脑动静脉畸形的Onyx胶介入栓塞治疗疗效观察

目的 探讨Onyx胶介入栓塞治疗脑动静脉畸形(BAVMs)的方法及疗效.方法 回顾性分析10例应用Onyx胶进行血管内介入栓塞的BAVMs患者的临床特点、治疗经验及疗效.结果 10例患者Onyx胶介入栓塞治疗均获成功;基中4例完全栓塞(≥95%),2例获90%栓塞,4例获75%栓塞.结论 应用Onyx胶介入栓塞治疗BAVMs是较为安全、有效的方法.Onyx胶是比较理想的栓塞材料,但其远期疗效仍需大量病例随访观察.     

应用Onyx胶介入治疗脑动静脉畸形12例分析

目的:探讨新型液体栓塞剂Onyx胶在脑动静脉畸形血管内栓塞治疗中的应用价值及技术要点.方法:对采用Onyx胶栓塞治疗的12例脑动静脉畸形患者的临床资料进行分析.其中畸形血管团小于3 cm 6例,3～6 cm 4例,大于6 cm 2例,Spetzler-Martin分级Ⅱ级5例,Ⅲ级5例,Ⅳ级2例.结果:本组Onyx胶介入治疗的技术成功率为100%;6例完全栓塞,2例获90%栓塞,4例获75%栓塞.结论:Onyx胶是治疗脑动静脉畸形较为理想的栓塞材料;掌握栓塞技巧可以减少并发症的发生;Onyx胶介入治疗脑动静脉畸形的长期疗效有待随访结果的验证.     

Onyx胶术前栓塞高血运脑膜瘤的临床应用

目的:探讨应用Onyx胶术前栓塞高血运脑膜瘤的治疗体会。方法:对19例高血运脑膜瘤,应用Onyx胶进行血管内栓塞治疗。结果:19例均栓塞成功,栓塞90%以上10例,栓塞80%～90%5例,栓塞50%～70%4例。所有病例无栓塞并发症,脑膜瘤手术切除顺利。结论:合理而有效地使用Onyx胶,在临床上栓塞治疗高血运脑膜瘤,有较大的应用价值。     

Onyx胶栓塞治疗脑动静脉畸形的价值

目的 探讨Onyx胶栓塞在治疗脑动静脉畸形中的价值.方法 采用Onyx-18胶栓塞治疗18例脑动静脉畸形患者,畸形血管团人小均在3cm以上,其中6cm及以上者7例,所有畸形血管团为多支血管供血.结果 畸形血管团在影像学上完全栓塞4例,畸形血管团栓塞〉80%4例,栓塞50%～80%6例,栓塞〈50%4例.并发生颅内出血1例.结论 Onyx胶是治疗脑动静脉畸形较为理想的栓塞材料.血管内栓塞是脑动静脉畸形综合治疗中重要的组成部分,但需注意掌握栓塞技巧,减少并发症的发生.     

应用ONYX血管内栓塞治疗颅内动静脉畸形的探讨

脑动静脉畸形是颅内常见的先天性血管疾病,血管内栓塞治疗是其主要的治疗手段之一,Onyx胶是一种新型不粘胶,具有不粘管,可以在病灶内长时间缓慢注射等优点。自2006年4月起,作者开始应用Ohyx进行脑动静脉畸形的临床栓塞治疗,回顾17例应用Onyx栓塞的脑动静脉畸形,就Onyx液态栓塞系统的特殊性能及其特殊的操作技术体会报道如下。     

Onyx胶栓塞治疗脑动静脉畸形应用价值

目的探讨Onyx胶在治疗脑动静脉畸形中的应用价值.方法采用Onyx-18胶栓塞治疗12例脑动静脉畸形患者,畸形血管团大小均在3 cm以上,其中6 cm及以上者3例,所有畸形血管团为多支血管供血.结果12例BAVM中,畸形血管团栓塞80%以上2例,栓塞50%～80%7例,栓塞50%以下3例.发生颅内出血并发症3例,其中1例死亡.结论Onyx胶是治疗脑动静脉畸形较为理想的栓塞材料,但需注意掌握栓塞技巧,减少并发症的发生.     

动脉栓塞术治疗急性大咯血的临床疗效分析

目的评价动脉栓塞术治疗急性大咯血的临床疗效。方法对内科保守治疗无效的26例大咯血患者,通过介入动脉血管内栓塞治疗彻底栓塞引起出血的责任血管,观察患者的咯血情况。结果 26例患者均操作成功,24例咯血完全控制,2例患者在栓塞术后1周内再次出现咯血,行二次介入栓塞治疗后出血停止,3个月内均未见复发,一次栓塞有效率92.3%(24/26),总有效率为100%,未出现严重并发症。结论动脉栓塞术治疗大咯血安全、有效、微创,值得在临床推广应用。     

应用ONYX胶介入治疗脑动静脉畸形临床研究

目的:探讨Onyx胶栓塞治疗脑动静脉畸形的临床价值及技术要点。方法:回顾性分析应用Onyx胶介入治疗AVM患者25例,总结其疗效、并发症及预后情况,评价Onyx胶应用于AVM介入治疗中的临床价值并总结其技术要点。结果:25例完全栓塞者13例,80%以上栓塞4例,50%~80%以上栓塞8例。术中1例微导丝刺破血管出血,术后1例单侧肢体偏瘫,均经治疗后逐渐恢复。随访6~12个月,未发现畸形血管团再通。结论:应用Onyx胶栓塞治疗AVM具有较大的优越性和良好的疗效;在应用过程中应熟练掌握其性能、适应证和栓塞技巧,从而提高治愈率,减少和避免并发症的发生。     

明胶海绵（GS）颗粒和聚乙烯醇（PVA）颗粒支气管动脉内栓塞治疗急性大咯血的近期疗效比较

目的：比较使用明胶海绵（GS）颗粒和聚乙烯醇（PVA）颗粒行支气管动脉内栓塞治疗急性大咯血的近期疗效。方法 A组：选取本院40例急性大咯血患者,先行选择性支气管动脉插管造影,使用聚乙烯醇（PVA）颗粒＋弹簧圈栓塞。B组：外院39例急性大咯血患者使用明胶海绵（GS）颗粒＋弹簧圈栓塞。评价栓塞后的近期疗效,按照栓塞材料进行分组对照、统计分析。结果 A组40例成功栓塞治疗患者中7例17.5％（7/40）近期再发咯血,原栓塞靶血管再通占4例（10%）。B组39例栓塞治疗患者中1例（3%）患者15日后原栓塞靶血管再通二次行栓塞治疗。A、B两组有效率差异有统计学意义（P〈0.01）。结论支气管动脉栓塞术治疗大咯血,使用明胶海绵颗粒的近期疗效优于PVA颗粒。     

支气管动脉栓塞治疗老年人肺结核大咯血的疗效观察

目的:探讨老年人肺结核大咯血的支气管动脉栓塞后临床疗效.方法:41例经内科药物止血治疗无效的62～75岁急性大咯血病人,咯血史3～10a,发病时咯血量300～600mL,采用Seldinger技术,用明胶海绵为栓塞材料,采用选择性支气管动脉栓塞治疗.结果:41例病人中有9例在栓塞0.5～3mo内复发,经再次栓塞后出血停止.复发率为20.9%.结论:支气管动脉栓塞治疗是对老年肺结核病人急性大咯血积极、有效的救治方法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.