中药泡脚联合液氮冷冻治疗较大型跖疣临床疗效观察

目的观察中药泡脚联合液氮冷冻治疗较大跖疣(疣体直径≥0.5)临床疗效,以期指导临床用药。方法将113例患者随机分为两组,对照组采用液氮冷冻治疗,治疗组采用中药联合液氮冷冻治疗,两周为1个疗程,共观察3个疗程。结果从第2个疗程开始,治疗组的疗效优于对照组(P<0.05),3个疗程结束时,治疗组相比对照组具有明显的疗效(P<0.01)。结论中药联合液氮冷冻治疗较大跖疣不但可以缩短疗程,还可减少复发。     

液氮冷冻联合咪喹莫特乳膏封包治疗掌跖疣疗效观察

掌跖疣是人乳头瘤病毒（HPV）感染所致,因疣体位于掌跖部,对患者工作生活有较大影响;治疗较为棘手。我科应用液氮冷冻联合咪喹莫特乳膏封包治疗多发性掌跖疣取得较为满意的疗效。1资料及方法1.1病例选择118例为我科门诊2013年9月至2014年8月就诊患者,疣体均位于掌跖部,数目≥3个,具有典型表现,符合诊断标准。     

液氮冷冻和钬激光治疗跖疣疗效观察

1 临床资料 120例跖疣患者均来自本科门诊。其中男68例，女52例；年龄6～78岁，平均32岁；病程1月～2年，平均7．8月；疣体单个至10余枚。患者随机分为钬激光治疗组80例，液氮冷冻组40例。两组一般资料具有可比性。     

冷冻配合穴位注射治疗跖疣45例

我们于2002年3月开始以冷冻配合穴位注射治疗疣45例，疗效显著，现报道如下：     

5%苯扎溴铵溶液联合液氮冷冻治疗多发性跖疣的临床观察

目的:观察5%苯扎溴铵溶液联合液氮冷冻治疗多发性跖疣的临床疗效。方法:选取80例泛发性跖疣患者,随机分为治疗组和对照组,每组40例。治疗组先予5%苯扎溴铵溶液浸泡至疣体松软、范围缩小,再进行冷冻治疗;对照组单纯用液氮冷冻治疗,比较两组疗效。结果:治疗组治愈30例、显效6例、好转4例;对照组治愈12例、显效9例、好转9例、无效10例。治疗组临床有效率(90.0%)明显优于对照组(52.5%),差异具有统计学意义(χ2=19.30,P<0.05)。结论:5%苯扎溴铵溶液浸泡联合液氮冷冻治疗泛发性跖疣疗效显著,且副作用少,患者容易接受,值得临床推广。     

液氮冷冻与阿维A口服联合治疗多发性跖疣疗效观察

目的 观察液氮冷冻与阿维A 口服联合治疗多发性跖疣对患者疼痛程度及远期疗效的影响.方法 选择2016年1月至2019年12月期间在某医院门诊部就诊的95例多发性跖疣患者为观察对象,随机分为两组.对照组47例进行单纯液氮冷冻治疗,观察组48例实施阿维A胶丸联合液氮冷冻治疗.比较两组的皮损评分、疼痛评分、临床疗效、不良反应...     

液氮冷冻联合卡介菌多糖核酸治疗多发性跖疣疗效观察

我科于2008年1月～2011年1月使用液氮冷冻联合卡介菌多糖核酸治疗多发性跖疣,并与单纯液氮冷冻治疗多发性跖疣进行对比,现将结果报告如下。     

高频电力、冷冻联合治疗跖疣86例疗效观察

跖疣是皮肤科常见而且难以治疗的疾病之一,虽治疗方法很多,但治疗效果不佳。我科从2003年开始采用高频电刀冷冻联合治疗跖疣例,收到了良好效果,现将结果报告如下。     

CO2激光、电灼和液氮冷冻三种疗法治疗掌跖疣144例

寻常疣是常见的皮肤病 ,其中掌跖疣比较难治。我院皮肤科于 2 0 0 0年 2月～ 2 0 0 2年 2月采用CO2 激光、电灼和液氮冷冻治疗掌跖疣 1 44例 ,取得良好疗效。为了探讨较好的治疗方法 ,现报告如下。1　临床资料与方法1 .1　一般资料　 1 44例患者中男 87例 ,女 5 7例 ,年龄 6岁～ 65岁 ,平均 31岁 ,病程 2周～ 1 3年 ,平均 5个月。随意分为 3组 ,甲组 73例 ,共 1 1 8个皮损 ,采用CO2 激光治疗 ;乙组 2 7例 ,共 5 1个皮损 ,采用电灼治疗 ;丙组 44例 ,共 83个皮损 ,采用液氮冷冻治疗。1 .2　治疗方法　甲组 :局部常规消毒 ,以 2 %利多卡因…     

液氮冷冻治疗丝状疣临床疗效观察

我科采用液氮喷射法冷冻治疗丝状疣109例,取得了满意的疗效,现报告如下。     

国产5％咪喹莫特乳膏治疗生殖器疣荟萃分析

目的：以循证医学的方法对国产5％咪喹莫特乳膏治疗生殖器疣的疗效、安全性以及预防生殖器疣复发的效果进行系统性评价。方法：检索中文科技期刊数据库（CNKI）、中国生物医学文献数据库（CBMDisc），由两名评价者独立提取资料并进行方法学质量评估。试验数据的统计分析采用Co-chrane协作网提供的RevMan4．2．8软件进行。结果：咪喹莫特乳膏单疗组，最终纳入8个临床随机对照试验，Meta分析结果显示，与安慰剂比较，疗效差异有统计学意义；与2．5％氟尿嘧啶软膏比较，疗效差异没有统计学意义。没有严重系统性不良反应的报道。咪喹莫特乳膏联合物理治疗组，最终纳入12个临床随机对照试验，Meta分析结果显示，以观察3个月或6个月没有在原位复发作为痊愈标准，与安慰剂组比较，疗效差异有统计学意义。结论：现有临床证据表明，国产5％咪喹莫特乳膏治疗生殖器疣有确切的疗效和较好的安全性，对预防生殖器疣复发也有确切的疗效。     

Efficacy of intralesional methotrexate in the treatment of plantar warts

Warts are tumors or growths caused by infection with human papilloma virus (HPV). Currently, over 170 HPV types have been identified. This study aimed to evaluate the efficacy and safety of intralesional injection of methotrexate (MTX) for the treatment of plantar warts. Sixty patients presented with plantar warts were divided into two groups. Group A patients were injected with intralesional MTX (2 mg/ml). Group B patients were injected with intralesional saline as a placebo. The injections were repeated every week for a maximum of six sessions or until complete clearance, whichever was earlier. The patients were followed up for 6 months after the last injection. In the intralesional MTX group, 2 patients (6.7%) showed complete improvement, 8 patients (26.7%) showed partial improvement, and 20 patients (66.7%) showed no improvement. In the intralesional saline group, 3 patients (10%) showed complete improvement, 4 patients (13.3%) showed partial improvement, and 23 patients (76.7%) showed no improvement. Reported adverse events were local reactions in the form of swelling, pain, and infection in both groups. There was no statistically significant difference between the therapeutic responses to intralesional MTX injection and saline.     

复方硝酸溶液治疗寻常疣多中心、随机开放、平行对照临床试验

目的 评价复方硝酸溶液(商品名思可得)治疗寻常疣的疗效和安全性,并与冷冻疗法进行比较。方法 采用多中心、随机开放、平行对照的临床试验。结果 主要疗效靶疣体清除率中思可得组为71.6%,冷冻组为77.5%(P=0.451)。次要疗效其他疣体清除率中思可得组为58.7%,冷冻组为75.3%(P=0.034)。思可得组不良反应发生率为4.1%,冷冻组为1.4%(P>0.05)。结论 思可得治疗寻常疣简便、安全、有效。     

Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud

BACKGROUND: Viral warts represent a large workload for dermatology departments. Cryotherapy with liquid nitrogen is the most widely used method of treatment by dermatologists and is increasingly used by general practitioners in the U.K. Existing data relating to the response to cryotherapy are virtually all derived from the use of a cotton wool bud as the applicator. There is an increasing trend to use the cryo-spray to freeze warts and it has been assumed that this is equally effective. In view of the workload involved it is important to test this assumption. OBJECTIVES: This prospective study was undertaken to compare these two methods of liquid nitrogen cryotherapy with regards to cure rate after 3 months of treatment. METHODS: Patients referred to two hospital dermatology departments with hand or foot warts were allocated to have liquid nitrogen applied with either a cryo-spray or with a cotton wool bud. Using either technique, liquid nitrogen was applied until ice-ball formation had spread from the centre to include a margin of 2 mm around each wart. Treatment was done fortnightly for up to 3 months. Plantar warts were pared and treated with a double freeze-thaw cycle. The endpoint of the study was complete clearance of all warts. RESULTS: Three hundred and sixty-three patients were enrolled, mean age 21 years (range 3-75), 188 male and 175 female. The mean duration of the warts was 98 weeks (median 78, range 2-936). The number of warts on the hands and feet varied from one to 80 (mean 5). The treatment groups were comparable with regards to baseline demographics. Two hundred and seven patients were evaluable. Cure rates at 3 months were 47% in the cotton wool bud group and 44% in the cryo-spray group (P = 0.8). Warts that had been present for 6 months or less (n = 31) had a greater chance of clearance (84%) compared with warts that had been present for more than 6 months (39%, n = 176) (P < 0.0005). CONCLUSIONS: Cryotherapy with liquid nitrogen for hand and foot warts in our study was equally effective when applied with a cotton wool bud or by means of a spray.     

5％咪喹莫特乳膏治疗外生殖器/肛周疣随机对照研究

目的评价5％咪喹莫特乳膏（艾达乐）治疗外生殖器／肛周疣的有效性和安全性。方法采用随机、双盲、平行对照、七个中心临床研究。患者随机入组，一组患者先接受咪喹莫特治疗16周或至所有基线疣消失，然后给予赋形剂4周。另一组患者先接受赋形剂治疗4周，然后再接受咪喹莫特治疗16周或至所有基线疣消失。每周外用乳膏3次（晚上应用，至少保留8h），每4周评估一次临床疗效。结果共144例患者人选。在研究结束时（20周），综合两个治疗组合并显示，基线疣计数减少≥50％的患者为75．0％（意向性治疗分析，ITT）和83．5％（符合方案完成试验集分析，PP），疣完全清除率分别为79．9％（ITT分析）和89．8％（PP分析）。在第4周时，咪喹莫特组基线疣计数减少≥50％的患者为48．6％，赋形剂组为19．4％，P=0．0004；咪喹莫特组疣完全清除率为22．2％，赋形剂组为6．9％，P=0．009。最常见的不良事件发生是用药部位的皮肤反应（38．9％），无严重不良事件发生。结论咪喹莫特乳膏治疗外生殖器／肛周疣疗效明显优于赋形剂，每周3次，疗程16周，安全有效，使用方便。     

Cold urticaria as a complication of cryotherapy in the treatment of viral warts

Cryotherapy with liquid nitrogen has been established as the first-line treatment for pediatric patients with viral warts. Cold-induced urticaria (CU) is a rare skin reaction triggered by cold stimuli. We present the case of a pediatric patient with viral warts who developed CU after receiving cryotherapy.     

溴夫定治疗带状疱疹的疗效和安全性评价

目的 评价溴夫定125mg每天1次和每天4次治疗带状疱疹的疗效和安全性.方法 多中心、随机、双盲、平行对照临床试验.226例带状疱疹患者分别接受溴夫定125mg每天1次(112例)或每天4次(114例)治疗,疗程7d,再随访3周.结果 新水疱停止出现时间,单次剂量组平均为3.88d,4次剂量组为3.79d,两组比较,差异无统计学意义.水疱完全消退时间、开始结痂时间、全部结痂时间、开始脱痂时间、全部脱痂时间、疼痛开始减轻时间和疼痛完全消失时间两组比较,差异均无统计学意义.单次剂量组有34.5%、4次剂量组有30.4%的患者皮损痊愈后仍存在疱疹相关疼痛.药物相关不良反应发生率分别为5.4%和9.6%.结论 溴夫定125mg每天1次和每天4次治疗带状疱疹同样有效,但单次剂量组更方便、安全.     

单次艾条灸治疗难治性跖疣的临床疗效观察

跖疣临床易诊而难治.我们采用单次艾条灸方法治疗难治性跖疣,取得一定疗效,现总结如下. 一、临床资料 1.临床资料:根据跖疣的诊断标准[1],共纳入235例跖疣病例,所有病例均来自于3个临床分中心的针灸科和皮肤科门诊,根据随机数字表随机分为艾灸组(120例)和水杨酸组(115例).两组的人口学特征、病程、病情,经统计学处理分析,差异均无统计学意义(P>0.05).     

钝性剥离手术联合高频双极电凝治疗跖疣临床疗效观察

我科自2010年6月至2011年12月采用钝性剥离手术联合高频双极电凝治疗跖疣,取得明显疗效,现报告如下. 一、资料和方法 1.临床资料:60例跖疣患者均为我院门诊确诊患者,皮损数目1～5个.其中男37例,女23例,年龄13～62岁,病程平均1个月至10年,疣体数目总计146个,面积最大25 mm×25mm,最小0.5 mm× 0.5 mm.