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Somatomedin activity was assayed in the plasma of children suffering from protein calorie malnutrition by a bioassay using rat cartilage and expressed as sulphate uptake ratio. The sulphate uptake ratio was particularly reduced in kwashiorkor. In marasmus there was a slight reduction and the levels were still in the normal range. Plasma growth hormone (GH) levels were raised in kwashiorkor but were in the normal range in marasmus. Reduction in sulphate uptake ratio was observed only when plasma albumin levels were less than 2.5 g/100 ml (25 g/l). A rise in plasma GH was also observed but only below this threshold level. 相似文献
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K. C. Nayak A. S. Sethi T. D. Aggarwal Dr. V. S. Chadda K. Krishana Kumar 《Indian journal of pediatrics》1989,56(3):371-377
The present study was undertaken to compare the disturbance in bactericidal power of neutrophils in 25 children having protein
caloric malnutrition age and sex matched healthy control subjects. There was a highly significant reduction in the percentage
of bacteria killed during incubation in children having PCM as compared to healthy control. A direct relationship existed
between total serum proteins and bactericidal activity of neutrophils in children having PCM. The impaired bactericidal power
of neutrophils can be attributed to impaired synthesis of lysosomal enzymes, glycolytic activity of neutrophils in children
having PCM. The exact mechanisms still remain to be elucidated. Decreased bactericidal activity of neutrophils may be one
of the mechanisms responsible for infection. 相似文献
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