粘膜下软骨离断术治疗鼻中隔软骨部偏曲

鼻中隔偏曲在影响鼻腔通气、鼻窦引流时，需要做矫正手术。根据鼻中隔偏曲的不同情况（C型偏曲、S形偏曲、棘突或嵴突），可以采用不同的手术方法。经典的鼻中隔矫正术（Killian手术）是在粘软骨膜及粘骨膜下将鼻中隔软骨的大部及偏曲的筛骨正中板和犁骨加以切除。我科近３年来对１１例以软骨偏曲为主的C形鼻中隔偏曲患者采用粘膜下软骨切割离断而非切除的方法来治疗，效果满意，报道如下。１．１一般资料本组病例均为鼻中隔软骨部呈C形向一侧偏曲且有临床症状的患者，其中男性９例，女性２例，年龄最小２０岁，最大３７岁。术前主要症１…     

292例鼻中隔偏曲致鼻源性头痛的手术治疗效果观察

选择鼻中隔粘膜下切除术及部分采用鼻中隔改建术施行了２９２ 例,其中畸形２１ 例,距状突２５ 例,“ Ｃ”形或“ Ｓ”形６８ 例,鼻中隔后上端膨大（ 高位偏曲）１７８ 例。一年后随访痊愈２３２ 例,好转４３ 例,无效１７ 例,总治愈率为９３ ．５ ％ 。结果提示鼻中隔偏曲致鼻源性头疼的患者为数不少,不可忽视。许多被内科诊断为“血管神经性头疼”、“偏头疼”患者,最后确诊为鼻源性头疼,治疗后获愈。     

鼻内窥镜下鼻中隔偏曲275例疗效分析

目的探讨鼻内窥镜下鼻中隔偏曲矫正术后疗效分析。方法用德国狼牌鼻内窥镜对275例鼻中隔偏曲行矫正术，其中鼻中隔左偏192例，鼻中隔右偏183例，术中合并切除双侧下鼻甲42例。结果术后3月随访，鼻塞、流涕、打喷嚏、头痛症状完全消失在25．3％-46．3％；好转53．3％；总有效率为92．3％。无一例并发症出现。结论鼻内窥镜下鼻中隔偏曲矫正术疗效好，操作简单，视野清晰，并发症少。     

鼻中隔偏曲再次矫正术

目的　探讨鼻中隔偏曲再次矫正术的手术方式和术后处理。方法　 14例患者行鼻中隔再次矫正术 ,取左侧鼻顶、鼻底双L型切口 ,其中 3例鼻中隔软骨前部偏曲加用对侧鼻前庭处切口 ,避开首次手术粘连部位 ,术后纱条对等填塞和抽出。结果　 14例均成功。随访 2年症状消失 ,鼻镜检查鼻中隔基本居中。结论　鼻中隔偏曲再次矫正术宜避开首次手术之粘连部位 ,采用鼻顶及鼻底的双L型切口 ,视野清晰 ,便于充分分离及切除偏曲部软骨及骨质 ,彻底纠正偏曲及改善临床症状     

飞行员鼻中隔粘膜下减张放射状切除整复术11例

应用鼻中隔粘膜下减张放射状切除整复术，对１１例飞行员鼻中隔偏曲患者进行了单纯方形软骨部偏曲和合并骨部偏曲切除整复术，术后１周１１例鼻中隔直，通气改善。本术２月、１年随访１０例，症状消失，鼻中隔平直，全部通气良好，各期随访病例均无鼻 穿孔和鞍鼻等并发病。     

鼻内镜下矫正鼻中隔偏曲35例临床观察

目的探讨鼻内镜下矫正鼻中隔偏曲的治疗效果。方法使用0°鼻内镜对35例鼻中隔偏曲患者进行鼻中隔矫正术治疗及临床愈后观察。15例鼻中隔偏曲的病人接受传统的鼻中隔矫正术后对照。结果 35例鼻中隔偏曲患者经鼻中隔矫正术,术后均取得满意效果,术后随访6个月,33例疗效好,2例好转。该方法彻底安全治疗了鼻中隔偏曲减少了鼻中隔穿孔鼻梁塌陷等并发症的发生。结论鼻内镜下行鼻中隔偏曲矫正术,手术视野清楚,直观方便简单易行,精确,安全,疗效确切等优点。     

鼻内窥镜下同期手术治疗鼻中隔偏曲并慢性鼻-鼻窦炎120例

目的：探讨鼻内窥镜下同期行鼻中隔矫正术及鼻、鼻窦手术的可行性及必要性。方法：对鼻中隔偏曲并慢性鼻-鼻窦炎（Chronic rhinosinusitis,CRS）120例患者,先行鼻中隔矫正术,同时再行同侧或对侧功能性鼻内窥镜手术。结果：治愈96例（80.0%）,好转24例（20.0%）,总有效率100%。术后并发鼻中隔穿孔3例（2.5%）,鼻道粘连3例（2.5%）。结论：在鼻内窥镜下行鼻中隔矫正术及鼻-鼻窦手术效果好,并发症少。     

改良鼻中隔偏曲矫正术的临床应用

目的探讨改良鼻中隔偏曲矫正术在鼻中隔偏曲矫正术中的应用效果。方法对37例鼻中隔偏曲患者应用改良鼻中隔偏曲矫正术,切除偏曲较大部分的尖部,不需切除的偏曲较小部分只做改形处理。结果37例术后鼻中隔居中,无穿孔,鼻中隔无飘动,鼻腔通气良好。结论改良鼻中隔偏曲矫正术方法简单易行,效果好,无近、远期并发症。     

鼻内镜下鼻中隔矫正术120例报告

鼻中隔偏曲,过去通常采用鼻中隔矫正术[1],将鼻中隔偏曲部软骨切除,偏曲的骨部咬除,使鼻中隔处于居中或接近居中,改善鼻腔功能.自鼻内镜在国内广泛应用以来,鼻中隔手术有了很大进展,鼻内镜下鼻中隔矫正术优于传统鼻中隔纠正术,并发症少.     

鼻内镜下鼻中隔偏曲矫正术120例临床分析

目的 探讨鼻内镜下鼻中隔偏曲矫正术的手术方法及疗效。方法 对1998年1月-2003年12月完成随访的120例鼻内镜下鼻中隔偏曲矫正术进行临床分析。120例鼻中隔偏曲患者均属中、重度，全部在局部麻醉下完成手术，术后随访1-24个月。结果 120例鼻中隔偏曲患者均得到彻底矫正，满意改善鼻腔通气、嗅觉功能，有效控制鼻中隔穿孔的发生和减少鼻息肉、鼻窦炎的复发。结论 鼻内镜下鼻中隔偏曲矫正术是治疗鼻中隔偏曲的理想方法，与传统方法相比，具有安全、疗效持久等优点。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.