青少年Coats病的诊治和随访

目的 观察青少年Coats病的眼底表现、治疗效果及随诊情况.方法 回顾性系列病例研究.收集:1962至2006年,经眼底检查和荧光素眼底血管造影确诊为Coats病的24例(26只眼)患者临床资料进行分析.患者初诊年龄1～18岁,平均7岁;男件18例,女性6例;双眼2例(均为女性),单眼22例;10只右眼,16只左眼.根据患者眼底病情给予激光光凝、冷凝或联合玻璃体切除术治疗.随访时间1～44年,平均5年.结果 在26只患眼中,眼底有毛细血管扩张、视网膜动脉瘤、无灌注区及黄斑渗出者7只眼;合并有渗出性视网膜脱离者15只眼;晚期病变已无光感或濒于失明者4只眼.共有21只眼行激光治疗,10只眼眼底渗出和出血吸收,视网膜复位,视力增进,其中6只眼视力在0.8以上;共计10只眼行玻璃体切除术,其中6只眼曾行激光治疗,2只眼外加冷凝治疗,术后视力最佳为0.1.在治疗后的随诊中,有5例眼底又出现新的病变,及时补充激光治疗,保持了较好视力.24只眼中,有10只眼(42%)视力增加,12只眼(50%)视力未改变,2只眼(8%)视力减退.结论 青少年Coats病的病灶在周边,渗出性病变多累及黄斑部.若早期发现并及时予以激光治疗,患者预后视力较好,但需长期随诊,随访中如发现新病变需补充激光治疗.     

不同病变阶段中心性晕轮状视网膜脉络膜萎缩的临床表现

目的:探讨中心性晕轮状视网膜脉络膜萎缩不同病变阶段的眼底影像学特征.方法:回顾分析中心性晕轮状视网膜脉络膜萎缩患者眼部检查及眼底荧光血管造影(fundus fluorescein angiography,FFA)检查,分析不同病变阶段荧光素眼底血管造影的影像学特征,总结该病发展转归的临床规律.结果:Ⅰ期:眼底彩色照相:黄斑区轻度色素紊乱,可累及或未累及中心凹.FFA示:中心凹附近高荧光,RPE和脉络膜毛细血管的萎缩面积及程度尚不足以透见下方粗大的脉络膜血管.Ⅱ期:眼底可见一类圆形的低色素区域,荧光造影可见与眼底彩照对应的高荧光区,随造影过程延长可见萎缩区荧光素渗漏.Ⅲ期:黄斑区萎缩灶外围边界模糊,其中可见一部分边界清晰、稳定的完全萎缩灶.FFA:萎缩灶内边界清晰的部分视网膜色素上皮细胞(retinal pigment epithelium,RPE)及脉络膜完全萎缩,周边在造影晚期可见未完全萎缩的脉络膜毛细血管渗漏区域.Ⅳ期:黄斑区边界清晰的视网膜脉络膜萎缩灶,黄斑中心凹累及.FFA可见与眼底像相对应的脉络膜萎缩灶,其中可透见粗大的脉络膜血管.周围部分未见活动性荧光素渗漏,病变稳定.结论:荧光素眼底血管造影能反映的脉络膜萎缩程度是不同阶段病变阶段的主要指标.     

病理性近视眼底荧光造影分析

目的:观察病理性近视的荧光素眼底血管造影(FFA)的特征.方法:选择-8.00D以上病理性近视患者共80例106眼行FFA检查,根据造影表现结合眼科常规检查情况进行分析.结果:造影显示视神经乳头出现异常荧光者21眼(19.8%).视网膜出现局灶性窗口样荧光32眼(30.2%),局灶性墨汁样渗漏荧光20眼(18.9%),局灶性荧光遮蔽18眼(17.0%).黄斑区的局灶性荧光遮蔽15眼(14.2%),局灶性荧光渗漏12眼(11.3%).视网膜血管的异常荧光共10眼(9.4%).视网膜下脉络膜新生血管25眼(23.6%),发生在黄斑区、后极部和周边部,呈单一或多发病灶.结论:病理性近视视网膜脉络膜呈现复杂多样的病变特征,尤其是脉络膜新生血管多发危害大,FFA为临床干预治疗提供依据.     

湿性年龄相关性黄斑变性OCT特点与视力的相关研究

目的 研究湿性年龄相关性黄斑变性OCT图像特征与患者视力的相关性.方法 纳入湿性年龄相关性黄斑变性患者106例106只眼,记录患者最佳矫正视力(EDTRS视力),并对患者眼底进行光学相干断层扫描分析,统计黄斑区视网膜厚度、黄斑区总容积、测量脉络膜新生血管膜厚度,脉络膜新生血管与黄斑中心凹距离.结果 患者视力与脉络膜新生血管病变的最大线性距离、黄斑区总容积、CNV厚度、CNV距中心凹距离呈明显相关关系(P＜0.05).结论 湿性年龄相关性黄斑变性患者中心视力与脉络膜新生血管病变的位置、大小、视网膜水肿程度明密切相关.     

IRVAN综合征一例

患者女,15岁,左眼缓慢视力下降2年于2005年10月来诊.眼科检查:右眼视力0.8,左眼视力手动/眼前,光定位好.双眼眼压正常.双眼前节未见异常.双眼玻璃体混浊.双眼底可见视盘表面及盘周动脉瘤样扩张,视盘鼻侧半环形硬性渗出,左眼黄斑区视网膜下片状硬性渗出(图1、2).左眼颞侧周边及鼻下方周边散在激光斑.2个月前在当地诊断为左眼遗传性黄斑营养不良、双眼Coats病,并且行荧光素眼底血管造影(FFA)后发现左眼无灌注区(NP)行激光治疗.给予糖皮质激素口服.治疗后视力未见好转.     

婴儿家族性渗出性玻璃体视网膜病变的荧光素眼底血管造影特征分析

目的 探讨婴儿FEVR的荧光素眼底血管造影特征。方法 回顾性分析2018年2月至2020年10月在我院检查确诊为FEVR 30例(60眼)的荧光素眼底血管造影特征。结果 1期25眼(A期5眼,B期20眼);2期24眼(均为B期),3期5眼(A期1眼,B期4眼),4期5眼(A期1眼,B期4眼),5期1眼(B期)。1期FFA主要表现为后极部静脉扩张,动静脉比约1:2～1:3,周边无血管区,周边血管分支增多且形态表现多样:如血管密集增生呈毛刷状、束状,走向杂乱无规律,末梢血管异常吻合,“V”字形无血管区尖端指向黄斑等。2期在1期基础上,后极部静脉扩张更明显,动静脉比约1:3～1:4,周边渗出较1期加重,病变范围更广,常累及全周,周边血管形态在1期基础上表现更杂乱无章,部分血管被牵拉呈垂柳状。3期在2期基础上,后极部静脉怒张,动静脉比可高达1:4～1:5,周边渗出较2期加重,周边局部纤维增殖,牵拉局部视网膜脱离,牵拉黄斑拱环血管变直,未累及黄斑区视网膜,常伴有荧光渗漏。4期主要表现为视网膜牵拉脱离呈镰状皱襞状,以向颞侧或下方牵拉居多,累及黄斑区,常伴有荧光渗漏。5期主要表现为视网膜全脱离,常伴...     

AIDS合并巨细胞病毒性视网膜炎的观察

目的 探讨获得性免疫缺陷综合征(AIDS)合并巨细胞病毒(CMV)性视网膜炎患者的眼底改变特点及眼底荧光血管造影特征.方法 已诊断为CMV性视网膜炎的AIDS患者共34例49只眼,进行常规视力、裂隙灯检查、眼底检查及荧光素眼底血管造影(FFA)检查,分析其眼底病变的临床特征.结果 29只眼视网膜上见大片融合性黄白色坏死灶,边界不清,伴视网膜出血及血管炎改变;FFA晚期病灶区域弥漫性荧光素渗漏.12只眼周边部视网膜颗粒状坏死灶,边界欠清,未见明显 视网膜出血、渗出及血管管壁改变;FFA显示病灶区域强荧光,晚期荧光素渗漏.4只眼视网膜前见大片灰白色增殖膜;4只眼继发视网膜脱离.结论 CMV性视网膜炎主要表现为进行性坏死性的视网膜炎,伴出血及血管炎.     

相干光断层扫描对532nm激光治疗糖尿病黄斑水肿的疗效观察

目的评价使用相干光断层扫描（OCT）对532 nm激光治疗糖尿病黄斑水肿的疗效进行观察的有效性。方法对糖尿病性有临床意义的黄斑部水肿病例46例（61只眼）,给予532 nm激光黄斑格栅样光凝、局灶光凝以及全视网膜光凝,在治疗前、治疗后3个月分别进行裸眼视力、眼底照相、荧光素眼底血管造影及OCT黄斑区视网膜厚度及视网膜容积等检查。比较光凝前后黄斑区视网膜厚度和视网膜容积的变化。结果在46例（61只眼）中,41只眼视力提高,17只眼不变,所有患者荧光素眼底血管造影显示黄斑区荧光渗漏不同程度减轻或消失,OCT显示光凝治疗前黄斑中心凹视网膜神经上皮厚度为（354.7±93.2）μm,光凝3个月后为（203.5±49.6）μm（P〈0.05）,光凝治疗前黄斑区6 mm直径神经上皮总体容积为（8.32±0.53）mm3,光凝3个月后为（7.24±0.41）mm3（P〈0.05）。结论 OCT可以对糖尿病性黄斑水肿进行定量的诊断,并且可以对激光光凝治疗后黄斑水肿的消退进行准确的测量和评价。     

以纤维蛋白沉积为主的中心性浆液性脉络膜视网膜病变一例

患者男,38岁.因右眼视物模糊1个月余来我院就诊.平素体健,无疾病史.全身检查未见明显异常.眼部检查:右眼视力0.4,不能矫正;左眼视力1.0.裂隙灯显微镜检查结果显示,双眼外眼及眼前节正常,右眼眼底可见黄斑区浓厚黄白色沉积(图1),中心凹反光消失;左眼眼底检查无异常发现.右眼光相干断层扫描(OCT)检查结果显示,黄斑中心凹下强反射光团聚集,伴有视网膜色素上皮(RPE)层下积液(图2).荧光素眼底血管造影(FFA)检查结果显示,右眼黄斑拱环颞上缘有一点状荧光渗漏灶(图3A);同步吲哚青绿血管造影(ICGA)检查结果显示,病灶局部脉络膜血管扩张,吲哚青绿渗漏(图3B);FFA晚期像可见黄斑区荧光渗漏灶逐渐扩大,荧光素积存(图3C);同步ICGA晚期像可见黄斑区染料积存和周边环形弱荧光(图3D).初步诊断为中心性浆液性脉络膜视网膜病变(CSC).建议行激光光凝治疗,患者拒绝.此后,患者未复诊,电话回访时自诉视力好转.     

非增生型糖尿病视网膜病变黄斑水肿患者黄斑区谱域光学相干断层扫描中高反射信号的特征分析

目的 观察非增生型糖尿病视网膜病变黄斑水肿(diabetic macular edema,DME)患者的黄斑区谱域光学相干断层扫描(spectral-domain optical coherece tomography,SD-OCT)中高反射信号(hyperreflectvie foci,HF)的临床特征.方法 NPDR伴发黄斑水肿患者34例(47眼)纳入研究,所有受检者均行最佳矫正视力(best corrected visual acuity,BC-VA)、裂隙灯显微镜、裂隙灯前置镜检查,彩色眼底照相、红外眼底照相、眼底荧光血管造影(fundus fluorescein angiography,FFA)和SD-OCT检查,依据FFA的结果分为局灶水肿组、弥漫水肿组和囊样水肿组.分析各组患者黄斑区OCT中HF的分布特征.结果 FFA检查47眼中局灶水肿27眼、弥漫水肿12眼、囊样水肿8眼.各类型黄斑水肿的SD-OCT图像特征如下:局灶水肿组HF主要分布在水肿的周围,硬性渗出或环形渗出的内侧;弥漫水肿组:在弥漫水肿的黄斑区各个区域都可以看到广泛的HF,分布于视网膜各个层次,甚至是内界膜表面.在水肿的视网膜局部出现囊腔样改变时,其囊腔中或其周围多见HF.囊样水肿组:囊样水肿的囊壁处有较多HF.黄斑囊样水肿中可见视网膜外层IS/OS层和外界膜层之间HF沉着.结论 HF在不同类型DME的SD-OCT中分布的特点表明HF是血管内脂蛋白或蛋白质渗出形成,HF是硬性渗出的前体,标志着早期的视网膜血管壁的损害.     

Photocoagulation in venous occlusive disease.

Fifty-one eyes with branch or tributary retinal venous occlusive disease underwent photocoagulation (1970-1973) after certain criteria were met: reduced visual acutity, fluorescein angiographic documentation of vessel permeability changes, and either dye leakage into the macula or neovascularization of the retina, or both. Eighty-four percent of the eyes responded to treatment with an improvement or stabilization in visual acuity, a reduction in collateral vessel caliber and permeability, and reduced dye accumlation in the macular area and increased fluorescein transit time. Photocoagulation is an affective means of reducing macular edema resulting from vascular compensatory changes following venous occlusion and decreases the risk of vitreous hemorrhage from sites of retinal neovascularization.     

Serous macular detachment secondary to distant retinal vascular disorders

PURPOSE: To report tomographic features of macular edema associated with distant retinal vascular disorders. METHODS: Six eyes with macular edema (three with extramacular branch retinal vein occlusion and three with Coats disease) underwent fluorescein angiography to detect dye leakage and optical coherence tomography to evaluate the macular features and measure the foveal height (distance between inner retinal surface and retinal pigment epithelium) and the retinal thickness (thickness of neurosensory retina) at the central fovea. RESULTS: Fluorescein angiography showed widespread nonperfusion and retinal vein staining in the eyes with a branch retinal vein occlusion not involving the macula. In eyes with Coats disease, nonperfused areas, telangiectatic retinal vessels, and aneurysms were seen in the peripheral fundus on fluorescein angiography. In one eye with Coats disease, telangiectatic vessels and aneurysms were seen in the nasal mid periphery of the optic disk. There was no dye leakage in the macular area in any eyes. Optical coherence tomography showed subretinal fluid and retinal swelling at the fovea in all eyes. The foveal height ranged from 300 to 697 microm (mean, 478 microm) and retinal thicknesses ranged from 170 to 280 microm (mean, 233 microm). CONCLUSION: Distant retinal vascular leakage causes serous retinal detachment in the macula. The macula is predisposed to collect subretinal fluid although retinal vascular leakage is far from the macula.     

间接检眼镜下激光光凝治疗青少年型Coats病

目的 探讨间接检眼镜下激光光凝治疗青少年型Coats病的效果和预后。方法 临床检查确诊为青少年型Coats病患儿19例19只眼纳入研究。首诊年龄27.0～146.0个月,平均年龄73.5个月。最佳矫正视力（BCVA）≥0.1者7 只眼;0.01～0.09者8只眼;数指3只眼;光感1只眼。所有患眼渗出均累及黄斑。黄斑渗出性视网膜脱离3只眼;黄斑下纤维化4只眼;黄斑轻度萎缩1只眼。渗出范围大于2个象限17只眼;小于2个象限2只眼。所有患眼均可见不规则扩张、纡曲、纽结的异常血管。其中,异常血管位于正上方或鼻上方2只眼;位于颞侧或颞下方17只眼。渗出性视网膜脱离13只眼。其中,未累及黄斑10只眼;累及黄斑3只眼。在全身麻醉下,应用双目间接检眼镜激光输出系统对异常的视网膜血管及伴明显渗漏的视网膜进行激光光凝。渗出性视网膜脱离范围广、脱离高度高者合并玻璃体腔注射曲安奈德2 mg 3只眼。治疗后6～51个月内随访视力、视网膜异常血管消退、视网膜下渗出吸收以及渗出性视网膜脱离复位的情况。结果 行玻璃体腔注射曲安奈德2 mg治疗的3只眼,异常血管明显消退、渗出明显减少,但因并发白内障,行白内障摘除手术1只眼;出现黄斑前增生膜,行前膜剥除术1只眼。随访期末,所有患眼异常血管均消退。黄斑外渗出完全吸收8只眼,其中黄斑渗出完全吸收4只眼;渗出明显减少9只眼;渗出无明显改变2只眼。渗出性视网膜脱离13只眼中,视网膜复位8只眼;脱离范围减少3只眼;无明显改变2只眼。渗出未完全吸收15只眼;黄斑下纤维化9只眼;黄斑轻度萎缩3只眼;后期病变区视网膜萎缩伴色素沉着,血管可闭塞成白线状。BCVA≥0.1者6只眼;0.01～0.09者11只眼;数指1只眼;光感1只眼。BCVA无变化15只眼;提高2只眼;下降2只眼。治疗结束时,患眼和对侧健康眼的球镜度数比较结果显示,患眼球镜度数高于对侧健康眼（t=3.6,P=0.003）。患眼和对侧健康眼的柱镜度数比较结果显示,患眼散光度数高于对侧健康眼（t=3.6, P=0.004）。但所有患眼矫正屈光度后视力无提高。结论 间接检眼镜下激光光凝治疗青少年型Coats病,可有效控制病变进展,且对患儿损伤小,出现并发症的风险低。眼内注射曲安奈德是有效的辅助手段,但并发症多,应用需谨慎。     

高度近视眼黄斑裂孔视网膜脱离的手术治疗

目的 探讨治疗高度近视眼黄斑裂孔视网膜脱离手术的方法。方法 对172只眼（169例）高度近视眼黄斑裂孔视网膜脱离行玻璃体切除联合眼内光凝黄斑裂孔、12％C3F8填充术。术后取面向下体位两周。结果 172只眼黄斑裂孔闭合、视网膜复位。1只眼在气液交换过程中出现脉络膜大出血而作硅油填充术。172只眼术后视力均有不同程度的提高。结论 玻璃体切除联合眼内光凝黄斑裂孔、12％C3F8填充术是治疗高度近视眼黄斑裂孔视网膜脱离和提高手术成功率的安全有效的方法。     

Progression of diabetic macular edema: correlation with blood retinal barrier permeability, retinal thickness, and retinal vessel diameter

PURPOSE: To study the progression of diabetic macular edema (DME) in relation to baseline retinal thickness, retinal vascular leakage, and retinal trunk vessel diameters. METHODS: In this single-center study, 45 patients were enrolled with 62 eligible eyes defined as having DME of a grade less than clinically significant macular edema (CSME). From the start, the patients were included in a multicenter study exploring the effect of ruboxistaurin versus placebo for 3.4 years. Subsequently, the patients were followed up for a mean of 5.7 years by optical coherence tomography, fundus photography, and vitreous fluorometry. Baseline values in eyes that progressed to photocoagulation treatment were compared with values from eyes that did not reach this endpoint. RESULTS: In the 22 eyes of 18 patients in which CSME was diagnosed and treated, mean retinal vascular leakage at baseline was 5.6 (95% CI 4.2-7.6) nm/s, whereas eyes that did not progress to photocoagulation had a significantly lower mean leakage at baseline of 3.4 (95% CI 2.7-4.3) nm/s. No significant difference was found for measures of baseline retinal thickness or summarized retinal trunk vessel diameters. Eyes that progressed to photocoagulation treatment (mean delay to treatment, 3.6 years) had significantly higher foveal thicknesses than did nonprogressing eyes, from 18 months after study initiation. CONCLUSIONS: Progression to photocoagulation treatment for CSME was associated with higher retinal vascular leakage at baseline, whereas baseline retinal vessel diameters and retinal thickness were comparable in progressing and nonprogressing eyes. Baseline leakage was the strongest predictor of progression from non-CSME to photocoagulation for CSME.     

Macular oedema and retinal neovascularisation in juvenile diabetics

Thirteen young diabetic patients with peripheral capillary non perfusion who presented with symptoms of mild maculopathy were reviewed retrospectively. In this group, peripheral retinal ischaemia was often overlooked and a rapidly progressive proliferative retinopathy developed. Fluorescein angiography of the peripheral retina showed capillary closure, but with preservation of arterioles and venules.In this series, half of the eyes lost vision. In seven eyes where the peripheral ischaemia was treated by pan retinal photocoagulation, the maculopathy resolved without any specific laser treatment to the macula.In young diabetics presenting with maculopathy, the peripheral retina should be examined for ischaemia, and if present, pan retinal laser photocoagulation should be performed. Focal treatment for the macular disease can be delayed until after the peripheral photocoagulation, as the maculopathy may remit.     

Inflammatory response after scatter laser photocoagulation in nonphotocoagulated retina

PURPOSE: Macular edema is one of the most serious adverse effects after retinal scatter laser photocoagulation. It has been suggested that the changes in the distribution of retinal blood flow or the inflammatory reaction after photocoagulation may be involved in the pathogenesis of macular edema, but little information is available about its exact mechanism. This study was designed to evaluate quantitatively leukocyte-endothelial cell interactions and vascular permeability in the nonphotocoagulated portions of the retina after partial scatter laser photocoagulation. METHODS: Argon laser photocoagulation was performed in one half of the retina in male pigmented rats (n = 90). In the other half of the retina, leukocyte dynamics after photocoagulation were evaluated in vivo with acridine orange digital fluorography. Retinal vessel permeability was quantified by using Evans blue dye. RESULTS: Scatter laser photocoagulation caused significant inflammatory leukocyte-endothelial interactions not only in the photocoagulated but also in the untreated half of the retina. In the nonphotocoagulated half of the retina, the number of leukocytes rolling along the major retinal veins increased after photocoagulation and peaked at 12 hours (14.3 +/- 4.5 cells/min per vessel). Leukocyte accumulation in the untreated half of the retina increased after photocoagulation, with a peak of 47.5 +/- 13.0 cells/mm(2) 24 hours after photocoagulation. Retinal vascular permeability in the untreated half of the retina gradually increased after photocoagulation. CONCLUSIONS: Scatter laser photocoagulation increased leukocyte rolling and subsequent accumulation in both the photocoagulated and the untreated portions of the retina. The accumulated leukocytes may be involved in the augmented vascular permeability in the untreated retina, resulting in retinal edema after photocoagulation.     

玻璃体手术联合黄斑裂孔光凝治疗高度近视黄斑裂孔性视网膜脱离

目的 探讨高度近视黄斑裂孔性视网膜脱离玻璃体手术中行黄斑裂孔光凝的适应证及手术技巧并评价治疗效果.方法 选择21例高度近视黄斑裂孔性视网膜脱离患者,行常规经平坦部玻璃体切除、重水下行黄斑裂孔激光光凝、气-液交换、C3F8填充玻璃体腔,术后保持头低位,随访1～6个月.结果 18例术后视网膜全部复位,3例气体吸收后视网膜脱离复发;术后视力提高者16例,不变者2例,下降者3例.结论 对于某些高度近视黄斑裂孔性视网膜脱离,行玻璃体手术,并在手术中行激光封闭黄斑裂孔能够到达复位视网膜、防止视网膜脱离复发的目的.     

Combined modified grid and panretinal photocoagulation for diffuse diabetic macular edema and proliferative diabetic retinopathy

PURPOSE: To determine the effectiveness of combined macular modified grid and peripheral panretinal photocoagulation in diabetic eyes with both macular edema and proliferative retinopathy. MATERIAL AND METHODS: We evaluated 52 eyes with diffuse diabetic macular edema and proliferative diabetic retinopathy. Treatment was performed in two sessions consisting of initial modified grid to the macula and panretinal photocoagulation to the inferior half of the peripheral retina, followed 2 to 4 weeks later by panretinal photocoagulation to the superior half. RESULTS: At one year, visual acuity was improved in 8%, stable in 79%, and worse in 13%. At two years, visual acuity was improved in 4%, stable in 72%, and worse in 24%. Macular edema resolved in 43 of 46 eyes (93%), and proliferative retinopathy was reduced in 25 of 29 eyes (86%) at last examination. CONCLUSION: Combined macular modified grid and peripheral panretinal photocoagulation is an effective treatment approach in diabetic eyes with both macular edema and proliferative retinopathy. Laser photocoagulation in those diabetic eyes with diffuse diabetic macular edema and proliferative diabetic retinopathy can be completed in less number of treatment sessions with this method, compared to conventional treatment techniques.     

早产儿视网膜病变注射雷珠单抗后荧光素眼底血管造影表现

目的　了解早产儿视网膜病变（ｒｅｔｉｎｏｐａｔｈｙｏｆｐｒｅｍａｔｕｒｉｔｙ,ＲＯＰ）注射雷珠单抗后的荧光素眼底血管造影（ｆｕｎｄｕｓｆｌｕｏｒｅｓ-ｃｅｉｎａｎｇｉｏｇｒａｐｈｙ,ＦＦＡ）表现。方法　选取２０１４年３月至１１月在深圳市眼科医院确诊为ＲＯＰ的１５例（３０眼）患者纳入研究,其中急进性后部型ＲＯＰ（ａｇｇｒｅｓｓｉｖｅｐｏｓｔｅｒｉｏｒｒｅｔｉｎｏｐａｔｈｙｏｆｐｒｅｍａｔｕｒｉｔｙ,ＡＰ-ＲＯＰ）８眼,阈值期ＲＯＰ１３眼,阈值前期Ⅰ型ＲＯＰ９眼。在表面麻醉下,经颞下方睫状体平坦部进针,向玻璃体内注射雷珠单抗０．０３ｍＬ。在注药术后１～２个月,气管插管全身麻醉下行ＦＦＡ检查,观察附加病变消退情况及视网膜周边血管发育情况。结果　注射雷珠单抗后,所有眼底附加病变消退,但周边视网膜均存在不同程度的无血管区。８眼ＡＰ-ＲＯＰ中６眼Ⅲ区无血管形成,继续随访观察;２眼Ⅱ区大范围无血管形成,血管末梢分支增多呈毛刷样,无荧光素渗漏,１周后再次注射雷珠单抗。１３眼阈值期ＲＯＰ中,１眼可见颞下方牵拉性视网膜脱离,行局部激光光凝;１２眼嵴完全消退,其中２眼视网膜血管基本发育完全;４眼Ⅲ区无血管形成,４眼Ⅲ区及Ⅱ区鼻侧２个钟点无血管形成,均无荧光素渗漏,继续随访观察;２眼Ⅱ区累计４个钟点无血管区伴末梢血管扩张及新生血管荧光素渗漏,行激光光凝。９眼阈值前期Ⅰ型ＲＯＰ中７眼嵴全部消退,２眼嵴变低平;４眼Ⅲ区及Ⅱ区鼻侧２个钟点范围无血管形成,５眼Ⅲ区无血管形成,均见末梢血管扩张,但无荧光素渗漏,继续随访观察。结论　注射雷珠单抗可促使ＲＯＰ病变消退,且不干扰周边视网膜血管化。