中草药喷雾对烧伤后创面色素沉着疗效观察

采用中草药离子喷雾加中药祛斑面膜，作不同深度烧伤创面愈后的康复护理，将皮肤美容技术用于烧伤后色素沉着的康复治疗100例，皆获得较好效果，有效率100％，实践证明应用本法有利于烧伤后及植皮后色素沉着减退。     

烧伤后面部色素沉着中西医结合治疗的临床效果探讨

目的 探讨和评价中西医结合治疗烧伤后面部色素沉着的临床疗效.方法 168例烧伤后面部色素沉着患者,给予中药面膜及低能量密度Q开关Nd:YAG激光治疗,其中局部应用中药面膜者56例(A组)、单纯照射低能量密度Q开关Nd:YAG激光56例(B组)、中药面膜联合低能量密度Q开关Nd:YAG激光治疗56例(C组).结果 138例患者色素沉着均有不同程度改善,其中C组最明显,56例患者中14例色素沉着治愈,26例显著改善,14例褪色有效,2例无明显变化,有效率为96.43%;A组与B组有效率分别为71.43%和78.57%.结论 以上3种方法 均能改善烧伤后皮肤色素沉着,其中中药面膜联合低能量密度Q开关Nd:YAG激光治疗效果最显著.     

透皮促渗方法联合应用的研究进展

透皮给药系统具有传统给药方式不可比拟的优势。但由于药物的低渗透量，使其应用受到一定限制。各种物理的、化学的促渗方法，包括透皮吸收促进剂、超声导入法、离子导入法、电穿孔法等可改善皮肤透过性，增加药物的透皮速率。而且几种方法联合应用的促渗效果更加显著。本文总结了近年来各种促渗方法联合应用的研究进展。     

面膜联合超声导入治疗面部烧伤后色素沉着75例疗效观察

<正>烧伤创面愈合后常会出现不同程度的色素沉着,早期消除烧伤部位色素沉着是烧伤康复的重要问题[1]。我科于2012年5月至2013年4月采用中药面膜联合超声导入氢醌乳膏治疗烧伤后皮肤色素沉着,取得较好治疗效果,现分析报告如下。资料与方法1临床资料选择我科面颈部烧伤创面愈合但存有色素沉着患者150例,其中男92例,女58例。年龄15~56岁,平均     

应用美容方法治疗面部烧伤后色素沉着

面部烧伤创面愈合 1～ 2周左右 ,烧伤部位会出现褐色或黑褐色色素沉着。面部色素沉着不仅影响外表美观 ,而且直接影响患者的心理 ,给患者造成极大的心理压力。针对这一现象 ,我科自 1994年开始 ,将美容方法应用于烧伤患者烧伤后的恢复 ,即用离子喷雾机、离子导入机、色素渗透液、中药祛斑面膜来治疗烧伤后面部色素沉着 ,取得了良好的效果 ,现将方法及经验介绍如下。1　临床资料本组 10 8例患者 ,男 69人 ,女 39人 ,年龄最大者64岁 ,最小者 5岁。其中Ⅰ度烧伤 8例 ,浅Ⅱ度烧伤5 9例 ,深Ⅱ度烧伤 4 1例。治疗 10次为 1个疗程。一般Ⅰ度烧伤 1…     

不同物理促透技术对芥子碱硫氰酸盐体外透皮吸收的影响

目的 比较微针、超声导入和离子导入3种物理方式促药物吸收技术对芥子碱硫氰酸盐(ST)体外透皮吸收的效果,探讨不同物理方式促进透皮吸收的规律.方法 采用改良Franz扩散池和SD大鼠腹部皮肤,分别在微针、超声导入或离子导入条件下进行透皮实验.以2 mg/ml ST水溶液为供体溶液,定时从接收池中取样,用高效液相色谱法(HPLC)测定不同时间点样品中药物含量,计算累积透过量和稳态透皮吸收速度.取各促透皮技术处理12 h后的皮肤制作病理切片,观察不同促透技术对皮肤结构的影响,探讨其促吸收机制.结果 单纯透皮条件下,ST累积透过量较少.不同促透技术对ST有较明显促透效果,排序如下:微针>超声导入>离子导入.微针在皮肤表面形成实质性孔道,促进ST透皮吸收的效果最明显.超声导入通过扰乱皮肤角质层的紧密结构促透.离子导入对皮肤结构影响较小.结论 本研究为不同透皮给药促透技术的选择提供了依据.     

探讨烧伤创面愈合后皮肤的美容护理

目的探讨烧伤后创面愈合皮肤的美容护理方法。方法选择我院接受皮肤烧伤愈合治疗31例患者为例,其中浅二度烧伤患者有9例,深二度烧伤患者有13例,三度烧伤患者9例,通过皮肤护理、局部按摩等方法实施美容护理。探究患者护理效果。结果通过美容护理,9例浅二度创面烧伤患者经过2个疗程的美容护理治疗,基本治愈率为88.9%,13例二度烧伤患者治疗4个疗程后,基本治愈率为76.9%,9例三度烧伤患者经过5个疗程的治疗后基本治愈率为77.8%。结论患者烧伤皮肤愈合后进行美容护理可以控制色素沉着,减少瘢痕,改善患者创面外观,而且还能改善肤色,对烧伤皮肤的康复一定程度上有促进作用,值得推广。     

脉冲强光治疗浅表性色素斑的疗效观察

目的 讨论脉冲强光(IPL)治疗浅表性色素斑的疗效.方法 脉冲强光治疗患者共计316例,其中雀斑198例,色素沉着明显的脂溢性角化症118例.每4周治疗一次,三次为1疗程.结果 疗效显著,治疗一次后患处改善度达50%以上,医生总体满意率96.7%.患者满意率95.3%.结论 应用脉冲强光治疗浅表性色素斑短期效果良好,不良反应小.     

直流电药物离子导入法在眼科治疗中临床应用价值探讨

目的 评价直流电药物离子导入法在眼科治疗中的临床疗效和应用价值.方法 将108例眼科疾病患者随机分为直流电药物离子导入组（治疗组）和阿司匹林抗凝药物治疗和维生素B族药物治疗组（对照组）各54例.治疗组用直流电药物离子导入法治疗,对照组患者应用相应临床治疗方法.治疗前后分别检查局部症状和不同疾病的相应指标.结果 治疗组总有效率为91.3%,优于对照组的54.3%（P〈0.01）.结论 直流电药物离子导入中药法是治疗眼科疾病的有效方法.     

中药离子导入治疗肺炎的临床观察

目的 观察中药离子导入治疗肺炎的疗效.方法 局部外用中药煎液离子导入治疗肺炎58例,并设对照组,观察临床症状及肺炎渗出影像的变化情况.结果 中药离子导入治疗肺炎的治疗总有效率为100%,对照组为94.8%;中药离子导入组肺炎渗出影像吸收率84.5%,对照组63.8%.结论 中药离子导人治疗肺炎配合药物治疗肺炎的渗出影像吸收优于单用药物治疗.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.