脑瘫并语言障碍患儿小组语言训练的效果观察

目的探究脑瘫合并语言障碍患儿采用小组语言训练的临床疗效和应用价值。方法选取我院2014年9月-2015年3月收治的脑瘫合并语言障碍患儿77例,按照随机数字法分为对照组37例和观察组40例,对照组患儿实行专业的护患一对一语言训练,观察组患儿实行小组语言训练,观察比较两组患儿的治疗效果。结果观察组和对照组患儿构音障碍发生情况差异无统计学意义(P0.05)。观察组患儿治疗总有效率为92.5%,对照组患儿治疗总有效率为94.6%,两组患儿治疗总有效率差异无统计学意义(P0.05)。结论将小组语言训练应用于脑瘫合并语言障碍患儿的临床治疗中,可有效改善患儿构音障碍,训练效果良好,应用价值高。     

脑瘫并语言障碍患儿小组语言训练的效果观察

目的探讨语言训练在脑瘫并语言障碍患儿康复中的临床效果。方法选取该院自2010年8月-2012年8月收治的108例脑瘫并语言障碍患儿随机分为观察组及参考组，各为54例，参考组患儿采用一对一语言训练，观察组患儿通过合理分组，进行小组语言训练，治疗6个月后采用Gesell测试量表对两组患儿的构音障碍测试及言语发育商进行比较，观察两组患儿临床治疗效果。结果两组患儿构音障碍测试及言语发育商比较差异无统计学意义（P〉O．05）；观察组患儿治疗总有效率为83．3％，参考组患儿治疗总有效率为85．2％，两组数据比较差异无统计学意义（P〉0．05）。结论脑瘫并语言障碍患儿采用小组语言训练与一对一语言训练效果无异，方便操作，有着显著的临床价值。     

语言认知康复系统对脑瘫儿童语言康复的效果

目的探讨语言认知康复系统在脑瘫儿童语言康复中的应用效果。方法选取焦作市妇幼保健院收治的84例脑瘫儿童作为研究对象,随机分为康复组和对照组,各42例,对照组患儿进行传统康复训练,康复组应用语言认知康复系统进行康复训练,比较两组患儿的语言康复效果。结果复组患儿的显效率、总有效率均显著高于对照组,差异均具有统计学意义(P<0.05)。结论在脑瘫儿语言康复训练中使用计算机语言认知康复系统,可有效改善构音肌群功能,强化语言康复效果,值得推广应用。     

小组语言训练应用于脑瘫合并语言障碍患儿的效果及对构音障碍的影响分析

目的:分析脑瘫合并语言障碍患儿应用小组语言训练模式干预后的效果。方法:采用随机数字表法将我院111例脑瘫合并语言障碍患儿分为两组,对照组(55例)给予一对一模式训练,观察组(56例)给予小组语言训练,对比两组患儿干预后的疗效、构音障碍及语言发育情况变化。结果:观察组总有效率(94.64%)高于对照组(81.82%),Gesell评分高于对照组(P<0.05)。结论:小组语言训练能够有效改善脑瘫合并语言障碍患儿的构音障碍,促进语言功能的恢复,节省临床人力物力。     

脑瘫患儿10例的语言训练方法

目的：观察脑性瘫痪患儿的语言康复训练的治疗效果。方法：10例脑瘫患儿在语言训练前和训练后的效果评价。结果：10例患儿都有所改善。结论：语言训练对有语言障碍的脑性瘫痪患儿是有效的．     

早期运动功能训练对脑瘫患儿语言功能及运动功能的影响

目的：探讨早期运动功能训练对脑瘫患儿语言功能及运动功能的影响。方法整群选取2013年1月—2014年6月期间92例确诊并在该院进行康复治疗的脑瘫患儿作为研究对象,采用随机数字表法分为两组各46例。对照组给予脑活素输注、针灸、水疗及高压氧等治疗,观察组联合应用早期运动功能强化训练(Bobath法)。比较两组患儿治疗效果及GMF评分。结果观察组治疗有效率明显高于对照组(93.48% vs 71.74%)(P<0.05)。观察组GMF评分明显低于对照组（38.62±4.22) vs (49.26±4.53）(P<0.01)。结论早期运动功能训练可明显改善并促进脑瘫患儿语言功能及运动功能,疗效确切,值得临床推广。     

趣味游戏语言康复训练在脑性瘫痪并语言发育迟缓患儿中的应用

目的观察趣味游戏语言康复训练在脑性瘫痪并语言发育迟缓患儿中的应用效果。方法选取2016年10月至2018年10月于郑州大学附属儿童医院就诊的85例脑瘫并语言发育迟缓患儿,根据入院时间段分为对照组(42例)和干预组(43例)。对照组接受传统语言康复训练,在此基础上,干预组接受趣味游戏语言康复训练。两组均干预3个月。比较两组干预前后Gesell发育诊断量表中语言能力和适应力两项的得分以及患儿家属工作满意度。结果干预后,干预组语言和适应力得分均高于对照组,差异有统计学意义(均P<0.05)。对照组和干预组总满意度分别为73.81%(31/42)、95.35%(41/43),干预组患儿家属工作满意度较对照组高,差异有统计学意义(P<0.05)。结论趣味游戏语言康复训练可有效提高脑瘫并语言发育迟缓患儿语言功能及适应力,提高患儿家属满意度。     

脑瘫合并语言发育迟缓伴构音障碍的语言治疗

目的探讨脑瘫伴语言发育迟缓和构音障碍儿童的语言治疗方法。方法采用中国康复研究中心制定的S-S语言发育迟缓检查法和构音障碍检查法,进行评定与疗效评价。结果治疗组15例,显效10例、有效4例、无效1例,显效率66.7%。对照组15例,显效7例、有效6例、无效2例,显效率46.7%。两组对比较差异有统计学意义(P0.05),治疗组疗效明显好于对照组。结论对脑瘫患儿进行语言的综合评定,根据评定结果制定个体化的语言治疗能改善患儿的交流态度,有效提高整体语言水平和言语发音的清晰度。     

脑外伤康复期语言交流障碍护理训练

目的探讨对脑外伤康复期患者行语言交流障碍护理训练所取得的临床效果。方法选择曾于新疆乌鲁木齐市友谊医院进行治疗的脑外伤患者40例，将这40例患者随机均分为观察组与对照组（n=20），当患者处于康复期时，对照组中患者利用常规方法来进行护理，观察组中患者在常规护理基础上对患者行语言交流障碍护理训练。在完成护理治疗后，观察患者治疗效果，对2组患者的语言交流功能恢复情况进行比较。结果2组患者除语言交流功能外，其它方面的治疗效果差异无统计学意义，均能完全康复，对2组患者的语言交流功能恢复情况进行比较，观察组中患者的有效率为90.O％，对照组中患者的有效率为70.0％，2组患者之间差异显著，具有统计学意义（P〈0.05）。结论脑外伤患者，在其康复期往往存在语言交流障碍，对患者行语言交流障碍护理训练能够取得较好的临床效果，可以使患者的语言交流障碍得到改善，尽快恢复语言交流功能，在临床上有重要作用和意义，值得在临床上进行推广。     

癫痫患儿伴语言障碍的语言训练

目的 提高癫痫伴语言障碍患儿的语言能力，协助其部分或完全恢复语言交流能力。方法 对30例3－6岁癫痫伴语言障碍患儿进行语言评价及有关训练，并指导家庭在家中协助治疗，每2个月进行小结。结果 经过1年的治疗，70％的语言发育迟缓患儿达到预期的训练目标，大部分构音障碍患儿得到矫正。结论 癫痫伴语言障碍患儿除药物治疗外，进行语言治疗是提高其生活质量的重要手段。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.