含氯复方消毒剂杀灭微生物效果及腐蚀性检测

含氯复方消毒剂为含二氯异氰尿酸钠、柠檬酸、丁二酸、碳酸氢钠、碳酸钠、十二烷基硫酸钠等的片剂,含有效氯２６０ ｍｇ／ｇ。采用载体定量杀灭微生物试验与金属腐蚀试验,观察其对微生物的杀灭效果及对金属腐蚀性。结果,含有效氯１００ｍｇ／Ｌ 该液对布片上大肠杆菌、金黄色葡萄球菌作用５ｍｉｎ,杀灭率＞９９．９０％; 含有效氯３０００ｍｇ／Ｌ 该液对布片上枯草杆菌黑色变种芽胞作用２５ｍｉｎ,杀灭率≥９９．９０％,对不锈钢片表面 ＨＢｓＡｇ作用１０ｍｉｎ,可破坏其抗原性．５０％小牛血清对其杀菌效果有一定影响。片剂置室温下２０ｄ或５４℃ １４ｄ,有效氯含量下降率分别为４．７８％与５．５９％。含有效氯５０００ｍｇ／Ｌ该液对铝、碳钢、铜、不锈钢的腐蚀速率分别为１．９１２、１．９４６、０．７０２、０．０００ ｍｍ／ａ。该片剂稳定性较好,其溶液对多数金属有不同程度腐蚀作用,杀菌效果受有机物影响。     

Evaluation of two buflomedil tablet formulations in patients with atherosclerotic disease

The bioequivalence of a 600-mg methocel tablet containing buflomedil hydrochloride in sustained-release form was determined relative to a 300-mg CAP/carbovax-coated tablet of buflomedil hydrochloride in immediate-release form. The tablets were given to 20 patients in a double-blind placebo-controlled clinical study with cross-over between the administration plans. The 300-mg tablets were given b.i.d., at 8 a.m. and 8 p.m. while the 600-mg tablets were taken once a day at 8 a.m. (+placebo at 8 p.m.). Plasma samples were collected at appropriate times up to 24 h after administration and were analysed for buflomedil with a validated high-performance liquid chromatographic procedure. Results showed an overall significant mean difference in absorption rate between the two formulations. The mean t_max (5-5 Ω 3–5 h) for the 600-mg tablet was longer (P>0–001) than the t_max value (1–8 ± 0–8 h) seen after administration of the first 300-mg tablet. Analysis of AUC _(0-∞) values indicated that the sustained-release preparation (32.1 ± 20-7 μg/ml h) was not significantly different from the 300-mg tablet b.i.d. (28-7 ± 16-0 μg/ml h).
Furthermore, it was seen that single administration of a 600-mg sustained-release tablet of buflomedil hydrochloride delivered the same amount of total drug as a 300-mg tablet given twice a day.     

Sustained-Release Potassium Chloride Overdose

Background: Although ingestion of sustained-release potassium supplements can cause life-threatening hyperkalemia in patients with abnormal renal function, only a few previous reports suggest that this may occur in patients with normal renal function. We report 2 cases of hyperkalemia in patients with normal renal function who developed hyperkalemia after ingesting sustained-release potassium preparations and describe the use of radiography and whole-bowel irrigation in their care. Case Reports: The first patient is a 50-year-old woman who ingested 100 K-Dur^® tablets (each tablet containing 750 mg KCl or 10 mEq potassium) in a suicide attempt 1 hour prior to presenting to the emergency department. She developed a peak serum potassium level of 9.7 mEq/L and had transient, potentially life-threatening electrocardiographic changes. The second patient was a 17-year-old man who ingested 20 to 30 Klor-Con^® tablets (each tablet containing 750 mg KCl or 10 mEq potassium) in a suicide attempt 10 hours prior to presentation. Although he developed a peak serum potassium level of 6.1 mEq/L, he had a persistently normal electrocardiogram. In both patients, the tablets were visualized on abdominal radiographs and the gastrointestinal tracts of both were successfully decontaminated using whole-bowel irrigation. Discussion: Although the sensitivity and specificity are unknown, the abdominal radiograph appears to be useful in detecting sustained-release potassium tablets. Whole-bowel irrigation as a primary method of gastrointestinal decontamination also appears to be effective although its use is not previously reported for sustained-release potassium overdoses.     

有机干扰物对含氯消毒剂杀菌效果的影响研究

为了解不同浓度有机干扰物对含氯消毒剂杀菌效果的影响,使用牛血清白蛋白作为有机干扰物,采用悬液定量和载体定量杀菌试验方法进行了实验室观察。结果,用含30 g/L牛血清白蛋白的菌悬液进行试验:有效氯为300 mg/L时可100%杀灭大肠杆菌,需要次氯酸钠溶液作用7.5 m in;三氯异氰尿酸钠片剂和二氯异氰尿酸钠粉剂作用15 m in;以含有效氯2500 mg/L的片剂和粉剂对枯草杆菌黑色变种芽孢作用30 m in,有效氯5000 mg/L次氯酸钠水溶液作用90 m in,杀灭率均达到100%。用含3 g/L牛血清白蛋白的菌悬液进行试验:以含有效氯50 mg/L作用7.5m in,3种剂型含氯消毒剂对大肠杆菌的杀灭率均可达100%。用含有效氯1000 mg/L的片剂和粉剂作用30m in;有效氯2000 mg/L的次氯酸钠水溶液作用60 m in,对枯草杆菌黑色变种芽孢杀灭率均可达100%。用载体法试验:以有效氯300 mg/L次氯酸钠溶液作用7.5 m in,杀灭大肠杆菌100%;以有效氯2000 mg/L次氯酸钠溶液作用60 m in,对枯草杆菌黑色变种芽孢杀灭率100%。结论,在高浓度有机干扰物条件下,含氯消毒剂片剂和粉剂杀灭细菌芽孢剂量明显高于液体制剂;在低浓度有机干扰物条件下,悬液法与载体法对含氯消毒剂杀菌试验结果基本一致。     

凝胶骨架型碳酸锂缓释片的体外释放度及释药特性

背景:目前国内外文献报道的碳酸锂缓释片多采用海藻酸、卡波姆等制备凝胶型骨架片,同样作为水溶性骨架材料的羟丙基甲基纤维素,也可作为碳酸锂的缓释基质.目的:研制凝胶骨架型碳酸锂缓释片,进行处方筛选考察其体外释放度及释药特性.设计、时间及地点:药物制剂研究,于2008-05/12在江苏恩华药业有限公司实验室完成.材料:碳酸锂(恩华药业股份有限公司);羟丙基甲基纤维素K4、K15、K100(上海卡乐康包衣技术有限公司);乳糖(镇江康富生物工程有限公司);聚乙烯吡咯烷酮K30(上海运宏化工制剂辅料技术有限公司).方法:以羟丙基甲基纤维素为骨架材料,按不同处方制备碳酸锂缓释片.分别考察不同羟丙基甲基纤维素的用量、黏度及片剂的硬度、片型对体外释放度的影响,通过释放度试验评价缓释效果,并初步研究其释药特性.主要观察指标:羟丙基甲基纤维索的不同黏度、不同用量、片剂的不同硬度、不同比表面积对碳酸锂缓释片释放度的影响.结果:凝胶骨架型碳酸锂缓释片的释药速度主要受羟丙基甲基纤维素黏度及用量的影响.随着片剂中羟丙基甲基纤维素黏度的增高,药物的释放速度变慢.含骨架材料为30%HPMCK15为优化的理想处方.以不同的压片压力制备的硬度为4～9 kg/cm2缓释片的释放曲线重叠,其释放速率几乎无差别.随着片剂的比表面积的增加,药物释放度略有加快.选择键型冲头压片,即可达到标准要求,其释放规律符合Higuchi方程.结论:选择合适的羟丙基甲基纤维素的黏度和用量,采用键型冲头压片,使片子硬度控制在4～9 kg/cm2,制备水溶性凝胶骨架型碳酸锂缓释片,体外试验具有明显的缓释效果,其释药为扩散与溶蚀并存的过程.     

圣剑速洁消毒片杀菌效果的试验观察

圣剑速洁消毒片出三氯异氰尿酸、碳酸钠、硼酸组成。采用载体定量杀菌试验,观察其杀菌效果。结果,以其含有效氯 150 mg/L溶液对布片上大肠杆菌作用 10 min,以其含有效氯 300mg/L溶液对布片上金黄色葡萄球菌作用5min,以其含有效氯1000 mg/L溶液对布片上枯草杆菌黑色变种芽胞作用15 min,杀灭率均达 100%;有机物对其杀菌效果有一定影响。在 37℃放置90d,该片剂有效氯含量下降率为2.83%。该复方为稳定性良好的消毒剂。     

Effect of structured dietary fiber on bioavailability of amoxicillin

The effect of structured dietary fiber on the bioavailability of amoxicillin (AMX) was evaluated. Ten healthy volunteers ingested one of two isocaloric, isonitrogenous diets providing 7.8 gm/day (diet I) and 36.2 gm/day (diet II) of structured fiber for 3 days. Then they ingested one tablet (500 mg) AMX after breakfast. The other diet was administered for an additional 3 days and the study was repeated. Plasma and urinary AMX concentrations were measured at 9 and 24 hours, respectively, by a microbiologic technique. An open one-compartment model was used for pharmacokinetic analysis. AMX was absorbed more slowly when ingested with diet I than with diet II: the absorption rate constant was 1.04 +/- 0.37 and 1.75 +/- 0.75 (P less than 0.05); lag time for absorption was 0.34 +/- 0.13 hours and 0.29 +/- 0.11 hours (P less than 0.05). The first-order rate constant and elimination half-life were similar. Bioavailability was higher with diet I: the AUC was 12.17 +/- 3.04 vs. 9.65 +/- 2.64 micrograms/ml/hr with diet II (P less than 0.05). A higher content of dietary fiber increased AMX absorption rate and decreased the amount of drug absorbed.     

Amoxicillin dose-effect relationship with Streptococcus pneumoniae in a mouse pneumonia model and roles of in vitro penicillin susceptibilities, autolysis, and tolerance properties of the strains.

We used a mouse model of pneumococcal pneumonia to assess the bactericidal effect of increasing doses of amoxicillin (AMX) against clinical strains with various susceptibilities to penicillin. Twelve strains that exhibited similar virulence in mice were selected. Three were penicillin susceptible (PS) (penicillin and AMX MICs = 0.01 to 0.03 microgram/ml), three were intermediately resistant (PIR) (penicillin and AMX MICs = 0.5 to 1 microgram/ml), and six were penicillin resistant (PR) (penicillin and AMX MICs = 1 to 8 micrograms/ml). Leukopenic Swiss mice were infected intratracheally with 10(7) CFU of each strain. Treatment was initiated 3 h after infection and consisted of a single subcutaneous injection of AMX at doses ranging from 2.5 to 10 mg/kg (PS strains), 5 to 100 (PIR strains), and 25 to 3,000 (PR strains). Bacterial killing kinetics were recorded in the lungs over 9 h. The maximal log CFU reduction (Emax) was observed 3 h postinjection. The relation between Emax and log10(dose/MIC) showed two populations. With seven strains (the three PS, the three PIR, and one of the six PR [MICs, penicillin/AMX = 4/1]) a good correlation was observed between Emax and log10(dose/MIC) (r = 0.772; P < 0.02). A bactericidal effect equal to 3.5 log10 CFU was observed at a log10(dose/MIC) = 2. At this ratio, with the five other PR strains, Emax varied from 0.4 to 1.6 log10 CFU. In brain heart infusion medium containing AMX at 50 times the relevant MIC, these five PR strains were tolerant in vitro. Treatment failure with AMX was found in vivo, with tolerant, highly resistant strains.     

稳定性二氧化氯杀灭微生物效果与腐蚀性试验观察

将亚氯酸钠和浓盐酸按等比例反应产生的二氧化氯气体被过碳酸钠吸收,制成稳定性二氧化氯。用前加柠檬酸活化。为了解其杀菌效果、稳定性与腐蚀性,进行了悬液定量杀菌试验、54℃存放试验与金属腐蚀试验。结果,含二氧化氯 200mg/L溶液作用20 min,对悬液中枯草杆菌黑色变种芽胞杀灭率为110%;以其1200 mg/L溶液作用20 min,可破坏悬液中HBsAg抗原性。未加柠檬酸的稳定性二氧化氯于54℃存放14d,二氧化氯含量下降率为0.038%;加柠檬酸活化后置室温下15min,其下降率即达14．28%。含二氧化氯500 mg/L的溶液对铝、铜有重度腐蚀(P＞3．800 mm/a)作用,对碳钢有中度腐蚀(R=0．7500 mm/a)作用,对不锈钢有轻度腐蚀(R=0．0100 mm/a作用。说明该剂杀菌效果较好,活化前稳定性较好,但对金属腐蚀性较大。     

The Usual Treatment of Trigeminal Autonomic Cephalalgias

Trigeminal autonomic cephalalgias include cluster headache, paroxysmal hemicrania, and short‐lasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, and rhinorrhea (SUNCT). Conventional pharmacological therapy can be successful in the majority of trigeminal autonomic cephalalgias patients. Most cluster headache attacks respond to 100% oxygen inhalation, or 6 mg subcutaneous sumatriptan. Nasal spray of sumatriptan (20 mg) or zolmitriptan (5 mg) are recommended as second choice. The bouts can be brought under control by a short course of corticosteroids (oral prednisone: 60‐100 mg/day, or intravenous methylprednisolone: 250‐500 mg/day, for 5 days, followed by tapering off the dosage), or by long‐term prophylaxis with verapamil (at least 240 mg/day). Alternative long‐term preventive medications include lithium carbonate (800‐1600 mg/day), methylergonovine (0.4‐1.2 mg/day), and topiramate (100‐200 mg/day). As a rule, paroxysmal hemicrania responds to preventive treatment with indomethacin (75‐150 mg/day). A short course of intravenous lidocaine (1‐4 mg/kg/hour) can reduce the flow of attacks during exacerbations of SUNCT. Lamotrigine (100‐300 mg/day) is the preventive drug of choice for SUNCT. Gabapentin (800‐2700 mg/day), topiramate (50‐300 mg/day), and carbamazepine (200‐1600 mg/day) may be of help.     

Preparation and pharmaceutical evaluation of acetaminophen nano-fiber tablets: Application of a solvent-based electrospinning method for tableting

In this study, we developed nano-fiber-based tablets with acetaminophen (AAP; Log P_ow = 0.51) for controlled-release delivery systems and evaluated in vitro drug dissolution and in vivo pharmacokinetics in rats. Nano-fibers made from methacrylic acid copolymer S (MAC; EUDRAGIT^® S100) and containing AAP were prepared using a solvent-based electrospinning (ES) method. In vitro dissolution rate profiles of AAP showed tableting pressure-dependent decreases and pH-dependent increases. The results of tablet tracking by X-ray irradiation showed tablets based on MAC nano-fibers did not disintegrate in the upper intestinal lumen and had the properties of a long-term-acting tablet. In addition, the in vitro release profiles of AAP from nano-fiber tablets prepared by dissolving MAC with AAP (NFT), nano-fiber tablets prepared by adsorbing AAP to drug-free MAC nano-fibers (NFT_adso), and tablets prepared by adsorbing half the amount of AAP to MAC nano-fibers containing the remaining amount of AAP (NFT_half) showed independent controlled-release aspects of AAP compared with physical mixture tablets (PMT). In vivo pharmacokinetic studies in rats after intraduodenal administration of 14 mg/rat AAP in NFT, NFT_adso, and NFT_half demonstrated that all these tablets based on MAC nano-fibers showed sustained-release profiles compared with PMT, and showed ultra-sustained release properties for AAP. These new tablets based on MAC nano-fibers did not disintegrate in the intestine in the lower pH region, and the tablets could regulate the release of AAP in a pH-dependent manner. The ES method is a useful technique to prepare nano-fibers and showed promising results as an oral delivery system for sustained-release regulation.     

一种二氧化氯消毒剂杀灭细菌芽胞效果的检测

以载体试验法对一种二氧化氯消毒剂 (维诺消净王 )的杀菌效果进行了试验观察。以含 50 0mg/L二氧化氯的溶液对布片上枯草杆菌黑色变种芽胞作用 10min ,杀灭率达 10 0 %。以含 50 %小牛血清的菌悬液染于布片上 ,对其杀菌作用没有明显影响。未经柠檬酸活化的该剂置于 54℃ 14d ,二氧化氯含量平均下降率为 4 79%     

Synergy between amoxicillin and gentamicin in combination against a highly penicillin-resistant and -tolerant strain of Streptococcus pneumoniae in a mouse pneumonia model.

In vivo synergy with beta-lactam antibiotics and aminoglycosides has been studied only with penicillin-susceptible Streptococcus pneumoniae strains. We evaluated the interaction between amoxicillin (AMX) and gentamicin (GEN) on the basis of in vitro checkerboard and time-kill curves and of findings in a mouse model of acute bacteremic pneumonia due to a highly penicillin-resistant and -tolerant S. pneumoniae strain of serotype 19 (penicillin and AMX MICs of 4 micrograms/ml; gentamicin MIC of 16 micrograms/ml). Checkerboard results at 18 h of incubation showed indifference. With regard to AMX alone, in vitro time-kill curves demonstrated synergy between AMX (1 microgram/ml) and GEN (16 micrograms/ml) at 5 and 8 h of incubation and for AMX (16 micrograms/ml) in combination with GEN (16 micrograms/ml) at 3, 5, and 8 h of incubation. In leukopenic mice, pulmonary killing curves after a single drug injection demonstrated that AMX (100 mg/kg of body weight) with GEN (16 mg/kg) was more effective than AMX alone (P = 10(-4). With repeated-dose treatment, a synergy was apparent at 8 h after four injections with AMX (100 mg/kg) in combination with GEN (8 or 16 mg/kg) (P < or = 0.05). The cumulative survival rate with AMX (100 mg/kg) every 8 h, combined with GEN (4 or 8 mg/kg) every 8, 12, or 24 h, was better than with AMX alone. Combined use of AMX and GEN may be a valuable therapeutic alternative for pneumococcal pneumonia due to highly penicillin-resistant S. pneumoniae strains.     

不同剂型复方含氯消毒剂杀菌效果的观察

为了解不同剂型含氯复方消毒剂杀菌效果,在实验室采用悬液定量和载体定量杀菌试验进行了观察。结果,以含有效氯200mg/L的片剂、1000mg/L的粉剂和2500mg/L的液体制剂,作用30min,对悬液内和载体上的枯草杆菌黑色变种芽孢杀灭率均达到100％。以含有效氯1 500mg/L的片剂和粉剂以及含2 000mg/L的液体剂型对悬液内和载体上HBsAg作用30min,可使其抗原性全部转阴。含体积分数25％小牛血清对三种剂型的含氯复方消毒剂杀灭悬液内枯草杆菌黑色变种芽孢的效果均有不同程度影响,对片剂影响更为明显。结论,三种剂型含氯消毒剂杀菌效果以片剂最好,但其受有机物影响最明显。     

In Vitro Activities of Oral β-Lactams at Concentrations Achieved in Humans against Penicillin-Susceptible and -Resistant Pneumococci and Potential to Select Resistance

The β-lactam susceptibilities of 65 strains of Streptococcus pneumoniae for which penicillin MICs covered a broad range were assessed. The order of potency was amoxicillin (AMX) = amoxicillin-clavulanate (AMC) > penicillin G > cefpodoxime (CPO) > cefuroxime (CXM) > cefprozil > cefaclor > loracarbef > cefixime. No decrease in susceptibility was seen following repeated subculture of two penicillin-susceptible strains of S. pneumoniae in AMX, AMC, cefaclor, or loracarbef, whereas repeated exposure to CPO and CXM resulted in 4- to 32-fold decreases in susceptibility for both strains. When one of these strains was exposed to concentrations of CPO, CXM, AMX, and AMC achieved in the serum of humans following the administration of an oral dose, all agents were rapidly bactericidal, with no decrease in susceptibility up to 72 h. This was consistent with antibiotic concentrations exceeding the MICs for 100% of the dosing interval. For a penicillin-resistant strain, MICs were exceeded for 29% of the 12-h dosing interval for 500 mg of AMX, 42% of the interval for AMC with 875 mg of AMX and 125 mg of clavulanate (875/125 mg of AMC) 21% of the interval for 500 mg of CXM, and 0% of the interval for 200 mg of CPO. Consequently, only 875/125 mg of AMC produced a sustained bactericidal effect. A four- to eightfold reduction in susceptibility to CPO and CXM and cross-resistance with cefotaxime, but not penicillin or AMC, were selected following exposure to simulated serum CPO and CXM concentrations. In addition, AMX and AMC were the only agents which consistently produced a >99% reduction in bacterial numbers in time-kill studies using concentrations of antibiotic achieved in middle ear fluid for all three strains of penicillin-resistant S. pneumoniae tested.     

Modulation of active pharmaceutical material release from a novel 'tablet in capsule system' containing an effervescent blend.

The objective of the present study was to obtain programmed drug delivery from hard gelatin capsules containing a hydrophilic plug (HPMC or guar gum). The significance of factors such as type of plug (powder or tablet), plug thickness and the formulation of fill material on the release pattern of diltiazem HCl, a model drug, was investigated. The body portion of the hard gelatin capsules was cross-linked by the combined effect of formaldehyde and heat treatment. A linear relationship was observed between weight of HPMC K15M and log % drug released at 4 h from the capsules containing the plug in powder form. In order to accelerate the drug release after a lag time of 4 h, addition of an effervescent blend, NaHCO(3) and citric acid, in the capsules was found to be essential. The plugs of HPMC in tablet form, with or without a water soluble adjuvant (NaCl or lactose) were used for obtaining immediate drug release after the lag time. Sodium chloride did not cause significant influence on drug release whereas lactose favourably affected the drug release. The capsules containing HPMC K15M tablet plug (200 mg) and 35 mg effervescent blend in body portion of the capsule met the selection criteria of less than 10% drug release in 4 h and immediate drug release thereafter. It is further shown that the drug release was also dependant on the type of swellable hydrophilic agent (HPMC or guar gum) and molecular weight of HPMC (K15M or 20 cPs). The results reveal that programmed drug delivery can be obtained from hard gelatin capsules by systemic formulation approach.     

Coadministration of gatifloxacin and multivitamin preparation containing minerals: potential treatment failure in an elderly patient

OBJECTIVE: To report a case of probable treatment failure in a patient receiving gatifloxacin and a multivitamin preparation containing minerals. CASE SUMMARY: A 77-year-old white woman was prescribed gatifloxacin for hospital-acquired bacterial pneumonia. She was also receiving calcium carbonate 500 mg twice daily and a multivitamin preparation containing minerals once a day. Three days after gatifloxacin was started, the patient was still febrile, coughing, and not responding clinically. It was noted that nurses were administering the gatifloxacin tablet at the same time as the multivitamin tablet. The time of administration for gatifloxacin was changed to 6 hours after the patient received her multivitamin preparation. Two days later, she clinically improved. DISCUSSION: Studies have shown that the bioavailability of gatifloxacin is decreased with concurrent administration of antacids containing aluminum or magnesium; dietary supplements containing zinc, magnesium, and iron; multivitamin preparations containing minerals; and sucralfate. An objective causality assessment revealed that the adverse drug effect was probable. CONCLUSIONS: This case illustrates the need to recognize this potential interaction and to know how to avoid possible treatment failure.     

JH含氯复方消毒剂性能的试验观察

JH含氯复方消毒剂为含三氯异氰尿酸与溴氯海因的片剂,含有效氯471g/kg。为了解其性能,进行了载体定量杀灭微生物试验、54℃存放稳定性试验、金属腐蚀试验。结果,以该剂含有效氯100mg/t溶液对布片上金黄色葡萄球菌、大肠杆菌、白色念珠菌作用10min,以其含有效氯750 mg/L溶液对布片上枯草杆菌黑色变种芽孢作用20min,杀灭率均达100％;以其含有效氯1500mg/L溶液作用20min,能将不锈钢片表面HBsAg破坏。小牛血清对其杀菌效果有一定影响。以其含有效氯1500mg/L溶液浸泡72h,不锈钢、铜、铝和碳钢的腐蚀速率分别为0.0016、0.1980、0.6345、1.7843mm/a。该片剂置54℃存放14d,有效氯含量下降率为0.85％。该剂有一定杀灭微生物效果,性质较稳定,对多数金属有一定腐蚀作用。     

柠檬酸活化二氧化氯消毒剂部分性能试验观察

一种固液二元制剂二氧化氯用柠檬酸活化而成,为研究其杀菌效果及其它消毒性能,采用载体定量杀菌试验进行了试验观察。结果,分别以含二氧化氯400 mg/L和500 mg/L的该消毒剂溶液对载体上大肠杆菌和金黄色葡萄球菌作用10 m in,各次试验杀灭率均达100%。以含二氧化氯1000 mg/L该消毒剂对枯草杆菌黑色变种芽孢和白色念珠菌分别作用20 m in和10 m in,各次试验杀灭率均达100%。有机物的存在对该消毒剂杀灭枯草杆菌黑色变种芽孢有轻度影响。该二氧化氯消毒剂密封包装于54℃恒温箱内放置14 d,二氧化氯含量平均下降率为0.88%。结论,该二氧化氯消毒剂有较强的杀菌效果,性能稳定。     

强力杀菌消毒剂杀灭微生物效果的试验观察

为了解含二氧化氯的强力杀菌消毒剂杀灭微生物的效果,在实验室用悬液定量杀菌试验对其进行了观察。结果,用含50mg/L二氧化氯的强力杀菌消毒剂溶液对大肠杆菌作用5min、对金黄色葡萄球菌作用10min、对白色念珠菌作用15min,用含300mg/K二氧化氯的消毒剂溶液对枯草杆菌黑色变种芽孢作用20min,杀菌率均为100％。另外,用含2500mg/L二氧化氯的强力杀菌消毒剂,按6ml/m~3喷雾作用15min,室内空气自然菌比对照组减少94.41％。