脑卒中生存质量量表中译本信度和效度及敏感度的初步研究

目的　引进并修订了Williams等编制的脑卒中生存质量量表 (SS QOL) ,并在我国脑卒中人群中进行信度、效度和敏感度的初步研究。方法　信度检验用加权kappa系数和Cronbach’sα系数来评价。采用人为推理判断方法评价内容效度 ;以Rankin量表分级作为外在效标来评估辨别效度 ;采用聚类分析方法考核量表的结构效度 ;通过相关分析考察量表的效标效度。各领域敏感度通过标准化效应大小 (SES)来评估 91例患者。结果　 3个月时实际随访评定 80例。SS QOL中译本各领域的重测信度和评定者间信度的kappa系数均在 0 .82～ 1.0 0之间 ;内容一致信度的Cronbach’sα系数在 0 .76以上 ,显示了良好的信度。以Rankin量表为外在效标的分组中 ,得分具有显著差异 ,具有良好的辨别效度。通过聚类分析将 12个领域聚为 6类。除“社会角色 (0 .10 )”和“视力 (0 .17)”领域外 ,SS QOL中译本各领域均显示了与对应的“准金标准”呈适度的相关性 (相关系数 0 .30～ 0 .84 ,P <0 .0 0 1)。大多数领域显示了理想的敏感度。结论　SS QOL中译本在轻、中度脑卒中患者中具有良好的信度、效度及敏感度 ,可用于脑卒中结局测量。     

老年脑卒中患者健康行为问卷编制及信效度检验

目的编制老年脑卒中患者健康行为问卷,并检验其信效度。方法以脑卒中二级预防指南为依据,结合健康行为的概念及内容,在参考文献基础上编制老年脑卒中患者健康行为问卷,对176例患者进行问卷调查,经过专家咨询确定问卷内容效度,采取Cronbachα系数和因子分析评价问卷的信度及结构效度。结果老年脑卒中患者健康行为问卷包括基本健康行为、保健行为、预警行为、避免有害环境行为和戒除不良嗜好行为5个维度24个条目。各因子的累积方差贡献率均大于50%。总内容效度指数(S-CVI)为0. 97,各条目(I)-CVI在0. 8～1. 0之间,问卷总Cronbachα系数为0. 734,各分量表Cronbachα系数为0. 622～0. 713。结论老年脑卒中患者健康行为问卷具有良好的内容效度、结构效度和内部一致性信度,可用于评估老年脑卒中患者的健康行为。     

肝病生存质量量表在慢性病毒性肝炎患者中的性能评估

目的:探讨肝病生存质量量表(Liver Disease Quality of Life Questionnaire,LDQOL1.0)中文版在慢性病毒性肝炎患者生存质量测试中的信度和效度.方法:使用LDQOL1.0中文版对100例慢性病毒性肝炎患者进行进行生存质量测试,回收有效问卷91例,使用克朗巴赫系数(Cronbachα)、天花板效应和地板效应来检测量表的信度;通过计算各个肝病特异性维度与S F-36的8个维度之间的相关系数来评估量表的标准效度;通过探索性因子分析来评估量表的结构效度;通过比较不同Child Pugh评分的患者的得分,评估量表的区分度.相关性检测使用Pearson相关系数,区分度检测使用方差分析进行多重比较.结果:Cronbach α在各领域中的分值为0.33(95%C I:0.08-0.52)-0.9(95%C I:0.90-0.99),80%领域分值0.7;天花板效应在0%-39.6%,地板效应在0%-34.1%,80%领域20%.标准效度提示12个肝病特异性领域里,有6个领域与SF-36的相近领域相关度较好(Pearson系数0.5,P0.05);因子分析提示肝病特异性12个领域里7个领域因子分析结果与原量表构想相似.区分度检测提示肝病特异性12个领域里7个的区分度较好(F:0.353-21.29,P0.05).结论:LDQOL1.0在中国慢性病毒性肝炎患者中测试生存质量,大部分领域信度、效度和区分度较好,可以用于临床工作.     

脑卒中专门化生存质量量表中译本在冀南地区信度、效度及敏感度的研究

分别采用Kappa系数、Cronbach's α系数,Rankin量表、"准金标准"的相关分析,标化效应(SES)评价冀南地区脑卒中患者信度,辨别效度、效标效度及敏感度.结果随访发病后60例轻、中度脑卒中患者的Kappa值、Cronbach's α系数均＞0.8;Rankin1～Rankin4组Rankin得分逐渐下降,其中精力、家庭角色、活动能力、自理、社会角色、上肢功能、工作/劳动的Rankin平均得分在4组间有显著差异(P＜0.05).除"社会角色"与"视力"领域外,其余各领域均与相应效标有较好相关性(r=0.37～0.89,P＜0.01);除情绪、个性外,其他领域SES均＞0.5.认为脑卒中专门化生存质量量表中译本在冀南地区轻、中度脑卒中患者中具有良好的信度、效度及敏感度.     

中文版SF-36量表用于中国老年军人生活质量调查的信度与效度评价

目的 探讨美国简明健康测量量表SF-36用于中国老年军人生活质量测量的可能性。方法 采用分层、整体抽样法，使用SF-36量表中文版对西安地区934例老年军人的生活质量进行测定，参照国际生活质量评价项目的标准程序，进行正式的心理测量学试验。结果 本次研究中，SF-36量表中文版的分半信度为0．892；同质性信度系数除社会功能、心理健康2个维度，其它6个维度变化范围为0．70～0．93，满足群组比较的要求。除社会功能、心理健康维度外，其它6个维度条目的维度相关性一致；因子分析产生的8个共因子与理论结构基本一致，结构效度的累积方差贡献为68．56％。结论 SF-36健康调查量表可用于中国老年人的调查，同时提示在精神和心理方面的个别语句经进一步修订后，将提高调查的可行性及相关方面的信度和效度。     

中文版SF-36 v2量表在中国农村老年人中的应用

目的探讨中文版SF-36v2量表在中国农村老年人群中应用的信度、效度。方法采用分层、整群抽样法,使用中文版SF-36v2量表对衡阳1040例农村老年人进行测定,参照国际生存质量评价项目的标准程序,进行正式的心理测量学试验。结果 SF-36v2量表折半信度为0.903;内部一致性系数除活力和社会功能2个维度外其他6个维度均≥0.7。主成分因子分析产生了两个主成分,能解释总方差的65.51%。结论 SF-36v2量表适用于中国农村老年人生存质量的评价,同时提示在精神和心理方面的个别语句需进一步修改,将提高其可行性及信度和效度。     

慢性泪囊炎患者生活质量量表的制定及评价

目的制订慢性泪囊炎患者生活质量量表,评价量表的效度、信度以及反应度。方法根据WHO生活质量量表制定原则,提出慢性泪囊炎生活质量量表的理论构想,广泛查阅国内外多种普适性生活质量量表及视力相关专用生活质量量表,广泛听取议题小组成员和慢性泪囊炎患者的意见,采用结构化决策的方法,构建初始量表。以访谈式测量40例慢性泪囊炎患者的生活质量,采用频数分布、离散趋势法、相关系数法、因子分析法、区分度分析法等5种方法多维度筛选条目,最终形成慢性泪囊炎生活质量量表(DQOLS)。结果研制出生理、心理、社会3个维度共17个条目组成DQOLS,与理论构想相符。DQOLS 24 h重测信度为0.987,分半信度系数为0.882,Cronbachα系数为0.881。因子分析提取了5个公因子,累计方差贡献率73.029%,第一公因子为慢性泪囊炎对生理方面的影响,方差贡献率48.485%。各维度与总分相关系数介于0.712⁰.896。DQOLS总分与SF-36总分、DLQI、EASI总分相关系数分别为0.776、0.764、0.672。患者鼻内窥镜下泪囊鼻腔吻合术治疗前后DQOLS总分差异有统计学意义,不同病程组患者的DQOLS总分差异均有统计学意义。结论 DQOLS可靠、有效、灵敏,准确反映了慢性泪囊炎患者生活质量的内涵,可作为慢性泪囊炎临床疗效评价的工具。     

SF-36量表用于老年人群信度及效度研究

目的 评价SF-36量表在老年人群的信度和效度.方法 采用多阶段抽样的方法,随机抽取海南省黎族地区的≥60岁老年人2 208人,采用访谈法填写SF-36量表.分析方法采用相关分析、信度分析及证实性因子分析.结果 量表分半信度为0.842 2;Spearman-Brown系数=0.914 3;Cronbach′s系数(α系数)除SF及MH维度外,其他维度均大于0.7;证实性因子分析(CFA)所有通径系数均有统计学意义,除9c及9h的通径系数外,其他的通径系数均大于0.5.拟合优度指数(GFI)= 0.77; χ2=11 74 2 . 63,P＜0.001,RMSEA =0.096,NFI=0.92;标准效度评价健康自评总分与量表总分相关系数r=0.726.结论 SF-36量表应用于海南省老年人群生命质量评价有较好的信度和效度.适用于老年人群生命质量的评价.     

WHOQOL HIV-BREF量表用于AIDS病人的信度和效度评价

目的评价WHOQOL HIV-BREF量表用于评价经高效抗反转录病毒治疗（HARRT）的艾滋病（AIDS）病人的信度、效度。方法 2008年7月-2009年6月,使用AIDS病人生存质量调查表,对102例确诊的AIDS病人进行调查,内容包括HIV-BREF量表、基本人口学资料以及AIDS相关症状等;采用相关分析、信度分析、因子分析和方差分析等统计方法考察量表的信度、效度和区分度。结果 HIV-BREF量表每个领域的分半信度和内部一致性信度系数〉0.60,重测信度系数〉0.50。每个条目跟相关领域的相关系数都〉0.54（有统计学意义）,大于该条目与其他领域的相关系数。因子分析提取的6个主成分分别代表了各个领域,累计贡献达到72.46%;其结果与量表的理论结构假设基本一致。HIV-BREF量表能够区分是否吸毒、不同感染阶段病人的生存质量,具有较好的区分度。结论 HIV-BREF量表有较好的信度、效度和区分度,在临床以及科研中,可用于评价AIDS病人的生存质量。     

SF-36量表用于甲亢患者生活质量测定的信度与效度评价

目的评价SF-36生命质量量表在甲亢患者中的信度和效度。方法利用面对面访谈的方式调查211名甲亢患者,用分半系数和Cronbach'sα信度系数分析SF-36信度。主成分因子分析和相关分析等方法分析效度。结果SF-36的分半系数为0.778,各领域Cronbach'sα信度系数分别为生理功能0.86,生理职能0.81,躯体疼痛0.75,总体健康0.65,活力0.16,社会功能0.96,情感职能0.77,精神健康0.42。主成分因子分析提取了6个主成分代表了量表的各个领域,与量表的结构构思基本相符。结论SF-36量表用于甲亢患者生存质量测定具有较好的信度和效度,因而具有一定的实用价值。     

Baseline pulmonary function and quality of life 9 years later in a middle-aged Chinese population

STUDY OBJECTIVE: This research examined the association of baseline pulmonary function with future quality of life (QOL). METHODS: We collected baseline pulmonary function data in 1993 and 1994, and assessed QOL using the Chinese 35-Item Quality of Life Instrument in 2002 in a cohort of 1,356 participants. We used Pearson correlation analysis, multivariate analysis of variance, and multivariate linear regression analysis to assess the relationship between pulmonary function and QOL. RESULTS: The baseline percentage of age- and height-predicted FEV1 (FEV1%) was significantly correlated with the resurvey total QOL score (r = 0.126, p < 0.001) and with QOL scores for the general (r = 0.074, p = 0.006), physical (r = 0.085, p = 0.002), independence (r = 0.178, p < 0.001), and psychological (r = 0.064, p = 0.018) domains but not with the social and environmental domains after adjusting for age and sex. These associations were weaker for the percentage of age- and height-predicted FVC. Multiple linear regression showed that the above associations were independent of baseline and resurvey smoking status. Inclusion of respiratory symptoms in the model reduced the regression coefficients from 0.82 to 0.41 for the total QOL score and from 1.43 to 0.94 for the independence domain score, for a 10% change in FEV1%. The age- and sex-adjusted mean total QOL scores were 78, 76, 76, and 69, respectively (p < 0.001), for the groups of normal, symptomatic only, impaired pulmonary function only, and both symptomatic and impaired pulmonary function. This trend was also significant for the general, physical, independence, and psychological domain scores. CONCLUSION: Impaired baseline pulmonary function has a significant negative impact on QOL in later life that is independent of age, sex, height, and smoking status and is largely mediated through the development of chronic respiratory symptoms.     

Quality of life of idiopathic pulmonary fibrosis patients.

Little attention has been paid to quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). Therefore, the aim of this study was to address this issue and study the relationship between QOL, depressive symptoms, and breathlessness in these patients. Forty-one IPF patients and 41 healthy persons matched for age and sex completed the World Health Organization Quality of Life assessment instrument-100. The IPF patients also completed the Beck Depression Inventory, the Bath Breathlessness Scale, a social support questionnaire and a question concerning perceived seriousness of illness. Compared to the control group, QOL in IPF patients was mainly impaired in the domains "physical health" and "level of independence". A number of relationships were found between pulmonary function tests and QOL. The QOL facet "negative feelings" was highly associated with scores on depression. Subjective breathlessness was related to depressive symptoms and QOL. Moreover, sex and effective/emotional breathlessness predicted overall QOL. In conclusion, the impairment of the quality of life areas "physical health" and "level of independence" are important issues in idiopathic pulmonary fibrosis. Subjective breathlessness, especially the effective/emotional scale, seems related to quality of life and depressive symptoms. Rehabilitation programmes are needed that are aimed at physiological aspects and psychosocial aspects of idiopathic pulmonary fibrosis in order to enhance the quality of life of these patients.     

老年人群明、暗视觉相关生活质量的初步研究

目的研究一个适合测量我国老年人的视觉相关生活质量量表。进而用其初步评价老年人群明视觉及暗视觉相关生活质量。方法以NEI—VFQ25项量表为基础形成中文视觉相关生活质量量表,将其中与功能相关的第二部分量表分为明视觉及暗视觉两部分。应用此表测量了300例20岁～70岁（分为三组）经检查无明显眼科疾病的正常人,通过统计学指标筛选,最终选择31个指标形成本研究使用的视觉相关生活质量量表。对此量表进行效度和信度的评价,观察正常老年人群明、暗视觉相关生活质量。结果该量表31项指标,包括全身情况、视觉相关功能、社会功能、精神心理四个方面。（1）内容效度：四个分项与总分的相关系数为0．942,0．774,0．635,0．433（P=0．000）;区分效度：r=9．353,P=0．000;（2）重测信度：r=0．721,P=0．000;克朗巴赫系数：a=0．853;分半信度：R=0．911。分析第二部分视功能相关量表得分：（1）明视觉相关项目得分中青年组（43．14±1．62）分、老年前期组（40．56±2．13）分、老年组（38．17±1．79）分;（2）暗视觉相关项目得分：中青年组（42．52±1．73）分、老年前期组（29．98±1．08）分、老年组（16．15±1．88）分;B组与A组比较中,明视觉相关生活质量得分下降4．65％（P〉0．05）差异无统计学意义,暗视觉相关生活质量得分下降28．57％（P〈0．05）差异有统计学意义;C组与A组比较中,明、暗视觉相关生活质量得分分别下降11．62％（P〈0．05）、61．90％（P〈0．05）差异均有统计学意义;B组与C组比较中,明视觉相关生活质量得分下降7．31％（P〉0．05）差异无统计学意义,暗视觉相关生活质量得分下降46．66％（P〈0．05）差异有统计学意义。结论该量表可以用来检测我国正常老年人群的视觉相关生活质量,具有较满意的效度、信度。随着年龄的增长,视杆系统功能衰退的速度快于视锥系统,该量表对于视杆系统功能衰退的反映与理论相符合。     

Quality of life and its correlates among heroin users in Taiwan

The aims of this study were to compare the quality of life (QOL) between subjects with and without heroin use and to examine the association of QOL with sociodemographic characteristics, characteristics of heroin use, family support, and depression among heroin users at entry to a methadone maintenance treatment program. A group of 123 heroin users who visited an outpatient addiction treatment clinic in southern Taiwan for methadone maintenance treatment were recruited into this study. We also recruited 106 subjects who had never used heroin as the control group. Their QOL status was assessed by the short form of the Taiwan Version of the World Health Organization Questionnaire on Quality of Life (the WHOQOL-BREF Taiwan version). The level of QOL between subjects with and without heroin use was compared, and the correlates of QOL among heroin users were examined. Heroin users had poorer QOL than nonusers in the physical, psychological, and social relationship domains but not the environment domain of the WHOQOL-BREF after controlling for the influences of other factors. In addition, heroin users with obvious depression had poorer QOL in all four domains than those without obvious depression. Also, heroin users who perceived higher family support had better QOL in the social relationship and environment domains. Heroin users had poorer QOL than nonusers in multiple domains. Relief of depressive symptoms and enhancement of family support should be important strategies to improve QOL in heroin users.     

Improvement in health status following bronchopulmonary hygiene physical therapy in patients with bronchiectasis

Chronic productive cough is a common symptom in patients with bronchiectasis that is associated with a reduction in health-related quality of life (QOL). Bronchopulmonary hygiene physical therapy (BHPT) is widely prescribed for patients with bronchiectasis, although the evidence for its efficacy is limited. We set out to prospectively evaluate the impact of BHPT on health-related QOL in patients with non-cystic fibrosis bronchiectasis. We assessed cough symptoms (0-100mm visual analogue scale; VAS) and cough-related QOL in 53 patients with stable non-cystic fibrosis bronchiectasis at baseline and >4 weeks after outpatient-based BHPT. Cough specific health status was assessed with the Leicester Cough Questionnaire (LCQ; total score range 3-21, higher scores representing better QOL). All patients with bronchiectasis complained of cough as the major symptom and had mean (SEM) FEV(1) of 2.1 (0.1)L. Cough-related health status was reduced at baseline; mean (SEM) LCQ score 14.3 (0.6). There were significant improvements in cough symptoms (mean cough VAS before 43.3 (3.6) vs after 27.5 (3.1); mean difference 15.8; 95% CI of difference 9.6-22; p<0.0001) and cough-related health status after BHPT (mean LCQ total score before 14.2 vs after 17.3; mean difference 3.1; 95% confidence interval of difference 2.4-3.9; p<0.001). A significant improvement was seen in all LCQ health-related domains (physical, psychological and social; all p<0.001). Our findings suggest that bronchopulmonary hygiene physical therapy can lead to a significant improvement in cough-related quality of life.     

聚乙二醇干扰素α-2a治疗慢性丙型肝炎患者生活质量的研究

目的 评价聚乙二醇干扰素α-2a对慢性丙型肝炎患者生活质量(QOL)的影响.方法 对干扰素治疗前的慢性丙型肝炎患者(A组102例)和健康对照人员(B组44例)进行生活质量综合评定问卷-74 (GQOLI-74)测定,比较两组QOL状况.A组患者中,分别给予聚乙二醇干扰素α-2a及利巴韦林治疗1年(A1组72例)或不进行任何抗病毒治疗(A2组30例).分别在治疗结束时及治疗结束半年后对各组患者进行GQOLI-74量表测定,比较A1和A2组患者各时段QOL差异.结果 A组患者QOL状况除心理功能(P＞0.05)外,GQOI-74量表中其他维度及总分均较B组下降(P值均＜0,05).无论干扰素治疗结束时还是治疗结束后半年时,A1组患者躯体功能、心理功能、社会功能维度及总分值均高于同期的A2组患者(P值均＜0.05).治疗结束时,A1组患者躯体功能、心理功能、社会功能维度及总分值均较治疗前高(P值均＜ 0.05);治疗结束半年后,A1组患者社会功能维度较治疗结束时高(P＜0.05).结论 慢性丙型肝炎患者的QOL低于健康对照人员,聚乙二醇干扰素α-2a可以改善慢性丙型肝炎患者QOL.     

The relationship between disease activity and quality of life in systemic lupus erythematosus

OBJECTIVE: To determine the quality of life (QOL) in SLE patients and correlate it with disease activity. METHODS: Lupus patients fulfilling the ACR 1997 criteria for SLE were included in this cross-sectional study. Patients were administered the World Health Organization Quality of Life-Bref (WHOQOL-Bref) to assess their quality of life. Disease activity was measured using Mexican Systemic Lupus Erythematosus Disease Activity Index (Mex-SLEDAI). RESULTS: The study group comprised 73 lupus patients (70 females and three males) with mean age 35.22 +/- 11.15 yr and mean disease duration 5.62 +/- 5.14 yr. Mean Mex-SLEDAI score was 3.31 +/- 3.19. Higher disease activity scores were associated with lower QOL scores in the physical (P = 0.001) and psychological domains (P = 0.01) but showed no significant correlation with the domains of social and environmental QOL. Patients with clearly active and probably active disease showed significantly lower scores in the physical (P = 0.01) and psychological (P = 0.02) domains than patients with inactive disease. However, no significant difference was found in the domains of social and environmental QOL. Age or disease duration did not affect the QOL in any of the domains. CONCLUSIONS: Physical and psychological QOL are impaired to a larger extent in active lupus. However, social and environmental QOL do not correlate with the disease activity status in lupus patients.     

Gastrointestinal symptoms and health related quality of life in patients with arthritis

OBJECTIVE: To evaluate the relationship between gastrointestinal (GI) symptoms and health related quality of life (QOL) in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). METHODS: A total of 1773 patients with arthritis participating in a longterm outcome study (OA of the hip or knee = 648, RA = 1125) completed mailed surveys that included assessments of GI symptoms and overall GI symptom severity, Short Form-36, the visual analog scale (VAS) for the EuroQol (Health QOL), a VAS global disease severity scale, and measures of disease and psychological status. The overall response rate exceeded 85%. RESULTS: Dyspepsia (heartburn, bloating, or belching) and upper abdominal/epigastric pain were identified as the most important GI contributors to reduction in QOL, and the simultaneous presence of both these symptoms was associated with lower QOL (54.5) compared to those without symptoms (70.9) on the 0-100 Health QOL scale. Similarly, those in the upper tertile of the global GI severity scale had Health QOL scores of 55.7 compared to 76.4 for those in the lower tertile. These differences in GI symptoms and GI severity, however, were reduced substantially when the effects of functional disability, pain, and depression were adjusted for: 62.3 to 68.6 (p = 0.003) and 63.7 to 70.3 (p<0.001) for the GI symptoms and GI severity scales, respectively. CONCLUSION: QOL is significantly impaired among unselected arthritis patients with GI symptoms compared to those without these symptoms. Dyspepsia and upper abdominal/epigastric pain are more strongly related to QOL measures than other GI symptoms, and are common among arthritis patients. It is possible to construct a simple scale of these 2 symptoms or to use the VAS GI severity scale and get a clinically useful idea of the current level of GI distress and alteration of QOL by GI problems. Two components of impairment can be identified, one that is smaller and unrelated to disease or psychological factors, and a second that is larger and includes these factors. Because GI symptoms can alter function, pain, and psychological status, it is likely that the true effect of GI symptoms on QOL is somewhere between the unadjusted and adjusted values cited above.     

A model of quality of life in the patients with Crohn's disease]

PURPOSE: To identify the integrated impact of psychological, social, and clinical factors onto the quality of life (QOL) in the patients with Crohn's disease. SUBJECTS AND METHODS: Two hundred twenty two out-patients participated in a cross-sectional questionnaire survey in which health-related QOL (SF36), disease-specific symptoms, psychological adaptation and social support were measured. Multi-variable regression models were used to test the impact of clinical, psychological, and social factors on the patient's QOL and symptom reports. RESULTS: The patient's symptoms and health-related QOL were significantly associated not only with disease activities, but also with the patient's psychological adaptation and the quality of social support. CONCLUSION: The results strongly suggest that a psychoeducational intervention may be useful in combination with a clinical intervention to improve the patient's QOL.     

Quality of Life and its Correlates in Patients With Obsessive-compulsive Disorder

The care of patients with obsessive-compulsive disorder (OCD) has raised quality of life (QOL) issues. The purpose of this study was to compare the level of QOL between patients with and without OCD, and to examine the associations between QOL and sociodemographic data, course of illness, psychopathology, perceived social support, and treatment characteristics. The QOL levels measured with the Taiwan version of the Short Form of the World Health Organization Questionnaire on Quality of Life were compared between 57 subjects with OCD and 106 subjects without OCD. The correlates of QOL were examined among subjects with OCD. The analysis revealed that QOL scores for the general, physical, psychological and social relationship domains were lower in the OCD group than in the control group; however, no difference in the environmental domain was found. Multiple factors were associated with poor QOL in subjects with OCD, including comorbid depression, severe obsession symptoms, perceived low social support, severe adverse effects of medication, combined use of mood stabilizers, and low social status. Different domains of QOL are differently affected by OCD. The QOL of subjects with OCD was correlated to multiple factors that were specific to individual subjects and influenced by interactions with treatment and the social environment.