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统计方法在医学科研中的正确应用 总被引:2,自引:0,他引:2
统计方法在医学科研中的正确应用汪涛金丕焕医学统计方法广泛应用于医学科学研究。但是由于许多医学科研工作者对统计方法的正确应用缺乏足够的知识,在实际应用时出现了不少问题,影响了结论的可信性。应杂志之邀,我们对医学科研论文中经常出现的统计问题进行了归纳整理... 相似文献
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完善科研设计进一步提高论文质量 总被引:1,自引:0,他引:1
中华神经科杂志的学术水平是我国神经病学界工作水平的反映。也就是说, 要提高杂志的质量, 首先必须提高国内神经科日常工作, 特别是科研的质量。作者总结本人、本单位或协作组的临床或实验研究工作写出文章, 是个自身提高的过程。文章投寄杂志发表交流则是个共同提高的过程, 读者从中学到新的知识, 作者则可从读者或编者的反馈获益。一篇好的文章应当能向读者提供客观、真实的信息, 其方法应详尽具体而能为他人所采用, 结果应能被其他学者所重复, 起关键作用的是研究工作设计的科学性。本刊2004年发表的自体外周血干细胞移植治疗进展型… 相似文献
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从本期开始,《上海精神医学》将开设一个方法学专栏,主要介绍中国精神医学研究中,研究设计、实施和研究报告中的常见问题。每期专栏将有不同的主题,欢迎广大读者对此提出建议。 相似文献
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在招募研究对象前需要注册该临床试验,将研究设计信息登记在被批准的开放性网站上[1]。研究者提供到注册系统的信息通常包括计划研究对象的样本量和特征、将研究对象分为研究组或对照组的随机方法或其他方法、 相似文献
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科研课题的研究设计与统计分析科研设计中常犯的错误 总被引:1,自引:0,他引:1
一、某些科研工作者在指导思想上存在的问题
1.临床科研流程倒置:在审阅临床研究论文时,常常产生很多科研工作的“流程”倒了的印象。按理说,进行一项科研工作,首先应当有科研假设,对科研假设深思熟虑之后,提出研究目标和实现目标的思路。在此基础上,结合专业知识和统计学知识,制定出完善的科研设计方案。进而在方案的指导下,有的放矢、循序渐进地实施科研课题。然而, 相似文献
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概述
精神卫生问题的发生、发展及对其管理都需要相对较长的时间,所以相当一部分精神病学研究—— 特别是能够明确回答有关生物、心理和社会因素复杂的相互作用的研究——要求对患者及其生活环境进行跨时长久的多种评估。然而,许多精神病学的研究人员使用不正确的统计方法来分析这一类型的纵向数据,这一问题会导致分析结果中出现无法识别的偏倚而由此得出不正确的结论。本文就纵向数据分析的话题做了介绍。文章探讨了纵向数据分析中使用的不同数据集结构、缺失数据的分类和处理以及使用纵向数据建立多元回归模型时对个体内相关性校正的方法。中文全文
本文全文中文版从2015 年10月26日起在http://dx.doi.org/http://dx.doi.org/10.11919/j.issn.1002-0829.215089可供免费阅览下载 相似文献12.
Walker RC Purnell GL Jones-Jackson LB Thomas KL Brito JA Ferris EJ 《Neurotoxicology》2004,25(4):533-542
Medical imaging is migrating from anatomic imaging to functional imaging and fused anatomic/functional imaging. The technology is being adapted for biomedical research using both clinical and small animal scanners. The ability to externally image real-time physiologic processes in both normal and deranged conditions, including various models to image gene expression, apoptosis, or drug biodistribution, has powerful impact on the exploration of biomedical and fundamental biological research. Positron emission tomography (PET) has a unique ability to not only provide such images but also to do so with high resolution (typically 1-2mm resolution for small animal scanners) and to provide both relative and absolute quantitation. This technology is revolutionizing biomedical and biological research. This article reviews the underlying principles involved in this technology, gives a brief history of its development, and then introduces the interested researcher to some of the important techniques that could be of use. 相似文献
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Helmchen H 《Fortschritte der Neurologie-Psychiatrie》2001,69(7):291-299
The methodology of clinical research will be commented upon according to the components of the research design: a precise question, hypotheses derived from that which can be examined empirically, the biometrical estimation of the sample size and its practicability, the selection of control groups, measures for assessing psychopathological phenomena, analysing the data and preparing the findings for publication, further the time structure of the research project, and some aspects of the framework of clinical research: patient access, financing of the needed resources and ethical implications. 相似文献
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Wilbert E. Fordyce 《Neuroscience and biobehavioral reviews》1981,5(3):391-396
The process of assimilation of physical disability and of patient management strategies in medical rehabilitation are analyzed in behavioral terms. Four major problem areas are identified: (1) the aversive characteristics of forced entry from accidental injury or illness into permanent disability; (2) relinquishing pre-onset behavior no longer appropriate because of the disability; (3) acquisition of disability appropriate behaviors; and (4) maintenance of performance or generalization of treatment effects. Each of those problem areas is analyzed in behavior-consequence terms. Case examples are presented to illustrate both analysis of problems in behavioral terms and contingency management strategies for helping. 相似文献
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Michael Shepherd 《European archives of psychiatry and clinical neuroscience》1982,232(6):501-506
Summary The increased interest in biological research related to mental disorders has underlined the need for the construction of stronger bridges between the basic sciences and clinical psychiatry. The underlying problems and possible solutions are discussed.The article previously appeared in the British Medical Journal 282:961–963 (1981). Permission to republish it has been granted to the author by the publisher 相似文献
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Clinical and basic research is necessary to improve neurological treatment. Such research should be a major responsibility both for universities and hospitals. The funding for this research is to an increasing degree linked to research and publication result. For the specialist education in neurology, it is a challange to combine the training with research activity. The Norwegian Neurological Association intends to stimulate research. The annual national conference is a key instrument for this, and included 93 free, original scientific presentations in 2006. Publishing selected contributions in this supplement should be regarded as a further research-stimulating activity, reflecting the focus on research in Norwegian neurology. 相似文献