围术期护理干预对行冠心病经皮冠状动脉成形术和支架植入术的患者的影响

目的探讨行冠心病经皮冠状动脉成形术与支架植入术患者应用围术期护理干预的临床意义。方法选取2015年4月至2016年8月的68例行冠心病经皮冠状动脉成形术与支架植入术患者进行研究,以随机为基本原则,将其分为对照组与观察组,各34例。对照组实施一般护理,在此基础上,予以观察组围术期护理干预。观察两组护理前后抑郁、焦虑情况。结果观察组护理后抑郁、焦虑评分分别为(27.69±2.88)分、(28.35±3.05)分,优于对照组,P0.05。结论围术期护理干预应用于行冠心病经皮冠状动脉成形术与支架植入术患者中,可明显改善患者心理状态。     

围术期程序护理在老年骨质疏松性椎体压缩骨折患者微创手术治疗中的应用

目的探讨围术期程序护理干预对老年骨质疏松性椎体压缩骨折（OVCF）患者微创手术治疗中护理质量的影响。方法选择老年OVCF行经皮球囊扩张后凸成形术（PKP）患者62例,采用随机数字表法分为观察组及对照组各31例,观察组采用程序护理,对照组采用常规护理。观察两组患者焦虑自量表(SAS）评分、抑郁自评量表（SDS）评分变化,比较两组患者术后并发症发生情况及护理满意度。结果护理干预后两组患者SAS评分及SDS评分均明显低于干预前,且观察组SAS评分及SDS评分均明显低于对照组,差异均有统计学意义（均P＜0.05）。观察组患者术后并发症发生率为9.7%,明显低于对照组的22.6%,差异有统计学意义（P＜0.05）。观察组护理满意度为96.7%,明显优于对照组的83.9%,差异有统计学意义（P＜0.05）。结论对行PKP的老年OVCF患者,围术期进行程序护理,能明显缓解其紧张焦虑情绪、有效防止术后并发症的发生、提高患者满意度,值得临床推广。     

冠心病经皮冠状动脉成形术与支架置入术的围术期护理效果观察

目的 探讨冠心病经皮冠状动脉成形术与支架置入术的围术期护理干预效果.方法 选择2012年6月—2014年9月在我院行经皮冠状动脉形成术与支架置入术治疗的冠心病患者88例作为研究对象,根据护理方式的不同分为观察组和对照组各44例,对照组采取一般常规护理,观察组行围术期护理,观察2组患者的护理满意度、手术前后焦虑程度.结果 护理后,观察组患者焦虑程度明显优于对照组,护理满意度明显高于对照组,差异显著(P<0.05).结论 冠心病患者经皮冠状动脉成形术与支架置入术治疗中采取围术期护理,能改善患者心理状态,提高护理满意度,具有积极的临床意义.     

自动痔疮套扎术治疗痔疮围手术期护理干预后效果观察

目的探究自动痔疮套扎术治疗痔疮围手术期护理干预后效果。方法选取2016年1月~2016年11月期间,本院进行治疗的50例痔疮患者作为研究对象,根据护理方法的不同,将其分为对照组(n=25)和观察组(n=25),对照组采用常规护理干预,观察组采用围术期护理干预,观察分析两组患者的护理满意度,SDS、SAS评分和术后并发症发生率。结果观察组患者的护理满意度高于对照组,SDS、SAS评分和术后并发症发生率低于对照组,两组差异显著,有统计学意义(P0.05)。结论采用围术期护理干预对痔疮患者具有较为突出的临床护理价值。     

急性心肌梗死患者经皮冠状动脉支架植入术的护理

目的：探讨急性心肌梗死患者实施经皮冠状动脉支架植入术的围术期护理干预措施,并总结护理效果。方法选择2013年4月—2015年7月我院收治的急性心肌梗死患者94例,均急诊行经皮冠状动脉支架置入术治疗。依据临床护理方案的不同将其分为研究组（n=46）与对照组（n=48）,在围术期对对照组患者行常规护理,对研究组患者行综合护理。比较2组患者护理干预效果。结果2组患者均顺利完成手术,住院期间未见死亡病例。研究组患者围术期并发症发生率及心理状态评分均优于对照组（P<0.05）。结论对实施经皮冠状动脉支架植入术的急性心肌梗死患者加强围术期护理干预,可有效减少并发症发生,提高临床治疗效果。     

激励式干预联合临床护理路径对冠心病患者介入治疗围术期情绪状态的影响

目的：探讨激励式干预联合临床护理路径对冠心病患者介入治疗围术期情绪状态的影响。方法：选取2018年3月—2020年6月河南科技大学第一附属医院收治的120例经皮冠状动脉介入治疗（PCI）的冠心病患者作为研究对象，随机分为对照组和观察组，每组各60例。对照组围术期实施临床护理路径干预，观察组围术期在临床护理路径干预基础上实施激励式干预。比较两组患者围术期血压心率变化、干预前后焦虑自评量表（SAS）评分和抑郁自评量表（SDS）评分、术后生活质量、护理满意度。结果：两组患者围术期干预前、术前1 d、干预后收缩压、舒张压和心率指标比较，差异无统计学意义（t=0.891、0.792、0.780、1.213、1.541、1.090、0.972、0.963、1.445,P>0.05）。干预前，两组患者SAS、SDS评分比较，差异无统计学意义（t=1.235、0.956,P>0.05）；干预后，两组患者SAS、SDS评分均比干预前降低，且观察组低于对照组，差异有统计学意义（t=5.475、5.605,P<0.05）。观察组生活质量评分中的生理功能、心理功能、社会功能及总体生活质量各维...     

对围鼻内窥镜手术患者应用综合护理干预的价值

目的:研究对围鼻内窥镜手术患者应用综合护理干预的价值.方法:选取2014年11月至2015年11月该院收治的鼻内窥镜手术患者90例作为研究对象,并随机分成观察组与对照组.对照组实行围术期常规护理措施,观察组围术期实行综合护理干预,对比两组患者护理效果.结果:观察组围术期护理后患者SAS评分、SDS评分均优于对照组(P＜0.05);观察组患者住院时间少于对照组患者(P＜0.05);观察组患者护理满意度显著高于对照组(P＜0.05).结论:对鼻内窥镜手术患者围术期实行综合护理干预效果明显,能缩减患者住院时间,降低患者围术期SAS评分、SDS评分,提高护理满意度.值得临床应用推广.     

护理干预对扁桃体低温等离子射频消融术患者术后疼痛及满意度的影响

目的 研究护理干预对扁桃体低温等离子射频消融术患者术后疼痛及满意度的影响。方法 选择2020年1月—2023年10月于九江市第一人民医院接受扁桃体低温等离子射频消融术治疗的80例患者为研究对象,依据随机数字表法分为对照组（40例）和观察组（40例）。对照组接受围术期常规护理干预,观察组接受围术期优质护理干预,对比2组术后疼痛情况[疼痛数字评分量表（numerical rating scale,NRS）评分]、负性情绪[焦虑自评量表（self-rating anxiety scale,SAS）、抑郁自评量表（self-rating depression scale,SDS）评分]及护理满意度。结果 术后12 h、1 d、3 d观察组的NRS评分均低于对照组（P<0.05）;观察组护理总满意率为92.50%,高于对照组的70.00%(P<0.05)。干预前,2组SAS、SDS评分比较,差异无统计学意义（P>0.05）;干预后,观察组SAS、SDS评分均低于对照组（P<0.05）。结论 接受扁桃体低温等离子射频消融术治疗的患者采用围术期优质护理干预,可有效减轻患者术后...     

急诊经皮冠状动脉介入术治疗的护理干预效果分析

目的：探讨急诊经皮冠状动脉介入 (PCI) 术治疗的护理干预效果。方法：选取2019年5月—2020年9月中国科学院大学深圳医院 (光明) 西院区收治的 70 例急诊经皮冠状动脉介入治疗患者作为研究对象,随机分为对照组和研究组,每组各 35 例。对照组治疗期间予以常规护理,研究组予以围术期综合护理,比较两组患者心理状态评分、并发症情况、护理满意度、术后康复情况。结果：两组患者护理前焦虑自评量表 (SAS)、抑郁自评量表 (SDS) 评分比较,差异无统计学意义 (t=0.056、0.033,P>0.05);研究组护理后SAS、SDS评分 [(28.63±7.54) 分、(31.45±8.74) 分] 均较对照组低 [(33.05±7.62) 分、(39.23±9.05) 分],差异有统计学意义 (t=2.439、3.658,P<0.05)。研究组造影剂过敏、心源性休克、造影剂肾病、再灌注损伤等并发症发生率低于对照组,差异有统计学意义 (χ²=5.285,P<0.05)。研究组的护理满意度为97.14%,较对照组的82.86%高,差异有统计学意义 (...     

个性化护理干预在十二指肠溃疡伴急性穿孔患者中的应用价值研究

目的：探讨个性化护理干预在十二指肠溃疡伴急性穿孔患者中的应用价值。方法：选取2018年1月-2022年1月南京医科大学附属南京医院收治的56例十二指肠溃疡急性穿孔患者作为研究对象,患者均拟行腹腔镜下十二指肠溃疡穿孔修补术,采用随机数字表法分为观察组与对照组,各28例。对照组围术期予以常规护理,观察组围术期予以个性化护理干预,比较两组手术一般指标、护理前后心理状态、护理满意度及术后并发症发生情况。结果：观察组排气时间、排便时间、首次下床活动时间早于对照组,引流管置管时间及住院时间短于对照组,差异有统计学意义(P<0.05)。护理前,两组焦虑自评量表(SAS)、抑郁自评量表(SDS)、护理满意度评分比较,差异无统计学意义(P>0.05);护理后,观察组SAS、SDS评分低于对照组,差异有统计学意义(P<0.05)。观察组护理满意度评分高于对照组,差异有统计学意义(P<0.05)。观察组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论：十二指肠溃疡并急性穿孔患者围术期实施个性化护理干预,可促进患者术后康复,降低术后并发症发生风险,并对改善患者焦...     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.