激光联合白内障超声乳化术对急性闭角型青光眼房角的重塑作用

目的:评估激光联合超声乳化白内障手术(phacoemulsifi-cation and intraocular lens,Phaco+IOL)作为初始治疗手段对急性闭角型青光眼房角的重塑作用。方法:选取37例39眼合并白内障首次发作的急性闭角型青光眼,平均眼压69.22±21.23mmHg,经过药物降眼压,完成激光虹膜成形联合周边切开术,病情稳定7～14d后,行超声乳化白内障吸除联合人工晶状体植入术,观察手术前后视力、眼压、房角开放状况和虹膜形态的变化。结果:随访时间3～27mo,患者术后视力均有提高,其中29眼未再使用用抗青光眼药物,最后4次随访平均眼压14.90±2.19mmHg,较激光术前明显下降(P<0.05),随访期间38眼眼压控制平稳,视野无进行性损害,1眼眼压波动在18～28mmHg,同时存在进行性视野损害,于术后10mo接受了滤过手术。OCT对虹膜形态的观察表明,所有患者虹膜均由术前的膨隆形变化为平坦型,房角开放度由激光术前平均10.86±5.11度增加为术后46.34±13.32度(P<0.01)。结论:激光联合Phaco+IOL治疗合并白内障的急性闭角型青光眼有助于开放房角,达到解除瞳孔阻滞,疏通房水引流的作用,避免滤过手术的风险,白内障术前激光治疗可以迅速缓解急性发作的症状,开放房角,控制眼压,加深前房,使白内障手术更安全稳定。     

Secondary Angle-Closure Glaucoma Due to Posterior Synechiae of Iris Following Combined Phacoemulsification and 23-Gauge Transconjunctival Vitrectomy

Purpose: To describe the clinical characteristics of eyes with secondary angle-closure glaucoma following combined phacovitrectomy. Methods: Retrospective case series. Results: Nine eyes developed angle-closure glaucoma due to iris posterior synechiae with an incidence rate of 1.82% (95% CI: 0.64 – 3%) among 493 eyes following phacovitrectomy. PDR with TRD was the most common surgical indication. Single piece IOL insertion and silicone oil were present in all cases. Fibrin in the anterior chamber was found in six eyes postoperatively. Mean degree of iris bombe was 310±79.37° at 3.55±1.87 weeks with a mean IOP of 32.56±5.89 mm of Hg. Systemic diabetes and grade of cataract were the only significant risk factors (r² =1; p= 0.016 and 0.049, respectively). Nd:YAG laser PI relieved the angle-closure attack in all cases. Conclusion: Systemic diabetes and advanced grade of cataract are significant risk factors for secondary angle-closure glaucoma following combined phacovitrectomy.     

Experimental Glaucoma Model in the Rat Induced by Laser Trabecular Photocoagulation After an Intracameral Injection of India Ink

A simple and reproducible rodent glaucoma model is required to elucidate the pathophysiology of damage to the optic nerve. We developed chronically elevated intraocular pressure (IOP) unilaterally in rats by injecting india ink into the anterior chamber of one eye using a 30-gauge needle. One week later, trapped carbon particles in the chamber angle formed a black band along the corneal limbus in the injected eyes. We performed direct laser photocoagulation without a gonio lens, and selectively burned the trabecular meshwork. Intraocular pressure was measured every week and laser photocoagulation was repeated until mean IOP in the experimental eyes rose above 25 mmHg. Unilateral IOP elevation was attained in all rats within 4 weeks. Twelve weeks after ink injection, we sacrificed the rats and excised the eyes for histologic analysis. The anterior chamber angle showed peripheral anterior synechia caused by laser photocoagulation, and carbon particles were engulfed by macrophages that infiltrated the ciliary cleft. In the optic nerve head, a remarkable decrease in the nerve fiber layer and cavernous degeneration were observed, suggesting glaucomatous optic nerve damage. This experimental rodent model should facilitate the study of the complex mechanisms involved in glaucoma.     

Nd:YAG激光虹膜切除术治疗葡萄膜炎继发闭角型青光眼

目的 评价Nd：YAG激光虹膜切除术治疗葡萄膜炎继发闭角型青光眼的临床效果。方法 回顾性分析27例葡萄膜炎继发瞳孔阻滞闭角型青光眼经Nd：YAG激光虹膜切除术治疗的情况。随诊时间2月到4年。结果1)一次激光所有患眼均成功击穿虹膜。虽经术后积极抗炎治疗．12眼(44％)发生虹膜孔关闭。多次激光治疗后，最终89％的患眼获得了通畅的激光孔。2)在46次激光治疗中，击射点数为3～376点，激光能量为12～2077mJ。所用激光能量较原发闭角型青光眼高。3)75％的患眼激光治疗后眼压控制正常，6只眼(22％)眼压不能控制行滤过手术。4)激光手术的并发症主要是激光时虹膜的出血和暂时的眼压升高。5)术前有活动性炎症的患眼，发生激光孔闭合的比例更高。结论 Nd：YAG激光虹膜切除术是治疗葡萄膜炎继发闭角型青光眼的一种安全有效的方法。为提高手术的成功率，应在积极抗炎的同时，尽早行激光虹膜切除术。若激光后虹膜孔反复关闭，应考虑手术周边虹膜切除术。     

Advanced cicatricial retinopathy of prematurity--outcome and complications.

AIMS: To assess the outcome and complications of patients with advanced retinopathy of prematurity (ROP). METHODS: All patients with eyes achieving stage 4 or 5 retinopathy of prematurity were reviewed. Twenty one eyes were diagnosed during ROP screening in maternity hospitals and 10 eyes were of infants transferred for treatment. RESULTS: Thirty one eyes of 17 patients were included. Thirteen eyes were treated for acute disease but progressed to stage 4 or 5; seven had cryotherapy and six diode laser photocoagulation. Cataract was found in 17 eyes (54.8%), glaucoma in seven eyes (22.6%), microphthalmos in 15 (48.4%), and corneal opacification in four eyes (12.9%). Fifteen eyes had surgical procedures; two (6.5%) had trabeculectomy, four (12.9%) had lensectomy, and nine (29%) retinal detachment repair. Transferred infants had their initial eye examination later than infants in hospitals screened by the authors and 80% of them had progressed beyond threshold ROP by the time they were transferred for treatment. Twenty nine eyes (93.6%) had visual acuities of 3/60 or less and only two eyes (6.5%) achieved 6/18 or less. CONCLUSION: The visual outcome of the eyes undergoing retinal re-attachment surgery was disappointing. Cataract, microphthalmos, and glaucoma were the most frequent complications, and surgical intervention was often required. The need for children who are blind as a result of ROP to have long term follow up is shown.     

Q-开关Nd:YAG激光虹膜切除术治疗闭角型青光眼的疗效观察

目的:观察Q-开关Nd:YAG激光治疗闭角型青光眼的疗效。方法:收集212例236眼门诊及住院闭角型青光眼患者,其中原发性闭角型青光眼204例228眼,葡萄膜炎继发青光眼8例8眼,进行Q-开关Nd:YAG激光虹膜切除术,非接触压平眼压计测量眼压,观察Q-开关Nd:YAG激光虹膜切除术后临床效果。结果:随诊3～24mo,激光虹膜切除术治疗前眼压均值21.36mmHg,治疗后终末眼压均值19.25mmHg,眼压控制良好219眼,有效率92.8%,配合降眼压药物治疗,眼压控制正常11眼(4.7%),眼压升高6眼(2.5%),再次激光无效后行小梁切除术。激光治疗术后前房加深,房角有不同程度加宽,视野未明显改变。结论:Q-开关Nd:YAG激光虹膜切除术是一种治疗闭角型青光眼安全有效的方法。     

超声乳化联合房角分离术治疗闭角型青光眼合并白内障

目的探讨超声乳化吸出联合房角分离术治疗闭角型青光眼合并白内障的临床疗效。方法闭角型青光眼合并白内障20例（22眼）。男12例（14眼）,女8例（8眼）。年龄64～85岁,平均（76．80±3．12）岁。其中急性闭角型青光眼18例,慢性闭角型青光眼4例,所有手术由同一医师完成,均采取超声乳化人工晶状体植入联合房角分离术,观察手术前、后眼压,视力,周边前房深度及房角的变化情况,随访3～12个月。结果患眼术前眼压范围7．8～30．013]mHg,平均（18．91±5．48）mmHg,术后平均（11．81±2．90）mmHg,t值4．77（P〈0．05）,差异有统计学意义,术后眼压较术前显著性降低。术前BCVA≤0．1者7眼,占31．80％,术后BCVA≤0．5者12眼,占54．5％,术后视力明显提高。术前周边前房深度〈1／2CT者18眼,术后22眼周边前房深度≥1CT,虹膜平坦,周边膨隆消失。术后房角关闭所在象限可见不同程度的开放,周边虹膜粘连范围缩小。2眼出现前房渗出．虹膜部分后粘连,1眼发生后囊破裂,未发生角膜失代偿等并发症。结论采用超声乳化吸出联合房角分离术治疗闭角型青光眼合并白内障是安全、有效的。     

Ophthalmic laser microendoscope ciliary process ablation in the management of neovascular glaucoma.

PURPOSE: To evaluate the potential efficacy of ophthalmic laser microendoscope photocoagulation of the ciliary processes in the management of intractable neovascular glaucoma. METHODS: Ten patients with intractable neovascular glaucoma underwent ophthalmic laser microendoscope ciliary process ablation via a pars plana incision. The device and surgical technique are discussed. RESULTS: Preoperative intraocular pressure (IOP) ranged from 36 mmHg to 62 mmHg (mean, 43.6 mmHg). Postoperative final IOP ranged from 3 mmHg to 27 mmHg (mean, 15.3 mmHg). This represents an absolute decrease of 28.3 mmHg (65%). Postoperatively, 9 eyes had an IOP of less than 21 mmHg, although 3 of these eyes required medication. One eye attained a final IOP of 27 mmHg. All eyes were treated once. Nine patients were treated with carbonic anhydrase inhibitors preoperatively, and six patients were able to discontinue this medication postoperatively. Phthisis was not observed, but hypotony evolved in two eyes with chronic retinal detachment. Follow-up ranged from 6 to 11 months (mean, 8.8 months). CONCLUSION: This new therapeutic modality, which combines endoscopic visualization of the ciliary processes with diode laser photocoagulation, can be effective in the management of intractable neovascular glaucoma.     

Akutes Winkelblockglaukom trotz vorhandener Nd:YAG-Laser-Iridotomie

BACKGROUND: Nd:YAG laser iridotomy is routinely used as a procedure for primary acute angle-closure glaucoma (AACG). The clear advantage of Nd:YAG laser iridotomy is to resolve pupillary block without opening the eye. Nevertheless it remains unclear whether Nd:YAG laser iridotomy is equally effective as surgical iridectomy. In this context cases in which AACG recurred despite patent Nd:YAG laser iridotomy are of interest. PATIENTS AND METHODS: In a retrospective study, we analyzed the charts of 90 patients who presented with unilateral primary AACG in our department over 3 years and were treated with a surgical iridectomy. Surgical iridectomy at the 12 o'clock position was performed using a self-sealing corneal incision. RESULTS: Of the 90 patients with primary AACG, 13 (14.4%) had already been treated with Nd:YAG laser iridotomy. Despite the laser iridotomy, these eyes developed recurrent AACG. The presenting intraocular pressure (IOP) of these 13 eyes was 49.07+/-12.65 mmHg. In 4 eyes, continuous medical glaucoma therapy was used prior to AACG, 8 eyes showed signs of glaucoma damage at the optic disk or/and the visual field. In 2 eyes, the presenting high IOP at AACG could be lowered by medication. All other eyes were operated at high IOP. The average interval between the Nd:YAG laser iridotomy and the AACG was 24.5 weeks. After surgical iridectomy, the IOP was reduced to 12.69+/-4.11 mmHg and was 16.62+/-3.86 mmHg at the end of the observation period. CONCLUSIONS: In spite of Nd:YAG laser iridotomy recurrent AACG can occur. Surgical iridectomy is capable of permanently resolving the pupillar block in these cases.     

激光虹膜周边切除术治疗慢性闭角型青光眼的远期疗效

目的观察慢性闭角型青光眼患者接受激光虹膜周边切除术（LPI）治疗的远期效果。方法对长期随访的66例（116眼）接受LPI的慢性闭角型青光眼患者进行回顾性研究,观察术前及术后的患者情况。结果20眼（17％）术后未用药,眼压控制在〈21mmHg;49眼（42％）经药物控制眼压正常;47眼（41％）用药情况下,眼压〉21mmHg,其中35眼接受进一步手术治疗。以术前眼压21mmHg为界将患眼分为2组。2组的LPI单独起作用者分别为17眼和3眼（χ^2=6．136,P=0．013）,青光眼失控者分别为15眼和32眼,差异有统计学意义（χ^2=26．68,P〈0．01）。结论对LPI术后慢性闭角型青光眼患者,尤其是术前眼压控制差的患者应密切随诊,以防止视功能进一步损害。     

To compare argon laser peripheral iridoplasty (ALPI) against systemic medications in treatment of acute primary angle-closure: mid-term results

PURPOSE: To compare the clinical outcome of argon laser peripheral iridoplasty (ALPI) against systemic medications in treatment of acute primary angle-closure (APAC). METHODS: Consecutive patients with APAC were recruited and randomized to receive one of two treatment options: immediate ALPI or systemic acetazolamide +/- mannitol. All eyes were followed up for at least 6 months after laser iridotomy. Main outcome measures were intraocular pressure (IOP) and requirement for glaucoma medications. RESULTS: A total of 41 eyes (39 patients) were randomized into the ALPI group, and 38 eyes (32 patients) into the medical treatment group. There were no significant differences between the two groups in sex, age, presenting IOP, and duration of attack. Mean follow-up duration +/- SD was 15.7 +/- 5.8 months. There were no significant differences between the two groups in mean final IOP and requirement for glaucoma medications. CONCLUSIONS: There were no statistically significant differences in mean IOP and requirement for glaucoma drugs between APAC eyes treated with ALPI and systemic medications.     

YAG激光虹膜周切术治疗药物难控制性急性闭角型青光眼

目的:探讨YAG激光周边虹膜切除术在药物难控制急性闭角型青光眼治疗中的作用。方法:回顾分析我院住院患者共124例124眼,其中男51例,女73例,入院诊断符合急性闭角型青光眼发作期临床特征,且药物治疗24h后眼压仍>21mmHg的急性闭角型青光眼患者,其中控制眼压为21~35mmHg者51眼(41.1%),眼压36~50mmHg者37眼(29.8%),50mmHg以上者36眼(29.1%)。视力范围为光感~0.3。所有患者均在表面麻醉下行YAG激光周边虹膜切除术治疗,术后继续观察眼压、视力、前房深度变化,眼压控制稳定后分别进行小梁切除术、青光眼白内障联合人工晶状体植入术,或单纯白内障超声乳化吸出联合人工晶状体植入术。结果:患者124例124眼急性闭角性青光眼患者行YAG激光虹膜周切术后,第2d检测眼压≤21mmHg者28眼(22.6%),眼压为22~35mmHg者60眼(48.4%),眼压36~50mmHg者25眼(20.2%),眼压>50mmHg者11眼(8.9%);激光术后视力增加3行者33眼（26.6%）,2行者31眼(25.0%),视力增加1行者44眼(35.5%),视力不增加者16眼(12.9%);119眼前房深度增加(96.0%); YAG激光虹膜周切术后并发前房出血98眼(79.0%)。眼压控制稳定后分别进行小梁切除术37眼,青光眼白内障联合人工晶状体植入术43眼,白内障超声乳化吸出联合人工晶状体植入术44眼。观察随访3~9mo,眼压控制≤18mmHg者95眼,眼压≤25mmHg者24眼,眼压为26~35mmHg者5眼,未见前房积血、黄斑囊样水肿等并发症。结论:YAG激光虹膜周切术在药物难控制性急性闭角型青光眼治疗中能明显降低眼压,为各种青光眼手术的治疗提供安全可靠的条件,有助于视功能保护和恢复,提高疗效。     

原发性闭角型青光眼中白内障超声乳化联合IOL植入术的疗效

目的:评价白内障超声乳化联合人工晶状体(intraocular lens,IOL)植入术治疗眼压控制的急性闭角型青光眼和慢性闭角型青光眼患者的疗效及安全性。方法:将45例60眼白内障眼压控制的急性闭角型青光眼和慢性闭角型青光眼随机分为两组,一组采用白内障超声乳化联合IOL植入术,一组采用激光虹膜切开术(laser iridotomy,LI)。比较两组眼内压、抗青光眼药物使用数目、并发症、前房内皮细胞计数的差别。结果:IOL组中,随访6mo后的眼内压由术前的14.82±4.23mmHg下降到10.94±1.24mmHg,而LI组的眼内压并无明显变化(15.34±4.13mmHgvs14.68±4.77mmHg),采用重复测量资料的方差分析显示两组的眼内压变化有显著统计学差异(F=36.452,P<0.01)。IOL组6mo后基本未采用抗青光眼药物,而LI组使用抗青光眼药物个数为0.24±0.41个(P<0.05)。两组在并发症及前房内皮细胞计数方面无统计学差异(P>0.05)。结论:白内障超声乳化联合IOL植入可有效降低眼压控制的急性闭角型青光眼和慢性闭角型青光眼的眼内压水平,该治疗方法安全有效,是这类患者首选的治疗方法之一。     

新生血管性青光眼的病因分析和手术治疗

目的 探讨新生血管性青光眼(neovascular glaucoma,NVG)的原发病因和手术治疗方案的选择.方法 对NVG患者97例108只眼的病因和手术资料进行分析总结.结果 在所有的患者中,视网膜静脉阻塞导致NVG的患者最多,其次为糖尿病视网膜病变;两者之合共67例74只眼,占总例数的69.1%,总眼数的68.5%.其他的病因包括眼缺血综合征5例6只眼,Coat病4例4只眼,慢性色素膜炎3例4只眼,慢性闭角型青光眼3例3只眼,以及一些相对少见的病因.37只眼接受或者补充完成了全视网膜光凝治疗,其中34只眼(91.9%)新生血管完全消退.47只眼接受了全周边视网膜冷凝治疗,其中38只眼(80.9%)的新生血管完全消退.在接受改良式小梁切除、术前或术后全视网膜光凝治疗的26只眼中,21只眼(80.8%)的眼压控制良好.在接受玻璃体切除+全视网膜光凝+小梁切除术的9只眼中,8只眼(88.9%)眼压控制良好.4只眼接受青光眼阀植入手术,在平均5.5月随访期内眼压控制良好.39只眼先后接受52次半周睫状体冷冻术,其中30只眼(76.9%)眼压控制良好.结论 NVG的病因复杂多样,手术治疗应该根据不同的临床特点制定个体化的治疗方案.     

Experiences with laser therapy in different forms of glaucoma with open and closed chamber angle

Results of laser treatment of open-angle and angle-closure glaucomas are communicated. Argon laser trabeculoplasty was performed in 78 eyes with open-angle glaucoma. The most favorable site for photocoagulation was the gone between the pigmented and nonpigmented trabecular meshwork. Forty-two eyes with angle-closure glaucoma were treated by argon laser gonioplasty. This method proved successful in chronic angle-closure glaucoma and for the prophylactic management of acute angle-closure glaucomas. A combination of argon laser gonioplasty and argon laser trabeculoplasty was used in 16 eyes. Both methods were found to be effective in treating certain forms of juvenile glaucoma. A further 11 eyes with acute angle-closure glaucoma were treated by Nd-YAG laser iridotomy, 9 of them successfully.     

恶性青光眼的临床特点与防治方法

目的探讨恶性青光眼的临床特点与防治方法。方法回顾分析12例（13只眼）恶性青光眼的临床资料及治疗方法。本组病例角膜直径9．5—11mm,平均10．8mm。眼轴长17．8～22．5mm,平均21．9mm,发生于慢性闭角型青光眼小梁切除术后11只眼,占84．6％。6只眼行药物治疗,其中2只眼联合YAG激光治疗;5只眼行晶状体摘除联合人工晶状体植入、后囊截开、前部玻璃体切除术;2只眼行晶状体摘除联合人工晶状体植入、小粱切除术,再次经睫状体平部行前部玻璃体切除、晶状体后囊膜部分切除术。结果出院时患者眼压在10-15mm Hg,中央及周边前房形成。随访观察10个月至5年,平均20个月,前房稳定,眼压15—21mm Hg,平均18．7mm Hg。结论恶性青光眼好发于小角膜、短眼轴的慢性闭角型青光眼小梁切除术后,药物治疗、无晶状体眼联合Y-AG激光治疗可以控制部分恶性青光眼,晶状体摘除联合人工晶状体植入、后囊截开、前部玻璃体切除手术可以治愈药物不能控制的恶性青光眼。     

The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine

We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy. A total of 36 eyes (29 patients) with chronic primary angle-closure glaucoma underwent Q-switched Nd:YAG laser iridotomy: 18 eyes were treated topically with 0.5% clonidine ophthalmic solution prior to and immediately following the procedure, and a control group of 18 eyes underwent Nd:YAG laser iridotomy without topical clonidine. The control group was selected to match the clonidine-treated group in terms of preoperative IOP, the extent of peripheral anterior synechia, and the total amount of laser energy delivered. None of the clonidine-treated eyes experienced an IOP rise greater than 4 mm Hg over baseline, wereas 4 of the nontreated eyes (22.2%) developed an IOP rise greater than 10 mm Hg. The mean IOPs were significantly lower during the first 4 h postsurgery in the clonidine-treated eyes.     

激光周边虹膜成形及切除术治疗药物难控制的急性闭角型青光眼

目的：探讨激光周边虹膜成形联合周边虹膜切除术,治疗药物难控制的急性闭角型青光眼的效果和安全性。方法：选取药物治疗24h后眼压仍高于21mmHg的原发性急性闭角型青光眼15例17眼和白内障膨胀期继发的急性闭角型青光眼4例4眼,共19例21眼,采用激光周边虹膜成形联合周边虹膜切除术,术后24h观察视力、眼压、角膜、周边前房深度、房角及并发症。结果：所有患者激光术后24h眼压均有大幅度的下降,术前眼压53.09±11.01mmHg,术后24h眼压下降至14.98±4.21mmHg,治疗前后差异有统计学意义（P〈0.01 ）。术后视力由术前手动～0.3提高至0.1～1.0。所有患者角膜水肿减轻或消退,周边前房深度增加,房角不同程度开放。其中虹膜出血11眼（52.4%）,轻度反应性虹膜炎21眼（100%）,无1眼发生角膜灼伤。结论：激光周边虹膜切除联合周边虹膜成形术,是降低药物难控制的急性闭角型青光眼眼压的一种安全有效的方法。     

原发性急性闭角型青光眼和慢性闭角型青光眼角膜内皮细胞的形态学观察

目的观察原发性急性闭角型青光眼和慢性闭角型青光眼角膜内皮细胞的形态学特点及差异。方法应用非接触型角膜内皮细胞计测量眼压基本控制的18例原发性急性闭角型青光眼18只急性发作眼及对侧18只临床前期眼和20例（26只限）中晚期慢性闭角型青光眼中央角膜内皮细胞的单位面积细胞密度（CD），最小细胞面积（MIN），最大细胞面积（MAX），平均细胞面积（AVG），平均细胞面积的标准差（SD）和细胞面积的变异系数（CV），并进行对比分析。结果原发性急性闭角型青光眼急性发作眼组和对侧临床前期限组比较、原发性急性闭角型青光眼急性发作眼组和慢性闭角型青光眼组比较，中央角膜内皮细胞的单位面积细胞密度显著性减少（P〈0．01），最小细胞面积、最大细胞面积、平均细胞面积、平均细胞面积的标准差和细胞面积的变异系数均有显著性增加（P〈0．01）。结论急性增高眼压对角膜内皮细胞造成显著损害，细胞密度明显下降，细胞多形性增加，损害程度与急性增高眼压持续时间有关；急性增高眼压较慢性增高眼压对角膜内皮细胞的损害更大。     

氩激光虹膜周边成形术治疗急性发作期原发性急性闭角型青光眼的疗效观察

目的观察氩激光虹膜周边成形术治疗原发性急性闭角型青光眼急性发作期的临床效果。方法将基础治疗1h后眼压≥50mmHg(1kPa=7.5mmHg)的103例(103眼)患者随机分为激光组52眼和药物组51眼。观察两组患者治疗前及治疗后30min、1h、2h、24h患者的症状、视力、角膜水肿程度、前房反应、周边前房深度、眼压降至21mmHg以下所用时间及24h后房角开放情况。结果治疗后激光组较药物组症状缓解明显,起效快;视力提高快、幅度大;两组患者周边前房都变深。两组患者治疗前后眼压差异均有统计学意义(均为P<0.05)。治疗后1h、2h两组患者角膜水肿程度为:激光组分别为1.48±0.62、1.37±0.53;药物组分别为1.69±0.67、1.57±0.59;两组比较差异均有统计学意义(均为P<0.05);治疗后30min和24h两组比较差异均无统计学意义(均为P>0.05);两组眼压降至21mmHg以下所用的时间:激光组(1.8±0.9)h,药物组为(6.5±2.2)h;24h后房角开放率激光组86.5%,药物组66.7%,两组比较差异均有统计学意义(均为P<0.05)。结论氩激光虹膜周边成形术是一种治疗原发性急性闭角型青光眼急性发作期的快速、安全和有效的方法。