液氮冷冻联合梅花针疗法治疗扁平疣疗效观察

目的探讨液氮冷冻联合梅花针疗法治疗扁平疣的疗效。方法将本院皮肤科门诊187例扁平疣患者随机分为治疗组106例(液氮冷冻联合梅花针治疗)、液氮冷冻组47例、CO2激光组34例,给予相应治疗。结果治疗组治愈例96(90.57%),液氮冷冻组治愈例38(80.85%),CO2激光组治愈例21(61.76%)。三组疗效比较,治疗组与液氮冷冻组治愈率比较,差异无统计学意义(P>0.05);液氮冷冻组与CO2激光组治愈率比较,差异无统计学意义(P>0.05);治疗组与CO2激光组治愈率比较,差异有统计学意义(P<0.05)。结论液氮冷冻联合梅花针疗法治疗扁平疣疗效好,操作简单、副反应小,优于CO2激光治疗,值得临床推广应用。     

冷冻联合鸡眼膏外敷治疗鸡眼疗效观察

1．1临床资料98例均为本科门诊2002年9月～2003年10月确诊的鸡眼患者，随机分为两组。治疗组50例，男11例，女39例；年龄18～78岁，平均36岁；病程2月～10余年。对照组48例，男13例，女35例，年龄19～72岁，平均32岁；病程3月～10余年。皮损分布在双足跖前部、趾侧及趾关节背面。两组病例年龄、性别及病程差异无显著性，具有可比性。     

CO2激光、电灼和液氮冷冻三种疗法治疗掌跖疣144例

寻常疣是常见的皮肤病 ,其中掌跖疣比较难治。我院皮肤科于 2 0 0 0年 2月～ 2 0 0 2年 2月采用CO2 激光、电灼和液氮冷冻治疗掌跖疣 1 44例 ,取得良好疗效。为了探讨较好的治疗方法 ,现报告如下。1　临床资料与方法1 .1　一般资料　 1 44例患者中男 87例 ,女 5 7例 ,年龄 6岁～ 65岁 ,平均 31岁 ,病程 2周～ 1 3年 ,平均 5个月。随意分为 3组 ,甲组 73例 ,共 1 1 8个皮损 ,采用CO2 激光治疗 ;乙组 2 7例 ,共 5 1个皮损 ,采用电灼治疗 ;丙组 44例 ,共 83个皮损 ,采用液氮冷冻治疗。1 .2　治疗方法　甲组 :局部常规消毒 ,以 2 %利多卡因…     

长脉冲1064nm Nd:YAG激光与二氧化碳激光及液氮冷冻治疗化脓性肉芽肿的疗效比较

目的评价长脉冲1064 nm Nd:YAG激光、二氧化碳激光及液氮冷冻治疗化脓性肉芽肿的疗效及安全性。方法将137例化脓性肉芽肿患者随机分为3组,分别采用长脉冲1064 nm Nd:YAG激光(A组)、二氧化碳激光(B组)及液氮冷冻(C组)治疗,评估治疗后6个月的疗效及安全性。结果长脉冲1064 nm Nd:YAG激光、二氧化碳激光及液氮冷冻治疗化脓性肉芽肿的1次治愈率分别为86.9%、78.3%和57.8%,总治愈率分别为100%、86.9%和97.7%,不良反应发生率分别为4.3%、15.2%和13.3%。3种方法治疗化脓性肉芽肿安全有效,其中1次治愈率及总治愈率以Nd:YAG激光组最好,不良反应差异无统计学意义。结论长脉冲1064 nm Nd:YAG激光治疗化脓性肉芽肿安全有效。     

调Q激光与液氮冷冻治疗扁平疣的疗效比较

目的:比较调Q激光与液氮冷冻治疗扁平疣的疗效和安全性。方法:将98例扁平疣患者随机分成调Q激光组和液氮冷冻组。两组分别采用调Q激光治疗和液氮冷冻治疗,均每隔4周治疗1次,最多4次,治疗结束后比较两组疗效,治疗开始6个月后评价两组复发情况并观察不良反应。结果:调Q激光组治愈率、有效率、复发率、不良反应发生率分别为84.00%、92.00%、7.14%、8.00%。液氮冷冻组治愈率、有效率、复发率、不良反应发生率分别为60.42%、70.83%、27.59%、81.25%,两组治愈率、有效率、复发率、不良反应发生率比较差异均有统计学意义(2值分别为6.82、5.97、4.03、50.43,P值均<0.05)。结论:调Q激光治疗扁平疣与液氮冷冻相比具有疗效好、安全性高的特点。     

激光和液氮冷冻治疗寻常疣疗效观察

1 临床资料 100例患者均来自本科2002年1月～2005年12月门诊，男40例，女60例，年龄1—61岁，平均35．60岁，病程1月～6年。随机分为闪光灯泵脉冲染料激光治疗组（治疗组）50例和液氮冷冻组（对照组）50例，两组在性别、年龄、病程上差异无显著性（P〉0．05）。两组皮损均分布在面部、手背、甲周、指（趾）端、指背及侧缘，皮损直经0．5～1．5cm，均为首次发病，未经任何治疗，所有病例均无严重心肺疾病，无寒冷性荨麻疹病史。     

液氮冷冻联合肌注IL—2治疗斑秃的临床观察

1998年3月～1999年5月,本人采用液氮冷冻联合白介素2(IL-2)治疗斑秃取得较好临床效果,现报告如下。 1 临床资料 38例均为我院皮肤性病科门诊患者,男23例,女15岁;年龄18～58岁;平均35.6岁;病程7天～5年。     

点阵CO2激光治疗原发性皮肤淀粉样变病疗效评价

目的：评价点阵CO₂激光治疗原发性皮肤淀粉样变病的疗效。方法：采用点阵CO₂激光治疗躯干及四肢原发性皮肤淀粉样变病，60～80 mJ/脉冲,每4周1次，共治疗3次。根据皮损大小、色素沉着及瘙痒对皮损进行评分。结果：共收集2017年12月至2018年12月10例患者，其中苔藓样淀粉样变性4例，斑状淀粉样变性6例。皮损大小、色素沉着及瘙痒由治疗前的36分，35分，38分下降至9分,12分，4分。三次治疗后的总有效率为100%，显效率为90%。未出现严重不良反应。结论：点阵CO₂激光治疗原发性皮肤淀粉样变病安全有效。     

CO_2激光与液氮冷冻疗法治疗甲周寻常疣126例对比观察

目的 比较CO_2激光与液氮冷冻法治疗甲周寻常疣的临床疗效。方法 对64例患者手指甲周寻常疣皮损进行CO_2激光治疗,并与62例采用液氮冷冻治疗的患者作对照。结果 两组患者痊愈率和痊愈患者的复发率均有显著差异(P<0.0001和P=0.006)。其中甲根部两组痊愈率无显著性差异(P=0.099),复发率亦无显著性差异(P=0.089)。结论 CO_2激光较液氮冷冻法治疗甲周疣临床疗效为佳,对甲根部或疣体较小甲下损害不明显的甲沟部、甲缘部患者,仍可选择冷冻法治疗。     

CO2点阵激光联合308 nm准分子激光治疗白癜风疗效和安全性meta分析

目的：评价CO₂点阵激光联合308 nm准分子激光治疗白癜风的临床疗效和安全性。方法：通过检索Cochrane Library、PubMed、Embase、万方、中国知网、维普数据库,收集CO₂点阵激光与308 nm准分子激光联合治疗白癜风相关的文献,运用软件（Revman 5.3）进行Meta分析。结果：13篇临床随机对照实验被纳入,其中1014处皮损给予CO₂点阵激光与308 nm准分子激光联合治疗,1005处皮损给予308 nm准分子激光单独治疗。结果显示：联合疗法总有效率和显效率优于单用308 nm准分子激光;两组不良反应发生率无明显差异。结论： CO₂点阵激光+308 nm准分子激光联合治疗白癜风的疗效优于单独使用308 nm准分子激光,且两种疗法的不良反应没有明显差异。     

Fractional CO2 laser plus topical antifungal versus fractional CO2 laser versus topical antifungal in the treatment of onychomycosis

Onychomycosis is an important medical disorder affecting both health and quality of life of patients. This study was done to compare the efficacy of CO₂ laser in combination with topical tioconazole versus CO₂ laser only versus topical tioconazole alone in onychomycosis. A total of 120 patients with onychomycosis were randomly assigned to three groups. Group A patients were treated with fractional CO₂ laser followed by topical tioconazole 28% for five sessions with 3 weeks interval. Group B patients were treated with only fractional CO₂ laser for five sessions with 3 weeks interval. Group C patients were treated with only topical tioconazole 28% for 16 weeks. The clinical effect, KOH examination, and culture for the affected nails in the three groups were analyzed. One month after the last session, regarding clinical response, 55% showed complete clinical improvement in Group A versus 30% in Group B versus 25% in Group C with a significant difference in between. There was a significant difference between the three studied groups as regard KOH test and culture after treatment. Fractional CO₂ laser combined with topical antifungal is a safe and effective treatment for onychomycosis.     

The efficacy of fractional CO2 laser in acne scar treatment: A meta‐analysis

Fractional CO₂ laser is a good option for treating acne scars. However, the clinical efficacy of this treatment modality requires further evidence. To perform a meta‐analysis to assess clinical improvements in acne scars with fractional CO₂ laser and non‐CO₂ laser therapies. Databases (PubMed, Embase, Cochrane Library) were searched using the search strategy to identify eligible studies. All statistical analyses were performed using the Review Manager 5.0, and a meta‐analysis was conducted to assess the effects of fractional CO₂ laser used as a treatment for acne scars. Eight studies were included for further analysis. There was no significant difference between fractional CO₂ laser and non‐CO₂ laser therapies in terms of clinical improvement, observer assessment (P = .19), patient assessment (P = .91), and incidence of post‐inflammatory hyperpigmentation (P = .69). The subgroup analyses showed that the duration of follow‐up had little effect on the evaluation of treatment effect. The efficacy of fractional CO₂ laser therapy in acne scars appeared to be equal to that of non‐CO₂ laser therapies. More well designed randomized controlled trials and more credible and standard evaluation criteria are needed, and the efficiency of combination therapy requires further analysis.     

超脉冲CO_2点阵激光联合外用药治疗顽固性白癜风的疗效评价

目的:评价超脉冲CO_2点阵激光联合外用药膏治疗顽固性白癜风的临床疗效。方法:将56例顽固性白癜风患者随机分成治疗组29例(皮损52块)和对照组27例(皮损48块),均外用丙酸氟替卡松乳膏及卡泊三醇每日1次,疗程12周。治疗组另给予CO_2点阵激光治疗,1次/3周,共4次。12周后评价疗效。结果:治疗组中有效皮损36块,有效率76.6%;对照组有效皮损18块,有效率42.9%,差异有显著性(P0.01)。结论:点阵激光联合外用药物治疗白癜风比单用药物疗效明显。     

CO2点阵激光与1550nm铒玻璃点阵激光治疗妊娠纹的自身对照研究

目的： 评价CO2点阵激光与1550nm铒玻璃点阵激光治疗妊娠纹的疗效及安全性。方法：收集妊娠纹患者,以前正中线分腹部为左右两侧,左侧妊娠纹采用10600nm CO2点阵激光,右侧妊娠纹采用1550nm铒玻璃点阵激光治疗。每次治疗间隔2个月,治疗3次,末次治疗后随访3个月。结果：剔除2例失访患者,共25例患者完成本研究。84%患者右侧和48%患者左侧的皮损改善51％～75％,差异有统计学意义（P<0.05）。自我满意度评分中80%患者对右侧满意,68%对左侧满意。治疗后20%患者左侧色素沉着,8%患者右侧色素沉着。患者在治疗过程中疼痛评分右侧（5.41±2.13分）高于左侧（4.19±2.12分）,两者差异有统计学意义（P<0.001）。两侧均未出现永久性色素改变。结论：1550nm铒玻璃点阵激光较10600 nmCO2点阵激光更能有效治疗妊娠纹。     

富血小板血浆联合CO2点阵激光治疗萎缩性痤疮瘢痕疗效和安全性Meta分析

目的：系统评价富血小板血浆联合CO₂点阵激光治疗面部萎缩性痤疮瘢痕的有效性及安全性。方法：检索从建库到2019年7月Cochrane Library、Embase、Medline、中国知网、万方数据库及维普数据库中富血小板血浆联合CO₂点阵激光治疗面部萎缩性痤疮瘢痕的随机对照试验,筛选符合要求的文献并根据Cochrane偏倚风险评估方法评价纳入文献质量, 采用Revman5.3软件进行Meta分析。结果：最终纳入5个RCTs和Meta分析,结果显示：①联合疗法的总有效率和治愈率均高于单用激光组（P=0.008,0.0002）;②联合疗法和单用激光组的红斑、水肿持续时间及疼痛评分无统计学差异（P=0.21,0.35,0.50）。结论：富血小板血浆联合CO₂点阵激光治疗萎缩性痤疮瘢痕的疗效优于单独使用CO₂点阵激光,不良反应无明显差异。     

CO2点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病疗效评价

目的：评价CO₂点阵激光联合萘替芬酮康唑乳膏外用治疗甲真菌病的临床疗效。方法：对2017年1月至2018年8月我科门诊甲真菌病患者患甲进行CO₂点阵激光照射（2周1次）,每日外涂萘替芬酮康唑乳膏治疗,共治疗16周。观察临床疗效、真菌学检查结果及不良反应发生情况。结果：共治疗35例患者,35个靶甲,其中指甲5个,趾甲30个;白色浅表型8个,远端侧位甲下型18个,近端甲下型9个。在第4次治疗后有效率为54.29%,真菌清除率为74.29%;疗程结束3个月后有效率为82.89%,真菌清除率为88.57%。结论：CO₂点阵激光联合萘替芬酮康唑乳膏治疗甲真菌病安全有效。     

Effects of CO2 fractional laser therapy on peripheral blood cytokines in patients with vitiligo

Vitiligo is a disease pathologically characterized by specific damage to melanocytes. The aim of this study was to explore the mechanism underlying CO2 fractional laser treatment of vitiligo by detecting the levels of Th1 cytokines (IL‐2 and IFN‐γ), Th2 cytokines (IL‐4 and IL‐10), and Th17 cytokines (IL‐17 and IL‐23) in peripheral blood. Twenty five vitiligo patients were enrolled in this study and were treated with a CO2 fractional laser four to eight times. The cytokines of 25 vitiligo patients and 20 healthy volunteers were measured by enzyme‐linked immunosorbent assay. After CO2 fractional laser therapy, six cases were cured, and the apparent efficiency was 72.0% (18/25), while the efficiency was 92.0% (23/25). Before CO2 fractional laser therapy, IL‐2 and IFN‐γ levels in vitiligo patients were higher than those in the control group, but the difference was not statistically significant (p > .05). IL‐4, IL‐10, IL‐17, and IL‐23 levels were also higher in vitiligo patients than those in the control group (p < .05). After treatment, IL‐2 and IFN‐γ levels in vitiligo patients were lower than before treatment, but the difference was not statistically significant (p > .05), while IL‐4, IL‐10, IL‐17, and IL‐23 levels were significantly lower compared with before treatment (p < .05). The results show that CO2 fractional laser treatment has a good curative effect in the treatment of vitiligo.