Esophageal Cancer

PURPOSE: To present the results of a prospective phase II study in esophageal carcinoma. PATIENTS AND METHODS: Patients received single doses of 1.8 Gy up to 27 Gy, then concomitant boost to a total of 50.4 Gy (PTV2 [planning target volume], single dose 1.8 Gy) and 64.8 Gy (PTV1, single dose 1.2 Gy in the morning and 1.8 Gy in the afternoon) concurrently with 800 mg/m(2)/d 5-fluorouracil and 20 mg/m(2)/d cisplatin (weeks 1 and 5). High-dose-rate brachytherapy (2-3 x 6 Gy) on Fridays of weeks 4-6 used a customized applicator facilitating central placement and circumferential dose homogeneity. RESULTS: 50 patients with squamous cell carcinoma (90%) or adenocarcinoma and mostly advanced tumor stage were treated (82% T3/T4 and 70% N1). Median overall survival (median OS 16 months; 1-year-OS 61%; 2-year OS 29%) was significantly longer for patients without nodal disease (35 vs. 11 months; p = 0.01). Hematotoxicity was grade 3 in 11/50, and grade 4 in 1/50 patients. Four percent of higher-grade nausea or vomiting occurred. Esophageal late toxicity was grade 3 in 9/50 patients, and grade 4 in 2/50 patients. CONCLUSION: Survival was excellent especially for patients without nodal disease in this dose-intensified schedule with acceptable tolerability.     

直肠癌合并膀胱癌1例报告

患者　男 ,79岁 ,尿频、尿急 2年 ,无痛性肉眼血尿 6d。直肠指检血染指套 ,B超示膀胱后方 3 .6cm× 3 .1cm低回声实质不均区 ,呈假肾征 ,膀胱内 5 .1cm× 3 .4cm稍强回声不均质区 ,形态不规则。直肠镜检见 :距肛缘 6cm处结节状黏膜突出 ,表面充血 ,水肿 ,糜烂 ,渗出。CT表现 :膀胱腔内充填不规则软组织密度影 ,宽基底附壁呈不均匀性生长 ,突向膀胱腔内 ,表面不规则 ,CT值 45HU ,膀胱后壁与周围间隙尚清。前列腺增大 4 .5cm× 5 .1cm× 6 .1cm ,突入膀胱腔内 (图 1 )。膀胱内气液平因保留导尿所致。直肠管壁 1 2点至 9点不均匀增厚 ,表面…     

CT对喉及梨状窝癌的诊断作用(附60例分析)

喉及下咽癌是耳鼻喉科常见的恶性肿瘤 ,在我国约占全身恶性肿瘤的 2 % [1] ,多数发生于中、老年患者 ,男性较女性多 ,发病机制一般认为与慢性炎症、病毒感染及长期的烟酒刺激有关。本文对 6 0例经临床、病理证实的喉及下咽癌进行回顾性分析 ,重点讨论ＣＴ对喉及下咽癌的诊断价值。1　材料与方法1.1　病人资料 :6 0例喉及下咽癌患者。男 5 0例 ,女 10例 ,年龄 30 82岁 (平均 6 0岁 ) ,全部行喉镜活检和手术及病理证实。1.2　扫描方法 :患者仰卧 ,颈部伸直 ,摆正位置 ,使扫描线与喉室或声门平行 ,平静呼吸下连续扫描。层厚 5ｍｍ ,层距 5ｍｍ …