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  • Wang ES,Temya-Feldslein J,Wu Y,et al.Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo.Blood,2004,104:2893-2902.
  • Elezkurtaj S,Kopitz C,Baker AH,et al.Adenovirus-mediated overexpression of tissue inhibitor of metallopmteinases-1 in the liver:efficient protection against T-cell lymphoma and colon carcinoma metastasis.J Gene Med,2004,6:1228-1237.
  • Kruger A,Arit MJ,Gerg M,et al.Antimetastalic activity of a novel mechanism-based gelatinase inhibitor.Cancer Res,2005,65:3523-3526.
  • O'Reilly MS,Boehm T,Shing Y,et al.Endostatin:an endogenous inhibitor of angiogenesis and tumor growth.Cell,1997,88:277-285.
  • Abdollahi A,Hahnfehh P,Macrcker C,et al.Endostatin's antiangiogenic signaling network.Mol Cell,2004,13:649-663.
  • Carmeliet P.Angiogenesis in life,disease and medicine.Nature,2005,438:932-936.
  • Ribatti D.Judah Folkman,a pioneer in the study of angiogenesis.Angiogenesis,2008,11:3-10.
  • Li ww,Hutnik M,Gehr G.Anfiangiogenesis in haematological malignancies.Br J Haematol,2008,143:622-631.
  • Wolpin BM,Mayer RJ.Systemic treatment of coloreetal cancer.Gastroenterology,2008,134:1296-1310.
  • Dong X,Han ZC.Yang R,et al.Angiogenesis and antiangiogenic therapy in hematologic malignancies.Crit Rev Oncol Hematol,2007.62:105-118.
  • Giatromanolaki A,Koukourakis MI,Pezzella F,et al.Pbosphorylated VEGFR2/KDR receptors are widely expressed in B-cell nonHodgkin's lymphomas and correlate with hypoxia inducible factor activation.Hematol Oncol,2008,26:219-224.
  • Folkman J.Antiangiogenesis in cancer therapy-endostatin and its mechanisms of action.Exp Cell Res,2006,312:594-607.
  • Bertolini F,Fusetti L,Mancuso P,et al.Endostatin,an antiangiogenie drug,induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human highgrade non-Hodgkin lymphoma.Blood,2000,96:282-287.
  • Ling Y,Yang Y,Lu N,et al.Endostar,a novel recombinant human endostatin.exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells.Biochem Biophys Res Commun,2007,361:79-84.
  • 王金万,孙燕,刘永煜,等.重组人血管内皮抑索联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究.中国肺癌杂志,2005,8:283-290.
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    2006(zl)
  • 2.0.TX;2-3.aspx'>Establishment of an HPA-1-to-16-typed platelet donor registry in China [其它论文] 2006(05)
  • Human platelet antigen genotyping by using sequence-specific primers and the particle gel agglutination assay 2005(04)
  • 2.0.TX;2-N.aspx'>Real-time quantitative PCR assay for analysis of platelet glycoprotein Ⅲ a gene expression [其它论文] 2005(03)
  • Ficko T.Galvani V.Rupreht R Real-time PCR genotyping of human platelet alloantigens HPA-1,HPA-2,HPA-3 and HPA-5 is superior to the standard PCR-SSP method [其它论文] 2004(06)
  • Liu TC.Shih MC.Lin CL Gene frequencies of the HPA-1 to HPA-8w platelet antigen alleles in Taiwanese,Indonesian,and Thai [其它论文] 2002(05)
  • Higgins M.Hughes A.Buzzacott N High-throughput genotyping of human platelet antigens using the 5'-nuclease assay and minor groove binder probe technology [其它论文] 2004(02)
  • Bres JC.Merieux Y.Dugas V New method for DNA microarrays development:applied to human platelet antigens polymorphisms [其它论文] 2005(02)
  • 卞茂红.刘淼.杨鹏 多重聚合酶链反应-微流芯片检测人血小板抗原系统基因型方法的建立与应用 [其它论文] -中华检验医学杂志2006(07)
  • Metcalfe P.Allen D.Kekomaki R 29th International Congress of the International Society of Blood Transfusion:HPA genotyping-where are mistakes made 2006(z2)
  • Mohanty D.Kulkarni B.Ghosh K Human platelet specific antigens and their importance 2004(08)
  • Andrei-Selmer C.Socher I.Bein G 29th International Congress of the International Society of Blood Transfusion:real-time analysis of HPA-la antigen-antibody interaction by surface plasmon resonance technology 2006(z2)
  • Castro V.Kroll H.Origa AF A prospective study on the prevalence and risk factors for neonatal thrombocytopenia and platelet alloimmunization among 9332 unselected Brazilian newborns [其它论文] 2007(01)
  • Ohto H.Miura S.Ariga H The natural history of maternal immunization against foetal platelet alloantigens [其它论文] 2004(06)
  • Kroll H.Yates J.Santoso S Immunization against a low-frequency human platelet alloantigen in fetal alloimmune thrombocytopenia is not a single event:characterization by the combined use of reference DNA and novel allele-specific cell lines expressing recombinant antigens [其它论文] 2005(03)
  • Mandelbaum M.Koren D.Eichelberger B Frequencies of maternal platelet alloantibodies and autoantibodies in suspected fetal/neonatal alloimmune thrombocytopenia,with emphasis on human platelet antigen-15 alloimmunization [其它论文] 2005(01)
  • Killie MK.Husebekk A.Kaplan C Maternal human platelet antigen-la antibody level correlates with the platelet count in the newborns:a retrospective s tudy [其它论文] 2007(01)
  • Bertrand G.Martageix C.Jallu V Predictive value of sequential maternal anti-HPA-la antibody concentrations for the severity of fetal alloimmune thrombocytopenia [其它论文] 2006(03)
  • Ghevaert C.Campbell K.Stafford P HPA-la antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia [其它论文] 2007(07)
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    <正>科技类文章一般需要列出关键词,本刊要求针对文章所研究的重点内容需标引2~5个关键词。关键词应使用全称而不是缩写词,请使用中国医学科学院医学信息研究所的《中文医学主题词表》(Cme SH)所列的词,或登录万方医学网:http://old.med.wanfangdata.com.cn/Mesh/Mesh.aspx查找。如果查不到相应的关键  相似文献   

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    <正>科技类文章一般需要列出关键词,本刊要求针对文章所研究的重点内容需标引2~5个关键词。关键词应使用全称而不是缩写词,请使用中国医学科学院医学信息研究所的《中文医学主题词表》(Cme SH)所列的词,或登录万方医学网:http://old.med.wanfangdata.com.cn/Mesh/Mesh.aspx查找。如果查不到相应的关键  相似文献   

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    脓毒症大鼠小肠功能变化的研究   总被引:25,自引:5,他引:25  
    目的 探讨脓毒症大鼠小肠屏障、吸收、通透及其蠕动功能的变化。方法 以 Wistar大鼠缺血再灌注复合内毒素血症制备动物模型。将动物随机分为正常对照 ( N)、肠系膜上动脉夹闭 1h后再灌注 1h( I/ R1)、2 h( I/ R2 )和 4 h( I/ R4 )以及再灌注 2 h后复合内毒素 2 h( I/ RL)共 5个组。分别测定各组动物血或小肠组织二胺氧化酶 ( DAO)、D 乳酸、D 木糖水平及肠蠕动 ,同时进行小肠普通光镜检查。结果  I/ R1、I/ R4和 I/ RL组血浆 DAO活性均显著升高 ( P均 <0 .0 5 ) ,小肠组织 DAO在 I/ R2和 I/ RL 组均显著降低( P均 <0 .0 5 ) ,从 N、I/ R1、I/ R2、I/ R4到 I/ RL,各组血浆 DAO和小肠 DAO的相关分析可见呈高度负相关( r= 0 .90 9,P<0 .0 0 1) ;I/ R 1、I/ R 2和 I/ RL组血浆 D乳酸均显著升高 ( P均 <0 .0 5 ) ;与 N组比较各组肠传输速度显著加快 ( P均 <0 .0 5 ) ;I/ R 1和 I/ RL组血中 D木糖浓度较 N组高 ,3h后仍高于 N组 ;血 DAO浓度与血 D乳酸浓度变化相关 ( r=0 .5 5 9,P<0 .0 5 )。结论 缺血再灌注后小肠的屏障、吸收、通透和蠕动功能均有不同程度的改变 ;缺血再灌注复合内毒素血症时再次加速或加重了小肠屏障、吸收、通透和传输功能的变化  相似文献   

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    胡国忠  何存弘  邱凤梅 《疾病监测》2011,26(12):993-996,1003
    目的 为掌握浙江省岱山县海岛地区居民健康状况和主要疾病死亡原因,评价居民健康水平,为政府和相关部门制定疾病预防控制策略提供参考依据.方法 对岱山县1986 -1988年和2009-2010年两个时期居民死亡资料进行比较分析,采用国际疾病分类法进行编码,以2000年全国标准人口构成比进行死亡率标化.结果 岱山县两个...  相似文献   

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    论护理工作中的“慎独”与“慎众”   总被引:1,自引:0,他引:1  
    "慎独"一词出自《礼记·中庸》中"莫见乎隐,莫显乎微,故君子慎其独也"。即当君子独处,无人监督的时候,总是小心谨慎地不做任何不道德的事情。"慎众"则是指在许多人违反原则时,君子却不随波逐流,不盲目  相似文献   

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    The treatment of diseases and injuries of the hip joint in both children and adults has been a major area of interest for surgeons treating injuries and non-traumatic conditions of the organs of locomotion. The work of prominent Polish surgeons and orthopaedists has contributed to progress in this branch of medicine over the last century.  相似文献   

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