窄谱中波紫外线联合局部序贯疗法治疗寻常型银屑病近期临床观察

目的评价窄谱中波紫外线(NB-UVB)联合卡泊三醇和哈西奈德局部序贯疗法治疗寻常型银屑病的疗效及不良反应。方法57例患者随机分为联合组(NB-UVB联合局部序贯疗法)及NB-UVB治疗组,以银屑病面积和严重度指数(PASI)评价疗效。结果联合组比NB-UVB组起效更迅速,不良反应发生率低。结论窄谱中波紫外线联合局部序贯疗法治疗寻常型银屑病疗效高,安全性好。     

卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病临床观察

目的:观察卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病的疗效及安全性.方法:76例银屑病患者随机分为卡泊三醇组(A组)36例和卡泊三醇软膏和卤米松乳膏序贯治疗组(B组)40例,A组患者每日涂药2次,B组患者按银屑病的序贯疗法用药.两组患者在疗后的第2周、4周、6周根据银屑病皮损而积和严重度指数(PASI)评分评判疗效,根据不良事件发生率分析其安全性.结果:随着疗程的增加两组患者的PASI评分均逐渐下降(P<0.01),B组下降更为明显(P<0.05);A组患者在治疗后2周、4周和6周的有效率分别为30.56%、55.56%和66.67%:B组患者的有效率分别为52.50%、67.50%和82.50%.B组的疗效明显优于A组(P<0.01);B组的不良事件发生率亦明显低于A组(P<0.01).结论:卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病具有起效快、疗效好、不良反应小的优点.     

卡泊三醇软膏联合卤米松乳膏治疗神经性皮炎疗效观察

目的评价卡泊三醇软膏联合卤米松乳膏治疗神经性皮炎的疗效和安全性。方法将87例神经性皮炎患者随机分为两组。治疗组:采用卡泊三醇软膏联合卤米松乳膏治疗;对照组:单用卤米松乳膏治疗,治疗1周和3周后进行疗效评定,随访6个月观察其复发率。结果治疗组的有效率为88.89%,对照组的有效率为69.05%,治疗组治疗1周及疗程结束后的总积分改善、有效率、复发率均优于对照组,差异有统计学意义。在不良反应方面,两组患者差异无统计学意义。结论卡泊三醇软膏联合卤米松乳膏治疗神经性皮炎的疗效较单独使用卤米松乳膏好,起效快,复发率低。     

卡泊三醇与卤米松序贯疗法治疗稳定期斑块状银屑病临床观察

目的探讨卡泊三醇与卤米松序贯疗法治疗稳定期斑块状银屑病的疗效与安全性。方法将120例患者随机分为三组,治疗组早晨外用卡泊三醇1次/d,晚上外用卤米松1次/d,对照Ⅰ组仅用卡泊三醇2次/d,对照Ⅱ组仅用卤米松2次/d。均治疗4周后观察疗效。结果卡泊三醇与卤米松序贯治疗组有效率(81.58%)与卡泊三醇(62.86%)及卤米松组(60.00%)相比,差异有统计学意义(P均<0.05),且不良反应少。结论卡泊三醇与卤米松序贯疗法治疗稳定期斑块状银屑病疗效好,不良反应少。     

皮肤镜观察外用药物治疗寻常性银屑病的效果及分析

目的皮肤镜动态观察寻常性银屑病外用卤米松乳膏、卡泊三醇软膏和卤米松乳膏/卡泊三醇软膏治疗后的疗效,及皮损血管的改变和临床评分mPASI的相关性。方法选择2018年6月-2018年9月在本院就诊的30例寻常性银屑病患者,随机分为2组,一组给予卤米松乳膏外用,另一组给予卡泊三醇软膏外用,30例患者的一侧上肢皮损给予卤米松乳膏/卡泊三醇软膏外用。患者于治疗0、2、4及6周使用皮肤镜观察皮损处血管的变化,同时对观察皮损做mPASI评分并记录,比较3种治疗方法的皮损mPASI评分与血管指标的差异及治疗后mPASI评分与血管直径随时间的关系。结果卤米松乳膏/卡泊三醇软膏的局部治疗皮损临床评分和皮肤镜血管变化(血管直径及血管密度)与单独外用卤米松乳膏、卡泊三醇软膏的恢复更明显。银屑病皮损临床评分mPASI与血管球直径随时间的变化趋势一致。结论卤米松乳膏/卡泊三醇软膏局部外用治疗寻常性银屑病的效果优于单独应用;皮肤镜在银屑病皮损恢复情况及临床药物疗效的观察中具有临床价值。     

卡泊三醇软膏和卤米松乳膏序贯疗法治疗寻常性银屑病疗效观察

笔者于2006年10月-2008年4月采用卤米松乳膏和卡泊三醇软膏序贯疗法治疗寻常性银屑病,取得较好疗效,现报告如下.     

氟芬那酸丁酯软膏联合卤米松乳膏序贯疗法治疗寻常型银屑病的随机对照研究

目的观察氟芬那酸丁酯软膏联合卤米松乳膏序贯疗法治疗寻常型银屑病的疗效和安全性。方法将120例患者随机分为治疗组(氟芬那酸丁酯软膏联合卤米松乳膏组)和对照组(他卡西醇软膏联合卤米松乳膏组),采用序贯疗法进行治疗,疗程8周。评价患者的银屑病面积和严重程度指数(PASI)评分并进行组间比较。结果治疗4周(66.7%vs 61.7%),8周(86.7%vs 88.7%)及治疗结束后4周(95.0%vs 93.7%)2组有效率(痊愈率加显效率)差异无统计学意义(P0.05),2组患者均未发生严重不良反应。结论氟芬那酸丁酯软膏联合卤米松序贯疗法治疗寻常型银屑病安全有效。     

中药痒疹方联合卡泊三醇软膏及卤米松乳膏治疗结节性痒疹29例临床观察

目的观察中药痒疹方联合卡泊三醇软膏和卤米松乳膏治疗结节性痒疹的临床疗效和安全性。方法将入选的87例结节性痒疹患者随机分为3组,各29例。全部患者日煎1剂中药痒疹方(组分:生地、土茯苓和蒺藜各30g,金银藤15g,荆芥、防风、红花、赤芍、三棱和莪术各10g)分早、晚服用。另外,治疗组每日早、晚各1次外搽卡泊三醇软膏,对照组每日早、晚各1次外搽卤米松乳膏,联合治疗组每日晨外搽卡泊三醇软膏1次,晚间外搽卤米松乳膏0.5h后再外用卡泊三醇软膏1次。治疗4周后判定疗效,治疗结束后随访2个月。结果治疗4周后,3组患者的结节数目、瘙痒程度和皮损积分均优于其治疗前,且联合治疗组均低于对照组和治疗组,联合治疗组有效率(75.86%)高于对照组(62.07%)和治疗组(51.72%),差异均有统计学意义(P均<0.05)。三组患者均无不良反应。结论中药痒疹方联合卡泊三醇软膏和卤米松乳膏治疗结节性痒疹疗效显著,无不良反应。     

卡泊三醇联合氟轻松序贯治疗头皮银屑病疗效观察

目的:评价卡泊三醇联合氟轻松治疗头皮银屑病的疗效及安全性。方法:70例患者随机分为序贯治疗组和对照组。序贯治疗组:外用卡泊三醇搽剂和氟轻松溶液;对照组外用卡泊三醇搽剂。治疗后第2、4、8周末进行疗效评价。结果:治疗2、4、8周后序贯治疗组有效率(48.57%、71.43%和91.43%)均明显高于对照组(25.71%、40.00%和60.00%),组间差异均有统计学意义(P0.05)。结论:卡泊三醇搽剂联合氟轻松溶液序贯疗法治疗头皮银屑病起效快、疗效好且不良反应小。     

阿法骨化醇联合卤米松及NB-UVB治疗进展期白癜风45例临床观察

目的观察阿法骨化醇联合卤米松及NB-UVB治疗进展期白癜风的临床疗效和安全性。方法 87例进展期白癜风患者随机分为两组,其中治疗组45例,予口服阿法骨化醇0.5μg 1次/d,卤米松外用皮损2次/d及NB-UVB隔日1次照射治疗,对照组42例予卤米松外用皮损2次/d及NB-UVB隔日1次照射治疗,疗程24周。分别于治疗后8、16、24周时进行疗效评价并记录不良反应。结果治疗后8、16、24周时,治疗组有效率分别为17.78%、31.11%和57.78%,对照组分别为7.14%、16.66%和23.81%,治疗组有效率高于对照组,差异有统计学意义(P均0.05)。两组中不同分型的白癜风治疗后有效率差异无统计学意义(P0.05),治疗过程中均未见明显不良反应。结论阿法骨化醇联合卤米松及NB-UVB治疗进展期白癜风患者疗效好,安全性高。     

Development of squamous cell carcinoma on an inflammatory linear verrucous epidermal nevus in the genital area

Inflammatory linear verrucous epidermal nevus is a rare cutaneous disorder characterized by pruritic, erythematous, and verrucous papules and plaques along the lines of Blaschko. Histopathologically, there is a benign verrucous proliferation of keratinocytes together with alternating parakeratosis and orthokeratosis as well as inflammatory changes. We report a patient who developed squamous cell carcinoma (SCC) on an inflammatory linear verrucous epidermal nevus and we discuss the importance of regular follow-up of patients with epidermal nevi.     

Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case

Inflammatory linear verrucous epidermal nevus is a variant of verrucous epidermal nevus, characterized by recurrent inflammatory phenomena. Despite well-established clinical manifestations, the differential diagnosis between inflammatory linear verrucous epidermal nevus and linear psoriasis remains difficult. Clinical history, physical examination and histopathology analysis may not be sufficient to confirm the diagnosis. We report the case of a 4-year-old girl in which the involucrin immunostaining was helpful in the diagnosis of inflammatory linear verrucous epidermal nevus. Our findings confirm that involucrin immunohistochemistry is a useful tool in such cases.     

Inflammatory linear verrucous epidermal nevus associated with erosive monoarthritis

Inflammatory linear verrucous epidermal nevus and linear psoriasis are different entities with clinical and histopathologic similarities. Isolated reports of inflammatory linear verrucous epidermal nevus with concomitant psoriasis or a positive family history of psoriasis have been described, and the possibility that inflammatory linear verrucous epidermal nevus may be a mosaic form of cutaneous psoriasis has been postulated. We report a 17‐year‐old boy with a congenital, linear, erythematous, keratotic plaque on the dorsum of the fifth finger of the left hand with ipsilateral nail dystrophy. Histopathologic examination showed epidermal hyperplasia with alternating orthokeratosis and parakeratosis. During follow‐up, he developed erosive monoarthritis of the distal interphalangeal joint. This case seems to confirm the association between inflammatory linear verrucous epidermal nevus and arthritis and supports a possible relationship between inflammatory linear verrucous epidermal nevus and psoriasis.     

Dithranol in the treatment of inflammatory linear verrucous epidermal nevus

A case of inflammatory linear verrucous epidermal nevus (ILVEN) is reported. Short contact treatment with dithranol resulted in complete relief from itching and a remarkable clearing of all linear lesions except from a small verrucous band on the shin. In patients with ILVEN it is advisable to try dithranol therapy before carrying out surgical procedures such as excision, cryotherapy, electrocautery. The prompt response to dithranol is best explained by the assumption that most of the lesions in this case of ILVEN represented true linear psoriasis.     

Case for diagnosis. Inflammatory linear verrucous epidermal nevus

Inflammatory linear verrucous epidermal nevus (Ilven) is a rare variant of epidermal verrucous nevus that commonly affects females. Clinically is characterized by the appearance, since birth, of recurrent inflammatory phenomena with chronic eczematous or psoriasiform aspects, usually unilateral, with severe pruritus, and refractory to therapy.     

Unilateral psoriasis: a case individualized by means of involucrin

Several authors have questioned the existence of unilateral (linear) psoriasis. These authors have suggested that the condition is actually an inflammatory linear verrucous epidermal nevus, or the result of an isomorphic effect on a pre-existing epidermal nevus. We report the case of a 25-year-old man, with no relevant personal or family history, who presented with a number of pruritic, punctiform erythematosquamous lesions that were linearly distributed over the left side of the body. Clinical examination and results of histopathologic and histochemical studies indicated unilateral psoriasis. Our findings confirm that involucrin immunohistochemistry can be a useful diagnostic tool in cases of this type. Treatment with keratolytics and topical calcipotriol led to a significant, but only temporary, improvement.     

手术治疗炎症型线状表皮痣1例

患儿女,11岁,左侧大腿淡红色斑块、丘疹10年余。组织病理示:表皮角化过度,伴角化不全,棘层肥厚,呈银屑病样增生,真皮内炎症细胞浸润。诊断:炎症型线状表皮痣。予手术切除后愈后良好,患者仍在随访中。     

Two cases of unilateral verrucous nevus.

We report two patients with epidermal nevus: one with linear verrucous nevus and one with inflammatory linear verrucous epidermal nevus. The patients first showed manifestations of nevus at different ages (soon after birth and at the age of seven), and the findings progressed differently. In both cases, warty plaques were located unilaterally, strictly following Blaschko's lines.     

Adult onset of inflammatory linear verrucous epidermal nevus.

Adult onset of inflammatory linear verrucous epidermal nevus (ILVEN) is reported in a 44-year-old Japanese man. A mild pruritic eruption appeared one year earlier and extended from the left dorsal foot to the gluteal region. Histologically, acanthosis and papillomatous thickening of epidermis as well as spongiotic edema and exocytosis with lymphocytes and neutrophils were observed. Topical tacalcitol was not effective, but the pruritus as well as the eruption slightly improved with topical corticosteroid and vaseline containing salicylic acid. This adult onset of ILVEN is considered to be a rare case.