根除幽门螺杆菌对出血性十二指肠溃疡自然病程影响的3年随访研究

目的：探讨根除幽门螺杆菌（Ｈｐ）对出血性十二指肠溃疡自然病程的影响。方法：选择胃镜证实的出血性十二指肠溃疡病人１３６例，均有Ｈｐ感染（胃粘膜Ｇｉｅｍｓａ染色和１４Ｃ尿素呼吸试验二项均阳性）。予奥米拉唑２０ｍｇ，每日２次；羟氨苄青霉素７５０ｍｇ，每日２次；甲硝唑４００ｍｇ，每日３次，疗程２周。疗程结束后４周复查胃镜和Ｈｐ，溃疡愈合者分Ａ组（Ｈｐ根除）和Ｂ组（Ｈｐ未根除）进入随访阶段，随访观察３年。结果：溃疡愈合１２４例（９１２％），Ｈｐ根除１１１例（８１６％）；Ｈｐ根除的溃疡愈合率为９９１％（１１０／１１１），显著高于Ｈｐ未根除的５６％（１４／２５，Ｐ＜０００５）；Ｂ组１年内溃疡复发率达１００％，显著高于Ａ组８３％（Ｐ＜００５）；Ｂ组３年累积再出血率１００％，显著高于同期Ａ组的９０％（Ｐ＜００５）。结论：根除Ｈｐ可提高十二指肠溃疡愈合率和减少溃疡复发率，尤可显著减少溃疡再出血率，提示根除Ｈｐ很可能改变出血性十二指肠溃疡的自然病程。     

毫米波加药物治疗Hp+消化性溃疡50例

目的探讨幽门螺杆菌阳性（Ｈｐ＋）的消化性溃疡（ＰＵ）愈合和复发的物理治疗（毫米波ｍｍＷ）及其联合药物治疗的前景．方法本组ＰＵ９３例采用ｍｍＷ辐射探头对ＰＵ患者体表胃投影区照射３０ｍｉｎ，（ｎ＝５０）每日１～２次，联合药物（甲哨唑＋西咪替丁）在Ｈｐ＋的ＰＵ愈合和复发的疗效进行研究，并与对照组４３例进行比较．结果ｍｍＷ治疗及联合药物治疗组与对照组单用药物Ｈ２受体阻滞剂西咪替丁相比较，结果治疗组溃疡愈合率及Ｈｐ根除率１００％（５０／５０）及９８％（４９／５０）．１年后复发率为４％（２／５０）；而对照组溃疡愈合率９０５％（３８／４３），Ｈｐ根除率５０８％（２５／４３），１年后复发率２０９％（９／４３）．说明Ｈｐ根除与溃疡复发有一定关系，２组相比有显著差异（Ｐ＜００５～００１）．结论ｍｍＶ联合药物治疗Ｈｐ＋ＰＵ愈合和复发优于单用Ｈ２受体阻滞剂．     

兰索拉唑、羟氨苄青霉素、替硝唑联合根除幽门螺杆菌的疗效观察

目的评价兰索拉唑（达克普隆）、羟氨苄青霉素、替硝唑三联疗法对幽门螺杆菌（Ｈｐ）相关性消化性溃疡的疗效。方法将８７例Ｈｐ阳性的十二指肠和（或）胃溃疡患者随机分为２组：第１组４３例,每次口服兰索拉唑３０ｍｇ、羟氨苄青霉素１０００ｍｇ、替硝唑５００ｍｇ,均每日２次,２周为一疗程;第２组４４例,给药方式同第１组,只是疗程缩短为１周,疗程结束后继续每日口服兰索拉唑３０ｍｇ,持续１周。疗程结束达４周时复查胃镜及Ｈｐ。３５例Ｈｐ根除后６个月行１４Ｃ－尿素呼气试验（ＵＢＴ）。结果第１组有３例因过敏性皮疹而退出观察,４０例用于统计学分析。第１组和第２组的Ｈｐ根除率分别为９００％和８１８％,十二指肠溃疡和胃溃疡的愈合率分别为９２５％和８８６％。６个月的Ｈｐ再感染率为８６％。结论第１组Ｈｐ根除率和溃疡愈合率均略高于第２组,两组相比差异无显著性（Ｐ＞００５）。两组均有较理想的溃疡愈合率和Ｈｐ根除率。     

根除幽门螺杆菌治疗十二指肠溃疡的随机对照研究

通过根除幽门螺杆菌（Ｈｐ）治疗（不加用任何抗酸或抑酸药物）观察十二指肠溃疡（ＤＵ）的愈合率。方法：１１５例Ｈｐ感染的ＤＵ患者随机分为两组,接受７天铋剂三联治疗。Ａ组口服替硝唑５００ｍｇ、克拉霉素２５０ｍｇ和胶体次构橼酸铋２２０ｍｇ各每日２次,疗程７天,Ｂ组在Ａ组基础上加服奥美拉唑每日２０ｍｇ,疗程４周。服药前和停止抗ＨＰ治疗后４周作胃镜检查及~ （１３）Ｃ－尿素呼气试验。结果：１０７例患者完成治疗和复查,８例失访。Ａ、Ｂ两组的ＤＵ愈合率分别为９２．５％（９５％可信区间为８５．４％～９９．６％）和９６．３％（９５％可信区间为９１．３％～１００％）;两组Ｈｐ根除率分别为９４．３％（９５％可信区间为８８．１％～１００％）和９８．１％（９５％可信区间为９４．５％～１００％）,统计学上均无显著差异（＞０．０５）。服药１周内上腹痛缓解率Ｂ组明显高于Ａ组（Ｐ＜０．００５）。两组方案均未发现有明显不良反应。结论：Ｈｐ感染的ＤＵ患者经根除ＨＰ治疗,溃疡能自行愈合而不需使用抑酸药物;奥美拉唑能迅速减轻或消除ＤＵ患者的上腹痛症状;本治疗方案具有Ｈｐ根除率高、疗程短、依从性好和不良反应少等优点。     

幽门螺杆菌的根除与十二指肠溃疡病程的关系

为观察不同方案对十二指肠溃疡患者幽门螺杆菌（Ｈｐ）的根除效果及其再感染与溃疡复发的关系，对８８例Ｈｐ阳性的十二指肠溃疡患者分组治疗并随访观察。结果：雷尼替丁＋羟氨苄青霉素＋甲哨唑，铋剂＋甲哨唑＋四环素和奥美拉唑＋羟氨苄青霉素对Ｈｐ的根除率分别是９２．９％、８１．３％和７６．９％；对十二指肠溃疡的４周愈合率分别是８５．７％、８１．３％和９２．３％。平均随访１２．４±３．１月，Ｈｐ未根除的３２例中２９例复查，溃疡复发１４例；Ｈｐ已根除的５１例中复查４５例，除１例溃疡复发与非甾体类消炎药相关外，６例复发与Ｈｐ再感染有关，１年总的Ｈｐ再感染率２０．０％。结果提示：根除Ｈｐ可防止十二指肠溃疡复发，已根除Ｈｐ者溃疡复发大多数与Ｈｐ再感染有关     

根除幽门螺杆菌和消化性溃疡再出血的关系研究

目的探讨根除幽门螺杆菌（Ｈｐ）对预防消化性溃疡再出血作用。方法对消化性溃疡并出血病人行急诊胃镜检查，取胃窦组织检测Ｈｐ。随机选择Ｈｐ阳性病人分为Ａ、Ｂ两组，分别用洛赛克（２０ｍｇ／次）＋羟氨苄青霉素（７５０ｍｇ／次）和单独用洛赛克（２０ｍｇ／次）治疗，每天２次，共２周。Ｈｐ阴性组（Ｃ组）单用洛赛克（２０ｍｇ／次）治疗，每天２次，共２周。之后，三组病人再用洛赛克（２０ｍｇ／次），一日一次，治疗２周。疗程结束，复查胃镜及检测Ｈｐ，并随访１８个月。结果Ａ、Ｂ、Ｃ三组病人经治疗后，溃疡愈合率分别为１００％，９６８％和９７５％，三组之间相互比较无明显差异，（Ｐ＞００５）。Ａ、Ｂ两组Ｈｐ根除率分别为８３３％和１８７％，两者比较有显著性差异（Ｐ＜００５）。随访１８个月后，Ａ、Ｂ两组的再出血率分别为２７％和３１３％，两者比较有显著性差异（Ｐ＜００５），而Ｃ组再出血率为１２５％，分别与Ａ、Ｂ两组比较，再出血率无显著性差异（Ｐ＞００５）。结论根除Ｈｐ能降低消化性溃疡再出血，所有Ｈｐ阳性的消化性溃疡并出血病人需要进行根除Ｈｐ治疗，以防溃疡再出血     

短程联合用药根除幽门螺杆菌的疗效观察

目的：为了寻求效佳、安全、短程根除幽门螺杆菌（Ｈｐ）的方法，对兰索拉唑（Ｌａｎ）、法莫替丁（Ｆａｍ）合用阿莫西林（Ａｍｏ）的二联疗法进行了临床观察。方法：４４例经胃镜检查证实为十二指肠溃疡患者、Ｈｐ阳性，随机分为二组分别接受Ｌａｎ和Ｆａｍ治疗。Ｌａｎ组：Ｌａｎ３０ｍｇＢｉｄ×１４天；Ｆａｍ组：Ｆａｍ２０ｍｇＢｉｄ×１４天，两组均同时服用Ａｍｏ０．５ｇｔｉｄ×１４天。结果：停药４周，行胃镜检查及Ｈｐ测定，结果表明二组的溃疡愈合率及Ｈｐ根除率相近，分别为８７５％及８５％；７５％及７０％。结论：本研究显示Ｌａｎ和Ｆａｍ加Ａｍｏ的二联疗法具有缓解症状快、疗程短，副反应小等优点，是较理想的根除Ｈｐ方案     

球部幽门螺杆菌感染与不同期十二指肠溃疡的关系

目的研究十二指肠溃疡（ＤＵ）的胃镜下和组织学愈合是否受球部幽门螺杆菌（Ｈｐ）感染的影响。方法对７０例活动期ＤＵ（Ａ）和４０例瘢痕期ＤＵ（Ｓ组）患者溃疡边缘粘膜活检标本采用快速尿素酶试验和改良姬姆萨染色检测Ｈｐ,并对粘膜固有层内中性多形核白细胞（ＰＭＮ）浸润状态进行观察。结果Ｓ组和Ａ组Ｈｐ阳性率各为６００％和７１４％,差异无显著性（Ｐ＞０．０５）。Ｓ组和Ａ组中Ｈｐ阳性者ＰＭＮ浸润率和ＰＭＮ计数（各为９１７％;２０３±０．５１和１０００％;２３４±０．４０）分别明显高于（Ｐ均＜００１）其Ｈｐ阴性者（各为５６３％;０６７±０．２９和６５０％;１１１±０．３２）。在Ｈｐ阳性者,Ｓ组ＰＭＮ浸润率和ＰＭＮ计数均与Ａ组相近（Ｐ＞０．０５）;在Ｈｐ阴性者,Ｓ组仅ＰＭＮ浸润与Ａ组相近（Ｐ＞０．０５）,其ＰＭＮ计数则明显低于Ａ组（Ｐ＜０．０１）。结论ＤＵ的胃镜下愈合可不受球部Ｈｐ感染的影响,但后者与溃疡边缘粘膜活动性炎症密切相关从而使ＤＵ的组织学愈合质量明显受其影响。     

龙黄合剂抑Hp实验及临床应用

目的探讨龙黄合剂体外抑Ｈｐ作用，及对Ｈｐ阳性十二指肠溃疡的疗效．方法采用纸片扩散法和琼脂稀释法，对龙黄合剂中单味中药及复合制剂进行体外抑Ｈｐ实验，并与部分中成药抑Ｈｐ效果对比．将１２８例Ｈｐ阳性十二指肠溃疡随机分成龙黄合剂组（Ａ组），雷尼替丁＋呋喃唑酮组（Ｂ组）及龙黄合剂＋呋喃唑酮＋雷尼替丁（Ｃ组）３组进行治疗，观察各组溃疡愈合率，复发率，Ｈｐ根除率，胃窦粘膜病理好转率，药物副反应发生率．结果龙黄合剂有较好体外抑Ｈｐ作用．Ｃ组Ｈｐ根除率为８４８％，溃疡１ａ复发率１３５％，胃窦粘膜炎症病理好转率为６５３％，副反应发生率为１３０％，均优于Ａ组（４５２％，３７５％，５７１％，７１％）及Ｂ组（３７５％，５００％，３７５％，１９５％），统计学处理有显著或极显著差异（Ｐ＜００５或００１）．３组溃疡愈合有效率分别为Ｃ组１０００％，Ａ组９００％，Ｂ组９０５％，统计学处理无显著差异（Ｐ＞００５）．结论体外试验证明龙黄合剂对Ｈｐ有较好抑制作用，龙黄合剂＋雷尼替丁＋呋喃唑酮用于Ｈｐ阳性的十二指肠溃疡治疗，可提高Ｈｐ根除率，减少复发率，副作用小，价格低廉，服用方便，适合国情，值得推广     

幽门螺杆菌感染与胃粘膜上皮细胞凋亡关系的研究

采用脱氧核糖核苷酸末端转移酶介导的缺口末端标记（ＴＵＮＥＬ）技术，对幽门螺杆菌（Ｈｐ）阴性患者及Ｈｐ阳性患者抗Ｈｐ治疗前后胃粘膜上皮细胞凋亡进行了原位观察。结果表明，Ｈｐ阳性患者胃粘膜上皮细胞凋亡指数（１７０１％）明显高于Ｈｐ阴性者（３５２％）（Ｐ＜００１）；胃粘膜上皮细胞凋亡指数与Ｈｐ感染程度明显相关（Ｐ＜００５）；Ｈｐ根除后凋亡细胞指数由１７８７％降至４１９％（Ｐ＜００１），而持续阳性者无明显降低。提示Ｈｐ感染能诱导胃粘膜上皮细胞凋亡，这可能是Ｈｐ引起胃癌和溃疡的重要机制之一。     

胃舒散联合呋喃唑酮和阿莫西林根除幽门螺杆菌阳性十二指肠溃疡及抗复发疗效观察

目的 :观察胃舒散、呋喃唑酮和阿莫西林对幽门螺杆菌 (Hp)阳性十二指肠溃疡 (DU)的疗效及根除Hp对溃疡复发的影响。方法 :73例 Hp阳性 DU患者随机分为两组 :三联组 4 1例 ,服用胃舒散 2 .0 g,呋喃唑酮 0 .1g,阿莫西林 0 .5 g,各 3次 /d ,2周后再继服胃舒散 4周。雷尼替丁组 32例 ,服用雷尼替丁 0 .15 g,3次 /d,共 6周。治疗前后均记录胃痛症状 ,内镜观察溃疡情况 ,并进行 2年随访。Hp检测采用 Warthin- Starry银染色法 ,1 4C-尿素呼气试验或快速尿素酶试验 ,2项阳性为 Hp感染 ,阴性为 Hp根除。结果 :6周治疗结束后 ,两组溃疡愈合率均为10 0 %。三联组临床症状缓解率、副反应发生率为 97.6 %和 18.8% ,雷尼替丁组为 93.8%和 9.4 % (均 P >0 .0 5 )。三联组 Hp根除率 (92 .7% )显著高于雷尼替丁组 (0 % ,P <0 .0 1)。 Hp根除的 38例中 ,1年及 2年溃疡复发率为(5 .3% ,10 .5 % )均显著低于 Hp持续感染者 (2 8.1% ,4 6 .9% ,P <0 .0 1)。结论 :以胃舒散为主的三联疗法具有疗效高、副作用少、溃疡复发率低的优点 ,是一种根除 Hp的较好方案。     

气管腺样囊性癌一例

气管腺样囊性癌一例王秀兰，江丽洁，文乾亨，陈儋峰，徐立患者女，３８岁，因咳嗽咳痰一年半，痰中带血并伴有胸闷、胸痛三个月入院。查体未见明显阳性体征。胸部ＣＴ片提示气管左侧软组织肿物。气管分叉断层及左主支气管后倾斜断层片提示，肿物位于气管下段左侧壁向下延...     

The hemodynamic changes of gastroduodenal regional blood flow after Helicobacter pylori eradication in patients with duodenal ulcer scar

Duodenal ulcer (DU) is frequently accompanied by Helicobacter pylori (Hp) infection and associated with the imbalance of aggressive factors and defensive factors. To investigate the possible relationship between Hp and regional gastric blood flow, 26 endoscopically proved DU (scar stage) and Hp infection patients were included and received triple therapy (colloid bismuth subcitrate 120 mg qid for 4 weeks, amoxicillin 500 mg qid for 2 weeks and metronidazole 250 mg tid for 2 weeks). Regional gastroduodenal blood flow (RGDF) was measured at DU scar area and antrum lesser curvature site by laser Doppler flowmetry during endoscopic examination, before and one month after triple therapy. In 22 patients with Hp eradication the RGDF was significantly elevated at antrum lesser site after triple therapy (p < 0.05) but there was no difference at DU scar area. However, in 4 patients without Hp eradication no difference of RGDF in these two points was found. Therefore, Hp appears to have direct effects on gastric microcirculation.     

十二指肠溃疡愈合质量的内镜诊断及与复发的关系

为探讨内镜对十二指肠溃疡的愈合质量的诊断价值及愈合质量与复发的关系，应用内镜下色素染色技术，将溃疡瘢痕分为Ｓａ、Ｓｂ、Ｓｃ三期，并对活动期溃疡病人分别给予阿莫西林、甲氰咪胍及阿莫西林加甲氰咪胍联合治疗。结果：Ｓａ期溃疡瘢痕较Ｓｂ 和Ｓｃ期更容易复发，Ｓｃ期无一例复发；甲氰咪胍组Ｓａ期比例有高于其它两组的趋势，且甲氰咪胍组两年溃疡复发率明显高于其它两组。研究表明，改善溃疡愈合质量可减少复发。     

维敏四联治疗Hp相关的消化性溃疡

目的应用维敏胶囊（胶态果胶铋）四联药物疗法治疗Hp相关的消化性溃疡（PU）2wk，停药4wk后经内镜、14C-UBT等方法观察溃疡的愈合及Hp根除的疗效方法经内镜确诊为PU，其中十二指肠溃疡（DU）169例；胃溃疡（GU）89例．受检前2wk内未服抗生素、铋剂及质子泵阻断剂，排除孕妇和溃疡出血者，并镜下活检病理排除恶性溃疡Hp检测：先行快速尿素酶检测（RUT），阳性者再行14C-UBT检测，其中DU的Hp阳性率为95．5％；GU的Hp阳性率为81．0％．四联治疗方法：对Hp阳性PU，给予维敏胶囊100mg，4次／d；兰索拉唑30mg，2次／d；阿莫西林0．5g，4次／d；甲硝唑0．4g，2次／d，疗程为2wk．停药后4wk，同时复查内镜及14G-UBT．结果DU愈合率91．2％，Hp根除率93．0％；GU愈合率86．0％，Hp根除率92．0％．DU和GU愈合率及Hp根除率差异不明显（P＞0．05）；四联疗法后肝肾功能无异常结论Hp与PU关系密切．采用四联治疗Hp相关的PU，有良好效果．14GUBT检测Hp感染具有很高的敏感性和特异性，无创伤性，是治疗后复查Hp的首选方法     

Peptic ulcer recurrence during maintenance therapy with H2-receptor antagonist following first-line therapy with proton pump inhibitor

We investigated the peptic ulcer recurrence rates during maintenance therapy with H₂-receptor antagonists (H₂RAs) following first-line therapy with a proton pump inhibitor (PPI). Patients with gastric ulcer (GU) or duodenal ulcer (DU) were enrolled in this study; 583 eligible patients (GU, 325; DU, 258) were administered lansoprazole (30 mg/day for 8 weeks for GU, and the same dosage for 6 weeks for DU) as first-line therapy, and a half dose of H₂RA as maintenance therapy for 12 months. Endoscopic photographs were taken before administration and after 8 (GU) and 6 (DU) weeks of lansoprazole administration. Ulcer stage was evaluated using the classification of Sakita and Miwa. Endoscopic examinations were performed 6 months or 12 months after the start of maintenance therapy or when a recurrence was suspected because of the appearance of subjective symptoms. The healing rates for GU and DU patients after completion of lansoprazole therapy were 79% in both groups, while the S₂-stage healing rates were 18% and 31%, respectively. At 1 year after the start of maintenance therapy, the recurrence rates were 25% for GU and 39% for DU patients. In DU patients, the recurrence rates from S₁-stage and S₂-stage were 49% and 20%, respectively (P = 0.004), but no significant difference was found between these rates in GU patients. The recurrence rates in H. pylori-positive patients before lansoprazole administration were 27% for GU and 43% for DU patients. We concluded that the maintenance therapy with a half-dose of H₂RA following PPI therapy was insufficient to prevent recurrences of GU and DU. Received: February 28, 2000 / Accepted: June 23, 2000     

胶体次枸橼酸铋合并交沙霉素或强力霉素两联疗法根除幽门螺杆菌研究

180例幽门螺杆菌(Hp)感染的消化性溃疡或非溃疡性消化不良(NUD)患者分3组接受胶体次拘椽酸铋(CBS)合并的两联治疗。A组方案为CBS 240mg,交沙霉素1000mg;B组为CBS 240mg,强力霉素100mg;C组(对照组)为CBS 240mg,羟氨苄青霉索l000mg。上述剂量每日2次,疗程2周。162例完成治疗后停药4周后胃镜复查。结果显示:A、B和C组的Hp根除率分别为69.6％(39/56)、16.3％(9/55)和43.1％(22/51),各组间的Hp根除率有非常显著差别(P<0.01或P<0.001):A、B和C组的十二指肠溃疡(DU)愈合率分别为86.9％(20/23)、60.8％(14/23)和75.O％(12/16),A组的DU愈合率显著高于B组(P相似文献   

克拉霉素、呋喃唑酮合并兰索拉唑或胶体次枸橼酸铋短程三联疗法根除幽门螺杆菌的研究

88例幽门螺杆菌(Hp)感染的卜:指肠溃疡(DU)和功能性消化不良患耆分两期研究.接受7天克拉霉素合并的j联治疗。I期乃预研究,28例随饥分婀组接受电托堪索500mg、呋喃畔刚200mg合}}I}变体次枸橼酸铋(CBS)240mg(A组)或、!索托哗30mg(B组)。¨?次治疗。60例进入ll;《Ij研究符心分AfllB同组.药物配合方棠M I期.似除CBS外.接他药物刊毓i或、{i l、I】彬j—IJ舒BlJ仃4例科】1例Iq约物驯f互『-?术。t限:i^_j’.火i方2例i^泶!Il!_,Ji.I垮jA、BiH f10H1)根除半分SIj为100~;i,(12,12)f1 J91.6‘％(11 12):Il㈣A,B纠i n0Hp橄除?}行}jl_乃92 6‘j;,(25,一’27)和90.0％(27,30)备组问的Hp撤除?爷无!It并蓐别(P>0.0j)。I、ll期·l,削J三J-t j幸j,,别乃64.2,}2,(18j28)和Ij】”i(3/58)(P<0.001)。lI期A、B两组的DU愈合率分别为94.4％(17/18)和100％(18/18)。lJ期r}·的两种低制m地程j联{j’}J、地较乃圳魁的Hp橄除玎案.7.5％(4/j3)的Hp曲株则电十￡。《豢味发耐药.足i青,j:欠帔的{:嘤味N     

Healing and relapse of duodenal ulcer during ranitidine therapy in the elderly. The RUDER Study Group.

A total of 2,109 outpatients with active duodenal ulcer (DU) entered an open, prospective study in order to investigate factors influencing healing and relapse during 2 years of ranitidine therapy (300 mg daily for healing, 150 mg as maintenance treatment). In a retrospective analysis, we evaluated the influence of age. Symptoms related to DU in 1,899 evaluable cases in patients over 65 years of age (n = 185) were identical to those of DU patients younger than 65 years old (n = 1,714). Rapid healing within 2 weeks of ranitidine therapy was less frequent in the elderly (32.5%) than in younger patients (40.7%) though identical healing rates (94.1%) in each group were achieved by continuation of ranitidine therapy for 8 weeks. Cumulative recurrence rates during the 2 years of long-term therapy were lower (17.3%) in old age than in patients under 65 years of age (23.3%). Adverse events were rare in both age groups. We conclude that DU healing during ranitidine is delayed in old age. Additional differences in relapse rates in favor of the elderly suggest that DU disease has a different course in the elderly.     

After the eradication of Helicobacter pylori infection, relapse is a serious problem in Turkey

Eradication of Helicobacter pylori (Hp) infection is strongly recommended in duodenal and gastric ulcer. In developed countries the recurrence rate is low; however, in Turkey, the Hp recurrence rate is suspected to be high as the prevalence of Hp infection is--as high as 70-80% in the asymptomatic population. We planned this study to determine the relapse rate of Hp infection after successful eradication therapy in Turkey. Fifty-two cases including 24 patients with duodenal ulcer and 28 patients with nonulcer dyspepsia were examined in this study. The eradication regimen was omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily, and metronidazole 500 mg three times a day for 1 week. All patients underwent upper gastrointestinal tract endoscopy. At least four samples from antrum and corpus were taken to enable histologic diagnosis of Hp infection. After the eradication therapy, endoscopy was repeated at 1, 3, 6, and 12 months, and Hp-positive patients were dropped from study. With the use of this regimen, the Hp eradication rate was 92.3% (48/52). After the eradication of Hp infection, relapse rates were 6.97%, 27.5%, and 11.11% at 3, 6, and 12 months, respectively. The cumulative relapse rate for 1 year was 41.46%. The results of this study revealed that after the eradication of Hp infection, recurrence is encountered very often as a problem in Turkey. We concluded that hygienic and environmental factors can affect these high relapse rates.