干扰素超声雾化治疗120例婴幼儿疱疹性口炎的疗效分析

目的观察干扰素超声雾化治疗婴幼儿疱疹性口炎的疗效。方法120例患者随机分为雾化组60例,对照组60例,对照组给予常规治疗,雾化组在常规治疗基础上加用干扰素超声雾化治疗,疗程3d。结果雾化组临床症状、体征和有效率与对照组相比,均有显著性差异(P<0.05)。结论干扰素超声雾化治疗婴幼儿疱疹性口炎安全、有效。     

超声雾化吸入治疗小儿疱疹性龈口炎临床观察

目的：观察超声雾化吸入治疗小儿疱疹性龈口炎的临床效果。方法：146例疱疹性龈口炎忠儿，治疗组77例采用常规治疗（抗病毒口服液及抗生素口服）＋超声雾化吸入，对照组69例采用常规治疗，不进行超声雾化吸入，观察临床疗效。结果：治疗组有效率为93．5％，对照组为71．3％，两组之间比较有显著性差异（P〈0．01）。结论：超声雾化吸入治疗小儿疱疹性龈口炎疗程短，见效快，无副作用。     

干扰素雾化治疗疱疹性口炎疗效观察

疱疹性口炎是因感染Ⅰ型单纯疱疹病毒所致的口腔粘膜、咽喉、口腔周围与颜面部皮肤的疱疹。多见于6岁以下儿童，尤其是6个月～2岁的要幼儿，起病急、易传染。近年来，笔者采用干扰素雾化给药法治疗200例疱疹性口炎取得较好的疗效。     

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目的    观察中西医结合治疗婴幼儿疱疹性口炎的临床疗效。方法    对2006年1月至2009年6月北京市海淀区中医医院口腔科门诊收治的48例婴幼儿疱疹性口炎患者,随机分为治疗组和对照组,对照组予以阿昔洛韦联合过氧化氢（H2O2）液湿敷黏膜,治疗组在对照组基础上,加用中药制剂睡前湿敷黏膜。观察两组的发热持续时间及溃疡愈合情况,并计算治疗有效率。结果    （1） 治疗组有效率（91.67％）明显高于对照组（62.50%）, 差异有统计学意义 （P < 0.05）。（2）治疗组的发热持续时间［（2.25±0.69）d］和溃疡愈合时间［（3.3l±1.66）d］均较对照组［（3.38±1.50）d和（4.18±0.67）d］明显缩短,差异均有统计学意义 （P < 0.05）。结论    中西医结合治疗小儿婴幼儿疱疹性口炎疗效显著,值得临床推广使用。     

口腔炎喷雾剂治疗儿童疱疹性口炎疗效观察

疱疹性口炎为儿童常见和多发病。1～5岁幼儿最为多见。常急性发作,全身反应也比较严重。患儿常因疼痛而拒食,哭闹不安。目前尚无特效治疗方法。近二年来作者用纯中药制剂口腔炎喷雾剂治疗儿童疱疹性口炎220例,取得了满意疗效。现报道如下。1　临床资料11　一般资料:将确诊为疱疹性口炎的患儿随机分为二组,治疗组220例中男性125例,女性95例。对照组196例中男性107例,女性89例。二组年龄均为6个月—8岁,以1—5岁最多见。发病至就诊1—2天不等。12　诊断依据:症状:发热、疼痛、拒食、流涎、口臭等。检查:口腔粘膜充血,疱疹或溃疡数个至数十个不…     

加味导赤白虎汤治疗口腔单纯疱疹的初步研究

对口腔单纯疱疹原发性疱疹性口炎和复发性疱疹性口炎病人191例进行了研究,随机选取47例为对照组。治疗组144例服用加味导赤白虎汤冲剂治疗。对照组中,22例使用各种抗生素,25例服用银柴冲剂。结果显示治疗组疗效明显优于抗生素组和银柴冲剂组,且治疗组未出现任何毒副反应。将加味导赤白虎汤冲剂,在体外作组织培养内的抗病毒实验,证明该冲剂在稀释成1∶10至1∶320的浓度内对腺病毒7型有灭活作用,而对原代人胚肾细胞无毒害性。推论该冲剂对单纯疤疹病毒可能有抑制作用。     

中西医结合治疗义齿性口炎疗效观察

目的:观察中西医结合治疗义齿性口炎的疗效.方法:51例义齿性口炎患者随机分为两组,治疗组按中医辨证分型施治,同时口服伊曲康唑胶囊;对照组仅口服伊曲康唑胶囊.疗程2周.观察两组临床症状变化及有效率,停药后2周复查比较复发率.结果:两组治疗后临床症状均有改善,与治疗前比较有临床意义(P<0.05),治疗组的临床疗效和控制复...     

口含型干扰素治疗疱疹性口炎初步探讨

口含型干扰素治疗疱疹性口炎初步探讨广州市儿童医院（５１０１２０）邓利琴裴霞常汝虚疱疹性口炎是因感染Ｉ型单纯疱疹病毒所致的口腔粘膜病。近来我们采用口含型干扰素糖丸治疗７０例疱疹性口炎，取得较理想疗效。现报告如下。材料和方法１．观察对象，１９９６年６月至...     

抗病毒口服液治疗原发性疱疹性口炎临床疗效观察

疱疹性口炎 (ＨｅｒｐｅｔｉｃＳｔｏｍａｔｉｔｉｓＨＳ)是发生于口腔粘膜的单纯疱疹病毒感染性疾病。原发性疱疹性口炎 (ＰｒｉｍａｒｙＨｅｒｐｅｔｉｃＳｔｏｍａｔｉｔｉｓＰＨＳ)表现为一种较严重的龈口炎—急性疱疹性龈口炎。儿童较多见。患儿常有发热、头痛等前驱期全身症状 ,口腔粘膜形成水疱、溃疡时疼痛剧烈 ,影响进食。目前尚无特效药物。本文应用中成药抗病毒口服液治疗 ,疗效满意。材　料　与　方　法1　病例选择 :　选取从 1997年 10月至 1999年5月门诊就诊的原发性疱疹性口炎患者 10 7例 ,男51例 ,女 56例 ,年龄为 6个月～ …     

利巴韦林治疗疱疹性口炎44例疗效观察

疱疹性口炎是儿童常见病，是由病毒引起的粘膜损害。我们应用利巴韦林（ＲＩＢＡＶＩＲＩＮ）治疗儿童疱疹性口炎４４例，经临观察，取得较满意的效果，现报告如下。临床资料１病例选则：患儿分两组：治疗组４４例，男２５例，女１９例；对照组３８例，男２３例，女１５例...     

The use of the ultrasonic spraying of interferon and larifan solutions for treating acute herpetic stomatitis in children]

Ultrasonic spraying of drug solutions was used in the treatment of 100 children suffering from acute herpetic stomatitis and its efficacy compared to that of common spraying of drugs in 100 children of the reference group. The results evidence that ultrasonic spraying accelerates cure by 2-3 days and is drug-saving. Interferon was found to be the most effective drug for acute herpetic stomatitis; larifan, used for the first time in the treatment of this condition, was inferior to it, though still effective enough.     

中药治疗婴幼儿疱疹性龈口炎的临床疗效观察

目的探讨中药方剂对婴幼儿疱疹性龈口炎的治疗效果,以期找到减少患者病痛的最佳治疗方案。方法收集婴幼儿疱疹性龈口炎60例,年龄6～24个月,随机分为中医治疗组和西医治疗组,各30例。中医治疗组用新的中药方剂进行治疗;西医治疗组用病毒唑注射和龙胆紫局部涂搽治疗,有感染者给予青霉素静脉注射。所有患者行血常规检查。比较新中药方剂与常规方法在疗效上的差异。结果中药治疗组的有效率为93.3%(28/30),高于西医治疗组66.7%(20/30),差异有统计学意义(P<0.05);中药治疗组的发热持续时间和溃疡愈合时间分别为(2.80±0.72)d和(3.00±0.96)d,较西医治疗组的发热持续时间(4.54±1.06)d和溃疡愈合时间(4.57±1.16)d,均明显缩短,且差异有统计学意义(P<0.05)。结论新的中药方剂能有效控制婴幼儿疱疹性龈口炎的症状并缩短病程。     

Use of an immunoglobulin with targeted action for the prevention and treatment of recurrent herpetic stomatitis in children

The results of parenteral (2 to 3 injections of 1.5 to 3 ml once on 3-rd to 4-th day) application of the prepared immunoglobulin with the titer of antiherpetic antibodies of 1:512 to 1:1024 in combined treatment of 2 groups of patients are summarized. In 34 children aged 2 to 12 years recurrent herpetic stomatitis was at its exacerbation. In 27 patients aged 1 to 3 an acute (primary) herpetic stomatitis was present and the group was considered, on grounds of the originally designed prognostic system, as being at high risk of transition into the chronic frequently exacerbating form of the disease. Positive immediate anti-recidive and preventive effect was obtained and confirmed in 12 to 24 months' follow-up.     

Changes of the immune status of children with relapsing herpetic stomatitis, suffering from allergic diseases, during licopide treatment

The efficiency of licopide in combination with traditional treatment was evaluated in 59 children aged 1-14 years suffering from allergic diseases and relapsing herpetic stomatitis. Immunological studies were carried out before and after a course of therapy: local oral immunity, cellular immunity (in the blast transformation test with phytohemagglutinin), lymphocyte populations and subpopulations, humoral immunity values (IgA, IgM, IgG, and IgE), and C3 complement component were evaluated. The results indicate that licopide in complex with traditional methods normalized the immunological values, had a favorable impact on the course of relapsing herpetic stomatitis, and led to a stable remission of allergic diseases (p<0.001).     

0.03%他克莫司软膏主动维持治疗儿童和青少年慢性唇炎的疗效及安全性评价

目的:采用主动维持疗法,观察0.03%他克莫司软膏治疗儿童和青少年慢性唇炎的疗效,并对其安全性进行评价。方法:本试验共分为2个阶段:治疗阶段(第一阶段)与主动维持阶段(第二阶段)。在试验第一阶段,将40例慢性唇炎患者随机分为2组,试验组25例,对照组15例。试验组首先湿敷复方氯己定溶液,再涂用0.03%他克莫司软膏。对照组仅湿敷复方氯己定,每天2次,连续2周。试验组中痊愈和显效的患者进入第二阶段,并随机分配至试验组或对照组,试验组采用间歇性主动维持疗法,对照组在本阶段不进行间歇维持治疗,如病损复发时采用常规治疗,两组的观察期均为6个月。结果:第一阶段,他克莫司组痊愈21例,显效3例,总有效率为96%,明显高于对照组(60%),差异有统计学意义(P<0.05)第一阶段试验结束后,试验组24例患者进入第二阶段,并随机分为试验组和对照组各12例。第二阶段试验组有效率为100%,对照组的有效率为91.7%,差异无统计学意义。试验组首次出现复发的时间均值为(95.5±9.2) d,对照组均值为(26.6±10.0) d,差异具有统计学意义。试验组患者复发率16.7%明显低于对照组患者58.3%,差异有统计学意义(P<0.05)。结论: 0.03%他克莫司软膏采用主动维持疗法能显著降低儿童和青少年慢性唇炎的复发,疗效好且安全。     

Staphylococcus aureus bacteremia complicating herpes simplex virus type 1 stomatitis: case report and review of the literature

BACKGROUND: Gingivostomatitis is a common clinical manifestation of primary herpes simplex virus type 1 (HSV-1) infection in children. The most common complication of herpetic gingivostomatitis is dehydration; rarely, it may be complicated by secondary bacteremia, and Kingella kingae and group A Streptococcus infections have been reported to be responsible for such episodes. METHODS: We describe the clinical course of a 4.5-year-old girl several years after a liver transplantation, who presented with high fever, vesicular lesions in the buccal region, and cervical lymphadenopathy. RESULTS: Viral culture from the vesicles grew HSV-1, whereas blood culture and bacterial culture from the vesicles grew methicillin-sensitive Staphylococcus aureus with identical antibiogram. Serology against HSV-1 confirmed a recent infection. The child was treated with cephalexin and improved gradually. CONCLUSIONS: Herpetic lesions of the oral mucosa might serve as a port of entry for pathogens including Staphylococcus aureus. Pediatricians and dentists should be aware of bacterial complications in children with herpetic stomatitis.     

Chromosomal breaks and sister chromatid exchanges (SCE) in patients with herpetic stomatitis

Chromosomal breakage and sister-chromatid exchanges (SCE) were studied in peripheral lymphocytes of 9 patients with primary herpetic stomatitis (PHS), 12 patients with secondary herpetic stomatitis (SHS) and 12 controls. The incidence of chromosomal breakage was significantly higher in PHS patients (mean 23%, P. = 0.0002) and in SHS patients (mean 20.25%, P. = 0.0003) compared to the controls (mean 4.2%). The incidence of SCE per 46 chromosomes was significantly higher in SHS patients (mean 16.564) compared with (P. less than 0.001) the controls (mean 11.367) and compared with (P. = 0.006) the PHS patients (mean 12.131). It is concluded that both PHS and SHS patients exhibit structural chromosomal damage; SHS patients in addition exhibit more repaired chromosomal lesions.     

DENLAS-10BM半导体激光对口腔软组织疾病治疗有效性和安全性研究

目的:评价DENLAS-10BM半导体激光在口腔牙龈组织良性增生治疗中的有效性及安全性。方法:随机选取66名志愿者,其中实验组33例,对照组33例。实验组使用DENLAS-10BM半导体激光治疗仪;对照组使用Sirona Dental Systems GmbH激光治疗机。术后7天对激光切割效果、止血效果、一周后愈合有效率、安全性进行评价;并对实验方案中的主要、次要及安全性评价指标进行评估。结果:试验组DENTAL-10BM半导体激光治疗仪手术完成时间为3.09±2.11min,对照组为3.12±1.56min,无统计学差异(P>0.05)。试验组I级止血率为96.98%,对照组I级止血率为96.97%,无统计学差异(P>0.05);试验组和对照组的有效愈合率均为100%,无统计学差异。试验组与对照组有效差值的单侧区间95%可信区间下界>-10%,试验组非劣于对照组。安全性分析,试验组不良事件2例(6.06%),对照组不良事件3例(9.09%),无统计学差异(P>0.05)。结论:DENTAL-10BM半导体激光治疗仪在临床止血效果、愈合有效率及手术完成时间无统计学差异,两者的临床效果和安全性具有一致性。