先天型淋巴水肿伴疣状表皮痣一例北大核心CSCD

患者女,47岁,左下肢肿胀47年,左足疣状表皮痣30余年、患者于出生2个月后发现左下肢较右下肢明娃增粗、肿胀,未予任何诊治,左下肢肿胀逐渐加重,但对日常生活影响不大,无疼痛及其他不适症状。该患者17岁时发现左足拇趾处出现散在疣状物,就诊于当地医院,给予冷冻处理。     

炎症型线状疣状表皮痣一例

患者女,22岁,因右侧胸背部疣状丘疹进行性增多、部分逐渐融合成斑块,伴阵发性剧烈瘙痒2年,来我院皮肤科就诊.患者既往体健,家族中无类似疾病患者.皮肤科检查:右侧胸背部可见不规则形条带状分布的淡粉红色至暗红色丘疹、斑块,触之较硬,部分皮损表面有白色角化性鳞屑或者表皮剥脱,Auspitz征阴性(图1).皮损组织病理:表皮角化过度伴角化不全,棘层肥厚,表皮突增宽延长,呈银屑病样增生,真皮浅层血管周围淋巴细胞浸润(图2).诊断:炎症性线状疣状表皮痣.治疗:给予0.05%地奈德乳膏和0.1%他扎罗汀乳膏外用,4周后皮损变平,痒感消失,目前仍在随访中.     

炎性线状疣状表皮痣3例

例1男,36岁,右足小趾、足背外缘沿小腿屈侧至腘窝出现暗红色角化性丘疹、斑块伴瘙痒32年.例2女,4岁,左下腹及腹股沟红色或红褐色丘疹、斑丘疹沿Blaschko线分布至外阴部,伴瘙痒3年半.例3男,26岁,右手背、手指、上肢至肩部暗红色丘疹、斑丘疹伴瘙痒3年.该3例皮损组织病理均示:表皮角化过度伴角化不全,棘层肥厚,呈...     

多发性寻常疣样疣状表皮痣1例

1 病例摘要 　　患者男,14岁,右侧颞部条状皮损14年,疣状物2年.出生时右侧颞部就有条状局限性稍隆起的斑丘疹,其大小与人体发育呈同步生长,近2年在该皮损外表面开始出现数个孤立的疣状物,无明显自觉症状. 　　……     

炎症性线状疣状表皮痣1例

患儿女,1岁.因左侧肢体条索状红色斑块、丘疹伴瘙痒12个月,于2008年12月来我院就诊.     

炎症性线状疣状表皮痣九例

炎症性线状疣状表皮痣以单侧分布的瘙痒性线状或带状炎症性皮损为特征、病理改变与银屑病相似。本病少见,国内已有报道[1,2]。近年来我们共诊断9例儿童炎症性线状疣状表皮痣,现报道如下。一、一般资料9例患者中,女7例,男2例,年龄2～10岁。发病年龄：出生时1例,生后4个月3例,生后10个月、1岁、1岁9个月、2岁及7岁各1例。二、临床资料1．临床表现：均表现为单侧分布的红色至暗红色丘疹、斑块,融合成线状或带状,表面有少量至中量灰白色鳞屑。分布于左侧大明唇4例,右侧大明唇3例,左下肢2例。皮损均伴有明显疾痒,其中4例疾痒严重一…     

泛发性炎症性线形疣状表皮痣

患者女。26岁。主诉：躯干、四肢条索状斑丘疹26年。现病史：患者出生2月后双下肢出现呈线状排列的淡红色丘疹,伴轻度瘙痒,未予重视,随年龄增长皮疹渐增多,泛发躯干四肢,部分皮疹融合成片,颜色逐渐转为淡褐色,患者自行涂擦药膏（具体不详）,皮疹无明显改善,近一年自觉瘙痒难忍,遂来我院门诊就诊。既往史及家族史：既往体健,无化工原料及重金属接触史;无急慢性传染疾病史,家族中无类似病史,无银屑病病史及家族史。     

炎症性线状疣状表皮痣1例

患儿男,10岁。因单侧躯体丘疹、斑块伴瘙痒7个月余,于2004年10月25日至我科就诊。7个月前无明显诱因患儿小腿胫前出现红色丘疹伴瘙痒,并逐渐向上、下蔓延。曾在当地医院诊断为“扁平苔藓”,用药不详,效果不佳。父母非近亲结婚,家族中无类似疾病患者。体格检查：系统检查未见异常。皮肤科检查：左侧躯体有多处呈带状或不规则形斑块,表面有角化性丘疹,     

炎症性线状疣状表皮痣

患者女,38岁. 主诉:左足背红色斑丘疹3年. 现病史:患者3年前发现左足伸侧出现一红色丘疹,自觉瘙痒,有时瘙痒剧烈.3年来丘疹逐渐增多,融合成斑块,并向近心端扩展,呈线状分布.患者曾在多家医院就诊,曾诊为线状皮炎、扁平苔藓等,给予多种外用糖皮质激素类软膏外用(具体不详),疗效不明显,于2009年10月来我院就诊.     

表皮痣综合征

报告1例并发癫癎的表皮痣综合征.患者女,21岁.出生后3个月颈部、躯干、四肢即出现弥漫分布的黑褐色、疣状角化性丘疹.患者3年前出现癫癎间断发作.家族中有同样疾病患者.皮损组织病理检查示表皮角化过度,基底层黑素增多.     

巨大先天性色素痣皮损处出现白毛1例

报告巨大先天性色素痣皮损处出现白毛1例。患者男,34岁。患巨大先天性色素痣34年。2年前发现胸部色素痣上部分胸毛变白,患者无白瘢风、晕痣及皮肤色素减退。先天性巨大色素痣上出现白毛值得研究。     

Small congenital nevi associated with melanoma: case reports and considerations

Melanocytic nevi, both congenital and acquired, are considered to be precursors of melanomas. Data about the malignant potential of these nevi are conflicting, particularly with reference to the nevus of the smallest size. Patients with preexisting melanocytic nevi (both congenital and acquired) have risks of developing melanoma that differ from those of subjects without them. The purpose of this study was to verify the presence of melanoma in preexisting nevi both congenital (congenital nevus associated melanoma) (CNAM) and acquired (ANAM). In particular, we investigated melanomas associated with small congenital nevi (SCN). A cohort of 190 patients with primary melanomas was studied. Congenital nevi were called "small" (SCN) when their diameters were less than 1.5 cm. Epiluminescence microscopy (ELM) was performed to further improve the clinical diagnosis and to observe the more subtle changes in the preexisting nevi. Forty of the 190 cases of melanoma were associated with preexisting nevi; of these, 15 had congenital features with a CNAM largest diameter of 1.5 cm. These 15 cases were melanomas of the superficial type with a mean tumor thickness lower than that of ANAM (0.33 vs 1.50). There were no differences between the locations of CNAM and other melanomas. Male patients were significantly more affected. ELM microscopy permitted us to detect the early malignant changes in nevi and thus to improve our diagnosis. A high percentage of small congenital nevi were found to be associated with melanomas. They may be considered as melanomas precursors. Because of their large number and frequency, prophylactic removal of all SCN is not feasible. However, they should be removed as soon as possible when clinical or ELM changes are observed.     

A case of unilateral,systematized linear hair follicle nevi associated with epidermal nevus-like lesions

Multiple hair follicle nevi are an extremely rare condition. In 1998, a case of unilateral multiple hair follicle nevi, ipsilateral alopecia and ipsilateral leptomeningeal angiomatosis of the brain was first reported from Japan. Very recently, hair follicle nevus in a distribution following Blaschko's lines has also been reported. In this paper, we observed a congenital case of unilateral, systematized linear hair follicle nevi associated with congenital, ipsilateral, multiple plaque lesions resembling epidermal nevi but lacking leptomeningeal angiomatosis of the brain. These cases implicate the possibility of a novel neurocutaneous syndrome. Additional cases should be sought in order to determine whether this condition is pathophysiologically distinct.     

Inflammatory linear verrucous epidermal nevus associated with arthritis

报告1例炎性线状疣状表皮痣并发关节炎.患者女,24岁.因右腹部和右下肢瘙痒性带状疣状红色斑块16年,右手中指和小指近端指间关节屈曲畸形3年就诊.通过临床和皮损组织病理学检查,诊断为炎性线状疣状表皮痣,患者同时有右手指间关节损害,阅读文献确诊该例患者为炎性线状疣状表皮痣并发关节炎.     

Inflammatory linear verrucous epidermal nevus associated with erosive monoarthritis

Inflammatory linear verrucous epidermal nevus and linear psoriasis are different entities with clinical and histopathologic similarities. Isolated reports of inflammatory linear verrucous epidermal nevus with concomitant psoriasis or a positive family history of psoriasis have been described, and the possibility that inflammatory linear verrucous epidermal nevus may be a mosaic form of cutaneous psoriasis has been postulated. We report a 17‐year‐old boy with a congenital, linear, erythematous, keratotic plaque on the dorsum of the fifth finger of the left hand with ipsilateral nail dystrophy. Histopathologic examination showed epidermal hyperplasia with alternating orthokeratosis and parakeratosis. During follow‐up, he developed erosive monoarthritis of the distal interphalangeal joint. This case seems to confirm the association between inflammatory linear verrucous epidermal nevus and arthritis and supports a possible relationship between inflammatory linear verrucous epidermal nevus and psoriasis.