长脉宽翠绿宝石激光脱毛的影响因素探讨

目的：探讨长脉宽翠绿宝石激光脱毛的疗效和影响因素。方法：用Gentlelase长脉宽翠绿宝石755nm激光进行脱毛，对治疗的762例1750个部位的脱毛结果进行疗效评价，并探讨影响疗效的因素。结果：1750个部位经过3次以上治疗后，均达到理想的脱毛效果，治疗区毛发数量显著减少，剩余少许新生毛发直径变细，颜色变浅。各部位治疗次数及能量均不同，腋毛、阴毛、下肢及胸腹背部的毛发治疗效果较好，一般经过3～6次可结束治疗，胡须、发际效果较差，女性上唇毛效果最差。结论：长脉冲翠绿宝石激光采用适当能量密度进行脱毛治疗，能安全有效地脱去毛发，不良反应小，值得推广。     

长脉冲翠绿宝石激光脱毛并发症的防治

目的 探讨长脉冲翠绿宝石激光脱毛并发症的发生原因及防治方法 .方法 使用长脉冲翠绿宝石激光,波长755 nm,脉宽20 ms,光斑直径12.5 mm,对2 562例（3 279部位）美容就医者进行脱毛,治疗能量12.0～16.5 J/cm2,两次间隔时间50～60 d.结果 治疗期出现红斑、皮疹、瘙痒、水疱、色素沉着或色素减退、瘢痕等并发症共236例（242部位）,效果不佳6例.结论 长脉冲翠绿宝石激光脱毛是一种安全有效的脱毛方法 ,治疗中规范操作能减少并发症的发生率.     

长脉冲翠绿宝石激光脱毛并发症的防治

目的 探讨长脉冲翠绿宝石激光脱毛并发症的发生原因及防治方法 .方法 使用长脉冲翠绿宝石激光,波长755 nm,脉宽20 ms,光斑直径12.5 mm,对2 562例(3 279部位)美容就医者进行脱毛,治疗能量12.0～16.5 J/cm2,两次间隔时间50～60 d.结果 治疗期出现红斑、皮疹、瘙痒、水疱、色素沉着或色素减退、瘢痕等并发症共236例(242部位),效果不佳6例.结论 长脉冲翠绿宝石激光脱毛是一种安全有效的脱毛方法 ,治疗中规范操作能减少并发症的发生率.     

长脉冲翠绿宝石激光脱毛并发症的防治

目的 探讨长脉冲翠绿宝石激光脱毛并发症的发生原因及防治方法 .方法 使用长脉冲翠绿宝石激光,波长755 nm,脉宽20 ms,光斑直径12.5 mm,对2 562例(3 279部位)美容就医者进行脱毛,治疗能量12.0～16.5 J/cm2,两次间隔时间50～60 d.结果 治疗期出现红斑、皮疹、瘙痒、水疱、色素沉着或色素减退、瘢痕等并发症共236例(242部位),效果不佳6例.结论 长脉冲翠绿宝石激光脱毛是一种安全有效的脱毛方法 ,治疗中规范操作能减少并发症的发生率.     

长脉冲翠绿宝石激光永久性脱毛疗效分析

目的评价长脉冲翠绿宝石激光对人体不同部位永久性脱毛的疗效。方法用Gentle LASE脉冲激光对身体各部位进行脱毛,回顾性分析达到永久性脱毛效果的298个部位的脱毛情况。结果5次脱毛后,四肢、腋窝脱毛率平均为82.50%~94.00%,男性腮部和女性唇周平均分别为82.50%、85.00%;而4次脱毛后,发际、骶部脱毛率平均分别为92.56%、94.87%。男性腮部和女性唇周5次脱毛后,脱毛率分别与其他各组之间两两比较差异均有统计学意义(P<0.05);而男性腮部和女性唇周之间,以及其他各组之间两两比较,差异均无统计学意义(P>0.05)。脱毛后,各部位毛发再生延迟,且随脱毛次数增加而延迟时间愈长(r为0.33~0.80)。男性腮部和女性唇周总脱毛次数较多,平均分别为8.00次和7.31次,次数多于其余各部位,效果差异有统计学意义(P<0.05),其余7组脱毛次数平均为3.25~4.83次,各组之间比较,差异无统计学意义(P>0.05)。总不良反应发生率为7.38%。结论长脉冲翠绿宝石激光对四肢、腋窝、发际脱毛效果较好,疗效优于女性唇周和男性腮部;随脱毛次数增多毛发再生延迟。     

激光脱毛效果欠佳因素的分析与对策

目的观察长脉冲波长为755nm翠绿宝石激光G脱毛的效果，分析造成部分病例治疗效果欠佳的可能因素。方法应用长脉冲翠绿宝石激光，波长755nm，光斑直径1．0cm，根据不同的皮肤类型及治疗部位选用不同治疗参数，胡须、腋毛、上肢首次能量密度分别是12～16J、16～18J、12～18J，下肢首次能量18～20J，比基尼首次能量密度16～18J。结果本组患者935例，758例疗效满意，177例疗效欠佳。疗效欠佳的部位多为男性颌面部，女性的眉毛、上唇与发际线。结论激光脱毛是安全、高效的脱毛方法。不同的皮肤类型和部位的毛发及不同的治疗周期，均会影响治疗效果。为临床上制定个性化的治疗方案提供参考。     

长脉冲紫翠宝石激光脱除多余体毛320例疗效分析

目的：评估长脉冲紫翠宝石激光对于脱毛的治疗效果。方法：使用波长为755nm的长脉冲紫翠宝石激光时320例门诊患者的不同部位、不同类型的体毛进行多次治疗，并按不同部位和类型分组，分析疗效。结果：经过多次治疗后，总有效率96．8％，仅1例出现暂时性色素沉着；疗效与治疗次数成正比，与治疗部位的毛发性质也相关。结论：使用长脉冲紫翠宝石激光脱毛效果良好，并发症少，是目前较为理想的脱毛方法。     

激光脱毛效果欠佳因素的分析与对策

目的 观察长脉冲波长为755 nm翠绿宝石激光G脱毛的效果,分析造成部分病例治疗效果欠佳的可能因素.方法 应用长脉冲翠绿宝石激光,波长755 nm,光斑直径1.0 cm,根据不同的皮肤类型及治疗部位选用不同治疗参数,胡须、腋毛、上肢首次能量密度分别是12～16 J、16～18 J、12～18 J,下肢首次能量18～20 J,比基尼首次能量密度16～18 J.结果 本组患者935例,758例疗效满意,177例疗效欠佳.疗效欠佳的部位多为男性颌面部,女性的眉毛、上唇与发际线.结论 激光脱毛是安全、高效的脱毛方法,不同的皮肤类型和部位的毛发及不同的治疗周期,均会影响治疗效果.为临床上制定个性化的治疗方案提供参考.     

长脉冲Nd:YAG 1064nm激光治疗耳廓再造术后耳廓脱毛的疗效观察

激光脱毛是目前最常用的体表脱毛方法,以往的报道以半导体激光和翠绿宝石激光为多[1-2]。耳后乳突区皮肤扩张法进行耳廓再造是一种新型的耳廓再造方法[3],该方法的最大弊端是再造耳廓皮肤常有头发残留,需常规接受术后脱毛治疗。2009年2月～2011年6月,笔者科室利用长脉冲可调脉宽YAG 1064nm激光治疗仪对60例耳再造术后耳廓多毛患     

长脉冲翠绿宝石激光治疗微静脉畸形的临床分析

目的：探讨长脉冲翠绿宝石激光治疗微静脉畸形的临床疗效及并发症发生情况,并与长脉冲染料激光进行比较。方法：应用长脉冲翠绿宝石激光和长脉冲染料激光治疗微静脉畸形11例,其中一半皮损用长脉冲翠绿宝石激光治疗,另一半皮损用长脉冲染料激光进行治疗,观察皮损红斑消退及并发症发生情况。结果：长脉冲翠绿宝石激光可有效地治疗微静脉畸形,治疗后3例发生色素沉着,1例发生色素脱失;而长脉冲染料激光治疗后2例发生色素沉着。两者治疗后均无瘢痕形成。结论：应用长脉冲翠绿宝石激光治疗微静脉畸形疗效显著,主要适用于隆起性、暗紫色的皮损,而长脉冲染料激光适用于扁平的淡红色皮损。     

Long-pulsed alexandrite laser-assisted hair removal at 5, 10, and 20 millisecond pulse durations.

BACKGROUND: Several laser systems with varying wavelengths, pulse durations, and energy fluences are currently utilized for hair removal. However, the ideal laser parameters and treatment candidates for photoepilation remain largely unknown. The medical literature lacks a wealth of experimental data to sufficiently document the long-term safety and efficacy of laser-assisted hair removal. This study examines the clinical efficacy and side effect profile of long-pulsed alexandrite laser-assisted hair removal utilizing laser pulse durations of either 5, 10, or 20 milliseconds (ms). STUDY DESIGN/METHODS: Laser-assisted hair removal was performed on 36 subjects with a long-pulsed alexandrite laser. Areas of unwanted hair growth on the face, back, and legs were divided linearly into four 1 cm2 or 2 cm2 quadrants. Experimental regions included a control quadrant and three additional quadrants, which were treated with the alexandrite laser using an average fluence of 18 J/cm2, with a 10 mm spot size at either a 5, 10, or 20 ms pulse duration. Hair counts and photographs were obtained before treatment, immediately following irradiation, 1 week and 1, 3, and 6 months postoperatively. RESULTS: All laser-treated quadrants displayed a significant delay in hair regrowth compared to control nontreated quadrants at postoperative week 1 and months 1 and 3. Hair counts were reduced by 66% at 1 month, 27% at 3 months, and 4% at 6 months. No significant differences in clinical efficacy or side effect profiles were observed between treatment quadrants, yet a trend towards less post-treatment erythema and hyperpigmentation was noted with the 20 ms pulse duration. CONCLUSIONS: Equivalent long-term hair removal for up to 6 months was achieved with the long-pulsed alexandrite laser at 5, 10, and 20 ms pulse durations at an average fluence of 18 J/cm2. Side effects were limited and transient.     

Long-Pulsed 1064-nm Nd:YAG Laser-Assisted Hair Removal in All Skin Types

BACKGROUND: Although there are several different laser systems available for the reduction of unwanted hair, no single system has been shown to be superior in providing safe and effective hair removal in every skin type. The purpose of this study was to evaluate the safety and efficacy of a high-energy, long-pulsed, 1064-nm Nd:YAG laser with a contact cooling device for hair removal in skin phototypes I-VI. METHODS: Thirty-six adult patients (skin phototypes I-VI) with dark terminal facial or nonfacial hair were treated with a long-pulsed Nd:YAG laser (1064 nm, 10-mm spot size, fluence of 30 to 60 J/cm2). The selected pulse duration was dependent on the skin type of the patient: Skin types I/II, III/IV, and V/VI received 10, 20, and 30 ms, respectively. Three consecutive laser treatments were delivered to 36 skin sites at 4- to 6-week intervals. Hair counts and photographic evaluations of skin sites were obtained at baseline, immediately before each treatment session, and at 1, 3, and 6 months after the final laser treatment. RESULTS: Peak hair reduction was observed 1 month after the series of laser treatments with a mean hair reduction ranging from 58% to 62% on facial sites and 66% to 69% on nonfacial sites. At 6 months after a series of three long-pulsed Nd:YAG laser treatments, a mean hair reduction of 41% to 46% on the face and 48% to 53% on the body was found depending on the skin phototype. Adverse reactions included mild to moderate treatment pain, short-term erythema, and rare occurrences of transient pigmentary alteration without scarring. CONCLUSION: The long-pulsed 1064-nm Nd:YAG laser with contact cooling is a safe and effective method of hair reduction in patients of all skin types. Side effects were limited and transient.     

Laser depilation of the natal cleft--an aid to healing the pilonidal sinus

BACKGROUND: Pilonidal disease is common. Excessive hair growth in the natal cleft is thought to be a factor in initiating these sinuses. It is chronic and intermittent in nature and treatment can be difficult. Hair removal by shaving or use of creams is often advised as a compliment to surgical treatments. However, access to the natal cleft can be difficult. Laser removal of hair in the natal cleft is considered as an aid to healing the pilonidal sinus. PATIENTS AND METHODS: Over a 5-year period, 14 patients with recurrent pilonidal disease were treated in our unit with laser depilation. They were all contacted by postal questionnaire, and those with ongoing disease were asked to return to the clinic for evaluation and possible further treatment. RESULTS: All patients returned the postal questionnaire. Of the 14 patients, 4 had on-going disease and received further depilation with the Alexandrite laser. All are now healed with no reported complications. All patients found the procedure painful and received local anaesthetic. CONCLUSIONS: Laser depilation in the natal cleft is by no means a cure for pilonidal disease. Removal of hair by this method represents an alternative and effective method of hair removal and, although long lasting, is only temporary. However, it allows the sinuses to heal rapidly. It is relatively safe, and simple to teach, with few complications. It should thus be considered as an aid to healing the problem pilonidal sinus.     

两种波长的激光对不同肤色脱毛的效果分析

目的评价长脉冲激光对不同肤色脱毛的疗效和安全性。方法用波长755nm和1064nm的激光对607例不同肤色患者脱毛4次后观察疗效及出现的不良反应。结果两种激光对女性唇部体毛和男性胡须的有效率虽相差不大,但其所产生不良反应差别却很明显,还发现肤色分型为Ⅰ型、Ⅱ型和Ⅳ型、Ⅴ型两种激光所产生的有效率和不良反应也差别很明显,其差异具有统计学意义（P〈0．05）。结论波长755nm的激光对肤色越浅的患者（Ⅰ型、Ⅱ型）治疗的效果好及所产生的不良反应发生率低;而波长1064nm的激光对肤色越深的患者（Ⅲ型以上）治疗效果好,所产生的不良反应发生率低。     

Comparing 18- Versus 12-mm Spot Size in Hair Removal Using a Gentlease 755-nm Alexandrite Laser

Background. Laser epilation is based on the principle of selective photothermolysis, absorption of laser energy by the target chromophore melanin. It is claimed that larger spot sizes may be more effective for hair removal at identical fluences.
Objective. To compare the efficacy of 18- vs. 12-mm spot size in hair removal using a Gentlelase Alexandrite laser from Candela Corporation (Boston, MA).
Methods. In this double-blind, randomized control trial, patients underwent laser-assisted hair removal on the axillary region. Regions were randomly selected and treated with either an 18- or a 12-mm spot size. Three treatments at 6-week intervals with a 755-nm Gentlelase Alexandrite laser (Candela Corp., Canton, MA) at a fluence of 16 J/cm² with cooling and delay times of 60 ms. Hair counts were taken before each treatment session and compared. The mean percentage hair reduction and student's paired t -test were used to compare 18 versus 12 mm versus control sites at each visit and compared it with the baseline hair count.
Results. There was a 10.3% difference in mean reduction favoring the 18-mm spot size treated area at the 6-month follow-up.
Conclusion. Our results indicate that a larger spot size appears to be more effective for laser assisted hair removal.     

Comparison of Long-Pulsed Diode and Long-Pulsed Alexandrite Lasers for Hair Removal: A Long-Term Clinical and Histologic Study

BACKGROUND: Unwanted facial and body hair is a common problem, generating a high level of interest for treatment innovations. Advances in laser technology over the past several years has led to the development and distribution of numerous red and infrared lasers and light sources to address this issue. Despite the impressive clinical results that have been reported with the use of individual laser hair removal systems, long-term comparative studies have been scarce. OBJECTIVE: To compare the clinical and histologic efficacy, side effect profile, and long-term hair reduction of long-pulsed diode and long-pulsed alexandrite laser systems. METHODS: Twenty women with Fitzpatrick skin types I-IV and dark terminal hair underwent three monthly laser-assisted hair removal sessions with a long-pulsed alexandrite laser (755 nm, 2-msec pulse, 10 mm spot) and a long-pulsed diode laser (800 nm, 12.5 msec or 25 msec, 9 mm spot). Axillary areas were randomly assigned to receive treatment using each laser system at either 25 J/cm2 or 40 J/cm2. Follow-up manual hair counts and photographs of each area were obtained at each of the three treatment visits and at 1, 3, and 6 months after the final laser session. Histologic specimens were obtained at baseline, immediately after the initial laser treatment, and 1 and 6 months after the third treatment session. RESULTS: After each laser treatment, hair counts were successively reduced and few patients found it necessary to shave the sparsely regrown hair. Optimal clinical response was achieved 1 month after the second laser treatment, regardless of the laser system or fluence used. Six months after the third and final treatment, prolonged clinical hair reduction was observed with no significant differences between the laser systems and fluences used. Histologic tissue changes supported the clinical responses observed with evidence of initial follicular injury followed by slow follicular regeneration. Side effects, including treatment pain and vesiculation, were rare after treatment with either laser system, but were observed more frequently with the long-pulsed diode system at the higher fluence of 40 J/cm2. CONCLUSION: Equivalent clinical and histologic responses were observed using a long-pulsed alexandrite and a long-pulsed diode laser for hair removal with minimal adverse sequelae. While long-term hair reduction can be obtained in most patients after a series of laser treatments, partial hair regrowth is typical within 6 months, suggesting the need for additional treatments to improve the rate of permanent hair removal.     

Evaluation of a Long-Pulsed Nd:YAG Laser at Different Parameters: An Analysis of Both Fluence and Pulse Duration

BACKGROUND: Effective hair removal continues to pose a challenge to the physician. The use of lasers represents a significant advance in epilation, but still requires further refinement. The long-pulsed Nd:YAG laser may offer advantages over other systems because of its significant depth of penetration and minimal absorption by epidermal melanin, but ideal parameters need to be determined. OBJECTIVE: To evaluate the efficacy of a long-pulsed Nd:YAG laser system and determine the optimal parameters for hair removal. METHODS: Twenty-two subjects were treated with a cryogen spray-cooled long-pulsed Nd:YAG laser. Four adjacent sites were assigned to each subject, where the following sets of parameters were utilized: 50 J/cm2 with a 25-msec pulse duration, 60 J/cm2 with a 50-msec pulse duration, 80 J/cm2 with a 50-msec pulse duration, and control. Hair counts were obtained immediately, 1 week, 1 month, and 3 months after treatment, and multivariate regression analysis was used to determine the significance of hair reduction. Acute reactions and adverse events were also evaluated. RESULTS: Treatment at all three sets of parameters resulted in significant mean hair reductions immediately, at 1 week, and at 1 month (P <.001). At 3 months, the higher settings of 60 J/cm2 and 50 msec and 80 J/cm2 and 50 msec were statistically significant for reduced mean hair counts (P =.014, P =.042, respectively), while the lowest setting at 50 J/cm2 and 25 msec was not significant (P =.079). Patient and physician assessments suggested optimal hair reduction at the highest fluence (80 J/cm2) and longest pulse duration (50 msec). The most common acute reactions were pain during treatment, erythema, and perifollicular edema, all of which were more severe with higher fluences. CONCLUSION: The long-pulsed Nd:YAG laser is a safe and effective method of hair removal. Increased fluence (60-80 J/cm2) and longer pulse duration (50 msec) settings were generally correlated with reduced hair counts and improved clinical outcome.     

Control of hair growth using long-pulsed alexandrite laser is an efficient and cost effective therapy for patients suffering from recurrent pilonidal disease

Pilonidal sinus (PNS) and its surgical management have a profound impact on hospital resources in terms of finances and productive man-hours. Surgical treatment has been the mainstay of treatment of both acute and chronic pilonidal sinus but recurrence is common. The control of hair growth in the sinus region plays an important role in preventing recurrence. Here, we discuss our experience of treating 19 patients suffering from recurrent pilonidal sinus with laser depilation and its long-term cost effectiveness. This is a retrospective study on patients who had recurrence of pilonidal sinus following multiple surgical treatments. They were treated using long-pulsed alexandrite laser for depilation in the sinus area, an outpatient procedure. Their clinical characteristics and outcomes were then evaluated. There was a significant reduction in hair density after laser treatment (p?<?0.001). The disease-free period after laser treatment was significantly longer than that one after surgical treatment (p?<?0.001). The average cost of repeated surgical treatment per disease-free month was significantly higher than that of laser treatment (p?<?0.001). Evidence suggests the role of natal cleft hair growth in the evolution of the pilonidal disease; therefore, control of hair growth should be considered as an adjunct to the initial treatment via surgery. Compared to surgical treatment of recurrences, laser depilation is an efficient and cost-effective method of preventing recurrence and reducing morbidity and loss of man-hours. We suggest that laser depilation of the pilonidal sinus should be funded by clinical commissioning groups.     

Hair Removal Using a 5-msec Long-Pulsed Ruby Laser

BACKGROUND: Unwanted hair is a widespread cosmetic problem. Many temporary methods of hair removal exist, with laser hair removal rapidly becoming the most widely used modality. OBJECTIVES: Our objective was to evaluate the efficacy and side effects of a long-pulsed ruby laser for epilation in patients with varying skin types and hair color 6 weeks and 6 months after treatment. METHODS: Seventy-four patients received one to four treatments with a long-pulsed ruby laser (694 nm, 5-msec pulse length, 6 mm spot size, 17.5-32 J/cm2) in different body areas. RESULTS: After a mean number of treatments of 1.98 (range 1-4) the mean clearance was 51-75% after 6 weeks and less than 25% after 6 months. A lower percentage of hair regrowth was observed in the facial region than on the trunk or legs and in dark hair compared to blond hair. CONCLUSION: Laser epilation provides a quick and relatively comfortable, but nonpermanent modality for hair removal with few side effects.     

Laser Hair Removal

BACKGROUND: The mechanism and permanence of laser-assisted hair removal remains a formidable task in the medical community. OBJECTIVE: The purpose of this study was to determine the safety and long-term efficacy of the long-pulsed or normal mode alexandrite infrared laser for hair depilation. METHODS: Beginning in October 1996, a total of 31 anatomic sites on 22 patients ranging in age from 25 to 59 years (mean 42 years) were evaluated to assess hair removal. Treatment sites included 17 upper lips, 9 legs, 2 backs, and 3 bikini regions. Eligible patients were of Fitzpatrick skin types I-III. Patients were treated using the long-pulsed alexandrite infrared laser at 755 nm, single-pulse technique, 10 mm spot size, 10% overlap, pulse durations of 5, 10, and 20 msec, and a fluence of 20 J/cm2. Subjective patient improvement and objective, blinded graded improvement was assessed at 1, 2, 3, and 6 months. RESULTS: Objective blinded grading at 6 months revealed that hair reduction varied both with the pulse duration and anatomic location. Maximum reductions observed were 40%, 56%, 50%, and 15% for the lip, leg, back, and bikini areas, respectively. Upper lip hair reduction increased from 40% to 54% at 6 months when a second treatment was performed 8 weeks after the initial treatment. CONCLUSION: The long-pulsed alexandrite laser is safe and effective in reducing hair growth. Treatment efficacy varies with the anatomic location, pulse duration, and number of treatments. A single-pulse technique utilizing a 10 msec pulse duration at 20 J/cm2 produced the greatest hair reduction. No permanent adverse effects occurred on skin types I-III at the parameters tested.