cience and TechnologyInner

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Research Status and Perspective on Correlation between Stomach Meridian Points and Stomach

就足阳明经穴与胃相关性的作用机理，查阅了大量文献资料，从古代文献研究、现代文献研究、展望进行了阐述。     

Clinical Application and Characteristics of KONG＇s ScalpAcupuncture and Daoyin Technique

Scalp Acupuncture and Daoyin Technique, which are summarized by Dr. KONG in the light of his long-term acupuncture practice, has been considered as one of the clinical diagnostic and treatment programs in Chinese medicine by the State Administration of Traditional Chinese Medicine. In this paper, the characteristics and clinical application of Scalp Acupuncture and Daoyin Technique are presented as follows.     

Randomized Controlled Trial on Mind-refreshing and Orifice-opening Needling Method and Cerebral Infarction

目的：观察醒脑开窍针法治疗脑梗死恢复期的，临床疗效。方法：600例脑梗死患者以病程分层随机，恢复期234例，随机分为治疗组116例，对照组118例。在西医常规治疗的基础上，治疗组采用醒脑开窍针刺；对照组采用传统针刺，均每日治疗1次，共治疗4星期。随访6个月。结果：两组患者基线资料可比性好，（P〉0．05）；治疗组疗效优于对照组（P〈0．05）。结论：醒脑开窍针剌是安全的，治疗脑梗死恢复期能够改善症状，减少致残，防止疾病进展，提高生活质量。     

Local Treatment of Obesity and Cellulitis with Acupuncture, Cupping and Massage

Purpose :Obesityandcellulites (OandC)aretwoofthemostcommonmetabolicdiseasesamongwomen .Theaimofthisstudyistestingthecombinationofacupunctureandphysiotherapeuticapparatus‘Celludist3C’forlocalre ductionofareasincaseofabdominalandgluteofemoralOandC .MethodsandMaterials:Eighteensubjects ( 2 0womenand 5men)weretestedwiththeapprobatedprogramincluded 1 0 procedures.Acupuncturewasperformedusingaspecialmethodofinsertionofneedlesatthelocalpointsontheupperexternalsideoftightsandatsomeadditionalpoin…     

Acupuncture and Irritable Bowel Syndrome： A Population-based Epidemiological and Clinical Study

目的：对上海市社区肠易激综合征（irritable bowel syndrome,IBS）的患病率情况进行调查研究,以了解现状、发现问题并提出相应对策,同时开展针灸干预治疗的疗效观察。方法：用整群、随机抽样方法,对上海长桥社区常住人口中18～80岁的1685人进行问卷调查,了解按Manning及罗马标准判断的有症状人群的症状学和患病率情况。对自愿进行针灸治疗的IBS患者进行电针治疗。结果：上海社区符合Manning标准的IBS人群患病率为11．45％,符合罗马标准的患病率为5．04％。男女人数之比为0．77：1,男性患病率低于女性,分别为10．62％、12．19％,但差异无显著性。有症状人群中,38．86％集中在46～65岁。针灸治疗IBS患者62例,电针天枢穴组（32例）有效率84．38％,电针大横穴组（30例）,有效率56．67％,两组有效率差异有统计学意义（P〈0．05）。结论：IBS是上海社区的常见病、多发病,需要开展更大规模大样本的流行病学调查,并广泛而深入地开展社区预防和医疗。针灸疗法是治疗IBS的有效方法,有必要进一号推广应用,     

Different Effects and Peripheral Mechanism between Manual-acupuncture and Eiectroacupuncture on Mast Cell Function and Acupuncture Analgesia by Nerve Block in Acupionts

目的:探讨阻滞穴位神经后针刺对于佐剂型关节炎(AA)大鼠镇痛效应和穴区肥大细胞脱颗粒的影响及进一步了解手针和电针镇痛效应的外周机制差异.方法:以佐剂型关节炎大鼠为炎症痛模型,以足三里为治疗穴位,采用利多卡因预处理(穴位注射2%盐酸利多卡因),将80只大鼠随机分为正常组(Control)、模型组(Model)、利多卡因预处理组(normal Lido)、电针组(Electroacupuncture,EA)、利多卡因预处理电针组(Lido EA)、犊鼻穴注射利多卡因足三里电针组(DLido ZEA)、下巨虚穴注射利多卡因足三里电针组(Xlido ZEA)、手针组(Manual Acupuncture,MA)、利多卡因预处理手针组(Lido MA)及犊鼻穴注射利多卡因足三里手针组(Dlido ZMA),每组8只.以大鼠缩爪反射潜伏期及肥大细胞脱颗粒率为观察指标.结果:EA及MA组痛阈都高于M组(P<0.05或P<0.01),两组肥大细胞脱颗粒率都明显高于M组(P<0.01).说明阻滞针刺穴位或同神经干近心端穴位神经对针刺的镇痛效应有明显的抑制作用,同样的操作在远心端穴位则无影响,神经阻滞对针刺(电针或手针)引起的穴区肥大细胞脱颗粒无明显影响.结论:在手针情况下,针刺镇痛有效神经传导信号在穴位的启动和针感的产生是在肥大细胞脱颗粒之后,它是产生神经信号的直接原因;而对电针情况,电信号是直接刺激神经感受器产生信号启动,肥大细胞脱颗粒成为伴随或反馈效应.     

Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone

α-Thujone (1a), a constituent of wormwood, has been suspected to cause adverse psychoactive reactions in addicted drinkers of absinthe. While the content of 1a in absinthe is too low for such effects, at higher doses it can indeed induce seizures and inhibit GABA(A) receptors (GABA(A)Rs). The effect of 1a on GABAergic synaptic currents and the mechanisms by which it modulates GABA(A)Rs remain unknown. To address these issues, cultured hippocampal neurons were used to investigate the action of 1a on GABAergic miniature inhibitory postsynaptic currents (mIPSCs) and on responses to exogenous GABA applications. Since lipophilic compounds often show nonspecific actions related to their hydrophobicity, the action of 1a was compared to that of dihydroumbellulone (2), a configurationally pseudoenantiomeric constitutional isomer. α-Thujone (1a) reduced mIPSC frequency and amplitude and also moderately affected their kinetics, indicating both pre- and postsynaptic mechanisms. Analysis of current responses to exogenous GABA revealed that 1a reduced their amplitude, affecting their onset, desensitization, and deactivation, suggesting an effect on receptor gating. In contrast, 2 caused only a weak or negligible effect on GABAergic currents, supporting the effects of 1a on GABAergic inhibition as being due to specific interactions with GABA(A)Rs.     

The Role and Significance of Brain-gut Peptide and Its Receptor's Expression in the Mechanism's Explanation of Cleaning Away Heat and Dampness

I .ClinicalApplicationofCleaningAwayHeatandDamp nessandPresentSituationofResearchontheActionMech anismThesyndromeofdampheatinthespleenandstomachisasymptomofdiseasemostfrequentlyseenintheclinicalapplica tionoftraditionalChineseMedicine ,andthemethodofcleaningawayheatanddampnessisusedasatypicaltherapyintreatingthedampheatinthespleenandstomach .Ancientphysicianshaveaccumulatedabundantexperienceintreatingthedampheatinthespleenandstomach .Sincetheestablishmentofthedoc trineofepidemicfebriledis…     

α-Amylase and lipase inhibitory activity and structural characterization of acacia bark proanthocyanidins

The bark extract of Acacia mearnsii showed strong lipase and α-amylase inhibition activities. Fractionation of the extract by column chromatography and subsequent (13)C NMR and MALDI-TOF-MS analysis revealed that the active substances are proanthocyanidin oligomers mainly composed of 5-deoxyflavan-3-ol units. In addition, 4'-O-methylrobinetinidol 3'-O-β-D-glucopyranoside, fisetinidol-(4α,6)-gallocatechin, and epirobinetinidol-(4β,8)-catechin were isolated as new compounds, and their structures were determined from spectroscopic data. Furthermore, a modified thiol degradation method using strongly acidic conditions was applied to the extract to yield three thiol degradation products derived from robinetinidol units. This method is useful for characterizing acacia proanthocyanidins (wattle tannins).     

Correlation between women＇s sub-health and reproductive diseases with pregnancies and labors

OBJECTIVE： To investigate whether female sub-health conditions and reproductive diseases areassociated with pregnancies and labors.METHODS： A cross-sectional survey was performed by using a structured questionnaire. A total of 1343 women aged 35 years or younger in six urban areas of Chengdu were included in the study.According to the Screening Criteria of sub-health conditions, these women were categorized into three groups： postpartum healthy group,sub-healthy group, and reproductive disease group. Data were double-entered using EpiData and the nanalyzed by SPSS.RESULTS： Pregnancy and labor were correlated with postpartum sub-health conditions. The number of pregnancies was negatively correlated with women＇s postnatal health but was positively correlated with the incidence of postpartum reproductive diseases.CONCLUSION： The number of pregnancies and labors is probably an important factor leading to sub-health conditions and the occurrence of reproductive diseases in women. Avoiding or reducing unwanted pregnancies and labors, enhancing the awareness of health among child bearing-age women are effective measures for preventing sub-health conditions.     

Acupuncture and moxibustion for malignant tumor patients with psychological symptoms of insomnia,anxiety and depression: a systematic review and Meta-analysis

OBJECTIVE: To evaluate the efficacy and safety of acupuncture and moxibustion therapy(AMT) for cancerrelated psychological symptoms(CRPS) of insomnia, depression and anxiety. METHODS: Seven databases were searched for randomized controlled trials(RCT) comparing AMT to routine care or conventional drug for alleviating CRPS of insomnia, depression, and anxiety before April 2020. Two independent reviewers performed the data extraction and assessed the risk of bias. RESULTS: A total of 30 RCTs invol...     

Prevention and Cure Osteoporosis with the Principium of Replenishing Qi and Nourishing Kidney Deficiency

Legislative GistPrimary osteoporosis is senile bonemetabolism disease.In the chapter Treatise onInnate Vital Essence in Ancient Times ( ShangGu Tian Zhen L un) of《Suwen》,it has beenclearly pointed out that the birth,growth,fulldevelopment,senility and death of man are close-ly related to the vicissitudes of the kidney -essence.Henceforth medical man in past dynas-ties took for vicissitudes of the kidney-essenceplaying the important role on individuals of allages.Therefor the abundant c…     

Part Ⅰ Fundamentals of Acupuncture and Moxibustion Lecture Eight The Ren and Du Meridians

ITheRenMeridian1.TheMeridian[Course]Themeridianstartsfromtheinteriorofthelowerabdomenandgoesdownwardtoemergefromtheperineum.Turningtothefrontandgoingthroughthepubichair,themeridianpassesalongtheanteriormidlineoftheabdomenandthechesttoreachthethroat.Thenitgoesfurtheruptocurvearoundthelipsandascendstothefaceandterminatesattheinfra-orbitalregion.[SummaryofIndications]Pointsofthismeridianaremainlyusedtotreaturinaryandgenitaldiseasesanddisordersalongthecourseofthemeridian.Somediseasesofthediges…     

Efficacy of scraping therapy on blood pressure and sleep quality in stage Ⅰ and Ⅱ essential hypertension: A systematic review and meta-analysis

Background: Scraping therapy is widely used in treating stage I and II essential hypertension in China.However, there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension.Search strategy: Seven electronic databases(Pub Med, Scopus, Cochrane Library, Web of Science, EBSCO,China National Knowledge Infrastructure and Wanfang Data electronic databases) were searched from inception to December 2022. Based on...     

HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages

Ethnopharmacological relevance

Evening primrose (Oenothera biennis L.) is a wild medicinal herb of Central American origin that is now globally widespread. Its traditional uses include treatment of rheumatoid arthritis and premenopausal pain both of which have an inflammatory component. The present study demonstrates the in vitro anti-inflammatory activity of three Oenothera biennis compounds.

Materials and methods

Oenotheralanosterol A and B (Oen-A &; Oen-B) along with gallic acid (GA) were isolated and characterized using column chromatography and NMR. The compounds were tested with LPS stimulated peritoneal mouse macrophages assaying for suppression of IL-6, TNF-α and NO synthesis. An HILIC method for the simultaneous quantitation of GA, Oen-A, and Oen-B in Oenothera biennis plant material was also developed as a means of monitoring quality of plant material.

Results

Significant inhibition of TNF-α and IL-6 by GA, Oen-A and Oen-B was observed (p < 0.05). Inhibition was concentration dependent and no synergistic or antagonistic effect on pro-inflammatory cytokines was found when used in combination (1:1) (p > 0.05). The HILIC analysis method was validated using Oenothera biennis root.

Conclusion

The study demonstrates the anti-inflammatory activity of Oenothera biennis root compounds and supports its traditional use in arthritis management. Active anti-inflammatory compounds were identified and quantified by the HILIC method.     

Efficacy and safety of a sequential treatment with clearing heat and eliminating phlegm and tonifying Qi and activating blood circulation in treating acute ischemic stroke: study protocol for a randomized controlled trial

OBJECTIVE:To investigate the short-term efficacy and safety outcomes following a sequential treatment with clearing heat and eliminating phlegm(CHEP) formula and tonifying Qi and activating blood circulation(TQABC)formula in patients with acute ischemic stroke(AIS) within a 72 h time window.METHODS:In this randomized, multicenter, doubleblinded, placebo-controlled trial, 500 participants will be randomly assigned in a ratio of 1∶1 to the CHEP+TQABC group or control group. In addition to guidelin...