试述古代文献中男女两性房事养生原则的异同

房事是正常成年人的生活必需,但男女的交合应有一定的原则,否则容易引起早衰甚至导致一系列疾病的发生。由于男女生理、心理不同以及社会因素等原因,古代医家关于男女两性房事养生原则的论述既有相同之处,又有所侧重。男女两性房事养生原则的相同点是都以"乐而有节"为基本原则,包括欲不可早、欲不可绝、欲不可纵、欲有所忌四个方面;不同点是古代文献对于男性房事养生重点强调了"欲不可纵",对于女性则主要强调了"欲不可绝",而"欲有所忌"中的"避会三期"对女性尤有重要意义。     

Human maximization testing of D&C Yellow no. 10 and Yellow no. 11

By the maximization test, using 0.5% D&C Yellow no. 11 in pet., 15 of 20 human volunteers became contact sensitized. All reacted to a challenge concentration of 1000 ppm and one down to 1 ppm. The high allergenic potential of this dyestuff was confirmed. There were no cross reactions to purified samples of D&C Yellow no. 10. In contrast, 5% solutions of pure D&C Yellow no. 10 failed to sensitize human subjects. Cross reactions to this substance in persons sensitized to D&C Yellow no. 11 are due to impurities.     

Extragenitaler Lichen sclerosus et atrophicus – Behandlung durch gepulsten Farbstofflaser

A 17-year old female patient with extragenital lichen sclerosus et atrophicus was treated with the pulsed dye laser. Local and systemic therapy before treatment showed no effect. The lesions were removed completely with four treatment sessions. As for side effects, no pigment changes and no visible scarring was observed. The patient experienced no recurrence within a follow-up time of 7 months. The mechanism whereby lichen sclerosus et atrophicus is altered by the pulsed dye laser is unknown.     

Case of schwannomatosis

A 40-year-old man presented to our hospital with painful tumors in his left carotid space and left knee. He had no family history of neurofibromatosis type II (NF II), no history of hearing loss or vestibular problems, and no symptoms of NF I. Magnetic resonance imaging (MRI) of the head revealed no intracranial tumors including vestibular schwannoma (VS). MRI of the left carotid and left knee demonstrated T₁-weighted mass lesions. They were excised and all of them were pathologically diagnosed as schwannoma. Thus, this case was diagnosed as definite schwannomatosis in reference to the diagnostic criteria.     

徐州市泉山区小学生特应性皮炎发病情况及发育状况调查

目的了解徐州市部分小学生特应性皮炎(AD)的发病情况及生长发育状况。方法对徐州市泉山区6～13岁年龄段的城市小学生进行问卷调查和身高体重的测量。结果调查有效的10714人中发现AD患者105例,其中男64例,女41例,总患病率为0.98%,男性患病率为1.11%,女性为0.83%,两者比较差异无统计学意义(P0.05)。各年龄组患病率与年龄无相关性(P0.05)。AD患者中哮喘和/或过敏性鼻炎的患病率为30.5%,非AD者哮喘和/或过敏性鼻炎的患病率为0.75%,两者比较差异有统计学意义(P0.005),AD患者中哮喘和/或过敏性鼻炎的患病率与年龄无相关性(P0.05)。各年龄组AD患者与正常学生的身高和体重比较身高差异无统计学意义(P0.05),仅7岁组、9岁组的男生及9岁组女生的体重比较,AD患者高于正常学生,差异有统计学意义(P0.05)。结论徐州市6～13岁年龄段男生与女生AD患病率没有差异,患病率与年龄无相关性,AD患者的生长发育水平与正常儿童没有差异。     

阿维A长期治疗儿童板层状鱼鳞病1例

回顾性分析1例板层状鱼鳞病儿童服用阿维A后皮损改善情况。患者初始口服阿维A 5mg/d治疗半年效果不明显,后加量至10mg/d,2周后疗效明显,黏着性鳞屑基本脱落。患儿口服阿维A已超过7年,暂未见明显生长发育迟缓。     

A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers

DESIGN: This phase I dose-ranging study of 2 weeks of twice-daily dextrin sulphate (DS), a sulphated polymer with in vitro activity against HIV, was designed in 2 parts. Part A was a randomized, placebo-controlled, double-blind, 3-arm trial (DS4%, DS1%, placebo) in HIV-negative women. In part B, HIV-positive women received DS4% and HIV-negative women were randomized to DS4% or no gel. RESULTS: One hundred women were enrolled from 2 sites (London and Antwerp): DS4% (n = 50, 20 of whom were HIV-positive), DS1% (n = 20), placebo (n = 10) and no gel (n = 20). There were no withdrawals related to adverse events and no cases of epithelial disruption. Spotting was reported by 24 women and numbers were significantly higher in all the gel groups (23 of 80), including placebo, compared with no gel (one of 20) (Fisher exact test P = 0.037). There was no evidence of a dose effect. Safety tests showed no evidence of systemic absorption. CONCLUSION: Although there was no clear explanation for the spotting, DS4% was well tolerated. It was decided to proceed with DS4% in an expanded safety study in Africa but to restrict entry to low-risk HIV-negative women, include a no-gel group, and monitor intermenstrual bleeding closely.     

二次剖宫产后腹壁子宫内膜异位症致补片替代1例

目的:探讨二次剖宫产后腹壁子宫内膜异位症术后疗效。方法:术中见病灶侵蚀范围大,腹壁缺损大,给予补片治疗。结果:术后随访无复发、无排异、腹壁无不适。结论:剖宫产后腹壁子宫内膜异位症给予补片治疗效果较好。     

反应性结节性增生1例

报告1例反应性结节性增生。患者男,57岁。左手无名指结节3年,无自觉症状。给予手术切除治疗。组织病理检查：真皮内有大量交叉和波浪状排列的成纤维细胞和胶原纤维,其周围无包膜,与周围组织分界不明显;边缘血管周围可见少量单一核细胞浸润。     

D&C nos. 10 and 11: chemical composition analysis and delayed contact hypersensitivity testing in the guinea pig

D&C Yellow no. 11 was found to consist predominantly of quinophthalone together with other minor components, though not 6'-methylquinophthalone. Quinophthalone was found to be a strong sensitizer in guinea pigs by means of a modified testing technique, and its threshold concentration for induction and challenge was 10 ppm. Purified D&C Yellow no. 10, which was found to consist of 6 derivatives of sodium sulfonated quinophthalone, did not sensitize or elicit a cross-reaction in quinophthalone-sensitized guinea pigs even at a challenge concentration of 5%. Commercial D&C Yellow no. 10 contained 0.95-170 ppm of quinophthalone, and it is suggested that skin sensitization by D&C Yellow no. 10 is caused by contaminating quinophthalone.     

Granuloma annulare with a mycosis fungoides-like distribution and palisaded granulomas of CD68-positive histiocytes

We describe 3 unusual cases of granuloma annulare with multiple macular lesions in a distribution that simulated mycosis fungoides in patients with no associated underlying diseases. Repeated biopsies showed typical well-formed palisading granulomas and no evidence of an atypical lymphocytic infiltrate. There was no vasculitis, neutrophilic, eosinophilic, or interstitial infiltrate. The patients had no associated underlying diseases. Most of the histiocytes in the palisading granulomas were strongly positive for CD68. The lymphocytes were a minor component of the granulomatous inflammation and were predominantly CD8(+) T-cells. The findings in these cases add to the spectrum of previously defined granulomatous eruptions of the skin.     

Benign Neonatal Eruptive Hemangiomatosis in Identical Twins

Abstract: Two cases of neonatal hemangiomatosis occurred in identical twins. Work-up for internal hemangiomas were performed on both infants and were negative. Twin no. 1, with extensive lesions, is currently taking oral prednisone, 2 mg/kg/day, with gradual resolution of the lesions. So far, no new hemangiomas have developed in twin no. 2.     

AUTORADIOGRAPHIC STUDIES OF HAIR GROWTH AND RHYTHM IN MONILETHRIX

SUMMARY. Two patients with monilethrix have been studied. The rate of growth of beaded hair in the scalp was slightly but significantly greater than that of the microscopically unaffected hair, but there was no significant difference between the growth rates of beaded and unaffected hair in the forearm.
There was no daily rhythm of node and internode formation, and no simple time cycle of any length could be discovered for the beading. Greater hair growth occurred during the day, and this achieved statistical significance at the 1% level for the normal shafts. Intradermal methotrexate in the doses employed had no effect either on growth rate or bead formation.     

Spontaneous resolution of facial papular mucinosis in a transplant patient

A 37-year-old male developed facial papules 6 months post renal–pancreatic transplant. Histological findings were consistent with localized papular mucinosis; electrophoresis showed no paraprotein. A trial of erbium and aura lasers, at ablative doses, produced no improvement. Independent treatments with oral doxycycline, itraconazole, acitretin, and isotretinoin also had no effect. The facial papules improved spontaneously, 2 years after first presentation and 8 months after treatment ceased. The patient remains clear of lesions.     

A peculiar acantholytic dermatosis

This paper reports a peculiar case seen in a 36-year-old woman who every summer since the age of 30 has developed numerous solitary vesicles or crusted papules with intense pruritus in the seborrheic zones. There are no general symptoms and no hereditary relations. The individual rash disappears completely in a week to a month and there is no eruption in winter. The clinical picture resembles that of Darier's disease, but histopathological tests reveal intraepidermal cleft or bulla formation due to acantholysis but no dyskeratosis. Clinicopathological consideration indicates a disease akin to familial benign chronic pemphigus, but as our case does not correspond to any known disease, it is therefore reported as a peculiar acantholytic dermatosis.     

Epidermodysplasia verruciformis induced by a new human papillomavirus (HPV-8)

Summary A new case of epidermodysplasia verruciformis (EV) is reported in a 35-year-old man characterized by multiple common warts, flat warts, psoriasis-form lesions, and pityriasis-versicolor-(PV) like lesions. There was no familial history, no mental retardation, and no malignant changes. Human papilloma virus type 8 was identified in PV-like lesions. Immunologic studies detected no abnormalities: Delayed skin tests, DNCB sensitization, levels of immunoglobulins, complement components, circulating immune complexes, number of circulating lymphocytes, lymphocyte membrane markers, proliferative responses to mitogens, Ts activity, and Ts subpopulations as detected by monoclonal antibodies were considered to be within normal limits. A treatment with a retinoid aromatic (RO 10-9359) improved the clinical status of the patient and did not modify the immune parameters.     

精子优选方法对人工授精治疗结局的影响

目的：回顾分析不同精子优选方法对人工授精治疗结局是否有影响。方法：选择2010年1月-2011年12月在本中心行AIH治疗的504对夫妇共732个周期为研究对象,按精子优选处理方法进行分组：上游法314个周期,密度梯度离心法418个周期,比较两种精子优选方法行人工授精在临床妊振率、流产率和子代性别的差异。结果：上游法和密度梯度离心法的周期妊娠率分别为8．6％、6．7％,流产率分别为25．9％、17．9％,差异无统计学意义（P〉0．05）;两种方法处理后行人工授精的婴儿性别比例比较差异无统计学意义（P〉0．05）。结论：上游法和密度梯度离心法应用在夫精人工授精中临床妊娠率、流产率无差异,精子优选方法对子代性别无预测意义。     

Systemic complement activation in psoriasis vulgaris

Nineteen patients with psoriasis vulgaris and no other cause for systemic complement activation were studied for evidence of such activation. There was a marked elevation in serum C5b-9 complexes with no other significant complement abnormalities, and no correlation between C5b-9 levels and disease activity. This is the most detailed study of complement in psoriasis yet attempted and confirms that complement activation is a feature of psoriasis vulgaris.     

McAb－BA－ELISA检测人血清青霉素特异性IgE

利用单克隆抗体及生物素亲和素系统，建立ＭｃＡｂ－ＢＡ－ＥＬＩＳＡ检测人血清青霉素特异性ＩｇＥ。２７例青霉素Ｉ型变态反应患者中，６例青霉素特异性ＩｇＥ（２２．２％）阳性；而１００例非青霉素过敏者均阴性，且随机使用青霉素无反应。结果尚表明青霉素特异性ＩｇＧ并未明显影响青霉素特异性ＩｇＥ的检测（Ｐ＞０．０５）。     

比拉斯汀在荨麻疹治疗中的应用

比拉斯汀是一种新型的H1受体拮抗剂,口服可治疗过敏性鼻炎和荨麻疹,其吸收较快,但食用食物和果汁后吸收减慢.已有数据证实,相比其他受体,比拉斯汀对H1的亲和力更高,并能降低组胺和细胞因子水平.在由组胺引起的皮肤风团和红斑上,比拉斯汀20 mg与西替利嗪10 mg相比具有等同疗效,可能有更快的抑制作用.比拉斯汀无抗胆碱作用,不影响驾驶,除此之外,比拉斯汀还具备良好的耐受性,无镇静作用、心脏毒性和肝脏毒性等优点.