结直肠癌患者血清可溶性E—选择素和细胞内黏附分子—1浓度的临床意义

目的：探讨结直肠癌患者可溶性E—选择素(sE-selectin)和细胞内黏附分子—1(ICAM—1)的血清浓度与结直肠癌转移的关系。方法：采用酶联免疫吸附实验方法(ELISA法)测定了64例结直肠癌患者可溶性E—选择素和细胞内黏附分子—1的血清浓度。同时测定癌胚抗原(CEA)的血清浓度。结果：可溶性B选择素的浓度和可溶性sICAM—1的血清浓度显著增高，P=0．001和P=0．032，伴有远处转移者增高显著，P=0．004和P=0．015。可溶性B选择素的浓度和可溶性sICAM-1的血清浓度与血清癌胚抗原的水平有相关性，P=0．025和P=0．038。结论：可溶性B选择素的浓度和sICAM—1的血清浓度的升高可能与结直肠癌的发展和广泛转移有关。     

非小细胞肺癌患者血清可溶性细胞间黏附分子-1的检测

目的 :探讨非小细胞肺癌 (NSCLC)患者血清可溶性细胞间黏附分子 1(sICAM 1)的水平及其与疾病进展的关系。方法 :采用酶联免疫吸附法 (ELISA)检测 5 4例NSCLC患者血清sICAM 1水平。结果 :NSCLC患者血清sICAM 1水平高于正常对照组 ,P <0 0 5 ,与肺癌的组织学分型无关 ,P >0 0 5 ,有转移的患者sICAM 1水平高于无转移者 ,P <0 0 5。结论 :NSCLC血清sICAM 1增高 ,sICAM 1参与了NSCLC的发展和转移     

结直肠癌侵袭性和手术切除对病人血清E-钙粘附素浓度的影响

 目的　检测 2 8例结直肠癌病人血清E 钙粘附素 (E Cad)浓度 ,探讨与结直肠癌侵袭性的关联性。方法　应用酶联免疫吸附法测定可溶性E Cad浓度。结果　血清E Cad浓度结直肠癌组显著高于对照组 ,DukesC组或有淋巴结转移组明显高于DukesA、B组或无淋巴结转移组 ,切除瘤体后上述各组的血清E Cad浓度均明显下降。结论　血清E Cad可能与人结直肠癌的浸润深度和淋巴结转移密切相关     

结直肠癌患者血清VEGF水平变化的临床意义

目的 :探讨结直肠癌患者血清血管内皮生长因子 (vascularendothelialgrowthfactor ,VEGF)水平变化的临床意义。方法 :采用双抗夹心ELISA法检测 45例结直肠癌患者血清VEGF水平 ,并与正常人比较。结果 :结直肠癌患者血清VEGF水平 [( 199 47± 15 6 69)pg/mL]显著高于正常对照组 [( 5 1 2 3± 2 2 66)pg/mL] ,P =0 0 0 0 ;有血管侵犯 [( 2 5 1 63±170 19)pg/mL ]、淋巴结转移 [( 2 66 3 9±162 49)pg/mL]和肝脏转移 [( 3 14 48± 2 19 89)pg/mL]的结直肠癌患者血清VEGF水平明显高于无血管侵犯 [( 12 1 2 3± 91 91)pg/mL]、无淋巴结转移 [( 189 2 6± 47 14 )pg/mL]和无肝脏转移 [( 15 7 65± 10 1 86)pg/mL]的患者 ,分别P =0 0 0 5 ,P =0 0 0 0 ,P =0 0 0 2 ;Duke’sC、D期的结直肠癌患者血清VEGF水平 [( 2 60 74±174 72 )pg/mL]显著高于Duke’sA、B期患者[( 115 63± 69 10 )pg/mL] ,P =0 0 0 1;结直肠肿瘤≥ 5cm的患者血清VEGF水平 [( 2 44 74±171 18)pg/mL]明显高于肿瘤 <5cm的患者[( 12 4 92± 92 62 )pg/mL] ,P =0 0 0 4。血清VEGF水平与患者性别、年龄和组织病理学类型无明显关系。结论 :血清VEGF有可能成为一个新的肿瘤标志物而用于结直肠癌诊断、病情进展的动态监测及预后判断的     

上皮性卵巢癌患者血清sICAM-1检测的意义

 目的　探讨血清可溶性细胞间粘着分子 1(sICAM 1)在上皮性卵巢癌中的临床意义。方法　利用ELISA法检测血清sICAM 1浓度。结果　卵巢上皮癌患者血清sICAM 1平均浓度和阳性率与良性卵巢瘤组和正常对照组相比有显著性差异 (P <0 .0 0 1) ;II～Ⅳ期显著高于临床Ⅰ期的患者 ;淋巴结转移阳性显著高于淋巴结转移阴性的患者 ;组织分化程度Ⅲ级者高于Ⅰ、Ⅱ级 (P <0 .0 1)。结论　血清sICAM 1检测可能有助于监测上皮性卵巢癌患者的病情和判断预后     

肿瘤型丙酮酸激酶在结直肠癌血浆中的测定及其临床意义

目的:探讨肿瘤型丙酮酸激酶(tumor M2 pyruvate kinase,TU M2-PK)在结直肠癌血浆中的浓度变化,及其作为肿瘤指标的临床应用价值.方法:使用Elisa方法测定16例健康对照组人群血浆TU M2-PK浓度,以及40例结直肠癌患者治疗前血浆TU M2-PK浓度(其中22例追踪测定术后血样浓度,7例追踪肿瘤复发转移后进行XELOX方案化疗1次后血样浓度).同时期测定血清癌胚抗原(CEA)浓度.结果:结直肠癌患者的血浆TU M2-PK值明显高于正常人(P＜0.01).血浆TU M2-PK值与Dukes分期较晚(P＜0.01)以及复发远处转移(P＜0.01)明显相关.在接受手术的患者中血浆TU M2-PK在原发肿瘤的病理分级不良(P=0.047)、淋巴转移阳性(P=0.030)、有远处转移(P=0.022)、Dukes D期(P=0.048)情况下明显升高.在特异性相同的情况下,血浆TU M2-PK敏感性比血清CEA高(80% vs 52.5%),联合检测的敏感性明显上升.追踪术后及化疗后患者血浆TU M2-PK浓度变化,发现其浓度显著下降(P＜0.01).结论:血浆TU M2-PK水平在罹患结直肠癌,尤其是发生浸润转移的患者中明显升高,并且在术后及化疗后下降明显,有望成为筛选和提示进展的诊断指标,并在检测疾病动态变化方面有良好的应用价值.     

结直肠癌患者血清中可溶性P-选择素和L-选择素水平及临床意义

背景与目的：结直肠癌是常见的消化系统恶性肿瘤,严重威胁着人类的健康。虽然现代诊疗技术不断发展,但近年来结直肠癌的发病率和病死率仍呈逐年上升趋势,早期诊断和防治肝转移有助于提高结直肠癌患者的生存率,对改善其预后有重要意义。P-选择素和L-选择素是近年肿瘤研究领域倍受关注的分子,其表达量及介导的黏附作用的改变在肿瘤细胞转移中起着重要作用,但2者与结直肠癌发生及临床分期的关系鲜见报道。本研究旨在探讨结直肠癌患者手术前后血清中P-选择素和L-选择素水平高低与临床病理特征的相关性。方法：选择132例结直肠癌患者及与其性别年龄相匹配的100名健康体检者。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测132例结直肠癌患者手术前后血清中P-选择素和L-选择素浓度,100名健康体检者为对照组,结合临床病理特征对P-选择素和L-选择素水平的变化进行分析。结果：结直肠癌患者术前血清P-选择素和L-选择素水平显著高于对照组(75.2±13.3 vs 26.6±9.6,89.2±12.7 vs 33.9±8.3,P<0.05);术后1周P-选择素和L-选择素水平较术前没有明显下降(63.8±11.1 vs 75.2±13.3,71.5±10.9 vs 89.2±12.7,P>0.05);而术后3个月则明显下降,与术前比较差异有统计学意义(34.8±10.4 vs 75.2±13.3,40.1±9.5 vs 89.2±12.7,P<0.01);本组结直肠癌患者,临床分期越高,P-选择素和L-选择素水平越高,其水平与肿瘤浸润深度、Dukes分期、组织学分级和淋巴结转移相关,而与年龄、性别及肿瘤部位无明显相关(P>0.05);同时,同一结直肠癌患者血清中P-选择素和L-选择素的表达无显著相关(r=4.114,P>0.05)。结论：血清中P-选择素和L-选择素的水平在一定程度上反映了结直肠癌的侵袭、浸润和淋巴结转移的程度,可作为预测结直肠癌发展及预后的重要指标。     

可溶性细胞间黏附分子-1在良恶性胸腔积液中的检测

目的:通过检测正常人血清和结核性胸膜炎、癌性胸腔积液患者血清及胸腔积液中可溶性细胞间黏附分子- 1(sICAM-1)水平,探讨其对鉴别良、恶性胸腔积液的意义。方法:采用酶联免疫吸附法(ELISA)检测20例正常人、20例结核性胸膜炎和17例恶性胸腔积液患者血清及胸腔积液中sICAM 1的水平。结果:结核性胸膜炎、恶性胸腔积液患者血清sICAM -1水平高于正常对照组,t值分别为9. 031和10. 816,P均<0 .05;恶性胸腔积液sICAM 1水平明显高于结核性胸腔积液,t=4 943,P<0 .05。结论:sICAM -1可能参与了结核性和肿瘤性胸膜病变的免疫病理生理过程,胸腔积液中sICAM -1 的检测可作为临床上鉴别良、恶性胸腔积液的一项参考指标。     

血清CD44v6表达在结直肠癌中的临床应用价值

目的 探讨血清可溶性细胞表面黏附分子sCD44v6在结、直肠癌中的临床应用价值.方法 96例不同Duke分期结、直肠癌患者和24例健康者,分别采用酶联免疫吸附法(ELISA)定量检测其血清sCD44v浓度,化学发光免疫法检测血清CEA浓度;并结合临床资料进行分析.结果 结、直肠癌患者sCD44v6浓度为275.3±115.8 ng/ml,明显高于健康对照组(61.3±7.8 ng/ml)(P＜0.05),若以健康对照组的(-x)+2s(76.9 ng/ml)作为正常上限值,其阳性率为73.96%;sCD44v6水平随癌肿Duke分期的升级和肿瘤细胞的转移而呈现递增趋势,各组之间比较差异有统计学意义(P＜0.05).与CEA相比,sCD44v6水平在反映癌组织浸润和转移程度上更直接、敏感.结论 结、直肠癌患者sCD44v6水平和阳性率均显著增高,并与肿瘤的分期和扩散转移程度密切相关;术前sCD44v6水平检测可作为结、直肠癌患者病程和转移预测的一个重要指标.     

血清糖类抗原242、可溶性细胞间黏附分子-1水平与结直肠癌患者临床特征和预后的关系

目的 探讨血清糖类抗原242(CA242)、可溶性细胞间黏附分子-1(sICAM-1)水平与结直肠癌患者临床特征和预后的关系。方法 选取67例结直肠癌患者和50例健康体检者,检测两组受试者血清CA242、sICAM-1水平,比较不同临床特征结直肠癌患者血清CA242、sICAM-1水平。以血清CA242、s ICAM-1中位数为分界,将结直肠癌患者分为低表达组和高表达组,比较两组患者的总生存期和5年生存率。结果 结直肠癌患者血清CA242、sICAM-1水平均明显高于健康者（P﹤0.01）。分化程度为低分化、浸润深度为T3～4、临床分期为Ⅲ期、有淋巴结转移、有远处转移、有神经和脉管侵犯结直肠癌患者血清CA242、sICAM-1水平分别高于分化程度为中高分化、浸润深度为T1～2、临床分期为Ⅰ～Ⅱ期、无淋巴结转移、无远处转移、无神经和脉管侵犯患者（P﹤0.05）。以血清CA242水平中位数为分界,将67例结直肠癌患者分为CA242低表达组（n=34）和CA242高表达组（n=33）,CA242低表达组结直肠癌患者平均总生存期为（37.29±4.15）个月,明显长于CA242高表达组患者的（...     

Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer.

A diversity of adhesive interactions occur between the cancer cell and host extracellular matrix which potentiate neoplastic expansion and metastatic dissemination. In miscellaneous malignant diseases, tumour progression has been observed to be associated with alterations in adhesion molecule expression. Recently, circulating soluble intercellular adhesion molecules have been identified. In this study, serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined in patients with gastric cancer. The study group consisted of 27 patients with previously untreated gastric adenocarcinoma. Four patients had stage II, two patients stage III and 21 patients stage IV disease according to the TNM classification. Nineteen patients had distant metastasis. The sera obtained from 18 healthy volunteers served as controls. Serum sICAM-1 and sE-selectin concentrations were determined by enzyme-linked immunosorbent assay (ELISA). In addition, we also studied other tumour-associated antigens, i.e. CEA and CA 19-9. Serum sICAM-1 levels were significantly increased in patients with gastric cancer (P < 0.0001). However, sE-selectin levels did not differ from the controls. sICAM-1 concentrations were also significantly higher in patients with distant metastasis and peritoneal spread (P = 0.0045 and P = 0.0157 respectively), whereas sE-Selectin levels were elevated only in patients with peritoneal metastasis (P = 0.033). Serum concentrations of sICAM-1 and sE-selectin correlated with CEA levels (P = 0.0013 and P = 0.003 respectively). Elevated levels of sE-selectin were associated with poorer prognosis (P = 0.0099), whereas sICAM-1 had no significant impact on survival. Our results suggest that increased sICAM-1 serum levels may reflect widespread disease and contribute directly to the progression of gastric cancer. Further investigation of the molecular mechanisms of adhesive tumour-host interactions may lead to a better understanding of the natural history of gastric cancer.     

Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence.

Sera from 40 patients with newly diagnosed bladder cancer (28 superficial tumours (pTa and pT1) and 12 muscle-invasive tumours) were assessed by enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of soluble E-cadherin (sE-cadherin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). Corresponding frozen sections of primary tumour were analysed for E-cadherin expression using the monoclonal antibody, HECD-1 and standard immunohistochemistry. Patients with bladder cancer had significantly higher concentrations of sE-cadherin compared with a control group (P = 0.017). No difference was found between the two groups with regard to sE-selection (P = 0.403), sVCAM-1 (P = 0.942) and sICAM-1 (P = 0.092). High levels of sE-cadherin were related to poor histological grade (P = 0.009), number of superficial tumours at presentation (P = 0.008) and a positive 3 month check cytoscopy in superficial disease (P = 0.036). Abnormal E-cadherin expression was associated with increasing tumour stage (P = 0.009) and grade (P = 0.03). There was no correlation between high levels of soluble E-cadherin in sera and abnormal E-cadherin expression by the tumour (P = 0.077). Elevated levels of sE-cadherin are found in sera of patients with bladder cancer and correlate with known prognostic factors.     

Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery

The serum concentrations of the cell adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 63 patients with colorectal cancer and in 51 controls by an enzyme-linked immunosorbent assay (ELISA). Their relationship to clinicopathological variables and patient survival and changes in their levels after surgery were examined. Colorectal cancer patients showed significantly higher serum levels of E-selectin, ICAM-1 and VCAM-1 compared with healthy controls. There was a significant association between the serum levels of these molecules, disease stage and the presence of both lymph node and distant metastases. Both ICAM-1 and VCAM-1 levels correlated with serum E-selectin and carcinoembryonic antigen (CEA) levels. Serum levels of all three molecules decreased significantly after radical resection of the tumour. Elevated pre-operative E-selectin, ICAM-1 and VCAM-1 levels were significant prognostic factors, although not independent of stage, for patient survival. These findings suggest that serum concentrations of E-selectin, ICAM-1 and VCAM-1 may reflect tumour progression and metastasis. Since these markers are linked to CEA levels, it is uncertain whether their measurement will prove cost-effective in colorectal cancer management.     

Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer

OBJECTIVES: To analyse the behaviour of pre-surgical serum levels of soluble (s)E-selectin and vascular cell adhesion molecule (sVCAM) in patients with colorectal cancer, and to evaluate their possible correlation with carcinoembryonic antigen (CEA), pro-inflammatory cytokines and clinicopathological features with respect to their prognostic value in predicting metastatic disease. METHODS: Pre-surgical serum levels of sE-selectin, sVCAM, interleukin-6 (IL-6), IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and CEA were measured in 194 patients with colorectal adenocarcinoma, 40 patients with benign colorectal diseases and 59 healthy subjects. RESULTS: sE-selectin, sVCAM, TNF-alpha and IL-6 levels were significantly higher in patients with colorectal cancer compared to either healthy subjects or patients with benign disease. Positive rates of sE-selectin, sVCAM and TNF-alpha levels were significantly associated with Dukes' stage D colorectal cancer, and all three variables were independently associated to the presence of distant metastases. Positive sE-selectin, sVCAM and TNF-alpha levels were significantly associated to CEA. TNF-alpha and CEA levels were independently related to the presence of positive levels of sE-selectin and/or sVCAM. CONCLUSIONS: Our findings suggest that the host inflammatory response to cancer cells, and/or their released products (i.e. CEA), might be responsible (via cytokine release) for the elevation in circulating adhesion molecules in patients with colorectal cancer.     

Serum concentrations of soluble adhesion molecules in patients with colorectal cancer.

The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 48 patients with colorectal cancer before treatment, and their relation to clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with colorectal cancer in comparison with a group of healthy subjects (P < 0.00001). Levels of circulating ICAM-1 and VCAM-1 were increased both in patients with local and those with metastatic disease. Although elevated in some patients soluble E-cadherin and E-selectin concentrations were not significantly elevated compared with the control group (P = 0.71 and P = 0.052 respectively). The levels of circulating ICAM-1 were significantly correlated with those of VCAM-1 and E-selectin. A correlation was also found between the serum concentrations of E-selectin and ICAM-1 and alkaline phosphatase, total white cell count and platelet count. VCAM-1 was positively correlated with age and negatively with degree of tumour differentiation and haemoglobin concentration. The biological implications and possible clinical relevance of these findings are discussed.     

Levels of soluble intercellular adhesion molecule-1 and total sialic acid in serum of patients with colorectal cancer

BACKGROUND AND OBJECTIVES: Serum soluble intercellular adhesion molecule-1 (sICAM-1) and total sialic acid (TSA) are related to the metastatic potential of cancer cells. The purpose of the present investigation was to determine sICAM-1 and TSA levels in colorectal carcinoma and correlate their levels with the cancer stage. METHODS: The sera from 65 patients with colorectal cancer (18 at Dukes' B, 24 at Dukes' C, 23 at Dukes' D) were extracted before treatment. The concentrations of sICAM-1 and TSA were measured by enzyme-linked immunoassay and the thiobarbituric acid method, respectively, and compared with those from a healthy control group (n = 42). RESULTS: Mean serum sICAM-1 and TSA levels were found to be higher in the total patient group than in the control group (P < 0.0001). The concentrations of sICAM-1 and TSA were significantly higher in patients with Dukes' C and Dukes' D. The correlations between sICAM-1 and TSA became more significant as the stage of the disease increased (r = 0.58, P < 0.05 in Dukes' B, r = 0.88, P < 0.01 in Dukes' C and r = 0.81, P < 0.01 in Dukes' D). CONCLUSIONS: The results of this investigation indicate that sICAM-1 and TSA are the best of the tested markers. These markers should prove useful for monitoring malignant disease stage and for evaluating the effectiveness of various therapeutic approaches for colorectal carcinomas.     

胰腺组织及血清VCAM-1、ICAM-1在胰腺癌手术治疗前后的变化研究

目的 研究胰腺组织与血清血管细胞黏附分子-1(VCAM-1)和细胞间黏附分子-1(ICAM-1)在胰腺癌手术治疗前后的变化.方法 选择90例胰腺癌患者(胰腺癌组)、90例急性胰腺炎患者(急性胰腺炎组)和90例同期健康体检者(正常组),于术前和术后第7天检测3组患者血清可溶性血管细胞黏附分子-1(sVCAM-1)、可溶性细胞间黏附分子-1(sICAM-1)、糖链抗原19-9(CA19-9)和癌胚抗原(CEA)水平;胰腺癌组和急性胰腺炎组患者均于术中切取胰腺典型部位组织行VCAM-1、ICAM-1水平检测,并对上述指标进行分析.结果 术前和术后第7天,胰腺癌组患者血清sVCAM-1、sICAM-1、CA19-9和CEA水平均高于急性胰腺炎组、正常组,差异均有统计学意义(P﹤0.05).术前,急性胰腺炎组患者血清sVCAM-1、sICAM-1、CA19-9和CEA水平均高于正常组,差异均有统计学意义(P﹤0.05).术前,胰腺癌组中胰腺组织VCAM-1、ICAM-1水平均明显高于急性胰腺炎组,差异有统计学意义(P﹤0.01).术后第7天,急性胰腺炎组患者血清sVCAM-1、sICAM-1、CA19-9、CEA水平与正常组比较,差异无统计学意义(P﹥0.05).胰腺癌组中,术后第7天患者血清sVCAM-1、sICAM-1、CA19-9和CEA水平均明显低于术前,差异有统计学意义(P﹤0.01).胰腺癌组患者血清sVCAM-1、sICAM-1与CA19-9均呈正相关(P﹤0.05);胰腺癌组患者血清sVCAM-1、sICAM-1与CEA无相关性(P﹥0.05).结论 胰腺癌患者的血清sVCAM-1、sICAM-1水平明显升高,术后迅速降低,其血清sVCAM-1、sICAM-1与CA19-9呈正相关,在早期诊疗胰腺癌过程中有较高的应用价值.     

结直肠癌术后肝转移的危险因素分析及预测模型构建

目的:分析结直肠癌术后肝转移的危险因素并构建预测模型.方法:选取2011年1月至2015年12月于苏州市第九人民医院行根治性手术切除的247例结直肠癌患者作为观察对象,依据随访是否出现肝转移分为转移组、非转移组.对两组各项指标进行单因素筛选,再行Logistic多因素回归分析,并建立预测模型,应用受试者工作特征(rec...     

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.

The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P = 0.0361).     

sICAM-1在胃癌患者中的表达

[目的]探讨血清可溶性细胞间黏附分子(sICAM—1)在胃癌患者中的临床意义，并与CEA、CA19—9进行比较。[方法]应用酶联免疫吸附法分别检测68例胃癌患者治疗前后的sICAM—1及CEA和CA19—9，并结合临床特征进行分析。[结果]sICAM—1、CEA、CA19—9检测的敏感性分别为82．4%、35．3％、44．1％；特异性分别为95％、75％、80％。3种指标联合检测，其敏感性为89．6％；特异性为87．5％。sICAM—1、CEA、CA19—9含量与胃癌的临床分期、肿瘤直径、淋巴结转移程度及有无远处转移有关，手术前后3种标志物含量具有明显的差异，而术后3种标志物含量与对照组相似。[结论]sICAM—1能较好地反映胃癌的临床病程和病理特征，是胃癌的一种理想的肿瘤标志物，3种标志物的联合检测能够用于胃癌的诊断、预后评估及监测病情的进展。