介入联合中药治疗肾囊肿疗效分析

目的：评估超声引导下肾囊肿介入治疗配合中药治疗的疗效。方法：将2003年7月至2009年7月收治的150例肾囊肿患者分为常规组（超声引导下穿刺抽吸及无水酒精硬化治疗,60例）和研究组（超声引导下穿刺抽吸及无水酒精硬化治疗联合中药治疗,90例）,3个月后复查超声,观察两组患者的疗效。结果：研究组治愈73例、有效17例、无效0例,治愈率88％,有效率100％。常规组治愈43例、有效12例、无效5例,治愈率72％,有效率91％。两组治愈率和有效率比较,差异有统计学意义（P〈0．05）。结论：超声引导下穿刺抽吸及无水酒精硬化治疗联合中药治疗肾囊肿可以提高治愈率和有效率,是一种简便。安全,有效的方法。     

超声引导下肾囊肿穿刺无水酒精治疗疗效评估

目的 探讨超声引导下经皮穿刺治疗肾囊肿的安全性和疗效.方法 198例肾囊肿患者超声引导下穿刺注入无水乙醇硬化治疗肾囊肿,并分别于3、6、12个月后复查超声,评估其疗效.结果 198例患者均穿刺成功,172例获得3个月～1年随访,3个月治愈率51.7%,6个月治愈率83.7%,12个月治愈率93.6%,总有效率96.7%.结论超声引导下肾囊肿穿刺注入无水乙醇硬化治疗,安全、经济、有效,已作为肾囊肿首选治疗方案.     

超声引导下无水酒精注射硬化治疗肾囊肿的价值与体会

目的探讨超声引导下无水酒精注射硬化治疗肾囊肿的价值和体会。方法对42例肾囊肿患者,48个病灶行超声引导下肾囊肿穿刺无水酒精硬化治疗。结果12个月后随访一次性治愈率87.5%。结论超声引导下无水酒精注射硬化治疗肾囊肿方法简便、安全,值得临床推广应用。     

超声引导下经皮肾囊肿穿刺抽液及无水酒精硬化疗效观察

目的探讨超声引导下经皮肾囊肿穿刺抽液及无水酒精硬化治疗的疗效.方法在超声引导下选择肾囊肿的最佳进针部位穿刺抽液及无水酒精硬化治疗,以及对肾囊肿的治愈率进行分析.结果分别于术后3个月、6个月随访观察,68例患者78个囊肿,除2个囊肿经2次穿刺治疗外,76个囊肿均为1次穿刺治疗成功,经1次穿刺治疗有效率为97.4%.结论超声引导下经皮肾囊肿穿刺抽液及无水酒精硬化治疗,方法简便、安全,并发症少,是一种有效的治疗方法.     

超声引导穿刺治疗肾囊肿17例

目的探讨超声引导下经皮穿刺治疗肾囊肿的方法。方法经超声引导穿刺抽液后注入无水酒精硬化治疗肾囊肿17例。结果17例肾囊肿患者均获得穿刺成功,术后随访1个月~1年,有效率100%,治愈率94.1%。结论超声引导下经皮穿刺抽液注入无水酒精硬化治疗肾囊肿,是一种简便、经济、损伤小、安全可靠的治疗方法,可作为肾囊肿治疗的首选。     

超声引导介入治疗肾囊肿117例

目的:探讨超声引导下注射无水酒精硬化治疗肾囊肿的临床应用及治疗效果。方法:对117例肾囊肿患者采用超声引导下经皮穿刺囊内注入无水酒精进行硬化治疗。结果:117例肾囊肿患者介入治疗均获得成功,术后随访3-12个月,治愈率达95.7%,有效率100%。结论:超声引导下注入无水酒精治疗肾囊肿,特别是采用无水酒精反复冲洗肾囊肿的方法,疗效更加明显,可作为在治疗肾囊肿的首选方法。     

超声下穿刺无水乙醇硬化治疗肾囊肿疗效观察

目的评价超声引导下穿刺无水乙醇硬化治疗肾囊肿疗效。方法回顾性分析2004—2008年在超声引导下穿刺抽尽囊液并注入无水乙醇硬化治疗肾囊肿96例。结果96例肾囊肿患者1例囊内出血,1例酒精过敏,术后随访1个月-1年,有效率100％,治愈率95．8％。结论超声引导下穿刺无水乙醇硬化治疗肾囊肿是一项有价值的介入性治疗,方法简便易行、安全有效、并发症少、疗效确切,可作为肾囊肿的首选治疗方法。     

超声引导下穿刺治疗肾囊肿的体会

目的：探讨超声引导穿刺治疗肾囊肿的的应用价值。方法：经超声引导下对50例56个肾囊肿患者的穿刺治疗。结果：50例肾囊肿患者经过穿刺治疗3个月及6个月复查囊肿消失。结论：超声引导穿刺治疗肾囊肿是一种简单经济有效的治疗方法。     

超声引导下穿刺硬化治疗肾囊肿39例疗效观察

目的：探讨超声引导下细针穿刺硬化治疗肾囊肿的疗效。方法：2001—2003年在B超引导下采用无水乙醇行细针穿刺硬化治疗肾囊肿39例。结果：术后3个月随访，有效率为100％。结论：在超声引导下对肾囊肿行穿刺硬化治疗简单易行，并发症少，疗效确切，是肾囊肿的最佳治疗方法之一。     

B超引导下穿刺治疗肾囊肿疗效分析

目的：探讨B超引导下经皮穿刺治疗肾囊肿的疗效。方法：2004年5月至2007年10月在B超引导下穿刺注入无水乙醇硬化治疗肾囊肿89例,其中包括肾盂旁囊肿5例。结果：89例患者均穿刺成功,术后随访3个月至2年,治愈率92%（82/89）,有效率100%。结论：在B超引导下经皮穿刺注射无水乙醇硬化治疗肾囊肿,方法简便经济,疗效确切,可做为肾囊肿首选治疗方案。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.