户外空气中可吸入颗粒物对出生体重的影响

目的 研究空气污染物可吸入颗粒物(PM10)对新生儿出生体重的影响.方法 利用某地所有助产机构的2003～2005年围产保健数据和2002～2005年该地区各空气污染监测点监测的每日可吸入颗粒物(PM10)浓度数据,根据末次月经和分娩日期计算每位产妇孕期暴露于可吸入颗粒物(PM10)的水平,从而分析孕期接触可吸入颗粒物(PM10)对新生儿出生体重的影响.结果 不同的胎儿性别、母亲年龄、母亲职业、母亲原地址、孕期高危情况、孕次分组间出生体重有显著性差异;在不同孕期,＜67.6μg/m3、67.6～162.4μg/m3和＞162.4μg/m3的3个可吸入颗粒物(PM10)暴露组间出生体重有显著性差异.多元线性回归分析显示,可吸入颗粒物(PM10)的浓度每增加10μg/m3,新生儿出生体重会减少2.2～2.7g.结论 影响新生儿出生体重的因素有很多,其中户外空气中较高可吸入颗粒物(PM10)污染是一个重要因素,与新生儿低出生体重有关.     

空气污染与出生体重关系的病例对照研究

目的 研究空气污染物可吸入颗粒物(PM10)、二氧化硫、二氧化氮对新生儿出生体重的影响.方法 收集了广州市某区2003～2005年孕满37周时分娩,且婴儿出生体重低于2 500克的产妇为低体重组,按照同一天分娩,选取婴儿出生体重高于2 500克的产妇为正常组.调查的因素包括产妇的年龄、职业、文化程度、出生地、是否有准生证、孕周、是否有高危因素、末次月经时间、分娩日期、孕次、产次;产妇丈夫的职业、文化程度;新生儿的性别、出生身高、体重.用2002～2005年的空气污染数据估计暴露水平.结果 孕早期可吸入颗粒物(PM10)暴露低出生体重组高于正常组,孕中期、孕期可吸入颗粒物(PM10)暴露低出生体重组低于正常组,差异有显著性(t值分别为3.837、-11.080、-5.525,P＜0.01);孕中期二氧化硫暴露、孕期二氧化硫暴露两组之间比较低出生体重组低于正常组,差异有显著性(t值分别为-3.350、-2.015,P＜0.01).产妇年龄、产次、孕次低出生体重组高于正常组,妊娠天数低出生体重组低于正常组,两组之间比较有显著性差异(t值分别为55.934、17.367、12.756、-23.047,均P＜0.01);孕妇出生地(OR=0.76,95% CI:0.63～0.92)、孕妇所属地区(OR=2.41,95% CI:2.19～2.65)、孕期高危因素(OR=8.51,95% CI:7.22～10.04)、有无准生证(OR=3.01,95% CI:2.58～3.52)、婴儿性别(OR=1.56,95% CI:1.35～1.81)、孕妇文化程度(OR=0.88,95% CI:0.78～0.99)与低出生体重的发生有关,均有显著性统计学意义(P＜0.05).多元Logistic回归分析显示控制其他混杂因素后,孕晚期二氧化氮(β=0.639,P＜0.01)和可吸入颗粒物(PM10)(β=-0.348,P＜0.01)暴露水平在模型中有统计学意义.结论 空气污染物与出生体重有关,空气污染对妊娠结局的影响值得关注.     

孕期空气污染物暴露与活产单胎新生儿出生体重的关联性分析

目的 应用多元线性模型探讨孕期不同空气污染暴露与出生体重之间的关联性。方法 采用多阶段随机抽样方法，自行设计问卷调查2010-2013年西安市曾经怀孕的育龄妇女及其生育子女，最终共纳入4 631例产妇。污染数据和气象资料由常规监测数据整理获得。根据母亲孕周和分娩日期计算孕妇各孕期污染物个体暴露水平。分别以不同孕期空气污染暴露（单污染物、双污染物、三污染物）和子女出生体重作为自变量和因变量，通过逐步校正混杂因素共建立3个多元线性模型，其中模型一仅分析空气污染暴露变量，模型二在模型一的基础上进一步校正母亲及新生儿个体差异因素，模型三在模型二的基础上进一步校正气象因素。结果 不同性别、孕周、母亲生育年龄、母亲文化程度、户籍、家庭经济情况分组的婴儿，其出生体重差异有统计学意义（P<0.01）。考虑污染物的协同作用后，模型一的差异无统计学意义（P>0.05），孕中期接触NO₂的平均浓度每增加10 μg/m³，出生体重会减少13.3 g（模型二减少10.9 g），接触PM₁₀每增加10 μg/m³，出生体重减少6.6 g（模型二减少5.9 g）；孕晚期接触NO₂每增加10 μg/m³，出生体重减少13.7 g（模型二减少9.8 g）。结论 控制气象因素后，孕中期NO₂、PM₁₀的暴露水平以及孕晚期NO₂的暴露对婴儿出生体重具有负效应。     

太原市孕期空气污染暴露对早产的影响

目的探讨太原市空气污染物暴露对早产的影响。方法选择太原市城区2005年11月1日至2007年8月1日出生的围生儿为研究对象。出生数据来源于太原市出生监测系统,数据清洗后符合研究质量要求的为31145例,早产组1092例,对照组30053例。研究协变量共计15项,包括母亲年龄、民族、文化程度、家庭住址、家庭收入、职业、职业暴露、吸烟、饮酒、父亲吸烟、采暖方式、叶酸增补、产前检查、怀孕季节、围生儿性别。空气污染数据来源于太原市环境保护监测站,包括SO2、NO2、PM10的逐日平均浓度。应用Logistic回归模型,控制混杂因素,基本模型建立后,分别以其中一种大气污染物为目标变量,建立怀孕初期和怀孕末期3个月单污染物、双污染物、三污染物影响的Logistic回归模型。结果怀孕初期3个月,控制了混杂因素和其他污染物的影响后,NO2最高污染物水平(≥25.43μg/m3)与最低污染物水平(<22.12μg/m3)相比,早产的危险度(OR值)升高22.7%。关于PM10的影响,未发现有统计学意义(P>0.10)。本研究未发现怀孕初期SO2空气污染对早产的有害影响。临产前3个月,单污染物模型中,NO2每升高一个四分位数,早产的危险度(OR值)升高19.1%。与怀孕初期相比,SO2空气污染对早产的影响明显增加,三污染物模型中OR值由0.615～0.771上升到0.823～1.045,PM10的影响减小,三污染物模型中OR值由1.136～1.231降为0.885～1.014。但SO2和PM10对早产的影响无统计学意义(P>0.10)。结论本研究进一步证实了孕期NO2暴露对早产的影响,未来研究需要进一步探讨适宜的研究设计和孕期暴露敏感时段。     

北京市大气污染对不良妊娠结局影响的病例对照研究

目的 定量分析和评价北京市大气污染对新生儿早产、低出生体重及出生缺陷等不良妊娠结局的影响.方法 收集北京市海淀区妇幼保健院2007年7月-2009年7月分娩个案资料、同期北京市大气污染物二氧化硫(SO2)、二氧化氮(NO2)、可吸入颗粒物(PM10)及气象因素资料.采用多因素Logistic回归模型调整气象因素和妊娠期妇女个体信息的基础上,研究北京市大气污染物对不良妊娠结局的影响.结果 控制气象因素、孕妇分娩次数、年龄、胎儿性别、不良接触史等因素后,妊娠后第1个月SO2浓度每升高100μg/m3,对低出生体重的影响的OR值为1.50(95％CI:1.09～2.05);妊娠后前3个月、分娩前第1个月SO2浓度每升高100 μg/m3,对早产影响的OR值分别为1.50 (95％CI:1.04～2.18)和1.79(95％CI:1.30～2.46);分娩前第2个月PM10浓度每升高100 μg/m3,对早产的影响的OR值为1.45(95％CI:1.15～1.84);妊娠后3～8周内,NO2浓度每升高100 μg/m3,对出生缺陷的影响的OR值为2.85(95％CI:1.08～7.50).结论 本次调查的北京市妊娠期妇女在妊娠后期的大气PM10暴露浓度、妊娠早期的大气SO2暴露浓度与早产的发生存在统计学关联;妊娠3～8周时NO2暴露浓度与出生缺陷的发生存在统计学关联.     

低浓度空气污染与妊娠结局

立陶宛学者最近研究了空气污染与低出生体重和早产的关系。调查了１９９８年Kaunas市出生的３９９８名新生儿生出情况和他们的母亲孕期暴露于空气污染的情况。研究发现在控制混杂因素后，低出生体重调整的OR值随空气甲醛浓度的上升而上升；孕妇暴露于NO２的浓度每增加１０mg／m３其早产的危险就增加２５％（调整的OR＝１．２５，９５％CI：１．０７～１．４６）。妊娠前３个月孕妇暴露于空气污染物的情况对妊娠结局最有影响，而其他妊娠阶段暴露于空气污染物（如NO２和甲醛）与妊娠结局的低出生体重和早产关系不显著。说明新生儿低出生…     

901例新生儿出生体重和身长的影响因素研究

目的 探讨新生儿出生体重和身长的影响因素,为孕期保健提供科学依据.方法 收集昆明社区上报全国儿童营养与健康监测数据直报系统的数据,选取901例分娩母亲的年龄、文化程度、职业、产前保健次数、孕期体重以及901例新生儿出生体重和身长等指标,通过描述性分析、单因素分析和多元线性回归分析进行统计处理.结果 新生儿平均出生体重为3 241.80±394.30g,平均身长为50.09±1.18cm.单因素分析,不同体重新生儿的母亲职业、父亲职业、分娩孕周、母亲孕期增重比较,差异均有统计学意义(,值分别为104.482、322.546、36.771;F=47.98,均P＜0.05).不同身长新生儿的母亲文化程度、父亲文化程度、母亲职业、父亲职业、分娩孕周、母亲孕期增重比较,差异均有统计学意义(F=3.021,2.895;x2值分别为140.597、526.251、19.076;F=14.69,均P＜0.05).多因素分析,父亲文化程度、分娩孕周、孕期增重均影响新生儿出生体重(偏回归系数分别为0.038、0.037、0.063,均P＜0.05),产检次数、分娩孕周、孕期增重均影响新生儿出生身长(偏回归系数分别为0.044、0.061、0.114,均P＜0.05).结论 昆明市6个社区卫生服务中心的新生儿体重受父亲文化程度、产检次数、分娩孕周、孕期增重的影响;新生儿身长受产检次数、分娩孕周、孕期增重的影响.     

早产和低出生体重高危因素的回顾性资料分析

目的　探讨早产和低出生体重与孕期和孕前高危因素的关系。方法查阅铜陵市某医院 1999年 8月 - 2 0 0 0年 8月住院分娩的产妇病例 ,共 2 0 87份 ,记录孕期高危因素和既往异常妊娠史。在单因素分析的基础上 ,运用多因素L ogistic回归分析 ,分析早产、低出生体重分别与孕期高危因素的关系。结果早产和低出生体重发生率分别为 4 .5 %和 5 .1% ,4 5 .8%的低出生体重儿为早产。多因素 L ogistic回归分析表明 ,早产的主要高危因素 :非第一产次、妊娠并发症 (胎膜早破、胎盘早剥、前置胎盘和妊高征 ) ;导致低出生体重的主要高危因素 :双胎、母亲怀孕年龄 30岁以上、胎膜早破。结论预防早产和低出生体重应从孕前、孕期和产前     

围孕期空气污染暴露与子代先天性甲状腺功能减退的关系:基于中国30个省份的研究

目的探讨围孕期母体空气污染暴露水平对子代先天性甲状腺功能减退症(CH)发病风险的影响。方法回顾性收集中国2014年10月1日至2015年9月31日30个省份CH的发病率。遵循空气污染对妊娠期效应的滞后性和累积性原则,回顾性收集中国30个省份2014年1月1日至2015年9月31日PM2.5、PM10、NO2、SO2、CO和O3的平均暴露水平。构建二项Logistic回归模型,并纳入各省份人均国民生产总值、废水中铅、汞和砷的暴露量作为混杂因素,分析围孕期空气污染暴露对子代CH发病风险的影响。结果我国2015年CH的年发病率约为4.31/万人,其中浙江省(7.42/万人)和福建省(7.34/万人)的发病率最高,发病率最低的省份为新疆(1.88/万人)。围孕期母体PM2.5高暴露会显著增加CH的发病风险,围孕期PM2.5的暴露水平每上升1μg/m3,该地区CH高发的风险将会增加0.102倍(OR=1.102, 95%CI:1.001~1.213,P <0.05)。此外,围孕期NO2平均暴露水平的升高也会显著增加CH的发病风险(OR=1.211, 95%CI:1.033~1.419, P <0.05)。在双污染物模型中,围孕期母体PM2.5和NO2的高暴露仍会显著增加CH的发病风险,当对PM10的暴露水平进行调整后,PM2.5和NO2暴露对CH发病率的影响均最为显著(OR=1.585、1.580,均P <0.05)。但PM10、SO2、CO和O3对CH的发病风险没有显著的影响(OR=1.007、0.987、0.925、0.061,均P>0.05)。结论本研究通过大数据分析发现,围孕期母体PM2.5和NO2高暴露会显著增加子代CH的发病风险。围孕期空气污染暴露可能影响子代腺体功能的发育。     

空气污染对早产和低出生体重影响的流行病学研究现况

空气污染对不良妊娠结局的影响研究日益被国内外的专家所关注,空气污染物与早产和低出生体重的研究有待进一步开展。该文就近年来有关空气污染物(可吸入颗粒物、细颗粒物、CO、NO2、SO2等)对早产和低出生体重影响的流行病学研究进行了综述,为控制空气污染和减少不良妊娠结局的发生以及进一步探索其可能的机制提供有益的参考。     

Association between maternal exposure to elevated ambient sulfur dioxide during pregnancy and term low birth weight

This retrospective cohort study investigated whether the risk of delivering full term (37-44 completed weeks of gestation) low birth weight (LBW) infants is associated with differences in exposure to air pollutants in different trimesters. Full-term infants (37 completed weeks of gestation) with a birth weight below 2500 g were classified as term LBW infants. The study infants comprised 92,288 full-term live singletons identified from the Taiwan birth registry and born in the city of Taipei or Kaoshiung in Taiwan between 1995 and 1997. Maternal exposures to various air pollutants including CO, SO2, O3, NO2, and PM10 in each trimester of pregnancy was estimated as the arithmetic means of all daily measurements taken by the air quality monitoring station nearest to the district of residence of the mother at birth. The multivariable logistic regression model with adjustment for potential confounders was used to assess the independent effect of specific air pollutants on the risk of term LBW. This study suggested a 26% increase in term LBW risk given maternal ambient exposure to SO2 concentration exceeding 11.4 ppb during pregnancy compared to low exposure (<7.1 ppb) (OR=1.26, 95% CI=1.04-1.53). Since the relative risk of term LBW was reassessed according to exposure level in each trimester, mothers exposed to >12.4 ppb of SO2 in the last trimester showed 20% higher risk (OR=1.20, 95% CI=1.01-1.41) of term LBW delivery than mothers with lower exposure (<6.8 ppb). No significant elevation ORs was observed for other air pollutants.     

Ambient air pollution and low birth weight in Connecticut and Massachusetts

BACKGROUND: Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States. OBJECTIVES: We investigated maternal exposure to particulate matter with aerodynamic diameter < 10, < 2.5 microm (PM(10), PM(2.5)), sulfur dioxide, nitrogen dioxide, and carbon monoxide and birth weight for 358,504 births in Massachusetts and Connecticut from 1999 to 2002. METHODS: Analysis included logistic models for low birth weight (< 2,500 g) and linear models with birth weight as a continuous variable. Exposure was assigned as the average county-level concentration over gestation and each trimester based on mother's residence. We adjusted for gestational length, prenatal care, type of delivery, child's sex, birth order, weather, year, and mother's race, education, marital status, age, and tobacco use. RESULTS: An interquartile increase in gestational exposure to NO(2), CO, PM(10), and PM(2.5) lowered birth weight by 8.9 g [95% confidence interval (CI), 7.0-10.8], 16.2 g (95% CI, 12.6-19.7), 8.2 g (95% CI, 5.3-11.1), and 14.7 g (95% CI, 12.3-17.1), respectively. Lower birth weight was associated with exposure in the third trimester for PM(10), the first and third trimesters for CO, the first trimester for NO(2) and SO(2), and the second and third trimesters for PM(2.5). Effect estimates for PM(2.5) were higher for infants of black mothers than those of white mothers. CONCLUSIONS: Results indicate that exposure to air pollution, even at low levels, may increase risk of low birth weight, particularly for some segments of the population.     

Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study

Exposures to ambient air pollutants have been associated with adverse birth outcomes. We investigated the effects of air pollutants on birth weight mediated by reduced fetal growth among term infants who were born in California during 1975-1987 and who participated in the Children's Health Study. Birth certificates provided maternal reproductive history and residence location at birth. Sociodemographic factors and maternal smoking during pregnancy were collected by questionnaire. Monthly average air pollutant levels were interpolated from monitors to the ZIP code of maternal residence at childbirth. Results from linear mixed-effects regression models showed that a 12-ppb increase in 24-hr ozone averaged over the entire pregnancy was associated with 47.2 g lower birth weight [95% confidence interval (CI), 27.4-67.0 g], and this association was most robust for exposures during the second and third trimesters. A 1.4-ppm difference in first-trimester carbon monoxide exposure was associated with 21.7 g lower birth weight (95% CI, 1.1-42.3 g) and 20% increased risk of intrauterine growth retardation (95% CI, 1.0-1.4). First-trimester CO and third-trimester O3 exposures were associated with 20% increased risk of intrauterine growth retardation. A 20-microg/m3 difference in levels of particulate matter < or = 10 microm in aerodynamic diameter (PM10) during the third trimester was associated with a 21.7-g lower birth weight (95% CI, 1.1-42.2 g), but this association was reduced and not significant after adjusting for O3. In summary, O3 exposure during the second and third trimesters and CO exposure during the first trimester were associated with reduced birth weight.     

Association between ambient air pollution and birth weight in São Paulo, Brazil

Objectives: Previous studies have implicated air pollution in increased mortality and morbidity, especially in the elderly population and children. More recently, associations with mortality in infants and with some reproductive outcomes have also been reported. The aim of this study is to explore the association between exposure to outdoor air pollution during pregnancy and birth weight. Design: Cross sectional study using data on all singleton full term live births during a one year period. For each individual birth, information on gestational age, type of delivery, birth weight, sex, maternal education, maternal age, place of residence, and parity was available. Daily mean levels of PM₁₀, sulphur dioxide, nitrogen dioxide, carbon monoxide, and ozone were also gathered. The association between birth weight and air pollution was assessed in regression models with exposure averaged over each trimester of pregnancy. Setting: São Paulo city, Brazil. Results: Birth weight was shown to be associated with length of gestation, maternal age and instruction, infant gender, number of antenatal care visits, parity, and type of delivery. On adjusting for these variables negative effects of exposure to PM₁₀ and carbon monoxide during the first trimester were observed. This effect seemed to be more robust for carbon monoxide. For a 1 ppm increase in mean exposure to carbon monoxide during the first trimester a reduction of 23 g in birth weight was estimated. Conclusions: The results are consistent in revealing that exposure to air pollution during pregnancy may interfere with weight gain in the fetus. Given the poorer outlook for low birthweight babies on a number of health outcomes, this finding is important from the public health perspective.     

Relationship between low birthweight and air pollution in the city of Sao Paulo, Brazil

OBJECTIVE: Air pollution has been investigated as a potential determinant for low birthweight. The aim of the present study was to study the effect of air pollution on birthweight. METHODS: We analyzed all deliveries by mothers living in the municipality of Sao Paulo, Southeastern Brazil, between 1998 and 2000. We estimated the prevalence of low birthweight according to newborn, mother, and delivery characteristics. Only births occurring in the most central districts of the city were analyzed, totaling 311.735 events. For the evaluation of the effects of air pollution, we excluded preterm and multiple deliveries. Pollutants analyzed were ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2), suspended particles (PM10), and carbon monoxide (CO). The effect of maternal exposure to air pollution on birthweight was evaluated using linear and logistic regression. RESULTS: A total of 4.6% of newborns weighed less than 2,500 g at birth. Maternal exposure to CO, PM10, and NO2 during the first trimester of pregnancy was significantly associated with decreased birthweight. CONCLUSIONS: Our results reinforce the notion that maternal exposure to air pollution during the first trimester of pregnancy may contribute to lesser weight gain in the fetus.     

Association between air pollution and low birth weight: a community-based study.

The relationship between maternal exposure to air pollution during periods of pregnancy (entire and specific periods) and birth weight was investigated in a well-defined cohort. Between 1988 and 1991, all pregnant women living in four residential areas of Beijing were registered and followed from early pregnancy until delivery. Information on individual mothers and infants was collected. Daily air pollution data were obtained independently. The sample for analysis included 74,671 first-parity live births were gestational age 37-44 weeks. Multiple linear regression and logistic regression were used to estimate the effects of air pollution on birth weight and low birth weight (< 2,500 g), adjusting for gestational age, residence, year of birth, maternal age, and infant gender. There was a significant exposure-response relationship between maternal exposures to sulfur dioxide (SO2) and total suspended particles (TSP) during the third trimester of pregnancy and infant birth weight. The adjusted odds ratio for low birth weight was 1.11 (95% CI, 1.06-1.16) for each 100 micrograms/m3 increase in SO2 and 1.10 (95% CI, 1.05-1.14) for each 100 micrograms/m3 increase in TSP. The estimated reduction in birth weight was 7.3 g and 6.9 g for each 100 micrograms/m3 increase in SO2 and in TSP, respectively. The birth weight distribution of the high-exposure group was more skewed toward the left tail (i.e., with higher proportion of births < 2,500 g) than that of the low-exposure group. Although the effects of other unmeasured risk factors cannot be excluded with certainty, our data suggests that TSP and SO2, or a more complex pollution mixture associated with these pollutants, contribute to an excess risk of low birth weight in the Beijing population.     

某低污染区大气污染物对脑血管疾病死亡的影响

目的探讨低污染地区主要大气污染物对居民脑血管病死亡的影响。方法收集2002—2007年某地区脑血管病日死亡人数和主要大气污染物日平均浓度,经时间序列法平稳化序列后,再运用多元线性回归法进行相关性和确定性分析。结果①该地区大气中二氧化硫(SO2)、二氧化氮(NO2)、一氧化碳(CO)以及空气动力学直径10μm以下的可吸入颗粒物(PM10)日平均浓度与居民脑血管疾病死亡人数之间存在显著相关(P0.05),其中大气中SO2、NO2、CO浓度每升高10μg/m3,脑血管疾病死亡的相对危险度(OR)分别增加5.65%(95%CI,4.93%～6.37%)、1.03%(95%CI,0.24%～1.82%)和0.12%(95%CI,0.09%～0.14%),而PM10则呈显著负相关(P=0.00)。②居民日脑血管疾病死亡人数与大气污染物浓度存在线性回归(P0.05),回归方程为:^y=16.917+72.092(SO2)+26.190(NO2)-15.932(PM10)+2.062(CO)。③从标化后的偏回归系数可以得出,自变量SO2浓度对应变量脑血管疾病日死亡的影响最大。结论该地区居民脑血管病死亡与大气中SO2、NO2和呈正相关,存在线性回归,其中尤以SO2的影响最大,PM10则呈负相关;控制该地区SO2的污染水平是降低居民脑血管疾病死亡率的关键。     

深圳市空气污染与居民心血管疾病发病相关性的研究

目的探讨空气污染物〔可吸入颗粒物（PM10）、二氧化硫（SO2）、二氧化氮（NO2）、臭氧（O3）〕对心血管疾病门诊病人量和住院病人量的影响。方法收集深圳市中心区两大型综合医院的门诊量和住院病人量资料及同时期空气污染物浓度、气象监测资料,运用时间序列法进行回归分析,研究深圳中心城区2006年1月1日至12月31日空气污染物与居民心血管疾病发病的关系。结果空气污染物PM10、SO2、O3与医院住院病人量有一定相关性,随着污染物浓度的增加,医院的心血管内科住院病人量增加,并且有统计学意义。其中在空气污染严重的11、12月份心血管疾病的住院病人量最高。结论空气中PM10、SO2和O3是心血管疾病发病的环境病因,其中以O3影响最大。     

苏州市恶性肿瘤日死亡率与大气主要污染物的关系

[目的]探讨大气主要污染物对居民恶性肿瘤日死亡率的影响。[方法]收集2002～2007年苏州地区恶性肿瘤日死亡人数和大气中可吸入颗粒物（PM10）、二氧化硫（SO2）、二氧化氮（NO2）以及一氧化碳（CO）等污染物日平均浓度,经时间序列法平稳化后,再运用多元线性回归法进行相关性和确定性分析。[结果]（1）该地区居民恶性肿瘤日死亡率与7天前（1ag7）的大气中SO2、NO2及当日（1ag0）PM10平均浓度存在相关（P〈0．05）,其中S02和PM10每升高10μg/m^3,恶性肿瘤死亡的相对危险度（RR）和95％可信区间（Cl）分别为1．004（1．003～1．006,P〈0．01）和1．001（1．000～1．002,P〈0．05）,日死亡率分别上升0．44％（0．29％～0．60％）和0．10％（0．01％-0．19％）;而N02则呈负相关（P〈0．01）。（2）居民恶性肿瘤日死亡率与大气污染物日平均浓度存在线性回归（P〈0．05）,回归方程为：y=4．985＋3．963[SO2]-2．878[N02]＋0．577[PM10];模型预测的结果比较准确。（3）自变量SO2浓度标化后的偏回归系数为0．392,对应变量恶性肿瘤日死亡率的影响最大。[结论]该地区居民恶性肿瘤日死亡率与大气中SO2和PM10日平均水平呈正相关,与NO2则呈负相关;控制该地区SO2的污染水平可能有利于降低居民恶性肿瘤死亡率。