Evidence of trigonal denervation and reinnervation after radical retropubic prostatectomy

PURPOSE: Urinary incontinence continues to be a major consequence of radical prostatectomy. To understand the pathophysiology of this dysfunction we studied the impact of autonomic innervation of the superficial trigone on postoperative urinary continence. MATERIALS AND METHODS: To investigate nerve fiber density biopsies of the superficial trigone were obtained in 34 patients preoperatively as well as 6 weeks and 6 months postoperatively in 15 and 19, respectively. Specimens were Bouin fixed, paraffin embedded and processed for light microscopic immunohistochemical evaluation using an antibody against protein gene product 9.5, a general neuronal marker protein. In parallel we performed a comprehensive urodynamic evaluation, including determination of maximal urethral closure pressure and posterior urethral sensory threshold. RESULTS: Postoperatively protein gene product 9.5 immunoreactive nerve fiber density was generally decreased. However, nerve fiber density after 6 weeks of incontinence in 12 of 15 patients was only 7%, while 3 of 15 who were continent preserved 36% of initial nerve fiber density. After 6 months nerve fiber density in 19 patients increased in 3 with incontinence to 20% and in 16 with continence to 44% of intraoperative density. Urinary incontinence was associated with decreased trigonal innervation, a high sensory threshold and low maximal urethral closure pressure. CONCLUSIONS: Protein gene product 9.5 immunoreactive nerve fiber density corresponds with posterior urethral sensory threshold and urinary continence. Thus, preserving trigonal innervation and postoperative reinnervation may be important factors for achieving early postoperative urinary continence after radical prostatectomy.     

Vagal reinnervation in the long term after orthotopic heart transplantation.

BACKGROUND: Sympathetic reinnervation after orthotopic heart transplantation (HTx) has become an accepted phenomenon, particularly in long-term transplanted patients. Parasympathetic reinnervation, however, still remains questionable. METHODS: In 38 HTx recipients, mean age of 51.6 +/- 9.7 years (range, 29 to 70 years), with a time span after HTx of 4.6 +/- 2.8 years (0.5 to 10.5 years), we stimulated carotid baroreceptors using periodic neck suction at low (0.1 Hz) and high (0.2 Hz) frequencies to test sympathetic and vagal responses, respectively. Respiratory rate was fixed at 0.25 Hz. We simultaneously recorded surface electrocardiogram, finger blood pressure, respiration and neck pressure signals while patients rested in the supine position. Time series of RR intervals, respiration, and neck and blood pressures were generated and subjected to spectral analysis. RESULTS: All patients demonstrated a 0.25-Hz peak in RR-interval spectrum, caused by non-autonomic respiratory sinus arrhythmia. Thirteen patients (5. 2 +/- 3.5 years after HTx; range, 0.9 to 10.2 years) showed a baroreflex-induced sharp peak at 0.1 Hz in RR-interval power spectrum during 0.1-Hz neck suction, indicating sympathetic reinnervation. However at 0.2-Hz neck suction, 4 of the 13 sympathetically reinnervated patients displayed a baroreflex-induced 0.2-Hz peak, which could be suppressed with atropine administration-strong evidence for vagal reinnervation. CONCLUSIONS: Non-invasive carotid baroreflex stimulation is an appropriate tool to prove restoration of autonomic control after orthotopic HTx. Sympathetic reinnervation parallels parasympathetic reinnervation in long-term transplanted patients.     

Cardiac rupture after catheter ablation procedure

We describe a patient in whom cardiac tamponade developed owing to left ventricular rupture after a catheter ablation procedure. Rapid surgical exploration and use of cardiopulmonary bypass facilitated safe repair of the injury site and survival of the patient without complications.     

Left main coronary arterial lesion after microwave epicardial ablation

We present a case of left main coronary arterial lesion in a 62-year-old man who had undergone mitral valve replacement and microwave epicardial ablation. On postoperative day 90, the patient had an anterior myocardial infarction. The coronary angiography displayed the diagnosis of the left main trunk lesion. A myocardial revascularization was urgently performed, the postoperative course was uneventful, and the patient was in sinus rhythm. The left atrial epicardial ablation represents the ultimate step in the surgical treatment of chronic atrial fibrillation; nevertheless, the left main trunk lesion may occur as an extremely severe complication. The incorrect placement of the microwave probe may be responsible for the development of critical coronary artery stenosis.     

Ventral cardiac denervation reduces the incidence of atrial fibrillation after coronary artery bypass grafting

OBJECTIVES: Because the autonomic nervous system is an important determinant in the appearance of atrial fibrillation, we have assessed the role of ventral cardiac denervation for its prevention. METHODS: Patients undergoing low-risk coronary artery surgery were enrolled. No routine antiarrhythmic drugs were administered before or after the operation. Ventral cardiac denervation was performed in 207 patients, and 219 patients were used as control subjects. Denervation was performed before cardiopulmonary bypass. The groups were comparable regarding demographic, clinical, and operative variables. RESULTS: The additional time for the denervation was 5 +/- 2 minutes, and there were no associated complications. Postoperative atrial fibrillation was present in 15 (7%) patients undergoing ventral cardiac denervation (95% confidence interval, 4%-12%) and in 56 (27%) control subjects (95% confidence interval, 18%-35%). Patients submitted to ventral cardiac denervation had fewer and less severe episodes of atrial fibrillation, and no patient had atrial fibrillation after discharge. Ventral cardiac denervation was the most significant predictor of postoperative atrial fibrillation (odds ratio, 0.42; confidence interval, 0.23-0.78; P =.006). Age of greater than 65 years (odds ratio, 1.67; confidence interval, 0.96-2.9; P =.067) was a highly suggestive predictor. The analysis of the effect of ventral cardiac denervation correlated with the patient's age showed a more pronounced effect in patients younger than 70 years (odds ratio, 0.43; confidence interval, 0.22-0.86; P =.022) CONCLUSIONS: Ventral cardiac denervation is a fast and low-risk procedure. Its use significantly reduces the incidence and severity of atrial fibrillation after routine coronary artery bypass surgery. Patients younger than 70 years of age are expected to have a higher success rate than those older than 70 years.     

Partial cardiac denervation and sinus node modification for inappropriate sinus tachycardia

We describe a case of inappropriate sinus tachycardia refractory to medical therapy and catheter sinus node ablation, which was successfully treated by surgery with approaches on both the sinus node and cardiac autonomic ganglia.