成人线状IgA大疱性皮病1例

临床资料患者男,75岁。因全身起红斑水疱伴瘙痒4个月,加重1个月,于2005年12月14日收入我科。患者4个月前无明显诱因于胸部出现散在红斑,自觉瘙痒,皮疹逐渐增多,扩展至躯干、四肢,红斑部分融合,并在红斑基础上出现绿豆至蚕豆大小水疱,在外院病理活检提示为“表皮下水疱”,诊断为     

呈肿块样损害的腋窝乳房外Paget 病1例

1 病历摘要 患者女,89 岁.因右侧腋下红斑12 年,出现肿块7年于2009年8 月入院.患者于12年前无明显诱因右侧腋下出现一米粒大红斑,伴瘙痒,无红肿疼痛,红斑缓慢扩大,在外院多次按皮肤感染治疗无效.于7 年前红斑明显扩大,且中央出现肿块,表面潮湿,自觉瘙痒,偶有疼痛.病程中患者无发热、体重减轻等其他不适.既往有原发性高血压病史10 年.否认内脏肿瘤病史,家族史无特殊.     

女性单侧腋窝乳房外佩吉特病1例

<正>1 病历摘要患者女,59岁。因左腋窝出现丘疹、斑块伴瘙痒7年,加重3个月于2017年6月2日至我科就诊。7年前,患者无明显诱因左腋窝出现红斑、丘疹,伴明显瘙痒,无水疱、大疱、糜烂及渗出等,无畏寒、发热、咳嗽及     

以多形红斑为表现的疱疹样天疱疮1例

患者女,70岁。因全身反复出现环状红斑、水疱,伴瘙痒1个月余,于2005年6月22日收入我院。1个月前患者无明显诱因双下肢出现散在豆大红斑,瘙痒明显。红斑逐渐向外扩大成环状,中心部位红斑不消退,且很快变成水疱,易破溃,不久破溃而干燥。[第一段]     

表现为蝶形红斑的寻常狼疮1例

<正>患者女,57岁。面部红斑、斑块及结节伴瘙痒3个月。3个月前无明显诱因双侧颊部出现红斑,呈蝶形分布,自觉瘙痒,日晒后皮损无明显加重。就诊于当地医院考虑亚急性皮肤型红斑狼疮,予口服雷公藤多苷和泼尼松,以及外用丁酸氢化可的松软膏治疗,1个月后红斑面积扩大累及整个面部,出现斑块及结节,自觉瘙痒,为进一步诊治,遂于2014年9月25日来我科就诊。患者发病以来无发热、盗汗和咳嗽,无体重减     

急性苔藓痘疮样糠疹1例

1病历摘要 患儿男,14岁.因全身出现红斑、丘疹、鳞屑伴瘙痒2个月余,于2008年11月1日来我院就诊.2个多月前患儿无明显诱因腹部起鳞屑性红斑、丘疹,伴瘙痒,渐累及全身.     

蕈样肉芽肿

1 临床资料 患者男,70岁.因全身红斑、斑块,伴瘙痒7年,加重3个月就诊.7年前无明显诱因患者双髋及胸部出现许多红斑,伴剧烈瘙痒,以夜间为甚.皮损逐渐增多,累及躯干、四肢,在当地医院诊断为湿疹,予以中药口服及糖皮质激素外用,皮损可部分缓解,但不能完全消退.3个月前无明显诱因皮损突然增大、增多,泛发全身,自觉剧烈瘙痒,遂就诊于我科.患者自发病以来无发热,精神及食欲好,两便正常,体重无明显改变.2年前因胃溃疡在外院行胃大部切除术.     

结节性类天疱疮一例

患者男,34岁,因反复全身红斑、结节伴瘙痒11个月,双手足背部水疱9个月,加重20 d于2018年9月25日就诊于我院。2017年11月无明显诱因躯干、四肢逐渐出现多发大小不等红斑、结节,伴剧烈瘙痒,经“复方甘草酸苷、头孢菌素类抗生素（具体不详）等”输液治疗15 d后,皮疹数量减少,瘙痒较前减轻……     

可变性红斑角化病1例

可变性红斑角化病是一种罕见的遗传病.我科收治1例典型病例,但无阳性家族史,现报告如下. 患者男,22岁.因全身起红斑、脱屑伴瘙痒20年余,于2009年4月7日来我科门诊就诊.患者3个月大时于双上肢出现红斑,上覆少许鳞屑,伴明显瘙痒,于当地各医院就诊,给予治疗后(具体药物不详)无明显好转,并蔓延至四肢、面部,逐渐加重.     

疱疹样天疱疮一例报告

患者男,44岁.全身起瘙痒性红斑、水疱7个月.患者于7个月前无诱因发生双腋下铜钱大小暗红色斑疹,瘙痒.7月后于前胸,后背出现同样皮损,并有散在黄豆大小红丘疹.曾用磺胺类、抗组织胺类药物及中药等治疗无效.     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Self‐resolving superficial primary cutaneous mucormycosis in a 7‐week‐old infant

A 7‐week‐old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self‐resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.