急性心肌梗死后近期二尖瓣环运动速度的测定

目的:应用多普勒组织成像(DTI)测定二尖瓣环运动速度,定量分析急性心肌梗死(AMI)后近期患者的左室收缩和舒张功能。方法:研究对象为68例确诊首次AMI的患者和22例正常人。所有患者于发病后第3天、出院前、发病后4周、发病后12周,行常规超声心动图检查及DTI测定二尖瓣环运动速度频谱。结果:68例患者中有56例患者完成了12周的随访。随访的12周内,患者二尖瓣环收缩期运动速度(Sm)、二尖瓣环舒张早期运动速度(Em)始终低于对照组;除AMI后第3天以外,患者的二尖瓣环舒张晚期运动速度(Am)始终低于对照组、E/Em始终高于对照组。AMI后12周时的Sm、Em及Am均低于AMI后第3天水平(均P<0·05)。结论:DTI测量二尖瓣环运动速度,可作为定量检测AMI患者近期心脏功能状态的一种方法,具有一定的应用价值。AMI患者近期组织多普勒参数的变化需进一步研究。     

多普勒组织成像对正常人左心室收缩功能的分析

目的 :应用多普勒组织成像脉冲技术评价正常人左心室整体收缩功能。研究二尖瓣环舒缩速度与左心室整体收缩功能间的相关性 ,以及观察二尖瓣环舒缩速度与左心室射血分数间是否存在直线回归关系。方法 :转换多普勒组织成像速度模式 ,取心尖四腔心、二腔心、心尖左心室长轴切面 ,分别测量二尖瓣环后间隔、侧壁、前壁、下壁、前间隔及后壁的舒张早期峰值速度 (E)、舒张晚期峰值速度 (A)、收缩期峰值速度 (S)。应用改良Simpson法测量左心室射血分数。结果 :左心室射血分数与二尖瓣环前间隔S、E与肺静脉D波比值 (E/D) ,后间隔S ,前壁与后壁的E/D存在直线相关关系。结论 :多普勒组织成像测量二尖瓣环舒缩速度可反映左心室整体收缩功能。并且发现左心室收缩功能不仅与二尖瓣环收缩速度有关 ,而且与舒张速度也相关。二尖瓣环前间隔是反映这一现象的最好位点。     

组织多普勒显像评价终末期肾病患者的心室功能

目的 探讨组织多普勒显像参数评价终末期肾病患者心室功能的价值.方法 健康成人和左心室射血分数正常的终末期肾病患者各31例,均行二维及组织多普勒显像检测,记录左心室射血分数、左心室舒张末期内径、左心室收缩末期内径、室间隔和左心室后壁厚度;二尖瓣和三尖瓣口舒张早期及舒张晚期峰速,计算二尖瓣和三尖瓣口舒张早期与舒张晚期峰速之比.组织多普勒显像下心尖四、两腔测定左心室后间隔、侧壁、前壁、下壁以及右心室侧壁的收缩期运动速度、舒张早期和舒张晚期运动速度,计算二尖瓣和三尖瓣口舒张早期峰速与舒张早期运动速度之比、舒张早期运动速度与舒张晚期运动速度之比.比较两组左、右心室超声参数.结果 与健康成人相比,终末期肾病患者二尖瓣和三尖瓣口舒张早期峰速与舒张晚期峰速之比、二尖瓣和三尖瓣环平均收缩期运动速度、舒张早期运动速度、舒张早期运动速度与舒张晚期运动速度之比均减低;二尖瓣舒张早期峰速与舒张早期运动速度之比增高(P<0.05).结论 终末期肾病患者左、右心室存在舒张功能障碍,收缩功能亦受损;左心室射血分数正常的终末期肾病患者收缩功能亦受损.     

应用多普勒组织成像评价冠心病患者左心室舒张功能

目的 :探讨应用多普勒组织成像 （DTI）检测二尖瓣环运动速度评估冠心病左室舒张功能的临床应用价值。方法 :应用 DTI技术 ,对 5 3例冠心病患者和 48例正常对照者二尖瓣环运动速度进行测定 ,并与常规多普勒超声心动图检查结果对照分析。结果 :与正常组相比 ,冠心病患者舒张早期 DTI速度峰值 （Ve）显著减低 （P<0 .0 1） ,舒张早期与舒张晚期 DTI速度峰值的比值 （Ve/ Va）显著减低 （P<0 .0 5 ）。冠心病患者 Ve/ Va比值异常检出率显著高于二尖瓣血流 E/ A比值的异常检出率 （P<0 .0 5 ）。 Ve/ Va比值与 E/ A比值之间存在高度相关性 （P<0 .0 1）。结论 :DTI技术检测二尖瓣环舒张期运动速度参数可用于无创评价冠心病左室舒张功能 ,尤其对鉴别伪正常具有一定应用价值。     

应用组织多普勒成像技术对前壁心肌梗死左心室舒张功能的诊断研究

目的应用组织多普勒成像技术(DTI)诊断前壁心肌梗死左心室舒张功能。方法陈旧性前壁心肌梗死组患者45例,对照组健康成年人42例。均行二维超声心动图及DTI检查。结果心肌梗死组与对照组DTI测值比较:心肌梗死组梗死节段收缩期波峰值速度(Vs),舒张早期波峰值速度(Ve)明显低于对照组。二尖瓣环DTI心肌梗死组舒张期早期速度(Ea)明显低于对照组,而舒张晚期速度无显著差异。结论DTI为定量分析左心室舒张功能提供了有效检测手段。     

多普勒组织成像评价高血压患者的左心室舒张功能

目的　探讨应用多普勒组织成像 ( DTI)检测二尖瓣环舒张期运动速度评价原发性高血压左心室舒张功能的价值。方法　应用多普勒组织成像技术对 5 6例原发性高血压患者和 30例正常对照者二尖瓣环运动速度进行测定 ,并与常规多普勒超声心动图检测结果对照分析。结果　根据二尖瓣血流 E/A比值分组讨论 :1E/A<1(弛缓异常组 ) ,二尖瓣环 Ea/Aa和二尖瓣血流 E/A有较高的符合率。 2 E/A>1(假性正常组 ) Ea较正常组明显减低 ,Ea/Aa和二尖瓣血流 E/A相比有显著差异。结论　 DTI技术检测二尖瓣环舒张期运动速度可用于评价高血压患者左心室舒张功能     

多普勒组织显像测定正常人二尖瓣环运动速度

<正> 应用多普勒组织显像(DTI)技术测定二尖瓣环运动速度,探讨无创评价左心室收缩舒张功能的新方法。1资料与方法 正常人150例,其中男79例,年龄22-75岁,平均45岁,女71例,年龄21-74岁,平均44岁。分为≥45岁组和<45岁组两组。用Aspen声像仪,探头频率2-4MHz,于心尖四腔切面测二尖瓣前后瓣环收缩期运动速度(S),舒张早期运动速度(E),舒张晚期运动速度(A)。     

阻塞性睡眠呼吸暂停低通气综合征病人心脏结构及左心室功能变化研究

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)病人心脏结构及左心室功能的变化。方法选取我院60例OSAHS病人为观察组;我院门诊健康体检者60名为对照组。两组均接受彩色多普勒超声检测仪检查心脏结构和左心室舒张功能,并测定每搏量(SV)、左室短轴缩短率(FS)、左室射血分数(LVEF)、心输出量(CO)。比较两组心脏结构和左心室舒张功能的变化。结果观察组病人左室舒张末内径(LV)、左室后壁厚度(LVPW)、左房舒张末内径(LA)、室间隔厚度(IVS)、右室舒张末内径(RV)、肺动脉内径(PA)、右房舒张末内径(RA)、主动脉内径(AO)指标均高于对照组(P0.05);观察组病人二尖瓣血流频谱二尖瓣舒张早期血流速度(E)、E/二尖瓣舒张晚期血流速度(A)、室间隔舒张早期运动速度(Em)、室间隔Em/舒张晚期运动速度(Am)、左室后壁Em、左室后壁Em/Am、二尖瓣环Em、二尖瓣环Em/Am功能均低于对照组(P0.05),二尖瓣环Am、室间隔Am、左室后壁Am均高于对照组(P0.05);观察组病人FS、LVEF、二尖瓣环收缩期运动速度(Sm)、室间隔Sm及左室后壁Sm功能均低于对照组(P0.05)。结论 OSAHS病人心脏结构发生明显变化,且左心室收缩、舒张功能明显减弱。     

脉冲波组织多普勒超声心动图检测肥胖患者心脏结构和心功能

目的:应用脉冲波组织多普勒超声心动图检测超重和单纯肥胖患者的心脏结构和心功能,以探讨单纯肥胖患者早期心脏功能的改变。方法:根据体重指数将143例无其他心血管疾病者分为正常体重组(体重指数18.5～23.9kg/m2,n=57),超重组(体重指数24.0～27.9kg/m2,n=53),肥胖组(体重指数≥28.0kg/m2,n=33),比较各组间左心房内径(LAD)、室间隔(IVS)厚度、左心室后壁(PW)厚度、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室重量(LVM)、左心室射血分数(LVEF)、二尖瓣舒张早期血流速度峰值(E)和二尖瓣舒张晚期血流速度峰值(A);脉冲波组织多普勒超声心动图测量二尖瓣环侧壁收缩期运动峰速度(Sm)及二尖瓣环侧壁舒张早期运动峰速度(Em),E/A,E/Em的差异,并分析这些指标与体重指数的相关性。结果:与正常体重组比较,超重组左心房内径增大、室间隔增厚,差异有统计学意义(P0.05)。与正常体重组比较,肥胖组左心房内径、舒张末期室间隔厚度、左心室后壁厚度、左心室舒张末期内径、左心室收缩末期内径、左心室重量均增加,二尖瓣环侧壁收缩期运动峰速度、二尖瓣环侧壁舒张早期运动峰速度下降,而E/Em增加,差异均有统计学意义(P0.05)。心脏结构和心功能变化与体重指数的相关性:左心房内径,舒张末期室间隔厚度,左心室后壁厚度,左心室舒张末期内径、左心室收缩末期内径、左心室重量与体重指数呈正相关,传统的表示左心室收缩功能和舒张功能的超声参数左心室射血分数、E/A与体重指数均无相关性,而脉冲波组织多普勒超声心动图参数二尖瓣环侧壁收缩期运动峰速度、二尖瓣环侧壁舒张早期运动峰速度与体重指数呈负相关,E/Em与体重指数呈正相关。结论:单纯肥胖可导致左心房内径、左心室壁厚度、左心室内径增加,而脉冲波组织多普勒超声心动图能够早期检测出肥胖所致的亚临床收缩及舒张功能的改变。     

组织多普勒成像联合血浆N末端B型钠尿肽原评价左心室舒张功能

目的应用组织多普勒成像技术结合血浆N末端B型钠尿肽原（NT—proBNP）共同评价左心室舒张功能。方法随机选择120例左心室舒张性心力衰竭患者为研究组,120例心功能rF常且无心力衰竭症状和依据的患者为对照组。分别测取患者血浆NT—proBNP水平、左心室射血分数（排除收缩性心力衰竭患者）,二尖瓣血流频谱舒张早期速度（E）和二尖瓣血流频谱舒张晚期速度（A）并计算其比值E／A,二尖瓣环室间隔舒张早期峰值速度（Esep）和左心室游离壁舒张早期峰值速度（Elat）,两者的均值作为二尖瓣环舒张早期速度（Em）,并计算二尖瓣血流频谱舒张早期速度E和二尖瓣环舒张早期速度Em的比值E／Era,综合评价左心室舒张功能。结果研究组与对照组比较,平均血浆NT—proBNP水平增高（P〈0．01）,E／Era增大（P〈0．01）,E／A减小（P〈0．01）。研究组、对照组患者的平均血浆NT—proBNP水平与E／Era呈正相关。利用E／Em检出左心率舒张性心力衰竭阳性率高于E／A,联合NT—proBNP和E／Em诊断左心室舒张性心力衰竭阳性预测值为94％,阴性预测值为83％。结论血浆NT—proBNP水平与组织多普勒成像左心室舒张功能参数E／Em之间存在明显的相关性,联合NT—proBNP和E／Em较E／A能更好的诊断左心室舒张忡心力衰竭。     

多普勒组织成像和组织追踪技术对正常人心室长轴功能评价

目的探讨正常人左、右心室长轴功能的变化,为临床心脏功能评价提供正常值参考。方法应用脉冲多普勒组织超声技术和组织追踪技术观察110名正常成年人二尖瓣环和三尖瓣环不同位点,收缩峰值速度（Sm）,舒张早期峰值速度（Em）、舒张晚期峰值速度（Am）、Em/Am比值和各位点位移（D）的平均值,比较不同年龄组多普勒组织速度和位移,分析其变化规律和特点。结果二尖瓣环各位点Sm和D随着年龄段的增加而显著降低,左心室前壁和侧壁Sm和D高于其它位点,二尖瓣环平均Sm与年龄和左心室射血分数（LVEF）显著相关;二尖瓣环各位点Em和Em/Am随年龄明显降低,平均Em降低的年龄段比二尖瓣舒张早期充盈速度（E峰）早;三尖瓣环Sm与年龄无关,Em和Em/Am随年龄而明显降低。结论二尖瓣环和三尖瓣环多普勒组织速度和位移随年龄出现不同的变化特点,多普勒组织成像对舒张功能变化比传统超声心动敏感。     

Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value

OBJECTIVES: The aim of this study was to ascertain if left ventricular mitral annulus velocities measured by tissue Doppler imaging (TDI) are more powerful predictors of outcome compared with clinical data and standard Doppler-echocardiographic parameters. BACKGROUND: Tissue Doppler imaging of basal or mitral annulus velocities provides rapid assessment of ventricular long axis function. But it is not known if TDI-derived velocities in systole and diastole add incremental value and are superior to the standard Doppler-echocardiographic measurements as a predictor of outcome. METHODS: The study population consisted of 518 subjects, 353 with cardiac disease and 165 normal subjects who had full Doppler two-dimensional-echocardiographic studies with measurement of mitral inflow velocities in early and late diastole, E-wave deceleration time (DT), peak systolic mitral annular velocity (Sm) early and late diastolic mitral annular velocity (Em and Am) by TDI, early diastolic flow propagation velocity, and standard chamber dimensions. All subjects were followed up for two years. The end point was cardiac death. RESULTS: Tissue Doppler imaging mitral annulus systolic and diastolic velocities were all significantly lower in the non-survivors (all p < 0.05) as was DT (p = 0.024). In the Cox model the best predictors of mortality were Em, Sm, Am, left ventricular ejection fraction, left ventricular mass, and left atrial diameter in systole (LADs). By backward stepwise analysis Em and LADs were the strongest predictors. After forcing the TDI measurements into the covariate model with clinical and mitral DT <0.16 s, Em provided significant incremental value for predicting cardiac mortality (p = 0.004). CONCLUSIONS: Mitral annulus velocity measured by TDI in early diastole gives incremental predictive power for cardiac mortality compared to clinical data and standard echocardiographic measurements. This easily available measurement adds significant value in the clinical management of cardiac patients.     

超声心动图对老年舒张性心力衰竭患者心脏结构和功能改变的评价

目的通过超声心动图检查探讨老年舒张性心力衰竭(diastolic heart failure,DHF)患者心脏结构及舒张和收缩功能的变化情况。方法对129例老年DHF患者(DHF组)和79例年龄匹配的健康老年人(对照组)进行超声心动图检查,测量左心室容积、左心房容积、左心室质量,获取二尖瓣血流、右上肺静脉血流频谱,用组织多普勒测量二尖瓣环心室长轴方向的收缩期心肌峰值运动速度(Sm)、舒张早期心肌峰值运动速度(Em)等值,并进行分析。结果与对照组比较,DHF组患者左心室舒张末容积指数轻度增大,左心室质量指数明显增大,左心房容积指数明显增大,Sm和Em均明显下降,差异均有统计学意义(P0.01)。相关分析显示,Sm与左心室质量指数独立相关(β=-0.018,P0.01),左心房容积指数与老年DHF患者舒张功能不全程度独立相关(β=0.002,P0.01)。结论老年DHF患者总体表现为显著的向心性增厚,左心房的大小与舒张功能受损程度相关;收缩与舒张功能的损害,可能共同参与老年DHF发生和发展的过程。     

Assessment of left ventricular functions in patients with isolated coronary artery ectasia by conventional and tissue Doppler imaging

The authors sought to determine left ventricular functions by conventional and tissue Doppler imaging in patients with isolated coronary artery ectasia and controls. Peak early (E) and late (A) mitral inflow velocity, E/A ratio, E deceleration time, and isovolumetric relaxation time were obtained. Peak systolic velocity (Sm), diastolic early (Em), and late (Am) velocities were measured by tissue Doppler imaging. Interventricular septum velocities, including peak systolic (Ss), diastolic early (Es), and late (As) velocities, were recorded. Peak early (E) velocity, E/A ratio, and E deceleration time were different in both groups. Isovolumetric relaxation time was prolonged in patients with coronary artery ectasia than controls. Em and Em/Am ratio were lower in patients with coronary artery ectasia than controls. Diastolic early and Es/As velocities were lower in patients with coronary artery ectasia compared with controls. The authors showed that mitral inflow-lateral annulus and interventricular septum velocities were lower in patients with coronary artery ectasia than controls indicating left ventricular diastolic dysfunction.     

Assessment of left ventricular ejection fraction using long-axis systolic function is independent of image quality: a study of tissue Doppler imaging and m-mode echocardiography

Background: Quantitative assessment of left ventricular ejection fraction (LVEF) is technically difficult in patients with poor image quality (IQ). Mitral annulus velocity assessed by pulsed tissue Doppler imaging (TDI) and mitral annulus motion assessed by M-mode echocardiography has been shown to correlate with LVEF. Furthermore, mitral annulus sites are easy to identify even in patients with poor IQ. The purpose of this study was to determine whether these methods are useful for estimating LVEF in patients with poor IQ. Methods: One hundred ten patients underwent TDI and M-mode echocardiography simultaneously. Mitral annulus velocity and mitral annulus motion were obtained from each of the four mitral annulus sites. Mean mitral annular peak systolic velocities (Sm) and mean mitral annular motions (MAM) were calculated by averaging at each site. IQ was defined according to a previous report. Results: Both Sm and MAM were successfully measured in all patients. Mean Sm and mean MAM correlated with LVEF. These correlations were observed not only in patients with good IQ (p < 0.001, r = 0.61 for mean Sm; p < 0.001, r = 0.61 for mean MAM) or fair IQ (p < 0.001, r = 0.58 for mean Sm; p < 0.001, r = 0.68 for mean MAM) but also in patients with poor IQ (p < 0.05, r = 0.42 for mean Sm, p < 0.001, r = 0.61 for mean MAM). Using optimal cutoff values of mean Sm and mean MAM in each IQ group, sensitivity and specificity for identifying LVEF < 50% were comparable among three IQ groups. Conclusions: Assessment of long-axis systolic function by TDI and M-mode echocardiography enables estimation of LVEF even in patients with poor IQ.     

Assessment of left ventricular systolic and diastolic function by tissue Doppler analysis in patients with hypertension with or without hyperuricemia

OBJECTIVE: Hyperuricemia (HU) is a well-recognized risk factor for cardiovascular diseases. The independence of this association from other confounding factors has remained controversial. The possible contributory effect of HU to myocardial impairment produced by hypertension (HT), however, has not been clarified yet. The study was designed to assess the left ventricular (LV) systolic and diastolic function in patients with HT with or without HU. Tissue Doppler imaging (TDI) was used for detailed analysis as this method was superior to other conventional echocardiographic techniques. METHODS: The study participants consisted of 27 patients (men 56%, mean age+/-SD; 55+/-10 years) with HT without HU, and 27 patients with HT with HU (men 62%, mean age+/-SD; 56+/-9 years), and 27 age-matched healthy control participants (men 57%, mean age+/-SD; 53+/-11 years). Cardiac functions were determined using echocardiography, comprising standard two-dimensional and conventional Doppler and TDI. Peak systolic myocardial velocity at mitral annulus (Sm), mitral inflow velocities and early diastolic mitral annular velocity (Em), late diastolic mitral annular velocity (Am), peak systolic mitral annular velocity, Em/Am, and myocardial performance index were calculated by TDI. RESULTS: Mitral inflow velocities and tissue Doppler-derived mitral annular diastolic velocities were significantly different in the patient groups (HT without HU and HT with HU) compared with the control cases. Tissue Doppler-derived myocardial performance index (LV-MPI) was significantly impaired in the patient groups compared with those of the control's (0.48+/-0.09, 0.53+/-0.07, and 0.39+/-0.07, respectively, P<0.001). Significant differences were also observed between the patients who had HT without HU and the patients who had HT with HU regarding LV-MPI. Significant correlations were observed between the serum uric acid levels and LV function parameters.     

Assessment of left ventricular diastolic function and Tei index by tissue Doppler imaging in patients with Cushing's Syndrome

Background: The aim of this study was to assess left ventricular (LV) function and the Tei index by tissue Doppler imaging (TDI), and also to evaluate the relationship of serum cortisol level with the Tei index and LV function in patients with Cushing's Syndrome (CS). Methods: We prospectively evaluated 22 patients with CS and 23 control subjects. LV function was assessed by echocardiography. Early diastolic (Em), late diastolic (Am), peak systolic (Sm), mitral annular velocities, Em/Am, the Tei index, and E/Em were calculated by TDI. Mitral inflow velocities, color M-mode flow propagation velocity (Vp), relative wall thickness (RWT), and LV mass index (LVMI) were assessed by two-dimensional echocardiography. Result: Peak (E) velocity and the ratio of E to peak late (A) velocity (E/A) were lower in those with CS than in those without. Patients with CS had significantly higher RWT, IVRT, and LVMI than those controls. Vp was lower in the CS-patients than that in control subjects. Em and Em/Am were lower in patients with CS than those in controls. In patients with CS, the Tei index was significantly higher than control subjects. Conclusion: Serum cortisol level was positively correlated with the Tei index and E/Em ratio but negatively correlated with Em, Sm, and EF only in patients with CS. Serum cortisol level positively correlated with the Tei index and E/Em ratio but negatively correlated with Em, EF, and Sm. The parameters obtained from lateral mitral annulus by TDI can be used for identification of LV diastolic dysfunction in patients with CS.     

Assessment of left ventricular function by Doppler tissue imaging in patients with atrial fibrillation following acute myocardial infarction

AIMS: We studied tissue Doppler parameters in patients with atrial fibrillation following acute myocardial infarction, and their relation to P wave durations and P dispersion. METHODS: Echocardiographic examination was performed in 84 consecutive patients with first anterior acute myocardial infarction. In addition to other conventional echocardiographic parameters, the peak systolic (Sm), early diastolic (Em) and late diastolic (Am) velocities were obtained at the lateral corner of the mitral annulus by pulsed wave tissue Doppler. The Em/Am ratio and the ratio of early diastolic mitral inflow velocity to Em (E/Em), which is a marker of diastolic filling pressure, were calculated. Electrocardiogram was recorded from all patients on admission; P wave measurements were also performed. RESULTS: Atrial fibrillation occurred in 20 (23.8%) of 84 patients. The patients with atrial fibrillation had significant reduction of Em (5.6+/-1.5 vs. 8.7+/-2.7 cm/s, p < 0.001), Em/Am (0.61+/-0.27 vs. 0.84+/-0.23, p = 0.001) and Sm (7.1+/-1.0 vs. 8.3+/-1.9 cm/s, p < 0.001) values compared with those without. The E/Em ratio (14.45+/-4.62 vs. 7.47+/-2.79, p < 0.001), P maximum (102+/-11 vs. 95+/-11 ms, p = 0.02) and P dispersion (35+/-7 vs. 26+/-7 ms, p < 0.001) were significantly higher in patients with atrial fibrillation than in those without. In all patients, P dispersion showed significant correlation with Em (r = -0.33, p = 0.002), Sm (r = -0.40, p < 0.001) and E/Em (r = 0.32, p = 0.003). When E/Em > or = 10 was used as cutpoint, atrial fibrillation could be predicted with a sensitivity of 90%, and a specificity of 84%. CONCLUSIONS: The patients with atrial fibrillation following acute myocardial infarction have reduced systolic and diastolic mitral annular velocities and increased E/Em ratio, P maximum and P dispersion values compared to those without. P dispersion is correlated with systolic and diastolic left ventricular function after acute myocardial infarction. The E/Em ratio appears to be a useful parameter for assessing the risk of atrial fibrillation occurrence after anterior acute myocardial infarction.     

多普勒组织成像评价肥厚型心肌病左室舒张功能

目的应用多普勒组织成像脉冲技术测量二尖瓣环舒张速度,以评价肥厚型心肌病左室舒张功能.方法对90例肥厚型心肌病患者及50例正常人进行常规超声心电图及多普勒组织成像检查,测量各房室内径,室壁厚度,射血分数及二尖瓣环各点舒张早期峰值速度(Ea)、舒张晚期峰值速度(Aa).两组指标比较采用成组t检验.结果肥厚型心肌病患者室间隔厚度(25.5±6.6)mm,左室后壁厚度(9.9±2.3)mm,左室内径(42.9±5.9)mm,左房内径(39.9±4.7)mm,LVEF(71.9±4.3)%,二尖瓣血流E/A为1.42±0.7.肥厚型心肌病患者Ea较正常人减低.Aa无明显差异.结论肥厚型心肌病左室长轴主动松弛功能较正常人减低.