Features of clinic, diagnostics and treatment of typhoid fever in young patients

Typhoid fever is a dangerous infection. The article analyzes the clinical aspects, diagnostic possibilities and casual treatment of the young men in organized group with typhoid. It's shown that despite early hospitalization (at average of 5.5 days) the main manifestations peculiar to the "classical" infection retained. The majority (61.5%) had disease of moderate severity, mild form were at 37,4% of patients. Complications occurred in 5.0% of the patients: pneumonia (2.8%), myocarditis (2.2%) and pancreatits (2.2%). Pathogen isolated from patients with typhoid fever had reduced susceptibility to fluoroquinolones. Antimicrobial therapy showed the advantage of the 3 generation cephalosporin (ceftriaxone) compared with ciprofloxacin or a combination of the latter with cefotaxime.     

飞行员感染伤寒一例

一、临床资料患者男性,28岁,歼-8飞行员,飞行时间760h。因“发热1周”于2006年5月30日来我院。患者2006年5月20日到西北出差,5月23日出现发热,体温最高达39.5℃,服用“扑热息痛片”后可暂降至正常,在当地医院查血常规示白细胞7.8×109/L,胸片未见异常,予以“青霉素、双黄连”静脉点滴1周后无明显效果。发病过程中无咳嗽咳痰、咽痛和盗汗等症状,发热第1天大便2次,为成形便,无腹痛。否认不洁饮食史,单位同事及家属无发热、腹泻等类似表现。否认蚊虫叮咬史。查体:体温38.5℃,脉搏70次/min,精神状态尚可,无高热萎靡。皮肤粘膜无黄染、皮疹及出…     

Roentgenographic findings in typhoid fever.

Barium meal examinations have been performed on 20 patients with proved or clinically suspected typhoid fever. There were distinct abnormalities in the terminal ileum early in the febrile stage of the disease. The abnormality was different in a single case of relapse of typhoid. The study is easily and safely performed and we feel that it is a valuable adjunct in the diagnosis of typhoid fever, particularly in those cases where a positive blood culture is not available to confirm the clinical impression. The result of the roentgenographic examination is obtainable immediately and treatment can be initiated early.     

伤寒患者肿瘤坏死因子和Cu－Zn超氧化物歧化酶活性的动态变化

采用双抗体夹心ＥＬＩＳＡ法和黄嘌呤氧化酶法动态检测了４３例伤寒患者血清肿瘤坏死因子（ＴＮＦ）和铜Ｚｎ超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ，ＳＯＤ－１）的活性。结果：伤寒患者病程初期ＴＮＦ活性明显升高，ＳＯＤ－１活性明显降低；极期ＴＮＦ和ＳＯＤ－１活性变化达到高峰。ＴＮＦ和ＳＯＤ－１活性变化与患者病期密切相关。提示：ＴＮＦ和氧自由基共同参与了伤寒患者的发病过程，是引起患者病理损伤的重要原因，这对于观察病情变化和判断疾病严重程度具有重要的参考意义。     

飞行员慢性咽炎误诊伤寒一例

一、临床资料患者男性 ,32岁 ,歼 - 6飞行员 ,飞行时间 130 0 h。 1999年 9月 10日因发热、咽痛 1d,送往某医院。既往因部队所在地有散在伤寒流行 ,患者于 8月 2 3日接种伤寒疫苗。住院时查体 :体温 39.5℃ ,呈急性病容 ,咽部充血明显 ,呼吸音粗 ,心率 12 0次 / min,肝脾未触及。诊断 :上呼吸道感染 ;沙门氏菌属感染。经抗感染、对症支持治疗 2 d,体温降至正常 ,症状消失。 9月 14日实验室检查结果示 :白细胞总数正常 ,中性粒细胞 0 .5 ,淋巴细胞 0 .48;伤寒杆菌抗原阳性。 9月 17日复查伤寒杆菌抗原仍为阳性 ;血清凝集反应 :O凝集价 1∶ 8…