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1.
The malonic dialdehyde content in murine plasma decreases considerably after 1–24 h of acute alcohol intoxication (3 g/kg
intraperitoneally). Zinc-metallothionein from rat liver administered in a dose of 2 mg/kg prior to alcohol normalizes the
malonic dialdehyde level, whereas a mixture modeling zinc-metallothionein (albumin, cysteine, and zinc) does not change it.
A 2- to 2.5-fold increase in the malonic dialdehyde content is observed in all cases after 3 days. It is assumed that the
effect of zinc-metallothionein is associated with its ability, similarly to other thiol compounds, to stimulate the metabolism
of ethanol and acetaldehyde and to reduce the toxicity of the latter by forming mixed compounds.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
1, pp. 46–49, January, 1995
Presented by I. V. Domoradskii, Member of the Russian Academy of Medical Sciences 相似文献
2.
M. N. Karpova V. V. Zhulin R. N. Glebov O. Yu. Pankov R. I. Kruglikov 《Bulletin of experimental biology and medicine》1994,117(2):134-136
Binding of3H-diazepam in rat cerebellum decreases by 14% (p<0.05) 11 months after termination of kindling and one day after injection of a test dose of corazole (30 mg/kg), while it
increases by 19.5% after a single injection of a convulsive dose of corazole (50–75 mg/kg). No changes are found in the cortex.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
2, pp. 135–137, February, 1994
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
3.
S. S. Pertsov T. S. Balashova A. A. Kubatiev A. S. Sosnovskii G. V. Pirogova V. M. Abramov 《Bulletin of experimental biology and medicine》1995,120(3):884-886
Acute emotional stress is shown to raise the level of malonic dialdehyde in the hypothalamus of August rats. After intraventricular
administration of interleukin-1β, the malonic dialdehyde level and the activity of antioxidant enzymes tended to rise selectively
in the hypothalamus (but not in the sensorimotor cortex) of August, Wistar, and WAG rats. In the presence of this interleukin,
acute emotional stress did not cause increases in lipid peroxidation products in the hypothalamus of August rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 244–247, September, 1995 相似文献
4.
M. V. Borisyuk V. V. Zinchuk V. N. Korneichuk I. N. Galushko 《Bulletin of experimental biology and medicine》1994,118(1):707-710
Hemoglobin affinity for oxygen (P50 parameter) and the content of malonic dialdehyde (MDA), Schiff's bases, and diene conjugates in the plasma and red cell mass
were examined in mixed venous blood of rabbits with pyrogenal fever. Correlation regression analysis of the tested parameters
showed that reduction of the actual affinity of hemoglobin for oxygen is conducive to activation of free-radical processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 27–30, July, 1994
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences 相似文献
5.
A. N. Koterov Z. A. Trebenok N. B. Pushkareva A. V. Nikol'skii 《Bulletin of experimental biology and medicine》1996,122(5):1088-1090
It is shown that zinc-metallothionein from rat liver increases 1.5-fold thein vitro incorporation of3H-thymidine in murine bone marrow cells. The same concentrations of zinc chloride and a mixture imitating zinc-metallothionein
(zinc, cysteine, and albumin) inhibit DNA synthesis. In mice receiving an intraperitoneal injection of zinc-metallothionein
10–15 min before γ-irradiation, the incorporation of3H-thymidine and the content of nucleated cells in the bone marrow is 1.5- to 2-fold higher than those in unprotected animals,
the number of endogenous splenic colonies in pretreated mice being 2.7-fold higher.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 11, pp. 505–508, November, 1996 相似文献
6.
P. V. Sergeev P. I. Sizov V. G. Filimonov G. A. Sheveleva A. S. Dukhanin 《Bulletin of experimental biology and medicine》1994,118(1):715-718
The barouterography method revealed that intravenous phenibut in a dose of 50 mg/kg and phenazepam in a dose of 2.5 mg/kg
have a suppressive effect on the contractile isometric (fetus-expelling) activity of the uterus in nonpregnant and pregnant
rabbits. Phenibut (150 mg/kg) and phenazepam (3 mg/kg) do not have an adverse effect on fetal development in rats. Clinical
trials of phenibut and phenazepam as gravidoprotectors in threatened abortions are recommended.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 35–37, July, 1994 相似文献
7.
G. A. Belokrylov O. Ya. Popova O. N. Derevnina I. V. Molchanova 《Bulletin of experimental biology and medicine》1994,117(5):497-499
It is shown that the effect of amino-acid preparations (levamine-70–70, cerebrolysin, and aviamine) is dose-dependent. Thus,
levamine-70 and cerebrolysin at 65 mg/kg do not affect the immune response but stimulate phagocytosis. Aviamine at 65 mg/kg
inhibits the immune response but stimulates phagocytosis and in a dose of 6.5×10−2 mg/kg boosts both processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 500–501, May, 1994
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
8.
A. N. Koterov Z. A. Trebenok I. V. Filippovich 《Bulletin of experimental biology and medicine》1994,118(2):828-830
Injecting mice with exogenous zinc-metallothioneine from rat liver at 2 mg/kg 5–10 min before their total-body irradiation
resulted in a significantly increased 30-day survival rate. The radioprotective effect of zinc-metallothioneine was not associated
with the influence of its constituents, since a model mixture composed of these (albumin, cysteine, and zinc) failed to protect.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8, pp. 139–141, August, 1994
Presented by B. B. Moroz, Member of the Russian Academy of Medical Sciences 相似文献
9.
V. Kh. Vaizov T. M. Plotnikova T. V. Yakimova O. E. Vaizova A. S. Saratikov 《Bulletin of experimental biology and medicine》1994,118(3):975-977
It is demonstrated that ammonium succinate is capable of increasing the survival of rats with acute brain ischemia. In transient
brain ischemia therapeutic injection of ammonium succinate prevents the development of postischemic hypoperfusion and hypooxygenation
of the brain. The antiischemic effect of ammonium succinate is due to a decrease of the oxygen affinity of hemoglobin and
to limitation of the accumulation of malonic dialdehyde, a secondary product of lipid peroxidation, in the brain. No vasotropic
activity of ammonium succinate is revealed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 276–278, September, 1994
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
10.
Synthesis and properties of the immunotoxin CD5-ricin 总被引:1,自引:0,他引:1
G. V. Vikha L. D. Uzhinova A. Zh. Kashaeva V. V. Goshev A. V. Krylov A. Yu. Baryshnikov R. G. Vasilov 《Bulletin of experimental biology and medicine》1995,119(1):70-73
Synthesis and properties of an immunotoxin produced by conjugating ricin with a novel monoclonal antibody (IgG3 of the ICO-104
class) are described. Cytolytic activity of the synthesized immunotoxin, determined by two independent methods and expressed
in LD50, is 0.3–0.6×10−7 M. Its specificity for target cells containing the CD5 antigen is shown.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
1, pp. 76–79, January, 1995
(Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences) 相似文献
11.
V. B. Prozorovskii V. G. Skopichev V. V. Petrov M. S. Dubrovnik 《Bulletin of experimental biology and medicine》1995,119(5):500-503
Nembutal-anesthetized rats under conditions of artificial respiration received intramuscular injections of phosphacol in doses
equal to 0.5, 5, and 50 LD50. The lung ventilation per se induced blood changes typical of hyperventilation alkalosis. Poisoned animals showed the development
of dose-dependent tissue acidosis. At a later stage of poisoning (2 hours) a high phosphacol dose induced decompensated acidosis,
which caused the death of some animals. Electron microscopy revealed that the previously described rat erythrocyte deformation
coincides in time with the changes of cytoskeleton content and depends on the dose of phosphacol but not on the blood pH.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5, pp. 517–520, May, 1995
Presented by S. N. Golikov, Member of the Russian Academy of Medical Sciences 相似文献
12.
A. A. Kubatiev T. S. Balashova V. Yu. Smirnova I. A. Strokov T. A. Konstantinovskaya 《Bulletin of experimental biology and medicine》1996,122(3):947-949
Effect of naftidrofuryl, a blocker of serotonin 5S2-receptors (Dusodril-retard), on the malonic dialdehyde content in the serum and erythrocyte membranes is studied in diabetics
with and without angiopathies. A 40-day treatment with Dusodril-retard normalizes the serum content of malonic dialdehyde,
an intermediate product of lipid peroxidation, and has no effect on the malonic dialdehyde content of the erythrocyte plasma
membrane. A negative correlation is established between blood levels of total cholesterol, β lipoproteins, and malonic dialdehyde
levels in patients with diabetes mellitus.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 338–341, September, 1996 相似文献
13.
Prolonged administration of naloxone (5 mg/kg body weight) during the juvenile period stimulated ovarian folliculogenesis
and pubescence in mice; the effect was absent in animals of other ages, when a single injection was given, or when the dose
of preparation was decreased.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 341–344, March, 1996
Presented by O. V. Volkova, Member of the Russian Academy of Medical Sciences 相似文献
14.
M. I. Arkhangel'skaya D. Drahotova 《Bulletin of experimental biology and medicine》1995,119(4):329-332
In experiments on rabbits under Nembutal anesthesia, intravenous injection of flunitrazepam in a single dose of 0.125 mg/kg
in combination with delta sleep-inducing peptide in a single dose of 60 nmol/kg raised the threshold of ventricular fibrillation
to a level that was significantly higher than that after injection of flunitrazepam alone in the same dose and comparable
to that after injection of this benzodiazepine alone in twice as high a dose (0.25 mg/kg), but without the side effects (persistent
hypotension and transient bradycardia) produced by the latter dose. It is concluded that the ability of jointly acting delta
sleep-inducing peptide and flunitrazepam to increase the electrical stability of the heart may have practical relevance to
the prevention of ventricular arrhythmias occurring under conditions of emotional stress and myocardial ischemia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 342–345, April, 1995
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences 相似文献
15.
T. N. Makarenko G. N. Chernobaeva L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1994,118(6):1303-1306
A satistically significant decrease in the content of cytochromes P-450 and b5 and in the activity of aniline hydroxylase and p-nitroanisole demethylase occurs in rat liver microsomes during the development
of experimental acute fatty hepatosis develoing within a 24-h period after intraperitoneal administration of 125 mg/kg tetracycline
hydrochloride. Under these experimental conditions tetracycline hydrochloride elicits only an insignificant disintegrating
effect on oxidative phosphorylation in liver mitochondria.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 612–615, December, 1994 相似文献
16.
I. A. Kavraiskaya 《Bulletin of experimental biology and medicine》1995,119(4):333-335
Experiments on pregnant rabbits infused with troxevasin showed that the rate of uteroplacental blood flow after infusion depended
on the dose and the initial (preinfusion) rate of this blood flow. After the dose of 140 mg/kg, the blood flow rate increased
if it was initially low and decreased if it was high. After a lower dose (70 mg/kg), the blood flow rate decreased to different
degrees depending on the initial blood flow rate in the uterus. The findings suggest that the use of troxevasin to treat the
fetus is indicated in cases of placental insufficiency.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 346–349, April, 1995
Presented by B. I. Tkachenko, Member of the Russian Academy of Medical Sciences 相似文献
17.
T. N. Makarenko A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1994,118(6):1294-1296
It is demonstrated that intraperitoneal administration of tetracycline hydrochloride in a dose of 125 mg/kg leads to the development
of acute fatty hepatosis in rats within a 24-h period, by which time the maximum accumulation of lipids and triacylglycerides
is observed in the liver. In addition, a direct dependence is established between the severity of fatty hepatosis and a decrease
in the cytochrome P-450 content. The cytochrome P-450 content is a dynamic predictor of tetracycline fatty hepatosis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 603–605, December, 1994 相似文献
18.
T. A. Gremyakova V. A. Amel'chenko G. A. Anisimov 《Bulletin of experimental biology and medicine》1995,119(1):48-51
The protective properties of recombinantSalmonella minnesota R595/pFS1 strain soon after immunization (1–3 days) are studied in a model of experimental mouse plague. Unlike the commercial
EV strainYersinia pestis vaccine produced at the Saratov Anti-Plague Institute (Mikrob Research-Manufacturing Conglomerate), the experimental recombinant
p preparation affords a high level of protection from the 1st day postvaccination, and surpasses the commercial preparation
in such parameters as LD50, mean survival time, and percentage of survivors. By the 21st day the protective indexes of both preparations are comparable.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 119, N
o
1, pp. 54–57, January, 1995
Presented by A. A. Vorob'ev, Member of the Russian Academy of Medical Sciences 相似文献
19.
V. I. Kirpatovskii N. V. Nikiforova Yu. V. Kudryavtsev O. N. Nadtochii 《Bulletin of experimental biology and medicine》1996,121(5):452-455
The ability of α-tocopherol in the form of an emulsion to augment the antioxidant reserve of kidneys during their ischemia
or storage is explored. Over 10 min after an intravenous injection of the emulsion into rats or rabbits at 10 mg/kg body weight,
the mean α-tocopherol concentration in the renal cortical layer rose from 6.7±0.2 to 7.4±0.2 μg/g (p<0.05); the injection also slowed the accumulation of malonic dialdehyde in cortical layer homogenates of intact and ischemic
kidneys during ascorbate-induced lipid peroxidation. In kidneys stored at 4°C in a preservative solution to which the α-tocopherol
emulsion had been added (10 mg/liter), lipid peroxidation was found to be inhibited after 24 and 48 h of storage.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 499–502, May, 1996 相似文献
20.
It is established that buprenorphine (0.3 mg/kg) induces considerable alterations in the phospholipid composition of hepatocyte
plasma membranes as a result of phosphatidylserine accumulation and a considerable loss of sphingomyelin and lysophosphatidylserine.
When administered in a dose of 0.03 mg/kg, buprenorphine facilitates normalization of the phosphoinositol turnover in hepatocyte
plasma membranes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8, pp. 164–165, August, 1994
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献