（miRNA）在银屑病的发病过程中发挥重要作用,但其调节角质形成细胞增殖的机制尚未明了。本文对miRNA种类及在银屑病中的自调控方式进行了综述。     

Effectiveness of ketotifen in the treatment of neurodermatitis in childhood

17 children suffering from neurodermatitis, aged 2 to 14 years, were treated with ketotifen at a dosage of 1 mg twice daily. In 7 children polyvalent therapy was given. Ketotifen therapy produced a pronounced alleviation of the itching within only two weeks and the patients became entirely itching free after 20 days on an average. The improvement of skin lesions appeared after two months of treatment. Patients became entirely skin lesions free between seven and nine months. In three patients the deterioration of skin lesions was triggered with infection. With regard to long-lasting of Ketotifen therapy, the side effects were not observed.     

特比萘芬治疗非皮肤癣菌性真菌病的研究进展

特比萘芬是一种合成的口服或局部外用的丙烯胺类化合物,通过抑制角鲨烯环氧化酶--一种合成麦角固醇的关键酶,而导致真菌细胞膜破裂及细胞死亡.该药口服后吸收良好,具较强的嗜脂性,在表皮、真皮和脂肪组织中有较高浓度.