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1.
Seong Su Hong Chul Lee Chang Hee Lee Mieon Park Moon Soon Lee Jin Tae Hong Heesoon Lee Mi Kyeong Lee Bang Yeon Hwang 《Archives of pharmacal research》2009,32(4):501-504
A new sesamin type furofuran lignan, (−)-sesamin-2,2′-diol (1), along with two known flavonoids (2 and 3) and three phenolic compounds (4–6) were isolated from the aerial parts of Isodon japonicus. The structures of these compounds were determined by analysis of spectroscopic data (1D-, 2D-NMR, HRMS and CD) and by comparison
of the data with those of related metabolites. 相似文献
2.
Saroyobudiono H Juliawaty LD Syah YM Achmad SA Hakim EH Latip J Said IM 《Journal of natural medicines》2008,62(2):195-198
A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D
and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388
cells with the result that compounds 2 and 4 showed the highest cytotoxicity. 相似文献
3.
Vatcharin Rukachaisirikul Nanthaphong Khamthong Yaowapa Sukpondma Souwalak Phongpaichit Nongporn Hutadilok-Towatana Potchanapond Graidist Jariya Sakayaroj Kanyawim Kirtikara 《Archives of pharmacal research》2010,33(3):375-380
Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (−)-drimenin (7) and diketopiperazine derivative (8), were obtained from the fungus Nigrospora sp. PSU-F12. Their structures were established by spectroscopic evidence. We also tested their cytotoxic (on African green
monkey kidney fibroblast and breast cancer cells), antioxidant (in the DPPH assay), and antibacterial (against the standard
Staphylococcus aureus ATCC 25923 and methicillinresistant S. aureus) activities. 相似文献
4.
Lee DG Lee SM Bang MH Park HJ Lee TH Kim YH Kim JY Baek NI 《Archives of pharmacal research》2011,34(12):2029-2035
A new lignan, (7R,7′R,8R,8′R)-8-hydroxypinoresinol 8-O-β-D-glucopyranoside 4′-methyl ether (7), was isolated from the flowers of Osmanthus fragrans var. aurantiacus along with six known lignans: (+)-phillygenin (1), phillyrin (2), (−)-phillygenin (3), (−)-epipinoresinol-β-D-glucoside (4), taxiresinol (5), and (−)-olivil (6). The structure of the new compound was elucidated on the basis of 1D- and 2D-NMR spectroscopic analysis and specific rotation
data. The compounds isolated from the flowers of O. fragrans var. aurantiacus were evaluated for inhibitory activities on nitric oxide production in lipopolysaccharide-stimulated macrophage RAW 264.7
cells. (+)-Phillygenin (1), phillyrin (2), and (−)-phillygenin (3) exerted the strongest inhibitory activities on NO production with IC50 values of 25.5, 18.9, and 25.5 μM, respectively. These compounds may prove beneficial in the development of natural agents
for prevention and treatment of inflammatory diseases. 相似文献
5.
Nguyen Xuan Nhiem Phan Van Kiem Chau Van Minh Ninh Khac Ban Nguyen Xuan Cuong Bui Huu Tai Young Ho Kim 《Archives of pharmacal research》2009,32(10):1373-1377
By various chromatographic methods, one new phenylpropanoid glycoside, heterosmilaside (1), two known phenylpropanoid glycosides, helonioside B (2), and 2′,6′-diacetyl-3,6-diferuloyl sucrose (3), and three known flavonoids, isoquercetin (4), quercetin-3-O-β-D-glucuronopyranoside (5), and quercetin-3-O-(2″-α-L-rhamnopyranosyl)-β-D-glucuronopyranoside (6) were isolated from the methanolic extract of the aerial part of Heterosmilax erythrantha Baill. Their structures were elucidated on the basis of spectroscopic analyses. All the isolated compounds were tested for
antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 5 and 6 showed significant antioxidant activity with SC50 values of 3.7 and 6.5 μg/mL, respectively. 相似文献
6.
Phan Van Kiem Nguyen Xuan Nhiem Nguyen Xuan Cuong Tran Quynh Hoa Hoang Thanh Huong Le Mai Huong Chau Van Minh Young Ho Kim 《Archives of pharmacal research》2008,31(11):1477-1482
By various chromatographic methods, two new phenylpropanoid esters of sucrose named hidropiperosides A (1) and B (2), and three known compounds as vanicosides A (3), B (4), and E (5) were isolated from the methanolic extract of the whole plant of Polygonum hydropiper L. (Polygonaceae). Their structures were elucidated by extensive spectroscopic methods including 1D-and 2D-NMR experiments,
as well as ESI-MS analysis. All the isolated compounds were tested for their antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl
(DPPH) radical scavenging assay system. Among them, compounds 2 and 3 showed significant antioxidant activity with their SC50 values of 23.4 and 26.7 μg/mL, respectively. 相似文献
7.
Fera Kurniadewi Lia D. Juliawaty Yana M. Syah Sjamsul A. Achmad Euis H. Hakim Kiyotaka Koyama Kaoru Kinoshita Kunio Takahashi 《Journal of natural medicines》2010,64(2):121-125
Two chalcone derivatives, 2′-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and
2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1–7 showed that compounds 2–4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme. 相似文献
8.
8,14-labdadien-13-ol (1) and dehydroabietic acid (2) were isolated from the fruit body of Phellinus pini. Elucidation of their structures was based on spectroscopic methods including IR, MS, and NMR (1D and 2D). Two compounds
were screened for their ability to inhibit NO production in LPS-activated RAW 264.7 cells. Compounds 1 and 2 at 30 μM and 50 μM, respectively, inhibited NO production in activated macrophages. 相似文献
9.
A new isoflavone glycoside from the stem bark of <Emphasis Type="Italic">Sophora japonica</Emphasis>
Hyun Young Park Soo Hee Kim Gi Beom Kim Jae Young Sim Soon Sung Lim Myong Jo Kim Wanjoo Chun Yong Soo Kwon 《Archives of pharmacal research》2010,33(8):1165-1168
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4′-O-β-d-glucosyl isoflavone, glycitein-4′-O-β-d-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory
effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC50 values of 3.2, 6.4, and 1.9 μM, respectively. 相似文献
10.
Four new glycosides, luteolin-7-methoxy-3′-O-(3″-O-acetyl)-β-D-gluco pyranuronic acid-6″-methyl ester (1), benzyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (2), 2-methoxy-4-(2-propen-1-yl)penyl-6-acetate-β-D-glucopyranoside (3), and 2-methoxy-4-(2-propen-1-yl)penyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (4), along with benzyl-β-D-glucopyranoside (5), 2-methoxy-4-(2-propen-1-yl)penyl-β-D-glucopyranoside (6), and pectolarigenin (7), were isolated from the whole plant of Dracocephalum tanguticum Maxim. The structures of 1-4 were elucidated by detailed spectroscopic analyses, including HR-ESI-MS and 2D NMR spectroscopic data. The inhibitory effects
against nitric oxide production in LPS-stimulated RAW264.7 cells of all seven compounds were also evaluated. 相似文献
11.
A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-D-glucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root of Anemone tomentosa and their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds 1–12 were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl
(DPPH) were evaluated. 相似文献
12.
A novel gallate of tannin, (−)-epigallocatechin-(2β→O→7′,4β→8′)-epicatechin-3′-O-gallate (8), together with (−)-epicatechin-3-O-gallate (4), (−)-epigallocatechin (5), (−)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4α→8′)-epigallocatechin (7), were isolated from the tea plant Camellia
sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially
available pyrogallol (1), (+)-catechin (2), and (−)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis
elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 ≈ 6, 9, 4, 5, 1. The LC50 (96 h) values of 8 and 9 were evaluated as 49 and 334 μmol L−1, respectively. These data show that many green tea polyphenols may be potential anthelmintics. 相似文献
13.
Shireen Shaharina Shamaun Mawardi Rahmani Najihah Mohd Hashim Hazar Bebe Mohd Ismail Mohd Aspollah Sukari Gwendoline Ee Cheng Lian Rusea Go 《Journal of natural medicines》2010,64(4):478-481
Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis. The new prenylated flavone hydroxyartocarpin (1) was characterized as 3-(γ,γ-dimethylallyl)-6-isopentenyl-5,8,2′,4′-tetrahydroxy-7-methoxyflavone and the known compounds were artocarpin (2), morusin (3), cycloartobiloxanthone (4), cycloartocarpin A (5) and artoindonesianin V (6). The structures of the compounds were determined by spectroscopic methods (IR, MS, 1H-NMR and 13C-NMR) and comparison with published data for the known compounds. 相似文献
14.
Ahmed Atef El-Beih Hikaru Kato Sachiko Tsukamoto Tomihisa Ohta 《Journal of natural medicines》2007,61(2):175-177
More than 50% of clinically used drugs are thought to be metabolized by cytochrome P450 (CYP) 3A4. Discovery of new, inexpensive,
CYP3A4 inhibitors will reduce drug dosages needed to cure patients. In our search for new inhibitors of the enzyme CYP3A4,
extracts from 102 marine fungi were screened. Seven of the extracts had potent CYP3A4 inhibitory activity. Four aromatic compounds
were isolated from an extract of a culture of one of these, a Penicillium sp., and were identified as 3-methoxyphenol (1), 4-methoxyphenylacetic acid (2), 4-(2-hydroxyethyl)phenol (3), and 4-hydroxy-2-methoxyacetanilide (4) by use of spectroscopic data. Interestingly, compound 3 at 250 μg mL−1did not inhibit CYP3A4 whereas compounds 1, 2 and 4 had CYP inhibitory activity with IC50 values of 2.0, 1.6 and 0.41 μg mL−1, respectively. 相似文献
15.
Muhammad A Anis I Khan A Marasini BP Choudhary MI Shah MR 《Archives of pharmacal research》2012,35(3):431-436
A new C-alkylated flavonoid (5,7-dihydroxy-3′-(4″-acetoxy-3″-methylbutyl)-3,6,4′-trimethoxyflavone (1), along with two known C-alkylated flavonoids (5,7-dihydroxy-3′-(3-hydroxymethylbutyl)-3,6,4′-trimethoxyflavone (2), 5,7,4′-trihydroxy-3′-(3-hyroxymethylbutyl)-3,6-dimethoxyflavone (3) and two new source C-alkylated flavonoids (5,7-dihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)-3,6,4′-trimethoxyflavone (4), 5,7,4′-trihydroxy-3,6-dimethoxy-3′-isoprenyl-flavone (5) were isolated from the aerial parts of Dodonaea viscosa. The structures of all compounds were established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The isolated
compounds were evaluated for their inhibitory effect on urease and α-chymotrypsin enzyme. All the compounds (1–5) exhibited mild inhibition against urease but remained recessive in case of α-chymotrypsin. 相似文献
16.
Hitoshi Yoshimitsu Makiko Nishida Fumio Hashimoto Mika Tanaka Yusuke Sakata Masafumi Okawa Toshihiro Nohara 《Journal of natural medicines》2007,61(3):334-338
One new chromone and six known flavonol glycosides were isolated from the stems and leaves of Delphinium hybridum cv. “Belladonna Casablanca” (Ranunculaceae). The new chromone glycoside was elucidated as 2-methyl-chromone-5,7-diol 7-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1). The six known flavonol glycosides were designated as compounds 2–5, being kaempferol-type glycosides, and compounds 6 and 7, being quercetin-type glycosides. The structures of these glycosides were determined by two-dimensional nuclear magnetic
resonance (2D NMR) spectroscopic analysis and chemical evidence. 相似文献
17.
Samir Kumar Sadhu Amina Khatun Panadda Phattanawasin Takashi Ohtsuki Masami Ishibashi 《Journal of natural medicines》2007,61(4):480-482
Five lignan glycosides, lyoniside, nudiposide, 5-methoxy-9-β-xylopyranosyl-(−)-isolariciresinol, icariside E3, and schizandriside, and three flavonoids, (−)-epicatechin, epiafzelechin-(4β→8)-epicatechin and procyanidin B2, together with β-sitosterol glucoside, were isolated from a methyl alcohol (MeOH) extract of Saraca asoca dried bark. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) and mass spectroscopic analysis.
Antioxidant activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay. 相似文献
18.
A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1–5 showed anti-inflammatory activities, with IC50 values in the range 6.3–9.1 μM. 相似文献
19.
Santi Thohinung Somdej Kanokmedhakul Kwanjai Kanokmedhakul Veerapol Kukongviriyapan Ornanong Tusskorn Kasem Soytong 《Archives of pharmacal research》2010,33(8):1135-1141
Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin IIIed (3); six known chaetoglobosins B-D (4–6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α,8α-epidioxyergosta-6–22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1–9 showed cytotoxicity against the human breast cancer (IC50 2.54–21.29 μM) and cholangiocarcinoma cell lines (IC50 3.41–86.95 μM). 相似文献
20.
Ik Hwi Kim Michiyo Umezawa Nobuo Kawahara Yukihiro Goda 《Journal of natural medicines》2007,61(2):224-225
Six compounds, schizandriside, resveratrol, (+)-catechin, (−)-epicatechin, (+)-gallocatechin, and (−)-epicatechin gallate,
were isolated from the roots of Ampelopsis japonica (Vitaceae). Their structures were determined on the basis of both chemical and spectroscopic data. 相似文献