Criteria for maximum oxygen uptake in progressive bicycle tests

Summary Different criteria for O₂ max in a progressive bicycle exercise were studied in 115 healthy subjects. In the repeated progressive tests performed on 16 men, aged 25–35 years, three types of O₂ response against work load were noticed: a linear increase, an unexpectedly high increase, and a plateau; the last two only appearing when O₂ max was achieved. The last three O₂ values at least were required to define the plateau. Most commonly, subjective exhaustion was achieved, respiratory quotient (R) was over 1.15 and maximal heart rate (HR) at the estimated level for age, though O₂ max was not achieved. No significant differences were found between peak O₂ in the first progressive test (mean=2.95 l/min), the second progressive test (mean=3.14 l/min), or the constant-load test (mean=3.05 l/min). In the progressive test performed once on 55 men and 44 women, aged 35–62 years, subjective exhaustion was achieved by most of the subjects, but the plateau in O₂ was shown only in 17 subjects, and the peak O₂ values were somewhat lower than expected. Moreover, R max did not correlate with peak O₂, and was over 1.15 only in 9 subjects, and HR max was often below the estimated level. Thus, the progressive test appeared to be convenient in testing the physical work capacity of the subjects, but the establishment of the physiological maximum was more difficult: the relatively uncommon plateau in O₂ was the only useful criterion for O₂ max, the value of other criteria being unacceptable.     

Influence of lifting technique on perceptual and cardiovascular responses to submaximal repetitive lifting

Oxygen consumption ( O₂), heart rate, ventilation and central rating of perceived exertion (RPE) in repetitive lifting while executing squat and stoop techniques were investigated in ten male forestry workers. In all five mass/frequency combinations studied, O₂ was significantly higher for the squat than for the stoop technique. No differences were found in RPE between the techniques. The O₂ and RPE recordings were also related to those obtained during maximal repetitive lifting (same lifting technique) and maximal treadmill running. The O₂ expressed as a percentage of that obtained during maximal repetitive lifting with the same lifting technique was defined as relative aerobic intensity (% O_{2max, lifting}). The % O_{2max, lifting} was not significantly different between the techniques except for the lowest mass lifted (1 kg). This study therefore would support the hypothesis that RPE is more closely related to % O_{2max, lifting} than to absolute aerobic intensity. Related to maximal treadmill running, it was demonstrated for both lifting techniques that relative RPE (percentage of the RPE during maximal running) was more accurate than relative O₂ (percentage of maximal O₂ during maximal running) for determining the % O_{2max, lifting} in repetitive lifting. The study showed that the higher O₂ during squat. lifting compared to stoop lifting was caused by the O₂ expended in lifting and lowering the body rather than the O₂ expended lifting and lowering the external mass. It was concluded that the stoop technique was not superior to the squat technique in terms of central RPE. Based on % O_{2max, lifting}, there may be a rationale for choosing the stoop technique during repetitive lifting with light masses, but not with heavy masses.     

The effects of continuous and interval training in women and men

Summary Fourteen Subjects (6 male, 8 female) participated in a training program upon a bicycle ergometer for 7 weeks. Group CT followed a continuous training regimen 4 days per week at 70% O₂ max. Group IT trained by an interval method at 100% O₂ max. The duration of each training session was assigned so that each subject would complete 10,000 kpm of work per session during the first week. Each subsequent week, the work load was increased 3000 kpm. Pretraining tests included O₂ max, standard 7 min tests at 80% O₂ and 90% O₂, an endurance test at 90%, and an intense anaerobic work bout at 2400 kpm. Variables assessed were O₂, HR, and blood lactic acid concentrations. The mean increase in O₂ max was 5.1 ml/kg min (15%) for both groups with a corresponding increase in maximal lactate of 20 mg-%. The response to the post-training tests was nearly identical for both groups: submaximal heart rate at the same absolute work load declined 17 beats/min (CT) and 15 beats/min (IT), submaximal lactate levels declined significantly, endurance ride duration increased 26 min. Continuous and interval training at 70% and 100% O₂ max respectively produce identical changes in heart rate response, blood lactic acid concentration and O₂ max when the total work load is equated per training session.     

Relationships of the anaerobic threshold with the 5 km, 10 km,and 10 mile races

Summary The purpose of present study was to assess the relationship between anaerobic threshold (AT) and performances in three different distance races (i.e., 5 km, 10 km, and 10 mile). AT, O₂ max, and related parameters for 17 young endurance runners aged 16–18 years tested on a treadmill with a discontinuous method. The determination of AT was based upon both gas exchange and blood lactate methods. Performances in the distance races were measured within nearly the same month as the time of experiment. Mean AT- O₂ was 51.0 ml·kg^–1·min^–1 (2.837 l·min^–1), while O₂ max averaged 64.1 ml·kg^–1·min^–1 (3.568 l·min^–1). AT-HR and %AT (AT- O₂/ O₂ max) were 174.7 beats·min^–1 and 79.6%, respectively. The correlations between O₂ max (ml·kg^–1·min^–1) and performances in the three distance races were not high (r=–0.645, r=–0.674, r=–0.574), while those between AT- O₂ and performances was r=–0.945, r=–0.839, and r=–0.835, respectively. The latter results indicate that AT- O₂ alone would account for 83.9%, 70.4%, and 69.7% of the variance in the 5 km, 10 km, and 10 mile performances, respectively. Since r=–0.945 (5 km versus AT- O₂) is significantly different from r=–0.645 (5 km versus O₂ max), the 5 km performance appears to be more related to AT- O₂ than VO₂ max. It is concluded that individual variance in the middle and long distance races (particularly the 5 km race) is better accounted for by the variance in AT- O₂ expressed as milliliters of oxygen per kilogram of body weight than by differences in O₂ max.     

A cycle ergometer test of maximal aerobic power

Summary An indirect test of maximal aerobic power (IMAP) was evaluated in 31 healthy male subjects by comparing it with a direct treadmill measurement of maximal aerobic power ( O₂ max), with the prediction of O₂ max from heart rate during submaximal exercise on a cycle ergometer using åstrand's nomogram, with the British Army's Basic Fitness Test (BFT, a 2.4 km run performed in boots and trousers), and with a test of maximum anaerobic power. For the IMAP test, subjects pedalled on a cycle ergometer at 75 revs·min^–1. The workload was 37.5 watts for the first minute, and was increased by 37.5 watts every minute until the subject could not continue. Time to exhaustion was recorded. Predicted O₂ max and times for BFT and IMAP correlated significantly (p<0.001) with the direct O₂ max: r=0.70, r=0.67 and r=0.79 respectively. The correlation between direct O₂ max and the maximum anaerobic power test was significant (p<0.05) but lower, r=0.44. Although lactate levels after direct O₂ max determination were significantly higher than those after the IMAP test, maximum heart rates were not significantly different. Submaximal O₂ values measured during the IMAP test yielded a regression equation relating O₂ max and pedalling time. When individual values for direct and predicted O₂ max and times for BFT and IMAP were compared with equivalent standards, the percentages of subjects able to exceed the standard were 100, 65, 87, and 87 respectively. These data demonstrate that the IMAP test provides a valid estimate of O₂ max and indicate that it may be a practical test for establishing that an individual meets a minimum standard.     

Independence of ventilation and blood lactate responses during graded exercise

The effect of power output increment, based on an increase in pedal rate, on blood lactate accumulation during graded exercise is unknown. Therefore, in the present study, we examined the effect of two different rates of power output increments employing two pedal rates on pulmonary ventilation and blood lactate responses during graded cycle ergometry in young men. Males (n=8) with an mean (SD) peak oxygen uptake of 4.2 (0.1) 1·min^–1 served as subjects. Each subject performed two graded cycle ergometer tests. The first test, conducted at 60 rev· min^–1, employed 4 min of unloaded pedaling followed by a standard power output step increment (SI) of 60 W every 3rd min. The second test, conducted at 90 rev·min^–1, employed 4 min of unloaded pedaling followed by a high power output step increment (HI) of 90 W every 3rd min. Venous blood was sampled from a forearm vein after 5 min of seated rest, 4 min of unloaded pedaling, and every 3rd min of graded exercise. Peak exercise values for heart rate, oxygen uptake ( O₂), and ventilation ( _E) were similar (P > 0.05) for SI and HI exercise, as was the relationship between _E and O₂, and between _E and carbon dioxide production ( CO₂). However, the relationship between blood lactate concentration and O₂ was dissimilar between SI and HI exercise with blood lactate accumulation beyond the lowest ventilatory equivalent of oxygen, and peak exercise blood lactate concentration values significantly higher (P < 0.05) for SI [12.8 (2.6) mmol·l^–1] compared to HI [8.0(1.9) mmol·l^–1] exercise. Our findings demonstrate that blood lactate accumulation and _E during graded exercise are dissociated. Blood lactate accumulation is influenced by the rate of external power output increment, while _E is related to O₂ and CO₂.     

Lipid metabolism during exercise I: Physiological and biochemical characterization of normal healthy male subjects in relation to their physical fitness

Summary On the basis of maximal oxygen uptake ( O₂ max) 18 normal, healthy men were divided into two groups of equal size: moderately trained subjects (MTR) each having O₂ max below 65.0 ml·min^–1·kg^–1 body weight (54.0±8.3) and well trained subjects (WTR), whose O₂ max exceeded 65.0 ml·min^–1·kg^–1 body weight (69.2±4.1). The WTR group had slightly (non significant, n.s.) higher percentage of slow twitch, oxidative (SO) fibers in M. vastus lateralis and higher (n.s.) activities of cytochrome c oxidase (CytOx), succinate dehydrogenase (SDH), 3-hydroxyacyl-CoA-dehydrogenase (HADH), and citrate synthase (CS), while lactate dehydrogenase (LDH) activity was lower (n.s.). In the MTR group only, the SO-%, and the activities of CytOx, SDH and HADH correlated positively with O₂ max, and LDH negatively with O₂ max. These correlations were not significant in the WTR group possibly because of the adaptations produced by training in this group. Multiple regression analysis was used to elucidate the best combination of variables to explain the variance in O₂ max. The best model consisted of the sum of relative activities of oxidative muscle enzymes (CytOx, SDH, HADH, CS), muscle LDH activity, body fat content (% F) and lean body mass. This model explained 69% of the variance in O₂ max; and of the individual variables % F was of utmost importance.     

Cardiopulmonary adjustment and metabolic response to maximal and submaximal physical exercise of boys and girls at different stages of maturity

Summary Cardiopulmonary and metabolic variables were investigated at maximal and submaximal bicycle ergometer exercises in 41 swimmers of both sexes, 8–18 years old. O₂ max and O₂ max·HR^–1 were higher in boys than in girls and increased with maturity, while O₂ max·kg^–1 and HVE were not influenced by this. The HV increased clearly during this growth period, the pubertal and postpubertal subjects showing 16 and 17% higher values for HV and HV·kg^–1 than those reported in normal schoolchildren populations. During the submaximal exercise at 70% O₂ max the highest HR values were found in the prepubertal group, whilst the lowest were observed in the postpubertal subjects. These findings suggest that a given percentage of O₂ max as a reference unit, is more reliable than a certain HR to obtain comparable results in subjects with different ages.Blood samples were collected before, during, and after the submaximal exercise. Blood glucose and FFA did not differ in relation to the stages of maturity. During exercise, insulin decreased in prepubertal children, did not alter in pubertal adolescents, and increased in postpubertal subjects. The lactate concentration, during exercise, increased in relation to maturity. The same results were found for HGH, but no differences were found with regard to sex. Since the pattern of HGH secretion during exercise is similar to that found after arginine and insulin administration it is assumed that the same mechanism (i.e., sex hormones) triggers the HGH release.Abbreviations HV heart volume - HV·kg^–1 heart volume per kg body weight - HR heart rate - average heart rate during the submaximal exercise - WL work load - W·kg^–1 watts per kg body weight - O₂ max maximal oxygen consumption - 70% O₂ max 70% of maximal oxygen consumption - O₂ max·HR^–1 oxygen pulse - HVE heart volume equivalent (HV/ O₂ max·HR^–1) - FFA free fatty acids - HGH human growth hormone     

Noninvasive measurement of human forearm oxygen consumption by near infrared spectroscopy

Summary This study reported on the application of near infrared spectroscopy (NIRS) to noninvasive measurements of forearm brachio-radial muscle oxygen consumption ( O₂) and recovery time (t _r) in untrained volunteers. Seven healthy subjects were submitted to four consecutive protocols involving measurements made at rest, the induction of an ischaemia, and during a maximal increase of metabolic demand achieved with and without vascular occlusion. Two isometric maximal voluntary contractions (MVC) of 30-s duration were executed with and without vascular occlusion and a 50% MVC lasting 125 s was also performed. The protocols were repeated on 2 different days. The results showed that, during vascular occlusion at rest, the time to 95% of the final haemoglobin (Hb) + myoglobin (Mb) desaturation value was independent of O₂. The MVC, performed during vascular occlusion, caused complete Hb + Mb desaturation in 15–20 s, which was not followed by any further desaturation when the second contraction was performed. No difference was found between O₂during MVC with and without vascular occlusion. A consistent difference was seen between O₂measured during occlusion at rest and O₂measured during MVC with and without occlusion. During prolonged exercise (125 s) Hb + Mb desaturation was maintained for the whole contraction period. The results of this study show that O₂can be measured noninvasively by NIRS. The O₂during MVC was very similar both in the presence and absence of blood flow limitation in most of the subjects tested. This would suggest that muscle O₂might be accurately evaluated dynamically without cuff occlusion.     

Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects

Summary Cerebral blood flow has been reported to increase during dynamic exercise, but whether this occurs in proportion to the intensity remains unsettled. We measured middle cerebral artery blood flow velocity (m) by transcranial Doppler ultrasound in 14 healthy young adults, at rest and during dynamic exercise performed on a cycle ergometer at a intensity progressively increasing, by 50 W every 4 min until exhaustion. Arterial blood pressure, heart rate, end-tidal, partial pressure of carbon dioxide (P _ETCO₂), oxygen uptake ( O₂) and carbon dioxide output were determined at exercise intensity. Mean vM increased from 53 (SEM 2) cm · s^–1 at rest to a maximum of 75 (SEM 4) cm · s^–1 at 57% of the maximal attained O₂( O_2max), and thereafter progressively decreased to 59 (SEM 4) cm · s^–1 at O_2max. The respiratory exchange ratio (R) was 0.97 (SEM 0.01) at 57% of O_2maxand 1.10 (SEM 0.01) at O_2max. The P _ETCO₂ increased from 5.9 (SEM 0.2) kPa at rest to 7.4 (SEM 0.2) kPa at 57% of O_2maxand thereafter decreased to 5.9 (SEM 0.2) kPa at O_2max. Mean arterial pressure increased from 98 (SEM 1) mmHg (13.1 kPa) at rest to 116 (SEM 1) mmHg (15.5 kPa) at 90% of O_2max, and decreased slightly to 108 (SEM 1) mmHg (14.4 kPa) at O_2max. In all the subjects, the maximal value of v _m was recorded at the highest attained exercise intensity below the anaerobic threshold (defined by R greater than 1). We concluded that cerebral blood flow as evaluated by middle cerebral artery flow velocity increased during dynamic exercise as a function of exercise intensity below the anaerobic threshold. At higher intensities, cerebral blood flow decreased, without however a complete return to baseline values, and it is suggested that this may have been at least in part explained by concomitant changes in arterial PCO₂.     

Effect of previous supramaximal work on lacticaemia during supra-anaerobic threshold exercise

Summary Twelve male and female subjects (eight trained, four untrained) exercised for 30 min on a treadmill at an intensity of maximal O₂ consumption (% O_2max) 90.0%, SD 4.7 greater than the anaerobic threshold of 4 mmol ·1^–1 (Th_an =83.6% O_2max, SD 8.9). Time-dependent changes in blood lactate concentration ([la_b]) during exercise occurred in two phases: the oxygen uptake ( O₂) transient phase (from 0 to 4 min) and the O₂ steady-state phase (4–30 min). During the transient phase, [la_b] increased markedly (l.30 mmol · l ^–1 · min ^–1, SD 0.13). During the steady-state phase, [la_b] increased slightly (0.02 mmol · 1^–1 · min^–1, SD 0.06) and when individual values were considered, it was seen that there were no time-dependent increases in [la_b] in half of the subjects. Following hyperlacticaemia (8.8 mmol -l^–1, SD 2.0) induced by a previous 2 min of supramaximal exercise (120% O_2max), [la_b] decreased during the O₂ transient (–0.118 mmol · 1^–1 · min^–1, SD 0.209) and steady-state (–0.088 mmol · 1^–1 · min ^–1, SD 0.103) phases of 30 min exercise (91.4% O_2max, SD 4.8). In conclusion, it was not possible from the Th_an to determine the maximal [la_b] steady state for each subject. In addition, lactate accumulated during previous supramaximal exercise was eliminated during the O₂ transient phase of exercise performed at an intensity above the Th_an. This effect is probably largely explained by the reduction in oxygen deficit during the transient phase. Under these conditions, the time-course of changes in [la_b] during the O₂ steady state was also affected.     

Aerobic fitness and body fat of young British males entering the army

Summary Aerobic fitness and percent body fat were measured in a sample of 438 male Army recruits between the ages of 17 and 30 prior to the commencement of training. The sample came from all areas of England and Wales. Aerobic fitness, as represented by maximal oxygen uptake ( O₂ max), was predicted from the Astrand submaximal bicycle heart rate test. Body fat was predicted from four skinfold measurements. Total group means ±SD were: age, 19.5±2.5 years; O₂ max 41.7 ±8.3 ml/kg·min; and body fat, 14.5±4.8% of body weight. O₂ max varied with age, athletic participation and aptitude score. No relationship was found with occupation of parent, prior civilian occupation or smoking severity. When adjusted for methodological differences, O₂ max was slightly below similar Army entrants in Norway and the United States.     

Role of decreased carbohydrate oxidation on slower rises in ventilation with increasing exercise intensity after training

In these studies, we examined whether the rightward shift in steady-state minute ventilation ( _E) versus O₂ uptake curves after training is more closely linked to the reduced CO₂ production from carbohydrate oxidation (CHO_OX) after training than to the attenuated increase in blood lactate concentration. Steady state _E values and gas exchange were measured in eight previously sedentary men who underwent exercise tests of 60 W + 40 W every 6 min before and after a 9 week training programme of cycling approximately 40 min a day. Following training, the slower rises in _E with increasing exercise intensities were associated with a reduced reliance on CHO_OX, (P < 0.01). Both before and after training, _E values in litres per minute rose as a linear _E = 18 · CHO_OX + 14, function of rates of CHO_OX in grams per minute (r = 0.99), irrespective of a marked shift to the right in arterialized venous blood lactate concentration versus CHO_OX curves following training (P < 0.01). Thus, slower increases in steady-state _E values with increasing exercise intensities following endurance training appeared to be more closely linked to the decreased reliance on CHO_OX than to the attenuated increase in blood lactate concentration.     

Maximal O2 uptake of boys and girls — ages 14–17

Summary White high school girls (n = 120) and boys (n = 120) aged 14–17 years, selected from 9th, 10th, 11th and 12 grades of a northern, midwest U.S. high school performed running exercise on a motor driven treadmill for determinations of maximal O₂ uptake ( O₂ max).The mean O₂ max for all age groups was 40.8±4.0 and 54.7±5.6 ml/kg·min^–1 for girls and boys respectively. The difference in O₂ max across age groups varied only from 40.2–41.2 ml/kg·min^–1 for girls and 54.0–56.3 ml/kg·min^–1 for boys. These differences were not significant (P>0.05). The reported O₂ max data are compared with those reported in other studies for bicycle ergometer and treadmill exercise using similar age groups.     

Oxygen uptake during swimming in a hypobaric hypoxic environment

Summary The purpose of this study was to determine oxygen uptake O₂) at various water flow rates and maximal oxygen uptake ( O_2max) during swimming in a hypobaric hypoxic environment. Seven trained swimmers swam in normal [N; 751 mmHg (100.1 kPa)] and hypobaric hypoxic [H; 601 mmHg (80.27 kPa)] environments in a chamber where atmospheric pressure could be regulated. Water flow rate started at 0.80 m · s^–1 and was increased by 0.05 m· s^–1 every 2 min up to 1.00 m · s^–1 and then by 0.05 m · s^–1 every minute until exhaustion. At submaximal water flow rates, carbon dioxide production ( CO₂), pulmonary ventilation ( _E) and tidal volume (V _T) were significantly greater in H than in N. There were no significant differences in the response of submaximal O₂, heart rate (f _c) or respiratory frequency (f _R) between N and H. Maximal _E,f _R,V _T,f _c blood lactate concentration and water flow rate were not significantly different between N and H. However, VO_2max under H [3.65 (SD 0.11) l · min^–1] was significantly lower by 12.0% (SD 3.4) % than that in N [4.15 (SD 0.18) l · min^–1] . This decrease agrees well with previous investigations that have studied centrally limited exercise, such as running and cycling, under similar levels of hypoxia.     

Changes in ventilation at the start and end of moderate and heavy exercise of short and long duration

Summary These experiments examined the effect of exercise intensity and duration on the magnitude of the abrupt change in ventilation at the start ( ) and end ( ) of exercise. Five subjects performed constant load treadmill exercise at 50% and 80% of their maximum oxygen consumption ( ) for 6 and 10 min while inspiring atmospheric air. The subjects also completed additional exercise tests at 80% for 10 min while inspiring an oxygen-enriched gas mixture. During each exercise trial ventilation was measured breath-by-breath. The and were determined by using non-linear curve-fitting techniques. The results showed that was greater at the start of the 80-% exercise tests compared to the 50-% tests and that at each level of exercise was greater than . The results also demonstrated that was inversely related to the intensity and duration of exercise. Furthermore, the was not altered subsequent to the inspiration of oxygen-enriched air. These findings have led us to postulate that the stimulus responsible for is reduced during exercise and that the degree of reduction is related to the intensity and duration of exercise. In addition, it was concluded that these changes might occur independently of peripheral chemoreceptor activity.     

Severe hypoxia decreases oxygen uptake relative to intensity during submaximal graded exercise

Summary The effect of severe acute hypoxia (fractional concentration of inspired oxygen equalled 0.104) was studied in nine male subjects performing an incremental exercise test. For power outputs over 125 W, all the subjects in a state of hypoxia showed a decrease in oxygen consumption ( O₂) relative to exercise intensity compared with normoxia (P < 0.05). This would suggest an increased anaerobic metabolism as an energy source during hypoxic exercise. During submaximal exercise, for a given O₂, higher blood lactate concentrations were found in hypoxia than in normoxia (P < 0.05). In consequence, the onset of blood lactate accumulation (OBLA) was shifted to a lower O₂ ( O₂ 1.77 l·min^–1 in hypoxia vs 3.10 l·min^–1 in normoxia). Lactate concentration increases relative to minute ventilation ( _E) responses were significantly higher during hypoxia than in normoxia (P < 0.05). At OBLA, _E during hypoxia was 25% lower than in the normoxic test. This study would suggest that in hypoxia subjects are able to use an increased anaerobic metabolism to maintain exercise performance.     

Oxygen uptake during running as related to body mass in circumpubertal boys: a longitudinal study

Summary To investigate the effect of endurance training on physiological characteristics during circumpubertal growth, eight young runners (mean starting age 12 years) were studied every 6 months for 8 years. Four other boys served as untrained controls. Oxygen uptake ( O ₂) and blood lactate concentrations were measured during submaximal and maximal treadmill running. The data were aligned with each individual's age of peak height velocity. The maximal oxygen uptake ( O _2max; ml · kg^–1 · min^–1) decreased with growth in the untrained group but remained almost constant in the training group. The oxygen cost of running at 15 km · h^–1 ( O ₂₁₅, ml · kg^–1 · min^–1) was persistently lower in the trained group but decreased similarly with age in both groups. The development of O _2max and O ₂₁₅ (1 · min^–1) was related to each individual's increase in body mass so that power functions were obtained. The mean body mass scaling factor was 0.78 (SEM 0.07) and 1.01 (SEM 0.04) for O _2max and 0.75 (SEM 0.09) and 0.75 (SEM 0.02) for O ₂₁₅ in the untrained and trained groups, respectively. Therefore, expressed as ml · kg^–0.75 · min^–1, O ₂₁₅ was unchanged in both groups and O _2max increased only in the trained group. The running velocity corresponding to 4 mmol · 1^–1 of blood lactate ( _la4) increased only in the trained group. Blood lactate concentration at exhaustion remained constant in both groups over the years studied. In conclusion, recent and the present findings would suggest that changes in the oxygen cost of running and O _2max (ml · kg^–1 · min^–1) during growth may mainly be due to an overestimation of the body mass dependency of O ₀₂ during running. The O ₂ determined during treadmill running may be better related to kg^0.75 than to kg¹.     

Skeletal muscle determinants of maximum aerobic power in man

Summary The interrelationship between whole body maximum O₂ uptake capacity ( O_{2 max}), skeletal muscle respiratory capacity, and muscle fiber type were examined in 20 physically active men. The capacity of homogenates of vastus lateralis muscle biopsy specimes to oxidize pyruvate was significantly related to O_{2 max} (r=0.81). Correlations of 0.75 and 0.74 were found between % slow twitch fibers (%ST) and O_{2 max}, and between % ST fibers and muscle respiratory capacity, respectively (P<0.01). Multiple correlation analysis (R=0.85) indicated that 72% (R ²=0.72) of the variance in CO_{2 max} could be accounted for by the combined effect of muscle respiratory capacity and the % ST fibers. When the % ST fibers was correlated with O_{2 max}, with the effect of respiratory capacity statistically removed, the relationship became insignificant (r=0.38). These data suggest that muscle respiratory capacity plays an important role in determining O_{2 max}, and that the relationship between % ST fibers and O_{2 max} is due primarily to the high oxidative capacity of this muscle fiber type.This research was supported by NIH grant (HL 20408-02)     

Aerobic performance capacity in paraplegic subjects

Summary To determine adaptation to prolonged exercise in paraplegics, maximal O₂ uptake ( ) and lactate threshold (LT) were evaluated during an arm cranking exercise in nine patients (P) and nine able-bodied (AB) subjects.Mean averaged 25.1 and 31.6 ml · min^–1 · kg^–1 in P and AB groups respectively. in P was found to be directly related to the level of spinal injury: the higher the lesion the lower the uptake. Lactate threshold expressed as a percentage of was higher in P (59%) than in AB (43%), and close to that observed in armtrained athletes.Since training has less effect on in paraplegics than in able-bodied subjects, attributable to a deficiency in the circulatory adaptation of paraplegics to exercise, the observed differences between AB and P in lactate threshold and submaximal exercise indicate that the possible effect of training in paraplegics is located at the level of intracellular chemistry, with a diminution in glycogenolysis (higher LT) and a higher rate of lipid utilization (lower RQ).