Level of Mobility Limitations and Falls Status in Persons With Multiple Sclerosis

Objective

To investigate whether fall rates are constant across levels of mobility limitations.

Design

Secondary analysis of baseline assessments from a stratified randomized controlled trial.

Setting

Community.

Participants

Persons with multiple sclerosis (N=365) were divided into 5 groups based on the mobility section of the Guy's Neurological Disability Scale (GNDS): no walking impairment (n=82); impaired walking, no aid (n=87); unilateral support (n=76); bilateral support to walk (n=78); or occasional wheelchair user (n=42).

Interventions

Not applicable.

Main Outcome Measures

Self-reported fall history (ie, retrospective) in the preceding 3 months.

Results

One hundred twenty-four persons in the overall sample reported falling in the last 3 months (fall prevalence, 33.97%). Of the total sample, 17.8% reported 2 or more falls in the last 3 months. Chi-square analysis revealed a significant difference in the proportion of fallers across GNDS categories (χ²=42.64, P<.001). Post hoc analysis revealed that the group who walked with bilateral support had the greatest proportion of fallers (52.6%), while the group without walking impairment had the lowest proportion (15.9%). An examination of recurrent fallers as a function of group found that there were more recurrent fallers (70%) in the group that had a walking impairment but used no aid, relative to the other groups.

Conclusions

The current findings highlight that fall rates including recurrent fall prevalence are not uniform across mobility aid categories in persons with MS. Those using bilateral assistance for gait have the highest prevalence of fallers, and those with walking limitations and not yet using an aid had the greatest prevalence of multiple falls.     

Interference between balance, gait and cognitive task performance among people with stroke living in the community

PURPOSE: To explore differences in cognitive-motor interference between people with stroke and controls when performing functional tasks and to compare dual task performance of stroke fallers and non-fallers. METHOD: Thirty-six people with stroke (mean age 66.5, SD 11.8, mean time since onset 16 months, range 7 - 56) and 24 controls (mean age 62.3, SD 11.61) performed balance and gait tasks in isolation and in conjunction with a cognitive task (remembering a seven item-shopping list). Three-dimensional movement analysis was used to assess anterior posterior (AP) and lateral (ML) sway; 5 m walk time, stride length and velocity. RESULTS: In the single task condition, people with stroke had greater AP sway, reduced velocity and stride length and a longer 5 m walk time than controls (p < 0.01). In the dual task condition, sway reduced and gait slowed in both groups (p < 0.01 for AP sway, stride length, velocity, walk time); only the increase in walk time was greater in people with stroke than in the controls (F = 4.2, p = 0.046). Cognitive performance was maintained during the balance trials but deteriorated during the dual task gait trials in people with stroke (p = 0.017). Similar trends were noted for fallers and non-fallers with stroke: Only group effects for stride length and velocity reached significance (p < 0.05) and only the reduction in stride length was significantly greater among fallers than non-fallers (F = 12.3, p = 0.001). CONCLUSIONS: People with stroke and controls employed similar strategies during the simultaneous performance of simple functional and silent cognitive tasks and maintained postural stability. Increased walk time and decreased cognitive recall were greater for people with stroke and reduced stride length distinguished fallers from non-fallers.     

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other parkinsonian symptoms. The brain structures underlying gait disorders and falls in PD and aging remain to be characterized. Using functional MRI in healthy human subjects, we have shown here that activity of the mesencephalic locomotor region (MLR), which is composed of the pedunculopontine nucleus (PPN) and the adjacent cuneiform nucleus, was modulated by the speed of imagined gait, with faster imagined gait activating a discrete cluster within the MLR. Furthermore, the presence of gait disorders in patients with PD and in aged monkeys rendered parkinsonian by MPTP intoxication correlated with loss of PPN cholinergic neurons. Bilateral lesioning of the cholinergic part of the PPN induced gait and postural deficits in nondopaminergic lesioned monkeys. Our data therefore reveal that the cholinergic neurons of the PPN play a central role in controlling gait and posture and represent a possible target for pharmacological treatment of gait disorders in PD.     

Postural Control Is Impaired in People with COPD: An Observational Study

Purpose: We investigated deficits in postural control and fall risk in people with chronic obstructive pulmonary disease (COPD).Method: Twenty people with moderate to severe COPD (mean age 72.3 years, standard deviation [SD] 6.7 years) with a mean forced expiratory volume in 1 second (FEV(1)) of 46.7% (SD 13%) and 20 people (mean age 68.2 years, SD 8.1) who served as a comparison group were tested for postural control using the Sensory Organization Test (SOT). A score of zero in any trial of the SOT was registered as a fall. On the basis of the SOT results, participants were categorized as frequent fallers (two or more falls) or as fallers (one fall). To explore the potential influence of muscle weakness on postural control, knee extensors concentric muscle torque was assessed with an isokinetic dynamometer. Physical activity level was assessed with the Physical Activity Scale for the Elderly.Results: People with COPD showed a 10.8% lower score on the SOT (p=0.016) and experienced more falls (40) than the comparison group (12). The proportion of frequent fallers and fallers during the SOT was greater (p=0.021) in the COPD group (four of 10) than in the comparison group (two of seven). People with COPD showed deficits in knee extensors muscle strength (p=0.01) and a modest trend toward reduced physical activity level. However, neither of these factors explained the deficits in postural control observed in the COPD group.Conclusions: People with COPD show deficits in postural control and increased risk of falls as measured by the SOT. The deficits in postural control appear to be independent of muscle weakness and level of physical activity. Postural control interventions and fall risk strategies in the pulmonary rehabilitation of COPD are recommended.     

Fall risk assessment in very old males and females living in nursing homes

BACKGROUND: Several studies identified muscle weakness, history of falls, gait deficit and balance deficit as the most common risk factors for falls. AIMS: To determine risk factors of fall in older males and females living in nursing homes and to compare characteristics of fallers and non fallers. METHODS: This is a cross-sectional study with a convenience sample of 40 nursing home elderly (13 males and 27 females), mean age 86.35, of which 17 (6 males and 11 females) fell at least once in the previous year and 23 (7 males and 16 females) had not fallen. Each participant filled a self-assessment questionnaire (general health questions and selected questions from the SF-36). An objective evaluation was performed with measurements of blood pressure and heartrate (supine and standing), lower extremity strength and power (dominate side only) by Biodex isokinetic dynamometry, dynamic postural stability by Biodex balance system (5 s trials at level 8) and gait assessment (6 min walk test at comfortable speed) by gait treadmill Biodex. RESULTS: The fallen males decreased significantly knee flexion peak torque (p=0.08), ankle plantarflexion peak torque and average power (p=0.05), compared with the not fallen group. The fallen females decreased significantly knee extension peak torque and average power (p<0.05), walking speed (p<0.005) and cadence (p<0.01), compared with the not fallen group. CONCLUSIONS: This study shows that the fallen males had greater deficits of ankle plantar-flexion strength and power, while fallen females had greater deficits of knee extension strength and power and less walking speed.     

The biomechanics and motor control of gait in Parkinson disease.

Parkinson disease is a progressive neurological condition characterised by hypokinesia (reduced movement), akinesia (absent movement), tremor, rigidity and postural instability. These movement disorders are associated with a slow short-stepped, shuffling gait pattern. Analysis of the biomechanics of gait in response to medication, visual cues, attentional strategies and neurosurgery provides insight into the nature of the motor control deficit in Parkinson disease and the efficacy of current therapeutic interventions. In this article we supplement a critical evaluation of the Parkinson disease gait literature with two case examples. The first case describes the kinematic gait response of an individual with Parkinson disease to visual cues in the "off" phase of the levodopa medication cycle. The second case investigates the biomechanics and motor control of turning during walking in a patient with Parkinson disease compared with elderly and young control subjects. The results are interpreted in light of the need for gait analysis to investigate complex functional walking tasks rather than confining assessment to straight line walking, which has been the trend to date.     

A pilot study of falls risk and vestibular dysfunction in older fallers presenting to hospital emergency departments

PURPOSE: To compare falls risk in older fallers and non-fallers, with an emphasis on dizziness and signs of vestibular dysfunction. METHOD: The fallers had presented to the Emergency Department of the Royal Melbourne Hospital, Australia following a fall and were discharged directly home (n = 20) (75% female, mean age 78 years). The non-fallers were an age and gender matched group, who had not fallen in the past 12 months (n = 20). All clients received a home-based assessment, which involved a comprehensive assessment of falls risk. RESULTS: Over three-quarters of the fallers took four or more medications, had balance impairments, and used a gait aid in the community. The fallers had a significantly higher falls risk score (P < 0.001), demonstrated significantly poorer balance (P < 0.001) and walked significantly more slowly (P < 0.001) than the non-fallers. There was no significant difference between the groups in their reports of dizziness (P = 0.68), although static balance testing (CTSIB condition 5) suggested a greater degree of underlying vestibular dysfunction in the group of fallers (P < 0.001). CONCLUSION: Older people discharged home from the ED following a fall are at high risk of falling in the future and have a greater level of vestibular dysfunction based on simple clinical testing. Additional clinically applicable tests of vestibular function are required to further investigate the relationship between vestibular dysfunction and falling in older people.     

Gait variability and fall risk in community-living older adults: a 1-year prospective study

OBJECTIVE: To test the hypothesis that increased gait variability predicts falls among community-living older adults attending an outpatient clinic. DESIGN: Prospective, cohort study. SETTING: Three outpatient geriatric clinics. PARTICIPANTS: Fifty-two community-living, ambulatory men and women aged > or = 70 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Subjects walked at a normal pace for up to 6 minutes wearing force-sensitive insoles that measured the gait rhythm on a stride-to-stride basis. Afterward, subjects reported fall status on a weekly basis for 1 year. The primary outcomes were the association between measures of the stride-to-stride fluctuations in gait rhythm and (1) subsequent falls during a 12-month follow-up period and (2) potential contributing factors. RESULTS: Almost 40% of the subjects reported falling during the 12-month follow-up period. Stride time variability was 106 +/- 30 ms in subjects who subsequently fell (n = 20) and 49 +/- 4 ms in those who did not experience a fall (n = 32) during the 12-month follow-up period (p <.04). Logistic regression also showed that stride time variability predicted falls (p <.05). Stride time variability correlated significantly with multiple factors including strength, balance, gait speed, functional status, and even mental health, but these other measures did not discriminate future fallers from nonfallers. CONCLUSIONS: These findings show both the feasibility of obtaining stride-to-stride measures of gait timing in the ambulatory setting and the potential use of gait variability measures in augmenting the prospective evaluation of fall risk in community-living older adults.     

Reliability and validity of the Tinetti Mobility Test for individuals with Parkinson disease

BACKGROUND AND PURPOSE: This study examined the interrater and intrarater reliability, concurrent validity, and criterion validity of the Tinetti Mobility Test (TMT) as a fall risk screening tool in individuals with Parkinson disease (PD). SUBJECTS: Thirty individuals with PD voluntarily participated in the study, and data from a retrospective review of 126 patient records were included. METHODS: Physical therapists and physical therapist students rated live and videotaped performances of the TMT. Tinetti Mobility Test scores were correlated with Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and comfortable gait speed. The ability of the TMT to accurately assess fall risk was determined. RESULTS: Interrater and intrarater reliability was good to excellent (intraclass correlation coefficient of >.80). Tinetti Mobility Test scores correlated with UPDRS motor scores (r(s)=-.45) and gait speed (r(s)=.53). The sensitivity and specificity of the TMT to identify fallers were 76% and 66%, respectively. DISCUSSION AND CONCLUSION: The TMT is a reliable and valid tool for assessing the mobility status of and fall risk for individuals with PD.     

Fall risk assessment in very old males and females living in nursing homes

Background:?Several studies identified muscle weakness, history of falls, gait deficit and balance deficit as the most common risk factors for falls.

Aims:?To determine risk factors of fall in older males and females living in nursing homes and to compare characteristics of fallers and non fallers.

Methods:?This is a cross-sectional study with a convenience sample of 40 nursing home elderly (13 males and 27 females), mean age 86.35, of which 17 (6 males and 11 females) fell at least once in the previous year and 23 (7 males and 16 females) had not fallen. Each participant filled a self-assessment questionnaire (general health questions and selected questions from the SF-36). An objective evaluation was performed with measurements of blood pressure and heartrate (supine and standing), lower extremity strength and power (dominate side only) by Biodex isokinetic dynamometry, dynamic postural stability by Biodex balance system (5?s trials at level 8) and gait assessment (6?min walk test at comfortable speed) by gait treadmill Biodex.

Results:?The fallen males decreased significantly knee flexion peak torque (p?=?0.08), ankle plantarflexion peak torque and average power (p?=?0.05), compared with the not fallen group. The fallen females decreased significantly knee extension peak torque and average power (p?<?0.05), walking speed (p?<?0.005) and cadence (p?<?0.01), compared with the not fallen group.

Conclusions:?This study shows that the fallen males had greater deficits of ankle plantar-flexion strength and power, while fallen females had greater deficits of knee extension strength and power and less walking speed.     

The effects of exergaming and treadmill training on gait,balance, and cognition in a person with Parkinson’s disease: A case study

Background: Parkinson’s disease (PD) commonly impairs posture, gait, and cognition. Exercise in the form of aerobic activity as well as exergaming may improve motor ability and cognition in persons with PD. Exergaming and treadmill training can be a practical form of exercise within the home; however, there is minimal research on this combined multimodal intervention for persons with PD. Objective: We investigated the effects of this combined intervention on cognition, balance, and gait in a person with PD through supervised lab sessions augmented by home-based sessions. Methods: This case study utilized an ABA single subject experimental design with 4 weeks of pre-intervention, followed by 8 weeks of intervention, and 4 weeks of post-intervention. The intervention consisted of treadmill walking and Xbox Kinect exergaming, 30 minutes each, performed unsupervised at home and at supervised lab sessions. The two standard deviation band method was used to determine significance. Results: MiniBEST test, 2-minute walk distance, sway area, endurance test, and a few parameters of gait initiation and gait improved significantly throughout the intervention period. Only a few measures sustained the improvement 4 weeks after completion of intervention. Conclusion: Eight weeks of treadmill and exergaming intervention with a person with PD improved static and dynamic postural control measures, but not gait, cognition, endurance, and clinical measures of balance. Longer and more intense multimodal intervention may be warranted.     

Postural effect on gait characteristics by using rolling walkers

This study was to examine the effect of leaning-forward posture (LFP) on gait parameters while using a rolling walker (RW).A cross-sectional study was conducted in which 23 older female adults were asked to walk with a RW on the GaitRite walkway in two posture situations: upright posture, and LFP caused by pushing the RW forward and then following the RW. The temporal and spatial gait parameters were obtained for data analysis.Results showed that compared with the upright posture, participants with LFP demonstrated significantly increased cadence, decreased velocity and gait cycle time (both swing and stance time decreased). Of spatial parameters, both step and stride length significantly decreased, but the base of support increased significantly.These indicate that LFP during ambulation with a RW could lead participants to a shuffling-like (many steps on short distance) gait pattern. They may help clinicians find proper rehabilitation interventions and appropriate patient education for this specific postural presentation.     

Posture of the trunk in the sagittal plane is associated with gait in community-dwelling elderly population

OBJECTIVES: The purpose of this study was to evaluate whether abnormal posture of the trunk in the sagittal plane would affect gait and functional performance in the elderly. BACKGROUND: There have been very few reports on whether posture of the trunk is related to gait and functional performance. METHODS: The study group included 237 participants with a mean age of 80.0 years (range 65-94 years). The posture of the trunk in a standing position of the sagittal plane was classified into five groups. We investigated the relationship between the trunk posture in the sagittal plane and age with gait parameters and functional performance such as timed up & go test and functional reach. RESULTS: In the elderly subjects of normal posture, there was no difference between those in the 65-79 years age group and those in the 80 years and older age group in terms of any gait parameters. Walking abilities were significantly decreased in the abnormal posture groups. Among the abnormal posture groups, elderly in the lumbar kyphosis group had walking disabilities that did not differ between age groups, whereas gait disturbance in the thoracic kyphosis group showed a positive relation with age. CONCLUSIONS: Posture of the trunk in the sagittal plane was associated not only with the distance and time parameter of gait, but also with functional performance in the elderly.     

Interference between balance,gait and cognitive task performance among people with stroke living in the community

Purpose. To explore differences in cognitive-motor interference between people with stroke and controls when performing functional tasks and to compare dual task performance of stroke fallers and non-fallers.

Method. Thirty-six people with stroke (mean age 66.5, SD 11.8, mean time since onset 16 months, range 7 – 56) and 24 controls (mean age 62.3, SD 11.61) performed balance and gait tasks in isolation and in conjunction with a cognitive task (remembering a seven item-shopping list). Three-dimensional movement analysis was used to assess anterior posterior (AP) and lateral (ML) sway; 5 m walk time, stride length and velocity.

Results. In the single task condition, people with stroke had greater AP sway, reduced velocity and stride length and a longer 5 m walk time than controls (p < 0.01). In the dual task condition, sway reduced and gait slowed in both groups (p < 0.01 for AP sway, stride length, velocity, walk time); only the increase in walk time was greater in people with stroke than in the controls (F = 4.2, p = 0.046). Cognitive performance was maintained during the balance trials but deteriorated during the dual task gait trials in people with stroke (p = 0.017). Similar trends were noted for fallers and non-fallers with stroke: Only group effects for stride length and velocity reached significance (p < 0.05) and only the reduction in stride length was significantly greater among fallers than non-fallers (F = 12.3, p = 0.001).

Conclusions. People with stroke and controls employed similar strategies during the simultaneous performance of simple functional and silent cognitive tasks and maintained postural stability. Increased walk time and decreased cognitive recall were greater for people with stroke and reduced stride length distinguished fallers from non-fallers.     

Kinetic alterations independent of walking speed in elderly fallers

OBJECTIVES: To determine if joint kinetic gait alterations in fallers persist when they attempt to walk at a faster speed that is more comparable with nonfallers' comfortable walking speed. DESIGN: Retrospective, case-control study. Stereophotogrammetric and force platform data were collected. SETTING: A gait laboratory. PARTICIPANTS: Sixteen elderly subjects who had at least 2 falls in the last 6 months from an unclear cause and 23 elderly subjects with no history of repeated falls. MAIN OUTCOME MEASURES: Differences in all major peak joint kinetic (moment and power) values during the gait cycle between elderly nonfallers walking at comfortable speed and elderly fallers walking at (1) comfortable and (2) fast speed. RESULTS: Statistically significant differences present at both comfortable and fast walking speeds were present in 4 sagittal plane parameters. There was an increase in peak external hip flexion moment in stance, a reduction in peak hip extension moment, a reduction in knee flexion moment in preswing, and a reduction in knee power absorption in preswing. CONCLUSION: The presence and persistence of 4 specific alterations in sagittal plane joint kinetics at both comfortable and fast walking speeds imply specific intrinsic pattern differences and allow for new insights into the mechanics of gait in elderly people who fall. The presence of these alterations also suggests they may serve as potential identifiable markers to detect those who may be at risk for falls.     

基于现实环境的功能性步态训练对社区卒中后康复期老人步态特征及害怕跌倒的影响

目的 探讨在现实环境下运用功能性步态训练来分析社区卒中后康复期老人步态特征的改变,以及对其害怕跌倒的影响。方法 选取在南京市某三级甲等医院康复出院的卒中患者进行追踪,采用随机数字表法分为干预组30例和对照组29例,对照组给予常规出院康复训练,而干预组在此基础上增加现实环境中的步态训练,分别在出院前,出院后8周采用便携式步态分析仪采集患者常速行走10 m的步态参数,同时采用单条目问题法和修订版跌倒效能量表分析老人跌倒恐惧的状况。结果 干预前,2组老人各项步态参数、跌倒效能得分比较无统计学意义（P>0.05）,经过干预8周后2组患者在患侧站立相、患侧摆动相、摆动强度、落脚强度、落脚时脚角度、步频、跨步时间变异性差异有统计学意义（P<0.05）,跌倒效能干预组差异有统计学意义（P<0.05）。干预前对照组害怕跌倒的老人为14例（48.28%）,干预组为13例（43.33%）;8周后对照组害怕跌倒老人为11例（37.93%）,干预组为5例（16.67%）,差异有统计学意义（P<0.05）。结论 基于现实环境的功能性步态训练对社区卒中后康复期老人步态特征及害怕跌倒有积极的改善效果。     

Effect of Increasing Obstacle Distances Task on Postural Stability Variables During Gait Initiation in Older Nonfallers and Fallers

ObjectiveTo compare the scaling of the postural stability variables between older nonfallers and fallers during gait initiation (GI) while stepping over increasing obstacle distances.DesignCross-sectional study.SettingUniversity research laboratory.ParticipantsA sample of participants (N=24) divided into 2 groups: older nonfallers (n=12) and older fallers (n=12). Participants had no known neurologic, musculoskeletal, or cardiovascular conditions that could have affected their walking, and all were independent walkers. All the participants had an adequate cognitive function to participate as indicated by a score of more than 24 on the Mini-Mental State Examination.InterventionsNot applicable.Main Outcome MeasuresThe primary dependent variables were peak anterior-posterior (AP) center of mass (CoM)-center of pressure (CoP) separation during anticipatory postural adjustments (APAs), AP CoM-CoP separation at the toe-off, and peak AP CoM-CoP separation during the swing. Secondary dependent variables were AP trunk angle during GI. Within- and between-repeated measures analysis of variance was used to compare means between groups across different task conditions for all the dependent variables.ResultsThere was a main effect of group for peak AP CoM-CoP separation during APA (P=.018), an interaction effect between group and condition for AP CoM-CoP separation at toe-off (P=.009), and a main effect of condition for peak AP CoM-CoP separation during the swing (P<.001). We also found a main effect of group for peak AP trunk angle during the swing (P=.028).ConclusionsFor GI while stepping over increasing obstacle distances, older fallers adopt a more conservative strategy of AP CoM-CoP separation than nonfallers prior to toe-off and demonstrate increased peak AP trunk lean during the swing. AP CoM-CoP separation prior to toe-off during the GI task may be a critical marker to identify fallers and warrants additional investigation.     

Reduced hip extension during walking: healthy elderly and fallers versus young adults

OBJECTIVES: To test the hypothesis that reduced hip extension range during walking, representing a limiting impairment of hip tightness, is a consistent dynamic finding that (1) occurs with increased age and (2) is exaggerated in elderly people who fall. DESIGN: Using a 3-dimensional optoelectronic motion analysis system, we compared full sagittal plane kinematic (lower extremity joint motion, pelvic motion) data during walking between elderly and young adults and between elderly fallers and nonfallers. Comparisons were also performed between comfortable and fast walking speeds within each elderly group. SETTING: A gait laboratory. PARTICIPANTS: Twenty-three healthy elderly subjects, 16 elderly fallers (otherwise healthy elderly subjects with a history of recurrent falls), and 30 healthy young adult subjects. MAIN OUTCOME MEASURES: All major peak joint angle and pelvic position values. RESULTS: Peak hip extension was the only leg joint parameter measured during walking that was both significantly lower in elderly nonfallers and fallers than in young adult subjects and was even lower in elderly fallers compared with nonfallers (all p <.05). Peak hip extension +/- standard deviation during comfortable walking speed averaged 20.4 degrees +/- 4.0 degrees for young adults, 14.3 degrees +/- 4.4 degrees for elderly nonfallers, and 11.1 degrees +/- 4.8 degrees for elderly fallers. Peak hip extension did not significantly improve when elderly subjects walked fast. CONCLUSION: An isolated and consistent reduction in hip extension during walking in the elderly, which is exaggerated in fallers, implies the presence of functionally significant hip tightness, which may limit walking performance. Overcoming hip tightness with specific stretching exercises is worthy of investigation as a simple intervention to improve walking performance and to prevent falls in the elderly.