精神分裂症患者家属心理控制感、家庭环境及心理健康分析

目的探讨精神分裂症患者家属心理控制感、家庭环境及其心理健康状况。方法采用家庭环境量表中文版（FES-CV）、多维度健康状况心理控制源量表（MHLC）及症状自评量表（SCL-90）对35名精神分裂症患者家属进行测评,并与常模对照。结果精神分裂症患者家庭亲密度、知识性及组织性评分明显低于对照组,而矛盾性评分高于对照组（P〈0.01）;精神分裂症患者家属与对照组比较,内控性（IHLC）心理倾向明显降低,外控性（PHLC）心理倾向明显增高（P〈0.01）,且心理健康水平低下,躯体不适主诉较多（P〈0.01）,常伴有焦虑和抑郁情绪（P〈0.05）。结论家庭心理环境对精神分裂症患者家属的心理健康水平产生重要影响,对早期干预十分必要。     

家庭环境与高中生心理健康水平的相关研究

目的探讨家庭环境与高中生心理健康的关系.方法采用家庭环境量表(FES-CV)和症状自评量表(SCL-90)对203名高中生进行测试,并与有关常模进行比较.结果与中国常模相比,FES-CV中多数分量表得分较低;女生在亲密度、情感表达分量表评分高于男生.SCL-90总分与FES-CV的亲密度、成功性、知识性、娱乐性、道德观、组织性呈显著负相关,与矛盾性呈显著正相关;不同心理健康水平的学生其FES-CV多数分量表评分有显著差异,有心理问题者其FES-CV多数分量表评分较低,矛盾性评分较高.结论家庭环境对高中生的心理健康有重要影响.     

家庭环境与医学生心理健康状况的关系及影响因素分析

目的探讨家庭环境与医学生心理健康状况的关系和相关的影响因素。方法整群、分层抽取我院临床相关各专业医学生580人,采用症状自评量表(SCL-90)、采用家庭环境量表中文版(FES-CV)和自制的社会人口统计学指标进行团体问卷调查,所得资料用统计软件SPSS 13.0对数据进行统计学处理。结果①FES-CV得分与中国常模的十个因子都有显著性差异,除矛盾性得分高于常模外,其它因子得分均低于常模。②家庭环境与医学生心理健康水平存在着显著相关性。③年级、性别、民族、专业满意度、是否是独生子女、家庭所在地、家庭经济情况等因素各自独立影响着家庭环境量表的单个或多因子。结论①家庭环境对医学生心理健康有重要的影响作用。②家庭关系受专业满意度、家庭所在地、家庭经济情况等因素的影响。     

家庭环境与高中生心理健康水平的相关研究

目的 探讨家庭环境与高中生心理健康的关系。方法 采用家庭环境量表（FES－CV）和症状自评量表（SCL－90）对203名高中生进行测试,并与有关常模进行比较。结果 与中国常模相比,FES－CV中多数分量表得分较低;女生在亲密度、情感表达分量表评分高于男生。SCL－90总分与FES－CV的亲密度、成功性、知识性、娱乐性、道德观、组织性呈显著负相关,与矛盾性呈显著正相关;不同心理健康水平的学生其FES－CV多数分量表评分有显著差异,有心理问题者其FES－CV多数分量表评分较低,矛盾性评分较高。结论 家庭环境对高中生的心理健康有重要影响。     

在校护生心理健康现状调查及影响因素分析

目的了解在校护生心理健康现状及其影响因素，为护生的职业心理教育提供依据。方法对643名在校护生进行问卷调查，问卷为症状自评量表（SCL-90），并分析学历、年龄、家庭环境、家庭收入、家庭子女数、年级及担任班级职务数等因素对护生心理健康的影响。结果①在校护生SCL-90得分除人际关系敏感、偏执外，其余7个因子得分均高于常模组（P〈0.01）。②相关分析显示．SCL-90得分与家庭子女数成正相关．其余各项呈负相关。结论在校护生心理健康状况不佳，应根据不同具体情况采取不同的心理指导。     

家庭环境与子女心理健康状况的研究

目的：探讨家庭环境因素对子女心理健康状况的影响，为进行有效的干预提供参考依据。方法：采用自制的家庭环境因素调查表、症状自评量表（SCL-90）和防御方式问卷（DSQ）分别对病例组、对照组的研究对象及其父母进行问卷调查。结果：病例组被试SCL-90总分及各因子分均高于对照组；病例组的家庭环境明显差于对照组；相关及回归分析提示子女的SCL-90得分明显与家庭气氛等家庭环境因素密切相关；父母之间、父子之间、母子之间的心理行为倾向性非常相关。结论：良好的家庭环境于子女心理健康有利，父母的心理行为方式影响子女的心理行为方式。     

家庭环境对12～16岁原发性癫癎儿童行为问题影响的研究

目的探讨家庭环境对12～16岁原发性癫癎儿童行为问题的影响。方法采用Achenbach儿童行为量表（CBCL）（家长用）和家庭环境量表中文版（FES-CV）对48例原发性癫癎儿童的行为和家庭环境进行调查,并分别与Achenbach儿童行为量表中国标准和家庭环境量表全国常模进行比较。结果癫癎儿童行为异常检出率为58.33%,明显高于CBCL中国常模（P〈0.01）;癫癎儿童家庭的亲密度（6.1±2.5）、文化性（4.0±1.8）、娱乐性（3.4±1.9）和组织性（5.3±1.7）比正常家庭明显为低,而矛盾性（3.3±2.1）和道德宗教观（6.1±1.5）明显为高;回归分析影响行为问题的因素,亲密度是造成癫癎儿童行为问题的危险因素。结论原发性癫癎儿童存在一定的精神行为问题,家庭环境是造成其发生行为问题的重要因素之一。     

青少年强迫症患者及亲属家庭因素的比较分析

目的：探索青少年强迫症患者及其亲属的父母教养方式和家庭环境特点及其差异.方法：采用父母教养方式评价量表（EMBU）和家庭环境量表中文版（FES-CV）对20例青少年强迫症患者、32例患者父母（为避免混淆,患者父母组称患者亲属组）及25例正常对照者进行比较研究.结果：与正常对照组相比,青少年强迫症组的父母情感温暖、理解较少,惩罚、严厉、拒绝、否认较多（P＜0.05）,患者在家庭中感受到的亲密度、道德宗教观、组织性较少,矛盾性和控制性较多（P＜0.05）;强迫症亲属组的父母过分干涉和过度保护较正常对照组少（P＜0.05）,家庭环境各因子与正常对照组无明显差异（P＞0.05）.青少年强迫症组与强迫症亲属组相比,患者的父母的过分干涉、过度保护、拒绝、否认、惩罚、严厉及偏爱较多,母亲的温暖、理解较少（P＜0.05）;患者感受到的家庭亲密度、情感表达、组织性较少,矛盾性和控制性较多（P＜0.05）.结论：青少年强迫症患者存在不良的父母教养方式和家庭环境,这些不良的家庭相关因素可能是父母与患者之间双向作用的结果.     

家庭环境因素对初中生心理问题影响的研究

目的探讨初中学生心理问题与家庭环境因素的关系。方法采用症状自评量表(SCL-90)和家庭环境量表(FES),对某市3所中学的1833名初中生进行测试,并对测试结果进行相关分析研究。结果初中学生存在的心理问题比较突出,相关分析表明SCL-90总分及各项因子分与FES的亲密度,情感表达、知识性、娱乐性、道德宗教观、组织性呈显著负相关,与FES的矛盾性呈显著正相关。结论初中学生心理问题与所处家庭环境密切相关,营造良好的家庭环境有助于初中学生的心理健康。     

初产妇孕龄、文化程度、家庭支持对心理健康的影响

①目的 对影响孕妇不同孕周、不同文化程度、不同家庭支持的心理健康因子（SCL-90）的指标进行分析，并对孕妇与常模妇女各项指标比较。②方法 对250例初产妇采用症状自评量表（SCL-90），分别在孕28周前及孕38周后进行调查测试。③结果 孕妇心理变化与常模妇女各项指标均有明显差异（P〈0．01），孕28周后强迫、抑郁、焦虑症状高于常模组，孕28周前低于常模组。孕28周前与临产前38周心理变化中躯体、强迫、焦虑症状3个单项因子及总分、总均分有统计学差异（P〈0．05）。④结论 孕妇与正常妇女相比，心理抗压能力明显减低，不同的心理状况对分娩方式的选择可能会有明显的影响。应加强孕妇的产前健康教育，开展分娩镇痛技术，加强家庭支持，改变产时服务意识，提高孕妇心理抗压力，帮助其平安渡过孕产期。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.