以表阿霉素为主治疗恶性肿瘤70例的疗效

本文报道以表阿霉素为主治疗恶性肿瘤70例的疗效.近期疗效中.以恶性淋巴瘤的疗效最好,总有效率92.9%.对其他肿瘤也有相当的疗效.毒性反应有骨髓抑制.脱发等,对心脏毒性并不大     

米托蒽醌治疗晚期肿瘤的临床观察

应用国产米托蒽醌为主的联合化疗方案治疗晚期恶性肿瘤25例,其中乳腺癌有效率为57％(4/7),肺癌45.5%(5/11),胃癌25％(2/4)。近期疗效与阿霉素组类似。主要毒副反应为白细胞下降,发生率为44%,与阿霉素差异不明显;心脏毒性、胃肠道反应及脱发等非血液毒性均比阿霉累轻,且易为病人接受;将有替代阿霉素的趋势。     

卡铂与阿霉素治疗肺癌疗效和毒性比较

观察以卡铂、阿霉素为主治疗肺癌的疗效及毒性,卡铂组的总有效率为47．89％,CR为8．59％、阿霉素组的总有效率为53．12％,CR为14．065,两者无明显差异,主要毒副反应为血液毒、消化道反应及脱发,卡铂组与阿霉素组血液毒性无明显差异,卡铂组消化道反应及脱发比阿霉素组轻。     

国产阿霉素治疗恶性肿瘤近期疗效及毒副反应的观察

对使用国产阿霉素组成联合方案治疗恶性肿瘤51 例的近期疗效和毒副反应进行了观察。在可供疗效分析的38 例中,完全缓解7 例,部分缓解14 例,总有效率55.3 % (21/38) ,与进口阿霉素疗效比较,无显著性差异( P> 0 .05) 。毒副反应主要为消化道反应和血液毒性。有异常心电图改变者占29 .4 % ,但无急性心衰和猝死发生。结果提示:国产阿霉素疗效并不逊色于进口阿霉素,毒副反应多能耐受,且药品价格明显低廉,在临床上完全可以取代进口阿霉素     

国产阿霉素治疗恶性肿瘤近期疗效及毒副反应的观察

对使用国产阿霉素组成联合方案治疗恶性肿瘤５１例的近期疗效和毒副反应进行了观察。在可供疗效分析的３８例中，完全缓解７例，部分缓解１４例，总有效率５５．３％（２１／３８），与进口阿霉素疗效比较，无显著性差异（Ｐ〉０．０５）。毒副反应主要为消化道反应和血液毒性异常心电图改变者占２９．４％，但无急性心衰和猝死发生。结果提示：国产阿霉素疗效并不逊色于进口阿霉素，毒副反就爽能耐受，且药品价格明显低廉，在临床上     

阿霉素治疗50例晚期恶性肿瘤的临床分析

本文分析了以阿霉素为主的联合化学疗法治疗50例晚期恶性肿廇的临床疗效、毒性反应及其与给药方法、剂量的关系。本组病例总有效率达38.0％,其中乳腺癌有效率36.4％,略高于国内报告。有效率、毒副反应发生率与累积剂量成正比,局部毒性反应发生率与给药方法有关。     

多西紫杉醇治疗晚期恶性肿瘤46例临床分析

目的：评价多西紫杉醇（艾素,江苏恒瑞医药股份有限公司产品）＋顺铂或卡铂、阿霉素治疗晚期恶性肿瘤的临床疗效及毒副作用。方法：化疗方案为：多西紫杉醇75mg／m^2,第1天,静脉滴注;联合顺铂30mg／m^2,第1～3天或卡铂300mg／m^2,第1天,静脉滴注,治疗非小细胞肺癌、鼻咽癌;联合阿霉素40mg／m^2,第1～2天,静注,治疗乳腺癌。结果：3组总有效率（CR＋PR）分别为,非小细胞肺癌为49．5％;鼻咽癌为55．6％;乳腺癌为83.3％。其毒性反应主要是骨髓抑制,轻度胃肠道反应。脱发、面色潮红、乏力、肌痛及少数病例末梢神经病变。结论：国产多西紫杉醇联合顺铂或卡铂、阿霉素治疗晚期恶性肿瘤,疗效满意,且毒性可耐受,适合临床应用。     

阿霉素联合治疗恶性肿瘤174例临床疗效及毒性反应观察

阿霉素联合治疗恶性肿瘤１７４例临床疗效及毒性反应观察（１６１０００）黑龙江省齐齐哈尔市肿瘤结核医院隋丽娟邵广春杨丹我院于１９９３年１０月开始先后随机选择应用阿霉素为主，联合化疗方案治疗恶性肿瘤患者１７４例，作近期疗效和毒性反应观察，报告如下１资料分析...     

吡喃阿霉素治疗晚期恶性肿瘤临床研究

目的 观察以吡喃阿霉素为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 30例晚期恶性肿瘤患者接受以吡喃阿霉素为主的联合化疗，均治疗24个周期以上，3～4周为1疗程。结果 本组30例中，CR1例，PR14例，总有效率50％。非小细胞癌，乳腺癌，恶性淋巴瘤，头颈部癌，大肠癌有效率分别为46．1％（6／13）、50％（3／6）、75％（3／4），50％（2／4）、33．3％（1／3）。结论 以吡喃阿霉素为主的联合化疗方案是治疗晚期恶性肿瘤的有效方法。吡喃阿霉素的毒性主要是骨髓抑制，其他毒性均较轻微。     

应用含吡喃阿霉素的BACOP方案治疗老年非霍奇金淋巴瘤

目的 吡喃阿霉素（THP）抗癌活性高，胃肠反应及心脏毒性、脱发比阿霉素小，用吡喃阿霉素代替BACOP方案中的阿霉素，治疗老年非霍奇金淋巴瘤（NHL），探讨其疗效和不良反应。方法 选择年龄55-74岁的非霍奇金淋巴瘤18例，Ⅰ期2例，Ⅱ期4例，Ⅲ期7例，Ⅳ期5例，用吡喃阿霉素联合环磷酰胺、长春新碱、强的松、平阳霉素治疗4。6个疗程，观察疗效和不良反应。结果10例完全缓解（CR），CR率为55．6％，6例部分缓解（PR），PR率33．3％，有效率88．9％；胃肠反应轻，心脏毒性、脱发发生率低且轻微。结论 用吡喃阿霉素代替阿霉素的BACOP方案，治疗老年NHL疗效高、副作用小，值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.