Diagnosis of nodal Langerhans cell histiocytosis by fine needle aspiration cytology

Langerhans cell histiocytosis (LCH) is a rare disease and disease confined to the lymph nodes is even more uncommon. Fine needle aspiration (FNA) cytology of LCH of the lymph nodes has rarely been described. A case study of LCH of the lymph nodes in a 23-year-old man is presented. FNA smears showed high cellularity composed of many isolated Langerhans cells (LCs) with nuclear grooves admixed with numerous eosinophils, lymphocytes, giant cells, macrophages, and neutrophils. Further immunohistochemical study of the excised lymph node sections revealed that the histiocytes were positively stained with CD1a. The presence of LCs with nuclear grooves and eosinophils suggests the possibility of LCH. FNA cytology is a valuable method for diagnosis.     

乳腺肿块细针穿刺细胞学与组织病理学对照分析

目的比较乳腺肿块细针穿刺细胞学与组织病理学检査结果。方法选择我院2015年1月~2016年10月收治的382例乳腺肿块患者作为研究对象,对患者分别行细胞学与组织病理学检査,对比两种检査方法的诊断结果。结果 382例乳腺肿块患者的FNAC检査结果:Ⅰ级341例(89.27%),Ⅱ级19例(4.97%),Ⅲ级4例(1.05%),Ⅳ级18例(4.71%),与组织病理学检测结果比较无明显差异(P0.05)。382例患者行FNAC诊断的准确率为98.43%,敏感性为78.57%,假阴性率为17.14%,特异性为98.33%,假阳性率为0。结论对乳腺肿块患者采用细针穿刺细胞学检查具有微创、安全、经济、准确率高、患者痛苦小等优点,但是也有一定局限性,应结合组织病理学检査,以提高诊断率,为临床诊断与治疗提供可靠依据。     

Secondary extramedullary plasmacytoma of the breast: Diagnosed by fine needle aspiration cytology

A 34years old female who was a known case of multiple myeloma presented with a mass in the right breast. Clinically a differential diagnosis of breast carcinoma or secondary involvement by multiple myeloma was considered. Fine Needle Aspiration Cytology (FNAC) of the mass was performed which showed dispersed population of plasma cells with eccentrically placed nuclei, abundant cytoplasm and the characteristic paranuclear hof.     

细针穿刺技术在乳腺癌手术治疗中的应用价值

目的 研究乳腺细针穿刺细胞学(FNAC)检查在乳腺癌手术治疗中的临床应用价值.方法 选取2004年1月至2009年1月在北京协和医院初诊考虑乳腺癌可能性大的530例女性患者行FNAC检查.根据FNAC结果决定进一步的治疗方案.所有患者均接受了乳腺手术,术后进行组织病理学诊断.结果 FNAC检查阳性的325例患者直接行乳腺癌根治性手术,术后组织病理学证实均为乳腺癌.FNAC检查阴性的205例患者接受开放活检手术,术后组织病理学证实137例为乳腺癌,68例为非乳腺癌.结论 FNAC有助于为怀疑乳腺恶性肿瘤者选择适当的术式.     

Role of fine needle aspiration cytology in diagnosis of breast lumps.

Objective: The aim of this study is to find out the common causes of breast lump and to determine the sensitivity and specificity of FNAC of breast lump. Materials and methods: This is a retrospective study of FNAC of breast done in pathology department of NMCTH from January 2003 to December 2005. FNAC findings were correlated with data from histopathology records to determine the sensitivity and specificity of FNAC. Results: FNAC of breast constituted 16% of all the FNACs. Age group of the patients ranged from 17 to 56 years with mean of 32 years. Fibroadenoma was the most common diagnosis. Malignancy was diagnosed in only 6.6% of the cases. Histological correlation was done in 21 cases. Sensitivity and specificity of FNAC of breast was found to be 83.3% and 100% respectively. Conclusion: FNAC of breast is simple, cost effective and less traumatic method for diagnosis of breast lump. It is highly sensitive and specific also, and can reduce the needs for open biopsies. So FNAC should be used as a routine method for determining the nature of breast lumps. Key words: FNAC, breast lump, neoplasm.     

结节病的细针吸取细胞学诊断

目的:探讨用细针吸取细胞学(FNAC)方法诊断结节病的方法。方法:对3例结节病FNAC标本和相对应病例的病理组织切片在光镜下进行分析。结果:主要特点是见到大量上皮样细胞散在分布或成团分布,还有多核巨细胞,前者核较肥胖,胞浆呈粉红色,细胞互相连接成团,没见干酪样坏死,与结核病不同。结论:此诊断方法具有简便、迅速、损伤少、诊断可靠的特点。     

乳腺细针针吸细胞学检查在基层医院应用的可行性分析

目的 分析基层医院乳腺细针针吸细胞学(fine needle aspiration cytology,FNAC)诊断的准确性,评价该检查方法在基层医院应用的可行性.方法 回顾北京市怀柔区中医医院有组织病理学结果的145例乳腺肿物细针针吸病例,将细胞学结果与组织学结果对照分析.结果 145例乳腺针吸病例中乳腺癌27例,纤维腺瘤45例,乳腺腺病40例,其他良性病变33例.针吸细胞学诊断乳腺癌的敏感性为92.6％,特异性为100％,准确性为98.6％.结论 FNAC检查操作简便,诊断准确性高,可以作为基层医院乳腺肿物的常规检查项目.     

乳腺肿块针吸细胞学检查682例临床分析

目的探讨针吸细胞学检查在乳腺肿块诊断中的临床应用价值。方法针吸细胞学检查乳腺肿块682例,其中500例与病理组织学检查结果对照。结果与组织病理学对照分析,针吸细胞学检查恶性肿瘤诊断的敏感性为98．7％,良性肿瘤诊断的特异性为95．5％,总准确率为97．4％。结论针吸细胞学检查对于临床诊断乳腺病变有独到价值,而且对恶性病例诊断更为可靠,此诊断技术简便,安全快速,特异性高,临床应用前景广阔。     

细针吸取细胞学在乳腺疾病诊断中的意义

目的:探讨细针吸取细胞学(fine neelde aspiration cytology,FNAC)在诊断乳腺疾病中的价值.方法:我院2003年10月～2008年5月门诊和住院的乳腺疾病患者362例,其中201例经病理组织学对照.结果:201例经病理组织学对照,良性肿瘤136例,恶性肿瘤65例,总符合率为97.50%,细胞学与病理组织学诊断完全一致的占91.54%,定性(良、恶性)正确而组织学类型不一致的占5.79%,良、恶性误诊率为2.49%.结论:FNAC对乳腺疾病的诊断有独到的临床价值.     

132例乳腺肿块针吸细胞学诊断与病理组织学诊断对比分析

目的比较乳腺肿块针吸细胞学检查在临床中的应用价值。方法分析132例乳腺肿块针吸细胞学诊断,并与术后病理组织学诊断结果相对比。结果针吸细胞学检查良性病变101例,乳腺癌31例,其中肯定为癌者29例,疑为癌2例,阳性率为93.9%,假阴性诊断2例,占6.1%,无假阳性报告。结论乳腺肿块针吸细胞学在乳腺肿块良恶性病变的鉴别中具有较高的应用价值。     

Diagnostic evaluation of childhood cervical lymphadenopathy by fine needle aspiration cytology

Lymphadenopathy is an age old affliction of mankind. It is one of the very common presentations in clinical practice. The present study was carried out to evaluate the merits and demerits of fine needle aspiration cytology (FNAC) as a diagnostic procedure in childhood lymphadenopathy in comparison to open surgical biopsy. Altogether 70 children with lymphadenopathy in the age group of up to 12 years were selected for FNAC. Only 38 could be motivated for open surgical biopsy. Out of 38 cases, FNAC was consistent with histopathology in 33 cases, thus giving a diagnostic accuracy or percentage of agreement-86.8%. The diagnostic accuracy of FNAC, sensitivity, specificity, positive predictive values of FNAC in the present study were fairly high ranging from 80%-100%. FNAC gave false positive diagnosis in 13.2% cases and false negative result in 13.2% cases.     

全数字化乳腺摄片、超声检查和细针穿刺对早期乳腺癌的诊断价值

目的 将数字化乳腺摄片、超声检查和细针穿刺细胞学检查与病理结果对照,评估三者单独应用在乳腺癌诊断中的价值.方法 对可以扪及乳腺肿块( ＜2cm)的患者行数字化乳腺摄片、超声检查和细针穿刺细胞学检查,再行肿块切除常规病理检查,比较各种方法的准确率.结果 在57例乳腺肿块患者中,有24例病理诊断为乳腺癌.数字化乳腺摄片和超声均能发现肿块,其中数字化乳腺摄片明确诊断乳腺癌19例,敏感性为79.17%(19/24),特异性为87.88%(29/33);超声诊断乳腺癌4例,敏感性为16.67%(4/24),特异性为96.97%(32/33);细针穿刺细胞学诊断乳腺癌21例,敏感性为87.50%(21/24),特异性为93.94%(31/33).数字化乳腺摄片和细针穿刺细胞学检查的敏感性优于超声检查(P＜0.01).数字化乳腺摄片和细针穿刺细胞学检查相比无显著性差异.结论 数字化乳腺摄片和细针穿刺细胞学检查在乳腺癌诊断中具有较高的准确率.     

乳腺肿块细针吸取细胞学与术中冰冻切片诊断比较

目的：分析乳腺肿块细针吸取细胞学(FNAC)与术中冰冻切片诊断(IFSD)的不同特征，探索两者的临床应用价值。方法：对乳腺肿块205例分别进行FNAC和IFSD检查。结果：乳腺良性病变FNAC和IFSD的准确率分别为96．4％和98．6％，乳腺恶性肿瘤FNAC和IFSD的准确率分别为91．0％和97．0％。FNAC假阴性率为2．4％，无假阳性诊断；IFSD未出现假阴性和假阳性诊断。结论：乳腺肿块FNAC和IFSD检查是两种实用、可靠的诊断方法。     

乳腺肿块63例可疑癌的针吸细胞学与病理对照分析

目的 探讨乳腺肿块细针针吸细胞学(FNAC)检查中可疑癌的诊断与临床病理关系。方法 总结1115例乳腺肿块FNAC检查中63例可疑癌的诊断标准及特点。结果 1115例乳腺肿块FNAC检查中，有328例获病理组织学对照，FNAC总正确率96．3％，总误诊率3．7％，假阴性率4．8％，潜在假阳性率1．7％。63例可疑癌占乳腺肿块的5．7％(63／l115)，正确率96．8％(6l／63)，误诊率3．2％(2／63)。结论 FNAC对可疑乳腺癌有较高确诊率。63例可疑癌中大多数为乳腺癌，良性病变少。