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Roberto Mongil Poce Carlos Pagés NavarreteJosé Antonio Ruiz Navarrete Javier Roca FernándezRicardo Arrabal Sánchez Agustín Benítez DoménechAntonio Fernández de Rota Avecilla José Luis Fernández Bermúdez 《Archivos de bronconeumología》2009
Introduction
The publication of the International Registry of Lung Metastases (IRLM) in 1997 was a turning point in favor of surgical resection of lung metastases. Prognostic groups were defined according to resectability, number of metastases, and disease-free interval. The objective of this study was to determine survival in patients who underwent resection of lung metastases from colorectal carcinoma and to evaluate how applicable the prognostic factors established by the IRLM are in this specific patient group.Patients and Methods
Patients with lung metastases from colorectal carcinoma who underwent resection between January 1, 2000, and November 30, 2006, were retrospectively analyzed. Survival was calculated using the Kaplan-Meier method, with log-rank comparisons between groups.Results
Survivals at 1, 3, 5, and 6 years was 92%, 75%, 54%, and 43%, respectively. The main finding was that 3-year survival was better in patients who underwent atypical resection of the metastasis (75%) than those who required lobectomy (55%). There were no significant differences in survival in terms of number of lung metastases resected or disease-free interval.Conclusions
Survival in patients requiring lobectomy for resection of lung metastases from colorectal carcinoma was worse than in those who underwent atypical resection. The number of metastases and disease-free interval may be questionable prognostic factors in the case of lung metastases from colorectal carcinoma. 相似文献2.
Jordi Freixinet Araceli Caballero-Hidalgo Beatriz González López-Valcárcel José Luis García Fernández Íñigo Royo Crespo Ángel Salvatierra Velázquez Emilio Canalís Arrayás Manuel Sánchez García Juan Torres Lanzas Gonzalo Varela Simó Ignacio Muguruza Trueba Manuel Mariñán Gorospe A. Cantó Armengod 《Archivos de bronconeumología》2009
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É. Pillebout J. Verine 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2014
Henoch-Schönlein purpura is a systemic vasculitis of the small vessels characterized by perivascular leucocyte infiltrates. It is an immunoglobulin A-related immune complex-mediated disease involving the skin, the joints and the gastrointestinal system. Renal disease may sometimes be associated to these clinical manifestations. Prevalence of the nephritis is highly variable, depending on the series. More rarely, other organs such as the lungs, the heart or the nervous system may be involved. The clinical diagnosis is confirmed by histopathology of the skin (leukocytoclastic vasculitis) and kidney (endo-capillary proliferative glomerulonephritis), showing IgA deposits in these tissues. Short-term prognosis depends on the severity of digestive involvement, but long-term prognosis depends on the renal disease. Recent publications of pediatric and adult series show that the chronic renal failure may progress, sometimes more than ten years after the initial flare. Treatment is usually supportive. The benefit of more specific treatments (corticosteroids or immunosuppressive drugs) in severe visceral forms (usually abdominal or kidney) has not yet been established. 相似文献
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Javier Hueto Pérez De Heredia Pilar Cebollero RivasJosé Antonio Cascante Rodrigo Isabel Andrade VelaIdoya Pascal Martínez Joan Boldú MitjansVíctor Manuel Eguía Astibia 《Archivos de bronconeumología》2012
Objective
To analyze the results obtained in a lung cancer screening program since its inception five years ago regarding correct referrals, diagnostic and therapeutic delay times and days of hospitalization. To compare the diagnostic-therapeutic delays and hospital stays with those obtained in patients evaluated with the standard system.Patients and methods
Included for study were all those patients evaluated in our Lung Cancer Screening Program (LCSP) in the last five years. For the cases with LC, we recorded the dates the patients were referred to a specialist, the first consultation, diagnostic tests, stage, start of treatment and days of hospitalization. We compared these same data with lung cancer patients who did not partake in the LCSP and were diagnosed between October 2008 and October 2010.Results
We evaluated 179 patients remitted to the LCSP, which represented 26.7% of the consultations; 166 (92.7%) of the referrals were correct, out of which 44.5% were LC. In 75.6% of these, the entire study was completed in the outpatient setting, and more than 85% of the cases met the current recommendations related with diagnostic-therapeutic delays. When these results were compared with the non-LCSP group (n = 151), differences were found in the data for hospitalizations: there was a lower percentage of hospitalizations (P < .0001) and shorter hospital stays (P < .0001) in the LCSP group. There were no differences between the two groups for diagnostic or therapeutic delays.Conclusion
In our setting, lung cancer screening programs allow for cancer studies to be carried out in the outpatient consultations in a large percentage of cases, and within the time periods recommended by current guidelines. In spite of this fact, we have detected that these programs are underused. 相似文献5.
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M. Piram I. Koné-Paut 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2014
Behçet's disease is a chronic multisystem vasculitis of unknown etiology. The disease is commonly described in young adults but can occur in childhood. Diagnosis is based on clinical manifestations since there are no pathognomonic laboratory findings. Early diagnosis in children is challenging due to the insidious nature of the disease and the low sensitivity of adult criteria in the pediatric population. The purpose of this review is to describe the demographic and clinical features of Behçet's disease in childhood, its complications and recent advances in therapeutics highlighting differences with the adult onset disease. 相似文献
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Jordi Freixinet Araceli Caballero-Hidalgo Beatriz González López-Valcárcel José Luis García Fernández Íñigo Crespo Royo Ángel Salvatierra Velázquez Emilio Canalís Arrayás Manuel Sánchez García Juan Torres Lanzas Gonzalo Varela Simó Ignacio Muguruza Trueba Manuel Mariñán Gorospe A. Cantó Armengod 《Archivos de bronconeumología》2009
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A. Daumas P. Rossi F. Bernard-Guervilly Y. Francès J. Berbis J.-M. Durand G. Kaplanski M. Ebbo J.-R. Harlé P.-J. Weiller J. Serratrice P. Disdier S. Gayet P. Villani B. Granel 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2014
Purpose
Aortic involvement that occurs in temporal arteritis is probably underestimated because it is usually asymptomatic. The characteristics of giant cell arteritis with aortic involvement are still poorly described and the relationship between aortitis and vascular outcome of the disease has not been clearly delineated. The objective of this retrospective study of 63 patients with giant cell arteritis, including 26 with aortic involvement, was to compare the features of patients with and without aortitis, and to assess the contribution of CT-scan and FDG-PET-scan in screening for vascular disease, monitoring, and therapeutic management of patients.Methods
This retrospective study was conducted in the internal medicine department of the university hospital in Marseille, France, from January 1, 2005 to September 30, 2011. Patients had at least three out of the five American College of Rheumatology criteria for temporal arteritis and aortic involvement was investigated in all patients using CT-scan. Aortic wall thickness greater or equal to 3 mm was considered to be abnormal.Results
Of 63 patients diagnosed with giant cell arteritis, 26 (41.3%) had aortic involvement diagnosed by aortic CT-scan. Age at diagnosis was significantly younger (66.8 vs 73.8 years; P = 0.002) in the group with aortitis. Inflammatory dorsal and low back pain, signs of vascular disease of the upper limbs (P = 0.009), and higher level of acute phase reactants were associated with aortitis. Aneurysmal lesions of the aorta were significantly more frequent in the group with aortitis. Twenty patients had both aortic CT-scan and FDG-PET-scan. For patients in whom aortic involvement was not demonstrated with CT-scan, FDG-PET-scan was always non-contributive. With corticosteroids, aortitis resolved within 6 months in all patients as evaluated by aortic CT-scan. However, aortitis persisted in 80% of cases at 6 months when evaluated with FDG-PET-scan, and in 66% of cases at 12 months, without influencing the treatment.Conclusion
This case series shows no specific features of aorta and its main roots involvement in giant cell arteritis, justifying a systematic screening by CT-scan. The high frequency of this arterial involvement could help physicians in the diagnosis of giant cell arteritis. Aortitis seems to be associated with vascular complications as highlighted by the frequency of aortic aneurysm and a case of early aortic dissection. Finally, the role of PET-CT-scan for screening vascular disease and therapeutic monitoring remains to be clarified. 相似文献18.
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A. Mahr C. Maldini 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2014
With more than 30 published prevalence estimates for Behçet's disease (BD), covering many different regions worldwide, the prevalence of BD is quite well described. Even though the interpretation of these data is complicated by between-study differences in methodology, which may substantially influence the results, these data suggest large geographic variations in frequency of BD, with prevalence rates of 20–420/100,000 inhabitants for Turkey, 2.1–19.5 for other Asian countries, 1.5–15.9 for southern Europe and 0.3–4.9 for northern Europe. Additional epidemiological studies or case series from North and South America, the Caribbean Islands, and individuals of sub-Saharan ancestry further suggest that the geographic distribution of BD is much wider than the boundaries of the ancient Silk Road. The few available incidence rates prevent from making strong inferences as to whether the frequency of BD has changed over time. Recent population-based studies of immigrants or migrant populations consistently indicate that migrants from areas of high BD prevalence remain at high risk for BD, which may even be close to the prevalence observed in their countries of origin. Genetic factors, which are not detailed in this review, seem to play a preponderant role in BD development, although they cannot explain the wide between-country disparities in BD prevalence. However, environmental risk factors, including infectious and non-infectious causes, remain poorly investigated and have not yet produced solid hints. 相似文献
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M. Pichon O. Lidove M.-L. Roudaire B. Barry P. Herman D. Gobert E. Pasqualoni C. Compain M.-P. Chauveheid T. Papo 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2012