尖锐湿疣与HLA抗原及HLA单倍型

尖锐湿疣与ＨＬＡ抗原及ＨＬＡ单倍型张庆瑞谷丽红杨德荣贺为东宋芳吉陈洪铎８０年代以来，尖锐湿疣（ＣＡ）的发病率明显增高，但人们发现并非所有的ＣＡ性伴或与ＣＡ患者有性接触者均临床发病；同时，也存在因非性接触而感染ＨＰＶ临床发病者［１，２］。这些现象表明，...     

安徽汉族人寻常性银屑病与HLA单倍型相关性研究

利用聚合酶链反应-序列特异性引物(PCR-SSP)法,对138例银屑病患者及149例健康对照进行PCR反应,分析单倍型的分布情况,探讨汉族人寻常性银屑病与HLA单倍型的相关性.     

多形红斑与HLA相关性研究

目的 研究多形红斑与ＨＬＡ相关性。方法 采用血清学技术和聚合酶链式反应－序列特异性引物技术,检测多形红斑患者ＨＬＡＩ类抗原和ＨＬＡⅡ类基因。结果 在３０例多形红斑患者中,ＨＬＡ－Ａ３０＋３１、Ｂ１３抗原频率较对照组明显增高（Ａ３０＋３１：Ｐｃ〈０．０１,ＲＲ＝６．６４;Ｂ１３：Ｐｃ〈１０＾－３,ＲＲ＝７．８８）。ＨＬＡ－ＤＱＢＩ＊０４基因频率在多形红斑患者较正常人对照组明显增高（ＤＱＢＩ＊０４：Ｐ     

物理性皮肤病

HLA与光敏性皮肤病（综述）;进食藜引起日光性皮炎1例;动物致外源性光感性皮炎1例;烧伤酊的药效学研究;低热烧伤111例临床分析     

潮汕地区麻风病与HLA的相关性

麻风病是由麻风杆菌引起的传染性疾病，但有研究认为(HLA)与麻风病存在一定相关性。国内报道甚少。随着分子生物学的进步，与疾病相关的HLA研究也从血清学进入基因水平。而我国在该方面的研究尚少。在1997～2000年我们对潮汕地区麻风治愈患者进行了HLA—I类血清学及PCR-SSSCP对HLA—ll抗原，HLA—DR2等位基因进行了DNA分型的检测，现报告如下。     

中国变态反应性皮肤病变应原检测方法回顾性分析

目的分析近10年来中国变态反应性皮肤病变应原检测方法使用的合理性。方法对中国医学数据库：万方、同方和维普2000-2009年收录的319篇变态反应性皮肤病变应原检测文献归纳总结,并根据各种变应原检测方法原理和疾病发病机制进行分析,判断其使用方法的合理性。采用时间序列分析方法分析不合理方法构成比的变化趋势。结果319篇文献中,使用合理方法检测变应原的构成比为58．8％,不合理检测为41．2％。且使用不合理方法检测变应原的构成比呈逐年增长趋势。结论中国部分临床医生对变态反应性皮肤病变应原检测方法使用的适应证掌握不准确,使用不合理检测方法占很高比例,有的检测方法使用甚至缺乏科学依据,有待管理部门制定统一标准,使变态反应性皮肤病的过敏原检测更加合理和规范。     

PPARs与皮肤病的关系研究进展

过氧化物酶体增殖物激活受体（PPARs）在过氧化物酶体增殖、脂肪生成、B氧化增加和细胞周期的调节等方面起着重要作用，它在皮肤生理及病理方面的作用逐渐受到重视。PPARct影响皮肤的成熟、分化和增殖，皮肤外伤后，PPARβ／δ一直保持表达直到创口愈合。PPARs对皮脂形成、皮肤肿瘤发展有不同的影响，在银屑病和色素性皮肤病中也起一定的作用。这些发现可为治疗皮肤病提供新途径。     

应用仲景方治疗皮肤病点滴体会

报道5例仲景方治疗皮肤病的病例,分别以四逆散治疗腹壁静脉炎,肾气丸治疗慢性荨麻疹,小柴胡汤治疗带状疱疹,葛根芩连汤治疗荨麻疹伴腹泻,真武汤治疗红皮病型银屑病。仲景方治疗皮肤病,只要辨证准确就会有满意的临床疗效。     

有无家族史白癜风与HLA—I类抗原的关联性研究

目的 探讨HLSA－I类抗原与中国北方汉族人群中有及无家族遗传史白癜风的相关性。方法 家庭史阳性及阴性白癜风患者各20例,采用HLA血清学分型技术检测HLA－A、B位点的抗原特异性。结果 与100例正常对照比较,有明确家族史的白癜风患者HLA－A10、B13、B15抗原频率显著增设,而无家族史的患者HLA－A30＋31、B15显著增高（Pc均＜0．01）,非节段HLA－A10、A30＋31、B1、B13、B15显著增高（Pc均＜0．01）,成年及未成年发病型HLA－B13、B15显著增高,儿童发病型则仅HLA－B13显著增高（Pc均＜0．01）。结论 该结果为进一步揭示白癜风的易感基因及免疫遗传发病机制提供了线索。     

HLA antigens in patients with chronic biologically false-positive seroreactions for syphilis and systemic lupus erythematosus

Summary HLA antigens were examined in 118 unrelated patients of whom 49 had definite severe systemic lupus erythematosus (SLE). HLA A1 was found in 45% of the 49 SLE patients and in 20% of the controls, which consisted of 900 blood donors. HLA B8 was found in 47% of the patients and in 20% of the controls (relative risk=3.5, P=0.000017), while HLA B7 was found in 22% of the patients and in 24% of the controls.Of the 118 patients 69 had chronic biologically false-positive (CBFP) seroreactions for syphilis. In 32 of these 69 patients definite or probable SLE was diagnosed during the observation time, which varied from 3 to 16 years. HLA B7 was found in 38% of these 32 patients, while HLA B8 was found in 25%. When the occurrence of these antigens was correlated to the length of the observation time it was found that 53% of the patients in whom the disease manifested first after 10 years follow-up were carriers of HLA B7 (P=0.0005) and only 12% had HLA B8 (relative risk=0.5). In patients with a faster development of the disease both of these antigens were found in about the same frequency as in severe SLE patients.In 37 of the 69 patients no definite diagnosis could be established even it 19 of them had clinical and serological manifestations compatible with SLE. HLA B7 was found in 46% and HLA B8 in 14% of these patients. Moreover it was found that 72% of the 18 patients who had only antilipoidal antibodies in their serum were carriers of HLA B7, while 21% of the 19 patients with other circulating auto-antibodies had HLA B7. D-locus antigens were examined in 35 patients. HLA D w3 was found in 54% of the patients and in 24% of the controls. Twelve of the patients with D w3 had severe SLE and nine of them had also HLA B8.     

白三烯及抗白三烯药物与皮肤病相关性的研究进展

白三烯作为一种重要的炎症介质参与了多种皮肤病的发生发展,抗白三烯药物对皮肤病的治疗也有一定的疗效。本文回顾了白三烯与相关皮肤病的文献,阐述了白三烯在皮肤病发展中的作用以及抗白三烯药物在皮肤病治疗中的应用。     

The role of HLA antigens in the development of paracoccidioidomycosis

BACKGROUND: Paracoccidioidomycosis is a systemic granulomatous disease that involves primarily the lungs and may disseminate to other organs and systems. It is caused by Paracoccidioides brasiliensis, a fungus that exhibits reversible thermal dimorphism and whose natural habitat is presently unknown. There are two main clinical forms: the acute (subacute) juvenile form and the chronic adult form. The former runs a more rapid course and is more severe than the latter. This mycosis is found throughout Latin America. Brazil accounts for 80% of reported cases. Presumably P. brasiliensis thrives in humid and hot places, especially near forests or farms. The infection is endemic in certain areas, especially in Brazil, Colombia and Venezuela, where nearly 100% of the population show cutaneous paracoccidioidina positive skin tests, indicating previous contact with the fungus, although a small percentage show clinical manifestations of the disease. METHODS: We compared the expression of HLA class I antigens in a healthy group (control) and in a group of patients with paracoccidioidomycosis (chronic adult form) using the Terasaki lymphocytotoxicity test modified by Amos for HLA antigen analysis. AIMS: To discover indications of whether or not individual susceptibility to P. brasiliensis might depend on some specific immunological defect. RESULTS: There is no evidence of association between a specific HLA antigen and paracoccidioidomycosis in the subjects studied. Further investigations are recommended.     

角层下脓疱性皮肤病的研究进展

角层下脓疱性皮肤病的病因与发病机制尚不完全清楚，可能是一种自身免疫性疾病，也可能是脓疱性银屑病的一种亚型，发病与多种炎症因子相关。病理特征为角层下脓疱内中性粒细胞浸润。鉴别诊断包括：脓疱疮、落叶性天疱疮、疱疹样皮炎、脓疱性银屑病、急性泛发性发疹性脓疱病和IgA天疱疮等。氨苯砜是治疗角层下脓疱性皮肤病的一线用药，英利昔单抗和咪唑立宾是有希望的有效治疗药物，但仍需更多的临床试验来证实。     

我国虫媒性皮肤病及其治疗

由医学节肢动物引起的皮肤损伤及皮肤病正逐渐引起重视。现就一些常见的由医学节肢动物引起的病征及其对策叙述如下。1　螨类引起的皮肤病1 1　疥疮　本病由寄生于人体的人疥螨成虫期引起的皮肤损伤。在我国主要分布于南方一些省市及自治区。成虫寄生于皮肤之表皮角质层间 ,啮食角质组织 ,并以其附肢在皮下开凿一条与体表平行而纡曲的隧道。故而局部的皮损表现为淡红色小丘疹 ,小水疱及隧道。隧道的盲端常有虫体隐藏 ,其呈针尖大小的灰白色小点。局部剧痒是疥疮的最突出症状 ,尤其夜晚更甚。常因剧痒抓挠而继发感染后出现脓疮 ,毛囊炎或疖肿…