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1.
A group of individuals who had granted or refused permission to have organs removed from a decreased relative for transplantation were interviewed. Organ donation was found to be a very delicate subject: the request for organ donation often comes unexpectedly and most relatives are not aware of the wishes of the decreased (donor codicil), which complicates the decision process. Some of the relatives who refused regretted their decision later. Remorse was also encountered in the group who gave their permission, although positive feelings were more common. The position of the member of staff who asks for permission is complicated. Suggestions are presented to improve the procedure. 相似文献
2.
Every year some 700 new patients and 150 patients in whom a transplanted kidney is no longer functioning are placed on the waiting list for kidney transplantation. Per year some 400 cadaver kidneys and 100 kidneys from relatives and partners are transplanted in the Netherlands, resulting in an annual shortage of 350 kidneys. By 'non-heart-beating donor' is meant a subject deceased after cardiac arrest, in contradiction to the brain-dead donor. In non-heart-beating donors it is possible via a catheter in the inguinal artery to occlude the aorta above and below the kidney level, following which the kidneys may be perfused with a refrigerated fluid and preserved. In this way, time is gained to obtain consent for transplantation from the relatives or to find it in the donor registration. A kidney originating from a non-heart-beating donor relatively often starts to function only late after transplantation, or even does not begin to function at all. Nevertheless, the number of kidneys becoming available in this way suffices to eliminate the current shortage of donor kidneys. The Organ Donation Law allows cooling of the kidneys in the cadaver in expectation of consent for organ donation. It appears necessary to carry out a test of kidneys of non-heart-beating donors to avoid transplantation of non-viable kidneys. 相似文献
3.
4.
Recently the first three liver transplantations from living donors were performed in The Netherlands. The motivations to proceed with this new procedure were threefold; the existing shortage of post-mortem organ donors, the successful transplants reported in the literature and the supposedly better organ quality and favourable-logistics of the procedure. This new procedure is in line with a recent advisory report on organ donation from the National Health Council of The Netherlands. As long as there is a shortage of post-mortem donors, living donation is a necessary treatment for patients with otherwise fatal liver insufficiency. However this should not keep public and governmental organisations from its continuing efforts to promote post-mortem donation. These should also include a discussion regarding changes to the organ donation law. 相似文献
5.
Haddow G 《Sociology of health & illness》2005,27(1):92-113
Abstract Organ transplantation is an innovative 21st century medical therapy that offers the potential to enhance and save life. In order to do so it depends on a supply of organs, usually from cadaveric donors who have suffered brain stem death. Regardless of whether and how the deceased recorded their wishes about donation, health professionals will approach the bereaved relatives, before organs are removed. In this article, the results from 19 semi‐structured interviews with Scottish donor families will be presented. These accounts will focus exclusively on the families’ beliefs about death, the dead body and bonds with the deceased, and whether these affected the donation decision or the organs donated. What the families said about brain stem death (BSD); how and when they understood that death had occurred; and whether the families thought that death caused a ‘disembodiment’ (that the self was no longer embodied) will be explored. Finally, attention will turn to the bereaved's previous relationship with the embodied person. I conclude that the phenomenology of embodiment, death and organ transplantation offers new answers to the question of ‘Who am I’? That is, in order to understand what identity is, one might look for what it is that is lost at death; the body, the self and relationships with others. 相似文献
6.
Terpstra OT Sterringa GJ Bouwman E Roep BO 《Nederlands tijdschrift voor geneeskunde》2005,149(1):12-16
Since 1921 and until recently, insulin by injection has been the only treatment for patients with diabetes mellitus type 1. After pancreas transplantation, which became possible in 1977, the next logical step to cure patients with diabetes mellitus type 1 is the transplantation of the islets of Langerhans. In the last few years, the results of islet transplantation are markedly improved thanks to developments in the isolation technique and better immunosuppressive protocols. Ongoing problems in islet transplantation are allo-immunity, auto-immunity and the growing shortage of donor pancreases. Alternatives to pancreas donation, be it post-mortem or from a living donor, could be: sources for islets are xenotransplantation with the aid of pig islets and beta-cell neogenesis from embryonic stem cells or pancreatic duct cells. 相似文献
7.
K.-H. Schulz S. Gold M. v. d. Knesebeck U. Koch 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2002,45(10):774-781
For a number of life-threatening diseases, organ transplantation remains the only therapeutic option. Today, the crucial issue is shortage of available organs for transplantation rather than technical problems, peri-operative mortality or allograft rejection. While surveys among the general public have consistently shown strong support for transplantation medicine and a high willingness to donate, the donation rate in Germany remains low and has decreased over the past years. In this paper, we discuss different factors that may influence donation rate and examine their potential of helping to increase organ donation. These factors – in order of the time course of the organ donation process – include: donor detection, referral, assessment of medical contra-indications, decision, maintenance, ex-/transplantation. We discuss factors of organizational, psychological and medical nature that may influence the number of organ donations in each of these phases and review available empirical data. Based on this analysis, we propose a heuristic six-step model of the organ donation process. Subsequently, we outline a possible “orchestra” of coordinated strategies that simultaneously act on different stages of the model and may thus help to increase the organ donation rate. 相似文献
8.
Kigawa M Hasegawa T Amemiya H 《[Nihon kōshū eisei zasshi] Japanese journal of public health》2001,48(7):521-533
OBJECTIVE: To investigate knowledge, attitudes and behavior regarding organ transplantation, and to estimate the impact of the first organ transplantation from a brain-dead donor under the Organ Transplantation Act. SUBJECTS AND METHODS: A telephone survey was made using the Random Digit Dialing method in May 1999. People living in the Tokyo Metropolitan area ages 20 years or over were asked about their knowledge, attitudes and behavior regarding organ transplantation, and their opinions on the first organ transplantation conduced in February 1999. The results were compared with an opinion poll made 7 months previously to estimate the impact of this first case. RESULTS: The number of respondents was 489 (response rate: 46.0%). 1) Knowledge of organ transplantation: most people knew that organ donation from brain-dead donors was possible under the act, and that written consent on a form and family member's agreement were necessary before donating. More people knew about donor cards. 2) Organ transplantation: more people were willing to donate their organs when they die, and to agree to donation when a family member died who had wanted to donate his/her organs on their death. In the poll 7 months before, fewer people were willing to donate their organs or to agree to donate their family member's organs after brain death compared with after heart arrest. However, no such difference between brain death and heart arrest was found in this later study, suggesting that the distinction between the two was no longer considered to be so important. 3) Respondents themselves having donor cards constituted 15.2%, showing a marked increase from 7 months earlier. Another 39.7% wished to carry a donor card; the most common reason for not carrying one was they did not know how to acquire it. 4) The first transplantation was considered to have contributed to the increase in knowledge, and a favorable change in attitudes and behavior toward organ transplantation. 5) Respondents who agreed to that organ donation from children aged under 15 should be possible constituted 46.4%, of the to be this not being allowed at the present time. 6) The majority of respondents considered that the brain death was diagnosed properly in the first case and that the donation was made voluntarily, concluding that the transplantation was made fairly. 7) Respondents who considered that the privacy of the donor and the recipients was violated were 46.2% and 36.1%, respectively. The attitude of the mass media toward the first transplantation was criticized by 56.9% of the respondents. 8) Respondents who had a favorable impression of the organ transplantation were 61.9%. Such people are likely to donate their organs, to agree to a family member's donation, and to have a donor card than people who had not gained a favorable impression. The two groups exhibited no difference in their knowledge concerning organ transplantation. CONCLUSIONS: An increase in knowledge and a favorable change in attitudes and behavior regarding organ transplantation was confirmed in this survey, as compared with results 7 months earlier, probably because the first transplantation took place. The majority of the respondents considered that the first transplantation was made fairly, although they criticized the attitude of the mass media invading the privacy of the donor and the recipients. Further studies should be made to facilitate effective delivery of donor cards to people who want to carry them, and to change the rules on organ donation from children. 相似文献
9.
J.-M. Pollok X. Rogiers 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2002,45(10):795-800
Liver transplantation is a safe and established treatment method for acute and chronic liver failure due to congenital or acquired liver diseases [1, 2]. With the success of liver transplantation the problem of donor organ shortage developed worldwide. It became obvious that the limited supply of donor organs cannot meet the demand, despite intensive efforts to increase donations. Thus, it is very important to try to prevent the development of liver diseases (i.e., hepatitis B vaccination) and to improve the currently available treatment strategies for diseases leading to liver cirrhosis (i.e., antiviral therapy). A further aspect is the improvement of surgical techniques and the postoperative and long-term treatment of transplanted patients. Hepatocyte transplantation has the potential to cure patients with metabolic liver disease or acute liver failure. It could also serve to bridge the time until an organ is available for transplantation. The use of hepatocytes from organs, which cannot be otherwise used because of injury or prolonged ischemia, or the use of genetically modified hepatocytes can counteract the shortage of available donor organs. Using the methods of tissue engineering can increase the efficiency of hepatocyte transplantation. Extracorporeal liver support systems offer the option for temporal compensation of missing liver function to treat patients with acute liver failure until regeneration of their own liver is achieved or until a donor organ becomes available for transplantation. 相似文献
10.
Knowledge regarding organ donation: identifying and overcoming barriers to organ donation 总被引:3,自引:0,他引:3
Four-hundred and fifty-five undergraduate students, 26 MBA students, and 465 people from the surrounding community responded to 21 true/false questions regarding factual knowledge about organ donation. The mean number of correct answers was 74.6%. The correct response rate, however, varied widely over questions. Four questions with very large error rates suggest possible 'barriers to donation'. Specifically, these questions concerned religious support for organ donation, the concept of brain death, the normally rigid separation of physician teams who are primarily responsible for the welfare of the donor and donee, and a mistaken belief that to be valid an organ donor card must be filed with the U.S. Department of Health and Human Services. Knowledge of organ donation facts was found to be related to whether subjects carried or requested an organ donor card, their attitude towards organ donation and their willingness to donate their own organs or the organs of a deceased loved one. These findings suggest strategies for raising public support for organ donation. 相似文献
11.
The impact of presumed consent legislation on cadaveric organ donation: a cross-country study 总被引:1,自引:0,他引:1
In the U.S., Great Britain and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries of continental Europe, however, cadaveric organ procurement is based on the principle of presumed consent. Under presumed consent legislation, a deceased individual is classified as a potential donor in absence of explicit opposition to donation before death. This article analyzes the impact of presumed consent laws on donation rates. For this purpose, we construct a dataset on organ donation rates and potential factors affecting organ donation for 22 countries over a 10-year period. We find that while differences in other determinants of organ donation explain much of the variation in donation rates, after controlling for those determinants presumed consent legislation has a positive and sizeable effect on organ donation rates. We use the panel structure of our dataset to test and reject the hypothesis that unmeasured determinants of organ donation rates confound our empirical results. 相似文献
12.
van der Vliet JA von der Möhlen-Tonino MA 《Nederlands tijdschrift voor geneeskunde》1998,142(52):2830-2832
The Organ Donation Act fills an old gap in the legislation, leading to improvement of the legal position of those involved. Much attention is given to the protection of the potential donor. A new consent procedure is introduced, including the registration of the consent or refusal of all persons aged 18 years or older. Because of the persistent shortage of donor organs the noncommittal nature of organ procurement is changed. Hospitals and nursing homes are obliged to have a protocol for organizing tissue donation. Also, conditions have been created for a just division of the available organs and tissues for transplantation. 相似文献
13.
Blok GA Morton J Morley M Kerckhoffs CC Kootstra G van der Vleuten CP 《Advances in health sciences education : theory and practice》2004,9(4):261-282
One of the major reasons for the shortage of donor organs is the high number of refusals by relatives. Studies have shown that the quality of communication with bereaved relatives influences whether to object or agree to organ and/or tissue donation. Breaking news of brain stem death, approaching relatives for permission to donate organs while also appropriately managing emotional reactions of relatives are complex tasks, which require knowledge of the domains as well as adequate skills to communicate information and understanding. In this study the effect of the European Donor Hospital Education Programme (EDHEP) on the self-efficacy of Intensive Care staff is evaluated. Self-efficacy scores significantly improved after attending EDHEP; an effect that was maintained at six month follow-up. EDHEP participants with high baseline scores on self-efficacy, maintained the increase at follow-up. EDHEP participants with low baseline scores on self-efficacy showed the greatest increase at the post-test. Increases in self-efficacy were significantly related to decreases in the perceived difficulty of requesting. Experience had a significant effect on both self-efficacy beliefs and perceived difficulty of requesting donation. As self-efficacy beliefs are perceived as better predictors for future behaviour than prior attainments, the results call for further research in this domain. The data indicate that training programmes should be tailored not only to working circumstances of participants, but should also take levels of experience and self-efficacy into account. Further study is necessary and the best way to proceed is to relate the outcomes of this study to behavioural outcomes. 相似文献
14.
G.A. Blok J. Morton M. Morley C.C.J.M. Kerckhoffs G. Kootstra C.P.M. van der Vleuten 《Advances in health sciences education : theory and practice》2005,9(4):261-282
One of the major reasons for the shortage of donor organs is the high number of refusals by relatives. Studies have shown that the quality of communication with bereaved relatives influences whether to object or agree to organ and/or tissue donation. Breaking news of brain stem death, approaching relatives for permission to donate organs while also appropriately managing emotional reactions of relatives are complex tasks, which require knowledge of the domains as well as adequate skills to communicate information and understanding. In this study the effect of the European Donor Hospital Education Programme (EDHEP) on the self-efficacy of Intensive Care staff is evaluated. Self-efficacy scores significantly improved after attending EDHEP; an effect that was maintained at six month follow-up. EDHEP participants with high baseline scores on self-efficacy, maintained the increase at follow-up. EDHEP participants with low baseline scores on self-efficacy showed the greatest increase at the post-test. Increases in self-efficacy were significantly related to decreases in the perceived difficulty of requesting. Experience had a significant effect on both self-efficacy beliefs and perceived difficulty of requesting donation. As self-efficacy beliefs are perceived as better predictors for future behaviour than prior attainments, the results call for further research in this domain. The data indicate that training programmes should be tailored not only to working circumstances of participants, but should also take levels of experience and self-efficacy into account. Further study is necessary and the best way to proceed is to relate the outcomes of this study to behavioural outcomes. 相似文献
15.
During the past 30 years, solid organ transplantation has developed into a routine medical procedure. Currently, one-year transplant survival rates for kidney, heart, liver and pancreas are between 80 and 90%; for most organs, the long-term results are fair with 5-year survival rates of 60%. Inclusion criteria for potential recipients have become less stringent. These days, potential recipients are rarely excluded on the basis of their calendar age alone. The development of more and stronger immunosuppressive drugs has facilitated transplantation across wider immunological differences between donor and recipient with good results. While the number of patients on the waiting lists for organ transplantation increased, the number of organs offered for donation decreased. This has resulted in waiting times of several years for most organ transplantations. While the short-term outcome has improved significantly over the past decades, the long-term outcome has not. Most renal transplants, for example, are lost due to chronic rejection. The challenge for the future will be to improve the long-term outcome of organ transplantation and to decrease the morbidity associated with chronic immunosuppressive therapy. 相似文献
16.
G. Kirste 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2002,45(10):768-773
In the Federal Republic of Germany the number of living organ donations is increasing. In 2001, 382 (16, 3%) kidney transplantations and 95 (12,5%) liver transplantations have been carried out by using organs or tissue of living donors. Graft survival in kidney transplantation is 91% for living related donation and 89% for living unrelated donation compared to 75% for cadaveric donation after a five year follow-up period. Detailed medical examinations of the donor and the recipient are an absolute prerequisite for organ donation. In Germany, living donation must be performed according to the criteria given in the Transplantation Act. 相似文献
17.
What role should age play in the allocation of organs for transplantation? Historically, older patients have not been listed as candidates for transplantation on the assumption that greater benefit could be obtained by favoring younger candidates, raising questions of equity and age discrimination. At the same time, organs offered for donation by the very old are frequently rejected because of concerns about length of viability. We examine a local case that challenges these practices: the liver from an elderly donor was successfully transplanted into an older patient. After exploring some of the potential problems with such a solution, we propose creating a second pool of organs from the very old for transplantation into older candidates, thus expanding the number of organs available, saving additional lives, and including the elderly more visibly in our transplant system. 相似文献
18.
Michielsen P 《Health policy (Amsterdam, Netherlands)》1990,16(2):117-122
As there is a world-wide shortage of organs for transplantation, the selection of the patients is more defined by the availability of transplantable organs than by the medical condition of the potential recipient. This shortage of cadaveric organs is mainly responsible for the use of living donors. With HLA identical sibling donors the results are better than with cadaveric organs, but the ethical problems are usually underestimated. For the parent-to-child donation, the HLA compatibility is less than what could be achieved with well-matched cadaveric donors. The use of genetically unrelated donors is unacceptable from the ethical as well as from the medical point of view. The short- and long-term risk of donation has been insufficiently documented. The experience with the introduction of an opting-out legislation in Belgium in 1987 demonstrates that the shortage of cadaveric organs can be overcome. Harmonization of the legislation is, however, necessary so as to achieve comparable organ retrieval rates between countries participating in organ-exchange organisations. 相似文献
19.
Sarah L White Richard Hirth Beatriz Mahíllo Beatriz Domínguez-Gil Francis L Delmonico Luc Noel Jeremy Chapman Rafael Matesanz Mar Carmona Marina Alvarez Jose R Nú?ez Alan Leichtman 《Bulletin of the World Health Organization》2014,92(11):826-835
Rising incomes, the spread of personal insurance, lifestyle factors adding to the burden of illness, ageing populations, globalization and skills transfer within the medical community have increased worldwide demand for organ transplantation. The Global Observatory on Donation and Transplantation, which was built in response to World Health Assembly resolution WHA57.18, has conducted ongoing documentation of global transplantation activities since 2007. In this paper, we use the Global Observatory’s data to describe the current distribution of – and trends in – transplantation activities and to evaluate the role of health systems factors and macroeconomics in the diffusion of transplantation technology. We then consider the implications of our results for health policies relating to organ donation and transplantation. Of the World Health Organization’s Member States, most now engage in organ transplantation and more than a third performed deceased donor transplantation in 2011. In general, the Member States that engage in organ transplantation have greater access to physician services and greater total health spending per capita than the Member States where organ transplantation is not performed. The provision of deceased donor transplantation was closely associated with high levels of gross national income per capita. There are several ways in which governments can support the ethical development of organ donation and transplantation programmes. Specifically, they can ensure that appropriate legislation, regulation and oversight are in place, and monitor donation and transplantation activities, practices and outcomes. Moreover, they can allocate resources towards the training of specialist physicians, surgeons and transplant coordinators, and implement a professional donor-procurement network. 相似文献
20.
Slooff MJ 《Nederlands tijdschrift voor geneeskunde》2001,145(12):563-567
Liver transplantations using a part of the liver from a living donor are already being performed around the world. The main arguments for performing such transplantations are the shortage of brain-dead donors and the consequently high mortality rate of patients on the waiting list for a liver transplantation. The disadvantages of this option are the mortality and morbidity risk for the living donor. The shortage of brain-dead donors could also be resolved by the implementation of special techniques such as split-liver and domino-liver transplantations or by using compromised and non-heart-beating donors. Furthermore, measures should be taken to reduce the shortage of brain-dead donors in the Netherlands. If such actions do not lead to an increase in the number of brain-dead donors and a willingness to restrict the indications for transplantation is not forthcoming then donation for liver transplantation by living donors is inevitable. Such a program should satisfy certain conditions and have the requisite medical-ethical and public support. 相似文献