肺癌胸部皮肤转移1例

1 病例介绍 患者,男,76岁,因胸痛1个月入院.曾在当地医院诊断为"带状疱疹",经抗病毒、镇痛等治疗,胸痛无缓解.查体:右锁骨上可触及-2.5×2.0 cm肿大淋巴结,质地中等,表面光滑,活动性差.左胸部可见数个散在直径约0.3～0.5cm暗红色的结节,结节部压痛明显.实验室检查血、尿常规,肝功能均正常.肺螺旋CT检查示左肺上叶可见-2.5cm的小结节影,周围有毛刺、分叶征象,有胸膜凹陷征.取右锁骨上肿大淋巴结及左胸部丘疹病理活检,诊断为肺腺癌,右锁骨上淋巴结,胸壁皮肤毛囊转移(见图1～3).予NP方案化疗1个周期自动出院.     

KAI1基因的表达与结肠癌转移的关系

目的探讨KAI1基因的表达与结肠癌转移的关系.方法用Northern blot及原位杂交分析法对10例正常人及24例结、直肠癌患者组织中的KAI1 mRNA表达分别进行检测.结果 North-ern blot分析显示,在正常及结肠癌组织中均有不同程度的KAI1 mRNA表达,原发性结肠癌伴淋巴结转移的KAI1 mRNA表达水平明显低于无淋巴结转移者(P＜0.01);原位杂交的KAI1 mRNA表达与Northern blot分析结果相一致,并发现KAI1 mRNA主要出现在原发性结肠癌细胞中,而肿瘤周围间质KAI1 mRNA相对呈低表达.结论 KAI1 mRNA表达在结肠癌的抗转移中具有一定的作用.     

结肠癌转移的生物学研究

结肠癌转移的生物学研究陶厚权１王瑞年２林言箴２上海第二医科大学１瑞金医院外科２病理教研室上海市２０００２５ＳｕｂｊｅｃｔｈｅａｄｉｎｇｓＣｏｌｏｎｉｃｎｅｏｐｌａｓｍｓ／ｐａｔｈｏｌｏｇｙＮｅｏｐｌａｓｍｓｍｅｔａｓｔａｓｉｓＲｅｖｉｅｗｌｉｔ...     

肺癌皮肤转移二例

例 1,男性 ,84岁 ,因咳嗽、咳痰半年 ,伴左胸痛半个月入院。入院后胸片及胸部CT检查考虑为左上肺癌 ,纤支镜病理活检结果为鳞癌。给卡铂 +VP 16化疗 ,4周后发现腰背部有一个 2cm× 2cm大小隆起肿块 ,表面呈溃疡状 ,质硬 ,较固定。另双上肢及胸部可触及多个 0 .5cm× 1.5cm的皮肤结节 ,活动差 ,表面未见破溃。皮肤结节活检报告为转移性鳞癌。骨骼ECT提示左胸第 8肋及左股骨转移。 4个月后死于全身衰竭。例 2 ,男性 ,75岁 ,因全身酸痛 6个月 ,发现右胸肿块 10天入院。曾以右胸肿块待查收住外科。入院查体 :贫血貌 ,右上肺呼吸音低 ,右胸锁…     

胃癌皮肤转移2例

例 1:男 ,82岁。因反复黑便 4月余 ,进食梗噎 1月余而入院。查体 :消瘦貌 ,胸腹壁可见 10多枚结节状隆起 ,大小一致 ,直径约 12× 12mm ,外观呈紫蓝色 ,扪之有软骨感 ,活动差 ,无压痛。浅表淋巴结未触及。心肺无异常。腹壁软 ,无压痛 ,肝脾肋下未及 ,未扪及腹块。血常规示WBC 2 8× 10 9/L ,Hb 41g/L ,CEA 5 .0 μg/L ,白蛋白 2 6 2g/L ,球蛋白 2 7 8g/L。B超 :后腹膜实质不均质包块 ,腹腔淋巴结肿大 ,左肾积水 ,腹水少量 ,胆囊炎。胃镜 :贲门及胃体小弯前后壁均为新生物占据 ,表面不整 ,糜烂 ,溃疡形成 ,贲门狭窄。皮下结节活检示转…     

结肠癌淋巴管生成与转移的研究进展

远处转移是恶性肿瘤的重要生物学特征，也是肿瘤难以彻底根治的主要因素。淋巴道与血道转移是肿瘤最重要的两条转移途径，研究表明：大多数上皮起源的肿瘤以淋巴道转移为主，且发生较早。结肠癌是胃肠道中常见的恶性肿瘤之一，预后较差。在决定结肠癌预后的众多因素中，淋巴转移是其中重要的一个因素。在具备手术条件的患者中，淋巴结转移率达50％，淋巴结转移与预后的相关性高于原发灶的浸润程度，已成为决定结肠癌预后的重要的独立预后指标。因此对肿瘤淋巴管生成和淋巴转移机制的研究，已成为提高治疗结肠癌疗效的关键所在，是目前继肿瘤血管生成机制研究的又一热点。现就结肠癌淋巴管形成与转移的研究进展综述如下。     

胰腺癌皮肤转移一例

患者,男,68岁,因全身多发肿块伴阵发性腹痛1个月就诊。该患者于1月前出现全身多发肿块,大小不等,以上腹部居多,同时伴脐周阵发性绞痛,每次约持续5～10 min,无发热、恶心、呕吐,无腹泻、黑便。患者自发病以来,肿块生长较快,且逐渐增多。     

西妥昔单抗治疗RAS野生型结肠癌骨髓转移二例

结肠癌是我国常见的恶性肿瘤之一,晚期疾病以血行转移为主,常见转移部位为肝脏和肺,其次为淋巴结转移和种植转移,发生骨髓转移者临床上极为少见,对其治疗的相关报道亦较少。本文介绍本科经治的2例RAS野生型结肠癌伴骨髓转移患者,应用西妥昔单抗治疗后有一定疗效,现将临床资料及治疗经过分享给大家。     

以皮肤转移为首发表现的胃癌1例

患者男,59岁。以“多发皮下肿物4个月”于2013年9月收入我院。患者4个月前无意中发现脐上皮下一直径约1 cm肿物,无痛痒感。之后在颈、肩、胸等处发现多个大小不等皮下肿物,无发热、恶心、呕吐、腹痛、腹胀等症状。饮食休息可,大便干结,无黑便,小便正常。患者有2型糖尿病病史10年,间断口服二甲双胍控制血糖在10 mmol／L左右。饮酒30年,250 g／d,家族中无肿瘤罹患者。入院查体：生命体征平稳,颈、肩、胸、腹壁、左肘部可见多个皮下肿物,大者直径约4 cm。局部皮肤充血,无破溃,表面光滑,质韧,活动度可,边界清,无触痛。腹软,未触及明显包块,无压痛及反跳痛,肝脾肋下未及,移动性浊音阴性,肠鸣音正常。肛诊未见明显异常。入院检查：血常规及肝肾功能均正常。肿瘤标记物：CEA 559．80 ng／mL, CA19-99．06 U／mL, CA72-460．97 U／mL,AFP 1．00 ng／mL,CYFRA 4．36 ng／mL,NSE 13．08 ng／mL。考虑为消化道肿瘤转移,遂行腹盆腔强化CT检查,结果示贲门胃底区胃壁不规则增厚,局部呈肿块样向腔内突起,边缘模糊,腹膜后血管间隙模糊,腹壁多处皮下见密度增高结节影,皮肤局限性增厚,盆腔内脂肪间隙模糊。诊断：贲门癌腹膜后、盆腔淋巴结转移。行胃镜检查,贲门后壁见直径约1 cm溃疡,表面覆污苔,周围黏膜僵硬;胃角变形,可见直径约1 cm溃疡,质硬,触之易出血;胃窦近幽门处可见一直径0．5 cm溃疡,表面不平,质软。对胃角、贲门、胃窦黏膜及部分腹壁病变活检,病理结果示：低分化腺癌伴印戒细胞癌（胃角、贲门、胃窦）;皮下肿物转移性低分化腺癌伴印戒细胞癌。遂行FOLFOX辅助化疗。2个周期后患者拒绝进一步治疗,要求出院,3个月后患者死亡。     

原发性肝癌胸壁皮肤转移1例报告

正肝癌常见的转移途径有血行转移、淋巴转移、种植转移和直接浸润,而以肝内血行转移最早、最为常见。肝癌细胞侵犯肝静脉后即可进入体循环,发生肝外远处转移,以肺转移发生率最高,其次为肾上腺、骨、卵巢等,皮肤转移者较为少见,仅占所有皮肤转移癌的0.2%~2.7%[1]。本文报道1例原发性肝癌胸壁皮肤转移患者。1病例资料患者男性,46岁,因"发现肝占位3月余,腹胀、乏力1个     

Intrabiliary metastasis in colorectal cancer

Endobiliary metastasis of colorectal cancers are rare. We report a 36 years-old patient, operated on 5 years ago for a left colon cancer with a left colectomy. He consulted for pain in the upper right quadrant without fever nor jaundice. Ultra-sound, CTscan, RMI and PET led to the diagnosis of endobiliary metastasis and the patient underwent a right hepatectomy. A review of the literature of the endobiliary metastasis follows this case-report. These tumours can mimic intrahepatic cholangiocarcinoma in clinical presentation, imaging or even histological examinations. The main goal of the imaging explorations is to establish the resecability of such tumours. Patients with endobiliary metastasis seem to have better survival than patients with intrahepatic metastasis.     

Ovarian metastasis from colorectal cancer

Controversies exist regarding the surgical treatment of the ovaries in women with primary colorectal cancer. A review of the authors' experience and the surgical literature reveals an incidence of ovarian metastases from colorectal cancer of approximately 6 percent. This problem may occur somewhat more frequently in premenopausal women. Resection of the ovaries at the time of colectomy is unlikely to affect survival. Removal of the ovaries at the time of bowel resection will prevent repeat laparotomy to resect an ovarian mass in approximately 2 percent of women with large bowel cancer. Oophorectomy should be performed in all postmenopausal females at the time of primary resection. Oophorectomy should be performed in premenopausal women if any gross abnormality of the ovary is detected or if peritoneal implants are seen at the time of primary resection.     

Brain metastasis from colorectal cancer

Purpose The mechanism of brain metastasis is not well understood, but the affinity between cancer cells and neural tissues may be involved in the process. The aim of our study is to elucidate the involvement of neural cell adhesion molecule (NCAM) and therapeutic parameters in patients with brain metastasis from colorectal cancer.Methods We retrospectively identified 17 patients with brain metastasis from colorectal cancer. Data were collected with regard to patients characteristics, location, and stage of primary tumor, and extent and location of metastatic disease. NCAM histochemical staining was undertaken using a paraffin block, and compared with 56 Dukes C patients and 13 Dukes D patients.Results Neural cell adhesion molecule expression was significantly higher in the primary tumors of the brain metastasis patients than in the lesions of the Dukes C and Dukes D control groups (p=0.0004). Patients whose tumor was managed by radiosurgery survived longer than patients who had had whole brain radiation or those who had been left untreated.Conclusion The fact that NCAM expression was high in the primary tumors of brain metastasis patients suggests that the affinity of cancer cells to a particular organ is important for circulation-mediated metastasis. Controlling local tumors using radiosurgery is certainly going to play an important role in extending survival and improving the patients quality of life (QOL).     

原发性胆汁性肝硬化并结节病1例

原发性胆汁性肝硬化并结节病在临床相当罕见. 本文报道1例中年女性患者, 因皮肤巩膜黄染1年余, 进行性加重6 mo入院. 入院后给予保肝退黄降酶等治疗, 经查体、血尿便常规以及免疫全套等检查, 确诊为原发性胆汁性肝硬化, 并且经淋巴结活检诊断为淋巴结结节病.     

Cutaneous metastasis in a patient with pancreatic cancer

Pancreatic cancer is known to metastasize rapidly. Liver and peritoneum are the most common sites of metastases in pancreatic cancer, followed by lungs, bones and brain. Less common sites of metastases such as muscle, skin, heart, pleura, stomach, umbilicus, kidney, appendix, spermatic cord and prostate have also been reported in pancreatic cancer. Cutaneous metastasis mostly occurs around umbilicus. A site other than umbilicus is rarely reported. The authors report a case of multiple skin metastases in a patient with primary pancreatic cancer and review the literature.